메뉴 건너뛰기




Volumn 14, Issue , 2013, Pages

The temporal and spatial profiles of cell loss following experimental spinal cord injury: Effect of antioxidant therapy on cell death and functional recovery

Author keywords

Antioxidant therapy; Apoptotic cell death; Behavioral test; Mn (III) tetrakis (4 benzoic acid) porphyrin; Nitro L arginine; Secondary spinal cord injury

Indexed keywords

ANTIOXIDANT; CASPASE 3; DNA FRAGMENT; GLYCERYL TRINITRATE; MANGANESE(III)TETRAKIS(4 BENZOIC ACID)PORPHYRIN; UNCLASSIFIED DRUG;

EID: 84887687794     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/1471-2202-14-146     Document Type: Article
Times cited : (17)

References (76)
  • 1
    • 0027475987 scopus 로고
    • Secondary injury mechanisms in acute spinal cord injury
    • Young W. Secondary injury mechanisms in acute spinal cord injury. J Emerg Med 1993, 11(Suppl 1):13-22.
    • (1993) J Emerg Med , vol.11 , Issue.SUPPL. 1 , pp. 13-22
    • Young, W.1
  • 2
    • 47349105023 scopus 로고    scopus 로고
    • Secondary pathology following contusion, dislocation, and distraction spinal cord injuries
    • Choo AM, Liu J, Dvorak M, Tetzlaffc W, Oxland TR. Secondary pathology following contusion, dislocation, and distraction spinal cord injuries. Exp Neurol 2008, 212:490-506.
    • (2008) Exp Neurol , vol.212 , pp. 490-506
    • Choo, A.M.1    Liu, J.2    Dvorak, M.3    Tetzlaffc, W.4    Oxland, T.R.5
  • 3
    • 0031015075 scopus 로고    scopus 로고
    • Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys
    • Crowe MJ, Bresnahan JC, Shuman SL, Masters JN, Beattie MS. Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys. Nat Med 1997, 3:73-76.
    • (1997) Nat Med , vol.3 , pp. 73-76
    • Crowe, M.J.1    Bresnahan, J.C.2    Shuman, S.L.3    Masters, J.N.4    Beattie, M.S.5
  • 6
    • 81255185486 scopus 로고    scopus 로고
    • Inhibition of inflammation and oxidative stress by angelica dahuricae radix extract decreases apoptotic cell death and improves functional recovery after spinal cord injury
    • Moon JY, Lee JY, Oh MS, Pak YK, Park K, Oh TH, Yune TY. Inhibition of inflammation and oxidative stress by angelica dahuricae radix extract decreases apoptotic cell death and improves functional recovery after spinal cord injury. J Neurosci Res 2012, 90:243-256.
    • (2012) J Neurosci Res , vol.90 , pp. 243-256
    • Moon, J.Y.1    Lee, J.Y.2    Oh, M.S.3    Pak, Y.K.4    Park, K.5    Oh, T.H.6    Yune, T.Y.7
  • 7
    • 0033789565 scopus 로고    scopus 로고
    • Free radical pathways in CNS injury
    • Lewen A, Matz P, Chan PH. Free radical pathways in CNS injury. J Neurotrauma 2000, 17:871-890.
    • (2000) J Neurotrauma , vol.17 , pp. 871-890
    • Lewen, A.1    Matz, P.2    Chan, P.H.3
  • 8
    • 0035149749 scopus 로고    scopus 로고
    • Reactive oxygen radicals in signaling and damage in the ischemic brain
    • Chan PH. Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cerebr Blood F Met 2001, 21:2-14.
    • (2001) J Cerebr Blood F Met , vol.21 , pp. 2-14
    • Chan, P.H.1
  • 9
    • 41549111029 scopus 로고    scopus 로고
    • Role of free radicals and poly(ADP-ribose)polymerase-1 in the development of spinal cord injury: new potential therapeutic targets
    • Genovese T, Cuzzocrea S. Role of free radicals and poly(ADP-ribose)polymerase-1 in the development of spinal cord injury: new potential therapeutic targets. Curr Med chem 2008, 15:477-487.
    • (2008) Curr Med chem , vol.15 , pp. 477-487
    • Genovese, T.1    Cuzzocrea, S.2
  • 12
    • 53049092441 scopus 로고    scopus 로고
    • Systematic administration of PEP-1-SOD1 fusion protein improves functional recovery by inhibition of neuronal cell death after spinal cord injury
    • Yune TY, Lee JY, Jiang MH, Kim DW, Choi SY, Oh Tae H. Systematic administration of PEP-1-SOD1 fusion protein improves functional recovery by inhibition of neuronal cell death after spinal cord injury. Free Radic Biol Med 2008, 45:1190-1200.
