-
1
-
-
33751244559
-
Identification of an Intestinal Folate Transporter and the Molecular Basis for Hereditary Folate Malabsorption
-
DOI 10.1016/j.cell.2006.09.041, PII S009286740601347X
-
A. Qiu, M. Jansen, A. Sakaris, S.H. Min, S. Chattopadhyay, E. Tsai, C. Sandoval, R. Zhao, M.H. Akabas, I.D. Goldman, Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption, Cell 127 (2006) 917-928. (Pubitemid 44792250)
-
(2006)
Cell
, vol.127
, Issue.5
, pp. 917-928
-
-
Qiu, A.1
Jansen, M.2
Sakaris, A.3
Min, S.H.4
Chattopadhyay, S.5
Tsai, E.6
Sandoval, C.7
Zhao, R.8
Akabas, M.H.9
Goldman, I.D.10
-
2
-
-
0036143484
-
Hereditary folate malabsorption: Family report and review of the literature
-
J. Geller, D. Kronn, S. Jayabose, C. Sandoval, Hereditary folate malabsorption: family report and review of the literature, Med. Baltim. 81 (2002) 51-68.
-
(2002)
Med. Baltim.
, vol.81
, pp. 51-68
-
-
Geller, J.1
Kronn, D.2
Jayabose, S.3
Sandoval, C.4
-
3
-
-
84875168040
-
Hereditary folate malabsorption
-
R.A. Pagon, T.C. Bird, C.R. Dolan, K. Stephens (Eds.) Internet, University of Washington, Seattle, Seattle, WA
-
K.M. Mahadeo, S.H. Min, N. Diop-Bove, D. Kronn, I.D. Goldman, Hereditary folate malabsorption, in: R.A. Pagon, T.C. Bird, C.R. Dolan, K. Stephens (Eds.), GeneReviews [Internet], University of Washington, Seattle, Seattle, WA, 2010.
-
(2010)
, GeneReviews
-
-
Mahadeo, K.M.1
Min, S.H.2
Diop-Bove, N.3
Kronn, D.4
Goldman, I.D.5
-
4
-
-
34548026299
-
The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption
-
R. Zhao, S.H. Min, A. Qiu, A. Sakaris, G.L. Goldberg, C. Sandoval, J.J. Malatack, D.S. Rosenblatt, I.D. Goldman, The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption, Blood 110 (2007) 1147-1152.
-
(2007)
Blood
, vol.110
, pp. 1147-1152
-
-
Zhao, R.1
Min, S.H.2
Qiu, A.3
Sakaris, A.4
Goldberg, G.L.5
Sandoval, C.6
Malatack, J.J.7
Rosenblatt, D.S.8
Goldman, I.D.9
-
5
-
-
49349106476
-
The clinical course and genetic defect in the PCFT in a 27-year-old woman with hereditary folate malabsorption
-
S.H. Min, S.Y. OH, G.I. Karp, M. Poncz, R. Zhao, I.D. Goldman, The clinical course and genetic defect in the PCFT in a 27-year-old woman with hereditary folate malabsorption, J. Pediatr. 153 (2008) 435-437.
-
(2008)
J. Pediatr.
, vol.153
, pp. 435-437
-
-
Min, S.H.1
Oh, S.Y.2
Karp, G.I.3
Poncz, M.4
Zhao, R.5
Goldman, I.D.6
-
6
-
-
78349241039
-
Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorption
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K. Mahadeo, N. Diop-Bove, D. Shin, E. Unal, J. Teo, R. Zhao, M.H. Chang, A. Fulterer, M.F. Romero, I.D. Goldman, Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorption, Am. J. Physiol. Cell Physiol. 299 (2010) C1153-C1161.
-
(2010)
Am. J. Physiol. Cell Physiol.
, vol.299
-
-
Mahadeo, K.1
Diop-Bove, N.2
Shin, D.3
Unal, E.4
Teo, J.5
Zhao, R.6
Chang, M.H.7
Fulterer, A.8
Romero, M.F.9
Goldman, I.D.10
-
7
-
-
78650055833
-
Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT; SLC46A1); a D156Y mutation causing hereditary folate malabsorption
-
D.S. Shin, S.H. Min, L. Russell, R. Zhao, A. Fiser, I.D. Goldman, Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT; SLC46A1); a D156Y mutation causing hereditary folate malabsorption, Blood 116 (2010) 5162-5169.
