Rodent intestinal folate transporters (SLC46A1): Secondary structure, functional properties, and response to dietary folate restriction

American Journal of Physiology - Cell Physiology

Volumn 293, Issue 5, 2007, Pages

  Qiu, Andong ^a   Sang, Hee Min ^a   Jansen, Michaela ^a   Malhotra, Usha ^a   Tsai, Eugenia ^a   Cabelof, Diane C ^b   Matherly, Larry H ^b,c   Zhao, Rongbao ^a   Akabas, Myles H ^a   Goldman, I David ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b KARMANOS CANCER INSTITUTE   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Heme carrier protein 1; Hereditary folate malabsorption; Intestinal folate absorption; Proton coupled folate transporters

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; ANTIBODY; FOLIC ACID; GLUTAMYL AMINOPEPTIDASE; MEMBRANE PROTEIN; MESSENGER RNA; METHOTREXATE; MONOGLUTAMYL; POLYGLUTAMYL; PROTEIN PCFT; PROTON COUPLED FOLATE TRANSPORTER; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; COMPUTER SYSTEM; CONTROLLED STUDY; DIET RESTRICTION; DRUG TRANSPORT; DUODENUM; ELECTRON; ELECTROPHYSIOLOGY; ENZYME SPECIFICITY; GENE; HELA CELL; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; JEJUNUM; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PH; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; RAT; SLC46A1 GENE; SMALL INTESTINE; STRUCTURE ANALYSIS; TISSUE DISTRIBUTION; XENOPUS;

AMINO ACID SEQUENCE; ANIMALS; ANION TRANSPORT PROTEINS; CELL MEMBRANE; DISEASE MODELS, ANIMAL; FOLIC ACID; FOLIC ACID ANTAGONISTS; FOLIC ACID DEFICIENCY; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINE, SMALL; KINETICS; MALE; MEMBRANE POTENTIALS; MEMBRANE TRANSPORT PROTEINS; METHOTREXATE; MICE; MICE, INBRED C57BL; MICROVILLI; MOLECULAR SEQUENCE DATA; OOCYTES; POLYGLUTAMIC ACID; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RATS; RNA, MESSENGER; TETRAHYDROFOLATES; XENOPUS;

HOMO SAPIENS; MUS; MUS MUSCULUS; RATTUS NORVEGICUS; RODENTIA;

EID: 36048936881     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00202.2007     Document Type: Article

References (37)