    • (2008) Free Radic Biol Med , vol.45 , pp. 1190-1200
    • Yune, T.Y.1    Lee, J.Y.2    Jiang, M.H.3    Kim, D.W.4    Choi, S.Y.5    Oh Tae, H.6
  • 13
    • 67651156234 scopus 로고    scopus 로고
    • Neuroprotective effect of Scutellaria baicalensis on spinal cord injury in rats
    • Yune TY, Lee JY, Cui CM, Kim HC, Oh TH. Neuroprotective effect of Scutellaria baicalensis on spinal cord injury in rats. J Neurochem 2009, 110:1276-1287.
    • (2009) J Neurochem , vol.110 , pp. 1276-1287
    • Yune, T.Y.1    Lee, J.Y.2    Cui, C.M.3    Kim, H.C.4    Oh, T.H.5
  • 14
    • 18744418274 scopus 로고    scopus 로고
    • Superoxide production after spinal injury detected by microperfusion of cytochrome c
    • Liu D, Sybert TE, Qian H, Liu J. Superoxide production after spinal injury detected by microperfusion of cytochrome c. Free Radic Biol Med 1998, 25:298-304.
    • (1998) Free Radic Biol Med , vol.25 , pp. 298-304
    • Liu, D.1    Sybert, T.E.2    Qian, H.3    Liu, J.4
  • 15
    • 0032819394 scopus 로고    scopus 로고
    • Elevation of hydrogen peroxide after spinal cord injury detected by using the Fenton reaction
    • Liu D, Liu J, Wen J. Elevation of hydrogen peroxide after spinal cord injury detected by using the Fenton reaction. Free Radic Biol Med 1999, 27:478-482.
    • (1999) Free Radic Biol Med , vol.27 , pp. 478-482
    • Liu, D.1    Liu, J.2    Wen, J.3
  • 16
    • 2942695288 scopus 로고    scopus 로고
    • The time course of hydroxyl radical formation following spinal cord injury: the possible role of the iron-catalyzed Haber-Weiss reaction
    • Liu D, Liu J, Sun D, Wen J. The time course of hydroxyl radical formation following spinal cord injury: the possible role of the iron-catalyzed Haber-Weiss reaction. J Neurotrauma 2004, 21:805-816.
    • (2004) J Neurotrauma , vol.21 , pp. 805-816
    • Liu, D.1    Liu, J.2    Sun, D.3    Wen, J.4
  • 17
    • 0037220717 scopus 로고    scopus 로고
    • Spinal cord injury increases iron levels: catalytic production of hydroxyl radicals
    • Liu D, Liu J, Sun D, Alcock NW, Wen J. Spinal cord injury increases iron levels: catalytic production of hydroxyl radicals. Free Radic Biol Med 2003, 34:64-71.
    • (2003) Free Radic Biol Med , vol.34 , pp. 64-71
    • Liu, D.1    Liu, J.2    Sun, D.3    Alcock, N.W.4    Wen, J.5
  • 18
    • 0033793219 scopus 로고    scopus 로고
    • The role of reactive nitrogen species in secondary spinal cord injury: formation of nitric oxide, peroxynitrite, and nitrated protein
    • Liu D, Ling X, Wen J, Liu J. The role of reactive nitrogen species in secondary spinal cord injury: formation of nitric oxide, peroxynitrite, and nitrated protein. J Neurochem 2000, 75:2144-2154.
    • (2000) J Neurochem , vol.75 , pp. 2144-2154
    • Liu, D.1    Ling, X.2    Wen, J.3    Liu, J.4
  • 19
    • 0036264281 scopus 로고    scopus 로고
    • Temporal and segmental distribution of constitutive and inducible nitric oxide synthases after traumatic spinal cord injury: effect of aminoguanidine treatment
    • Chatzipanteli K, Garcia R, Marcillo AE, Loor KE, Kraydieh S, Dietrich WD. Temporal and segmental distribution of constitutive and inducible nitric oxide synthases after traumatic spinal cord injury: effect of aminoguanidine treatment. J Neurotrauma 2002, 19:639-651.