-
(2010)
Blood 116
, pp. 5162-5169
-
-
Shin, D.S.1
Min, S.H.2
Russell, L.3
Zhao, R.4
Fiser, A.5
Goldman, I.D.6
-
8
-
-
52649117496
-
A novel loss of function mutation in the proton-coupled folate transporter from a patient with hereditary folate malabsorption reveals that Arg 113 is crucial for function
-
I. Lasry, B. Berman, R. Straussberg, Y. Sofer, H. Bessler, M. Sharkia, F. Glaser, G. Jansen, S. Drori, Y.G. Assaraf, A novel loss of function mutation in the proton-coupled folate transporter from a patient with hereditary folate malabsorption reveals that Arg 113 is crucial for function, Blood 112 (2008) 2055-2061.
-
(2008)
Blood
, vol.112
, pp. 2055-2061
-
-
Lasry, I.1
Berman, B.2
Straussberg, R.3
Sofer, Y.4
Bessler, H.5
Sharkia, M.6
Glaser, F.7
Jansen, G.8
Drori, S.9
Assaraf, Y.G.10
-
9
-
-
70350613227
-
Reversible severe combined immunodeficiency phenotype secondary to a mutation of the proton-coupled folate transporter
-
A. Borzutzky, B. Crompton, A.K. Bergmann, S. Giliani, S. Baxi, M. Martin, E.J. Neufeld, L.D. Notarangelo, Reversible severe combined immunodeficiency phenotype secondary to a mutation of the proton-coupled folate transporter, Clin. Immunol. 133 (2009) 287-294.
-
(2009)
Clin. Immunol.
, vol.133
, pp. 287-294
-
-
Borzutzky, A.1
Crompton, B.2
Bergmann, A.K.3
Giliani, S.4
Baxi, S.5
Martin, M.6
Neufeld, E.J.7
Notarangelo, L.D.8
-
10
-
-
76349112934
-
A novel PCFT gene mutation (p.Cys66LeufsX99) causing hereditary folate malabsorption
-
E. Meyer, M.A. Kurian, S. Pasha, R.C. Trembath, T. Cole, E.R. Maher, A novel PCFT gene mutation (p.Cys66LeufsX99) causing hereditary folate malabsorption, Mol. Genet. Metab. 99 (2010) 325-328.
-
(2010)
Mol. Genet. Metab.
, vol.99
, pp. 325-328
-
-
Meyer, E.1
Kurian, M.A.2
Pasha, S.3
Trembath, R.C.4
Cole, T.5
Maher, E.R.6
-
11
-
-
50549085728
-
The proton-coupled folate transporter (PCFT): Impacton pemetrexed transport andon antifolate activities as compared to the reduced folate carrier
-
R. Zhao, A. Qiu, E. Tsai, M. Jansen, M.H. Akabas, I.D. Goldman, The proton-coupled folate transporter (PCFT): impacton pemetrexed transport andon antifolate activities as compared to the reduced folate carrier, Mol. Pharmacol. 74 (2008) 854-862.
-
(2008)
Mol. Pharmacol.
, vol.74
, pp. 854-862
-
-
Zhao, R.1
Qiu, A.2
Tsai, E.3
Jansen, M.4
Akabas, M.H.5
Goldman, I.D.6
-
12
-
-
33847364471
-
Pemetrexed: Biochemical and cellular pharmacology, mechanisms, and clinical applications
-
DOI 10.1158/1535-7163.MCT-06-0343
-
S. Chattopadhyay, R.G. Moran, I.D. Goldman, Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications, Mol. Cancer Ther. 6 (2007) 404-417. (Pubitemid 46332443)
-
(2007)
Molecular Cancer Therapeutics
, vol.6
, Issue.2
, pp. 404-417
-
-
Chattopadhyay, S.1
Moran, R.G.2
Goldman, I.D.3
-
13
-
-
79952738916
-
The antifolates: Evolution, new agents in the clinic, and how targeting delivery via specific membrane transporters is driving the development of a next generation of folate analogs
-
I.D. Goldman, S. Chattopadhyay, R. Zhao, R.G. Moran, The antifolates: evolution, new agents in the clinic, and how targeting delivery via specific membrane transporters is driving the development of a next generation of folate analogs, Curr. Opin. Investig. Drugs 11 (2010) 1409-1423.