1. Bhandari SD, Joshi SK, McMartin KE. Folate binding and transport by rat kidney brush-border membrane vesicles. Biochim Biophys Acta 937: 211-218, 1988.
2. Birn H, Spiegelstein O, Christensen EI, Finnell RH. Renal tubular reabsorption of folate mediated by folate binding protein 1. J Am Soc Nephrol 16: 608-615, 2005.
3. Chattopadhyay S, Zhao R, Krupenko SA, Krupenko N, Goldman ID. The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line. Mol Cancer Ther 5: 438-449, 2006.
4. Chiao JH, Roy K, Tolner B, Yang CH, Sirotnak FM. RFC-1 gene expression regulates folate absorption in mouse small intestine. J Biol Chem 272: 11165-11170, 1997.
5. Fry DW, Yalowich JC, Goldman ID. Rapid formation of poly-gamma-glutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascited tumor cell in vitro. J Biol Chem 257: 1890-1896, 1982.
6. Geller J, Kronn D, Jayabose S, Sandoval C. Hereditary folate malabsorption: family report and review of the literature. Medicine (Baltimore) 81: 51-68, 2002.
7. Halsted CH, Ling EH, Luthi-Carter R, Villanueva JA, Gardner JM, Coyle JT. Folylpoly-gamma-glutamate carboxypeptidase from pig jejunum. Molecular characterization and relation to glutamate carboxypeptidase II. J Biol Chem 273: 20417-20424, 1998.
8. Henderson GB, Strauss BP. Characteristics of a novel transport system for folate compounds in wild-type and methotrexate-resistant L1210 cells. Cancer Res 50: 1709-1714, 1990.
9. Horne DW. Transport of folates and antifolates in liver. Proc Soc Exp Biol Med 202: 385-391, 1993.
10. Jansen M, Akabas MH. State-dependent cross-linking of the M2 and M3 segments: functional basis for the alignment of GABAA and acetylcholine receptor M3 segments. J Neurosci 26: 4492-4499, 2006.
11. Jaramillo-Juarez F, Aires MM, Malnic G. Urinary and proximal tubule acidification during reduction of renal blood flow in the rat. J Physiol 421: 475-483, 1990.
12. Kamen BA, Smith AK, Anderson RGW. The folate receptor works in tandem with a probenecid-sensitive carrier in MA104 cells in vitro. J Clin Invest 87: 1442-1449, 1991.
13. Lassmann T, Sonnhammer EL. Kalign, Kalignvu and Mumsa: web servers for multiple sequence alignment. Nucleic Acids Res 34: W596-W599, 2006.
14. Latunde-Dada GO, Takeuchi K, Simpson RJ, McKie AT. Haem carrier protein 1 (HCP1): expression and functional studies in cultured cells. FEBS Lett 580: 6865-6870, 2006.
15. Liu M, Ge Y, Cabelof DC, Aboukameel A, Heydari AR, Mohammad R, Matherly LH. Structure and regulation of the murine reduced folate carrier gene: identification of four noncoding exons and promoters and regulation by dietary folates. J Biol Chem 280: 5588-5597, 2005.
16. Mason JB, Rosenberg IH. Intestinal absorption of folate. In: Physiology of the Gastrointestinal Tract, edited by Johnson LR. New York: Raven, 1994, p. 1979-1995.
17. McEwan GT, Daniel H, Fett C, Burgess MN, Lucas ML. The effect of Escherichia coli STa enterotoxin and other secretagogues on mucosal surface pH of rat small intestine in vivo. Proc R Soc Lond B Biol Sci 234: 219-237, 1988.
18. Murphy RF, Powers S, Cantor CR. Endosome pH measured in single cells by dual fluorescence flow cytometry: rapid acidification of insulin to pH 6. J Cell Biol 98: 1757-1762, 1984.
19. Paulos CM, Reddy JA, Leamon CP, Turk MJ, Low PS. Ligand binding and kinetics of folate receptor recycling in vivo: impact on receptor-mediated drug delivery. Mol Pharmacol 66: 1406-1414, 2004.
20. Poe M. Acidic dissociation constants of folic acid, dihydrofolic acid, and methotrexate. J Biol Chem 252: 3724-3728, 1977.
21. 1-sensitive proton pump and a probenecid-sensitive folate transporter in human placental choriocarcinoma cells. Biochim Biophys Acta Mol Cell Res 1222: 309-314, 1994.
22. Qiu A, Jansen M, Sakaris A, Min SH, Chattopadhyay S, Tsai E, Sandoval C, Zhao R, Akabas MH, Goldman ID. Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell 127: 917-928, 2006.
23. Said HM. Recent advances in carrier-mediated intestinal absorption of water-soluble vitamins. Annu Rev Physiol 66: 419-446, 2004.
24. Sharif KA, Goldman ID. Rapid determination of membrane transport parameters in adherent cells. Biotechniques 28: 926-928, 930, and 932, 2000.
25. Shayeghi M, Latunde-Dada GO, Oakhill JS, Laftah AH, Takeuchi K, Halliday N, Khan Y, Warley A, McCann FE, Hider RC, Frazer DM, Anderson GJ, Vulpe CD, Simpson RJ, McKie AT. Identification of an intestinal heme transporter. Cell 122: 789-801, 2005.
26. Sierra EE, Goldman ID. Characterization of folate transport mediated by a low pH route in mouse L1210 leukemia cells with defective reduced folate carrier function. Biochem Pharmacol 55: 1505-1512, 1998.
27. Smith SB, Kekuda R, Gu X, Chancy C, Conway SJ, Ganapathy V. Expression of folate receptor alpha in the mammalian retinol pigmented epithelium and retina. Invest Ophthalmol Vis Sci 40: 840-848, 1999.
28. Stover PJ. Physiology of folate and vitamin B12 in health and disease. Nutr Rev 62: S3-S12, 2004.
29. Wang Y, Rajgopal A, Goldman ID, Zhao R. Preservation of folate transport activity with a low-pH optimum in rat IEC-6 intestinal epithelial cell lines that lack reduced folate carrier function. Am J Physiol Cell Physiol 288: C65-C71, 2005.
30. Wang Y, Zhao R, Goldman ID. Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier. Clin Cancer Res 10: 6256-6264, 2004.
31. Wang Y, Zhao R, Russell RG, Goldman ID. Localization of the murine reduced folate carrier as assessed by immunohistochemical analysis. Biochim Biophys Acta 1513: 49-54, 2001.
32. Weitman SD, Weinberg AG, Coney LR, Zurawski VR Jr, Jennings DS, Kamen BA. Cellular localization of the folate receptor: potential role in drug toxicity and folate homeostasis. Cancer Res 52: 6708-6711, 1992.
33. Williams WM, Huang KC. Renal tubular transport of folic acid and methotrexate in the monkey. Am J Physiol Renal Fluid Electrolyte Physiol 242: F484-F490, 1982.
34. Yang J, Chen H, Vlahov IR, Cheng JX, Low PS. Characterization of the pH of folate receptor-containing endosomes and the rate of hydrolysis of internalized acid-labile folate-drug conjugates. J Pharmacol Exp Ther 321: 462-468, 2007.
35. Zhao R, Gao F, Hanscom M, Goldman ID. A prominent low-pH methotrexate transport activity in human solid tumor cells: Contribution to the preservation of methotrexate pharmacological activity in HeLa cells lacking the reduced folate carrier. Clin Cancer Res 10: 718-727, 2004.
36. Zhao R, Hanscom M, Goldman ID. The relationship between folate transport activity at low pH and reduced folate carrier function in human Huh7 hepatoma cells. Biochim Biophys Acta 1715: 57-64, 2005.
37. Zhao R, Min SH, Qiu A, Sakaris A, Goldberg GL, Sandoval C, Malatack JJ, Rosenblatt DS, Goldman ID. The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption. Blood 110: 1147-1152, 2007.