    • (2002) J Neurotrauma , vol.19 , pp. 639-651
    • Chatzipanteli, K.1    Garcia, R.2    Marcillo, A.E.3    Loor, K.E.4    Kraydieh, S.5    Dietrich, W.D.6
  • 20
    • 0032947547 scopus 로고    scopus 로고
    • Peroxynitrite production and activation of poly (adenosine diphosphate-ribose) synthetase in spinal cord injury
    • Scott GS, Jakeman LB, Stokes BT, Szabo C. Peroxynitrite production and activation of poly (adenosine diphosphate-ribose) synthetase in spinal cord injury. Ann Neurol 1999, 45:120-124.
    • (1999) Ann Neurol , vol.45 , pp. 120-124
    • Scott, G.S.1    Jakeman, L.B.2    Stokes, B.T.3    Szabo, C.4
  • 21
    • 0035868484 scopus 로고    scopus 로고
    • Protein and DNA oxidation in spinal injury: neurofilaments-an oxidation target
    • Leski ML, Bao F, Wu L, Qian H, Sun D, Liu D. Protein and DNA oxidation in spinal injury: neurofilaments-an oxidation target. Free Radi. Biol Med 2001, 30:613-624.
    • (2001) Free Radi. Biol Med , vol.30 , pp. 613-624
    • Leski, M.L.1    Bao, F.2    Wu, L.3    Qian, H.4    Sun, D.5    Liu, D.6
  • 22
    • 0036123645 scopus 로고    scopus 로고
    • Increased protein oxidation and decreased creatine kinase BB expression and activity after spinal cord contusion injury
    • Aksenova M, Butterfield DA, Zhang SX, Underwood M, Geddes JW. Increased protein oxidation and decreased creatine kinase BB expression and activity after spinal cord contusion injury. J Neurotrauma 2002, 19:491-502.
    • (2002) J Neurotrauma , vol.19 , pp. 491-502
    • Aksenova, M.1    Butterfield, D.A.2    Zhang, S.X.3    Underwood, M.4    Geddes, J.W.5
  • 23
    • 68349087870 scopus 로고    scopus 로고
    • Temporal and spatial dynamics of peroxynitrite-induced oxidative damage after spinal cord contusion injury
    • Carrico KM, Vaishnav R, Hall ED. Temporal and spatial dynamics of peroxynitrite-induced oxidative damage after spinal cord contusion injury. J Neurotrauma 2009, 26:1369-1378.
    • (2009) J Neurotrauma , vol.26 , pp. 1369-1378
    • Carrico, K.M.1    Vaishnav, R.2    Hall, E.D.3
  • 24
    • 0030773502 scopus 로고    scopus 로고
    • The time course of malondialdehyde production following impact injury to rat spinal cord as measured by microdialysis and high pressure liquid chromatography
    • Qian H, Liu D. The time course of malondialdehyde production following impact injury to rat spinal cord as measured by microdialysis and high pressure liquid chromatography. Neurochem Res 1997, 22:1231-1236.
    • (1997) Neurochem Res , vol.22 , pp. 1231-1236
    • Qian, H.1    Liu, D.2
  • 25
    • 0030920387 scopus 로고    scopus 로고
    • 4-hydroxynonenal, a lipid peroxidation product, rapidly accumulates following traumatic spinal cord injury and inhibits glutamate uptake
    • Springer JE, Azbill RD, Mark RJ, Begley JG, Waeg G, Mattson MP. 4-hydroxynonenal, a lipid peroxidation product, rapidly accumulates following traumatic spinal cord injury and inhibits glutamate uptake. J Neurochem 1997, 68:2469-2476.
    • (1997) J Neurochem , vol.68 , pp. 2469-2476
    • Springer, J.E.1    Azbill, R.D.2    Mark, R.J.3    Begley, J.G.4    Waeg, G.5    Mattson, M.P.6
  • 26
    • 63849188041 scopus 로고    scopus 로고
    • Duration of lipid peroxidation after acute spinal cord injury in rats and the effect of methylprednisolone
    • Christie SD, Comeau B, Myers T, Sadi D, Purdy M, Mendez I. Duration of lipid peroxidation after acute spinal cord injury in rats and the effect of methylprednisolone. Neurosurg Focus 2008, 25:E5.
    • (2008) Neurosurg Focus , vol.25
    • Christie, S.D.1    Comeau, B.2    Myers, T.3    Sadi, D.4    Purdy, M.5    Mendez, I.6
  • 27
    • 12244312473 scopus 로고    scopus 로고
    • Peroxynitrite generated in the rat spinal cord induces oxidation and nitration of proteins: reduction by Mn (III) tetrakis (4-benzoic acid) porphyrin
    • Bao F, DeWitt DS, Prough DS, Liu D. Peroxynitrite generated in the rat spinal cord induces oxidation and nitration of proteins: reduction by Mn (III) tetrakis (4-benzoic acid) porphyrin. J Neurosci Res 2003, 71:220-227.
