PKCβ Phosphorylates PI3Kγ to Activate It and Release It from GPCR Control

PLoS Biology

Volumn 11, Issue 6, 2013, Pages

  Walser, Romy ^a   Burke, John E ^b   Gogvadze, Elena ^a   Bohnacker, Thomas ^a   Zhang, Xuxiao ^b   Hess, Daniel ^c   Küenzi, Peter ^a   Leitges, Michael ^d   Hirsch, Emilio ^e   Williams, Roger L ^b   Laffargue, Muriel ^f   Wymann, Matthias P ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^c FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^d UNIVERSITY OF OSLO   (Norway)

^e UNIVERSITY OF TURIN   (Italy)

^f University Hospital of Toulouse   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; G PROTEIN COUPLED RECEPTOR; IMMUNOGLOBULIN E RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PROTEIN KINASE C BETA; PROTEIN P110; PROTEIN P110 GAMMA; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CLUSTER ANALYSIS; CONTROLLED STUDY; DEUTERIUM HYDROGEN EXCHANGE; DOWNSTREAM PROCESSING; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME RELEASE; MASS SPECTROMETRY; MAST CELL; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; CALCIUM; CATALYTIC DOMAIN; CELL DEGRANULATION; CLASS IB PHOSPHATIDYLINOSITOL 3-KINASE; ENZYME ACTIVATION; ENZYME STABILITY; EXTRACELLULAR SPACE; MAST CELLS; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; MODELS, MOLECULAR; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN BINDING; PROTEIN KINASE C BETA; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; THAPSIGARGIN;

EID: 84879386607     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1001587     Document Type: Article

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