-
(2010)
Curr. Opin. Investig. Drugs
, vol.11
, pp. 1409-1423
-
-
Goldman, I.D.1
Chattopadhyay, S.2
Zhao, R.3
Moran, R.G.4
-
14
-
-
77957224999
-
Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2, 3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors
-
D.S. Kugel, Y. Wang, J. Wu, M. Stout, Z. Hou, A. Fulterer, M.H. Chang, M. Romero, C. Cherian, A. Gangjee, L. Matherly, Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2, 3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors, Mol. Pharmacol. 78 (2010) 577-587.
-
(2010)
Mol. Pharmacol.
, vol.78
, pp. 577-587
-
-
Kugel, D.S.1
Wang, Y.2
Wu, J.3
Stout, M.4
Hou, Z.5
Fulterer, A.6
Chang, M.H.7
Romero, M.8
Cherian, C.9
Gangjee, A.10
Matherly, L.11
-
15
-
-
77950400117
-
Membrane topological analysis of the proton-coupled folate transporter (PCFT-SLC46A1) by the substituted cysteine accessibility method
-
R. Zhao, E.S. Unal, D.S. Shin, I.D. Goldman, Membrane topological analysis of the proton-coupled folate transporter (PCFT-SLC46A1) by the substituted cysteine accessibility method, Biochemistry 49 (2010) 2925-2931.
-
(2010)
Biochemistry
, vol.49
, pp. 2925-2931
-
-
Zhao, R.1
Unal, E.S.2
Shin, D.S.3
Goldman, I.D.4
-
16
-
-
43649088482
-
N-linked glycosylation and its impact on the electrophoretic mobility and function of the human proton-coupled folate transporter (HsPCFT)
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E.S. Unal, R. Zhao, A. Qiu, I.D. Goldman, N-linked glycosylation and its impact on the electrophoretic mobility and function of the human proton-coupled folate transporter (HsPCFT), Biochim. Biophys. Acta 1178 (2008) 1407-1414.
-
(2008)
Biochim. Biophys. Acta
, vol.1178
, pp. 1407-1414
-
-
Unal, E.S.1
Zhao, R.2
Qiu, A.3
Goldman, I.D.4
-
17
-
-
36048936881
-
Rodent intestinal folate transporters (SLC46A1): Secondary structure, functional properties, and response to dietary folate restriction
-
A. Qiu, S.H. Min, M. Jansen, U. Malhotra, E. Tsai, D.C. Cabelof, L.H. Matherly, R. Zhao, M.H. Akabas, I.D. Goldman, Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction, Am. J. Physiol. Cell Physiol. 293 (2007) C1669-C1678.
-
(2007)
Am. J. Physiol. Cell Physiol.
, vol.293
-
-
Qiu, A.1
Min, S.H.2
Jansen, M.3
Malhotra, U.4
Tsai, E.5
Cabelof, D.C.6
Matherly, L.H.7
Zhao, R.8
Akabas, M.H.9
Goldman, I.D.10
-
18
-
-
0842304934
-
A prominent low-pH methotrexate transport activity in human solid tumor cells: Contribution to the preservation of methotrexate pharmacological activity in HeLa cells lacking the reduced folate carrier
-
R. Zhao, F. Gao, M. Hanscom, I.D. Goldman, A prominent low-pH methotrexate transport activity in human solid tumor cells: contribution to the preservation of methotrexate pharmacological activity in HeLa cells lacking the reduced folate carrier, Clin. Cancer Res. 10 (2004) 718-727.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 718-727
-
-
Zhao, R.1
Gao, F.2
Hanscom, M.3
Goldman, I.D.4
-
19
-
-
68849117681
-
Hypermethylation of the human proton-coupled folate transporter (SLC46A1) minimal transcriptional regulatory region in an antifolate-resistant HeLa cell line
-
N.K. Diop-Bove, J. Wu, R. Zhao, J. Locker, I.D. Goldman, Hypermethylation of the human proton-coupled folate transporter (SLC46A1) minimal transcriptional regulatory region in an antifolate-resistant HeLa cell line, Mol. Cancer Ther. 8 (2009) 2424-2431.
-
(2009)
Mol. Cancer Ther.