    • (2003) J Neurosci Res , vol.71 , pp. 220-227
    • Bao, F.1    DeWitt, D.S.2    Prough, D.S.3    Liu, D.4
  • 28
    • 27444435011 scopus 로고    scopus 로고
    • Peroxynitrite generated at the level produced by spinal cord injury induces peroxidation of membrane phospholipids in normal rat cord: reduction by a metalloporphyrin
    • Liu D, Bao F, Prough DS, Dewitt DS. Peroxynitrite generated at the level produced by spinal cord injury induces peroxidation of membrane phospholipids in normal rat cord: reduction by a metalloporphyrin. J Neurotrauma 2005, 22:1123-1133.
    • (2005) J Neurotrauma , vol.22 , pp. 1123-1133
    • Liu, D.1    Bao, F.2    Prough, D.S.3    Dewitt, D.S.4
  • 29
    • 0037049252 scopus 로고    scopus 로고
    • Peroxynitrite generated in the rat spinal cord induces neuron death and neurological deficits
    • Bao F, Liu D. Peroxynitrite generated in the rat spinal cord induces neuron death and neurological deficits. Neuroscience 2002, 115:839-849.
    • (2002) Neuroscience , vol.115 , pp. 839-849
    • Bao, F.1    Liu, D.2
  • 30
    • 0037439232 scopus 로고    scopus 로고
    • Peroxynitrite generated in the rat spinal cord induces apoptotic cell death and activates caspase-3
    • Bao F, Liu D. Peroxynitrite generated in the rat spinal cord induces apoptotic cell death and activates caspase-3. Neuroscience 2003, 116:59-70.
    • (2003) Neuroscience , vol.116 , pp. 59-70
    • Bao, F.1    Liu, D.2
  • 31
    • 2942657443 scopus 로고    scopus 로고
    • Hydroxyl radicals generated in the rat spinal cord at the level produced impact injury induce cell death by necrosis and apoptosis: protection by a metalloporphyrin
    • Bao F, Liu D. Hydroxyl radicals generated in the rat spinal cord at the level produced impact injury induce cell death by necrosis and apoptosis: protection by a metalloporphyrin. Neuroscience 2004, 126:285-295.
    • (2004) Neuroscience , vol.126 , pp. 285-295
    • Bao, F.1    Liu, D.2
  • 32
    • 2942623947 scopus 로고    scopus 로고
    • Catalytic antioxidants: a radical approach to new therapeutics
    • Day BJ. Catalytic antioxidants: a radical approach to new therapeutics. Drug Discov Toda 2004, 9:557-566.
    • (2004) Drug Discov Toda , vol.9 , pp. 557-566
    • Day, B.J.1
  • 33
    • 77954735594 scopus 로고    scopus 로고
    • Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential
    • Batinic-Haberle I, Reboucas JS, Spasojevic I. Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential. Antioxid Redox Signal 2010, 13:877-918.
    • (2010) Antioxid Redox Signal , vol.13 , pp. 877-918
    • Batinic-Haberle, I.1    Reboucas, J.S.2    Spasojevic, I.3
  • 34
    • 0031573475 scopus 로고    scopus 로고
    • Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury
    • Day BJ, Fridovich I, Crapo JD. Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury. Arch Biochem Biophys 1997, 347:256-262.
    • (1997) Arch Biochem Biophys , vol.347 , pp. 256-262
    • Day, B.J.1    Fridovich, I.2    Crapo, J.D.3
  • 35
    • 0034656837 scopus 로고    scopus 로고
    • Peroxynitrite scavenging by metalloporphyrins and thiolates
    • Crow JP. Peroxynitrite scavenging by metalloporphyrins and thiolates. Free Radic Boil Med 2000, 28:1487-1494.
    • (2000) Free Radic Boil Med , vol.28 , pp. 1487-1494
    • Crow, J.P.1
  • 36
    • 0033011947 scopus 로고    scopus 로고
    • Metalloporphyrins are potent inhibitors of lipid peroxidation
    • Day BJ, Batinic-Haberle I, Crapo JD. Metalloporphyrins are potent inhibitors of lipid peroxidation. Free Radic Biol Med 1999, 26:730-736.
    • (1999) Free Radic Biol Med , vol.26 , pp. 730-736
    • Day, B.J.1    Batinic-Haberle, I.2    Crapo, J.D.3
  • 37
    • 0034669186 scopus 로고    scopus 로고
    • Mitochondrial superoxide production in kainate-induced hippocampal damage
    • Liang LP, Ho YS, Patel M. Mitochondrial superoxide production in kainate-induced hippocampal damage. Neuroscience 2000, 101:563-570.