, vol.8
, pp. 2424-2431
-
-
Diop-Bove, N.K.1
Wu, J.2
Zhao, R.3
Locker, J.4
Goldman, I.D.5
-
20
-
-
11144237445
-
Antifolate resistance in a HeLa cell line associated with impaired transport independent of the reduced folate carrier
-
R. Zhao, S. Chattopadhyay, M. Hanscom, I.D. Goldman, Antifolate resistance in a HeLa cell line associated with impaired transport independent of the reduced folate carrier, Clin. Cancer Res. 10 (2004) 8735-8742.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 8735-8742
-
-
Zhao, R.1
Chattopadhyay, S.2
Hanscom, M.3
Goldman, I.D.4
-
21
-
-
67650073369
-
Role of the glutamate 185 residue in proton translocation mediated by the proton-coupled folate transporter SLC46A1
-
E.S. Unal, R. Zhao, I.D. Goldman, Role of the glutamate 185 residue in proton translocation mediated by the proton-coupled folate transporter SLC46A1, Am. J. Physiol. Cell Physiol. 297 (2009) C66-C74.
-
(2009)
Am. J. Physiol. Cell Physiol.
, vol.297
-
-
Unal, E.S.1
Zhao, R.2
Goldman, I.D.3
-
22
-
-
0032321487
-
Substituted-cysteine accessibility method
-
A. Karlin, M.H. Akabas, Substituted-cysteine accessibility method, Meth. Enzymol. 293 (1998) 123-145.
-
(1998)
Meth. Enzymol.
, vol.293
, pp. 123-145
-
-
Karlin, A.1
Akabas, M.H.2
-
23
-
-
69249143630
-
Identi.cation of a disulfide bridge essential for transport function of the human proton-coupled amino acid transporter hPAT1
-
M. Dorn, M. Weiwad, F. Markwardt, L. Laug, R. Rudolph, M. Brandsch, E. Bosse- Doenecke, Identi.cation of a disulfide bridge essential for transport function of the human proton-coupled amino acid transporter hPAT1, J. Biol. Chem. 284 (2009) 22123-22132.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 22123-22132
-
-
Dorn, M.1
Weiwad, M.2
Markwardt, F.3
Laug, L.4
Rudolph, R.5
Brandsch, M.6
Bosse-Doenecke, E.7
-
24
-
-
0037150070
-
Identification of human vesicle monoamine transporter (VMAT2) lumenal cysteines that form an intramolecular disulfide bond
-
DOI 10.1021/bi015779j
-
D.S. Thiriot, M.K. Sievert, A.E. Ruoho, Identification of human vesicle monoamine transporter (VMAT2) lumenal cysteines that form an intramolecular disulfide bond, Biochemistry 41 (2002) 6346-6353. (Pubitemid 34525999)
-
(2002)
Biochemistry
, vol.41
, Issue.20
, pp. 6346-6353
-
-
Thiriot, D.S.1
Sievert, M.K.2
Ruoho, A.E.3
-
26
-
-
67650526040
-
The functional roles of the His247 and His281 residues in folate and proton translocation mediated by the human proton-coupled folate transporter SLC46A1
-
E.S. Unal, R. Zhao, M.H. Chang, A. Fiser, M.F. Romero, I.D. Goldman, The functional roles of the His247 and His281 residues in folate and proton translocation mediated by the human proton-coupled folate transporter SLC46A1, J. Biol. Chem. 284 (2009) 17846-17857.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 17846-17857
-
-
Unal, E.S.1
Zhao, R.2
Chang, M.H.3
Fiser, A.4
Romero, M.F.5
Goldman, I.D.6
-
27
-
-
67650047730
-
Hereditary folate malabsorption: A positively charged amino acid at position 113 of the proton-coupled folate transporter (PCFT/SLC46A1) is required for folic acid binding
-
I. Lasry, B. Berman, F. Glaser, G. Jansen, Y.G. Assaraf, Hereditary folate malabsorption: a positively charged amino acid at position 113 of the proton-coupled folate transporter (PCFT/SLC46A1) is required for folic acid binding, Biochem. Biophys. Res. Commun. 386 (2009) 426-431.
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.386
, pp. 426-431
-
-
Lasry, I.1
Berman, B.2
Glaser, F.3
Jansen, G.4
Assaraf, Y.G.5
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