    • (2000) Neuroscience , vol.101 , pp. 563-570
    • Liang, L.P.1    Ho, Y.S.2    Patel, M.3
  • 38
    • 33845956041 scopus 로고    scopus 로고
    • Mn (III) tetrakis (4-benzoic acid) porphyrin administered into the intrathecal space reduces oxidative damage and neuron death after spinal cord injury: a comparison with methylprednisolone
    • Hachmeister JE, Valluru L, Bao F, Liu D. Mn (III) tetrakis (4-benzoic acid) porphyrin administered into the intrathecal space reduces oxidative damage and neuron death after spinal cord injury: a comparison with methylprednisolone. J Neurotrauma 2006, 23:1766-1778.
    • (2006) J Neurotrauma , vol.23 , pp. 1766-1778
    • Hachmeister, J.E.1    Valluru, L.2    Bao, F.3    Liu, D.4
  • 39
    • 84869069308 scopus 로고    scopus 로고
    • Mn (III) tetrakis (4-benzoic acid) porphyrin protects against neuronal and glial oxidative stress and death after spinal cord injury
    • Valluru L, Diao Y, Hachmeister JE, Liu D. Mn (III) tetrakis (4-benzoic acid) porphyrin protects against neuronal and glial oxidative stress and death after spinal cord injury. CNS Neurol Disord Drug Targets 2012, 11:774-790.
    • (2012) CNS Neurol Disord Drug Targets , vol.11 , pp. 774-790
    • Valluru, L.1    Diao, Y.2    Hachmeister, J.E.3    Liu, D.4
  • 40
    • 84874397642 scopus 로고    scopus 로고
    • Mn (III) tetrakis (4-benzoic acid) porphyrin scavenges reactive species, reduces oxidative stress, and improves functional recovery after experimental spinal cord injury in rats: comparison with methylprednisolone
    • doi: 10.1186/1471-2202-14-23. URL
    • Liu D, Shan Y, Valluru L, Bao F. Mn (III) tetrakis (4-benzoic acid) porphyrin scavenges reactive species, reduces oxidative stress, and improves functional recovery after experimental spinal cord injury in rats: comparison with methylprednisolone. BMC Neurosci 2013, 14:23. doi: 10.1186/1471-2202-14-23. URL: http://www.biomedcentral.com/1471-2202/14/23.
    • (2013) BMC Neurosci , vol.14 , pp. 23
    • Liu, D.1    Shan, Y.2    Valluru, L.3    Bao, F.4
  • 42
    • 84862577216 scopus 로고    scopus 로고
    • Stability, disposition, and penetration of catalytic antioxidants Mn-porphyrin and Mn-salen and of methylprednisolone in spinal cord injury
    • Wu L, Shan Y, Liu D. Stability, disposition, and penetration of catalytic antioxidants Mn-porphyrin and Mn-salen and of methylprednisolone in spinal cord injury. CNS Agent Med Chem 2012, 12:122-130.
    • (2012) CNS Agent Med Chem , vol.12 , pp. 122-130
    • Wu, L.1    Shan, Y.2    Liu, D.3
  • 43
    • 34547490741 scopus 로고    scopus 로고
    • Temporal and spatial profiles of cell loss after spinal cord injury: reduction by a metalloporphyrin
    • Ling X, Liu D. Temporal and spatial profiles of cell loss after spinal cord injury: reduction by a metalloporphyrin. J Neurosci Res 2007, 85:2175-2185.
    • (2007) J Neurosci Res , vol.85 , pp. 2175-2185
    • Ling, X.1    Liu, D.2
  • 44
    • 0029922989 scopus 로고    scopus 로고
    • Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondiral respiration in immunostimulated macrophages using a manganese mesopophyrin superoxide dismutase mimetic and peroxynitrite scavenger
    • Szabo C, Day BJ, Salzman AL. Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondiral respiration in immunostimulated macrophages using a manganese mesopophyrin superoxide dismutase mimetic and peroxynitrite scavenger. FEBS Lett 1996, 381:82-86.
    • (1996) FEBS Lett , vol.381 , pp. 82-86
    • Szabo, C.1    Day, B.J.2    Salzman, A.L.3
  • 45
    • 84943442523 scopus 로고
    • Surgery of experimental spinal cord injury equivalent to crush injury of fracture dislocation of spinal column
    • Allen AR. Surgery of experimental spinal cord injury equivalent to crush injury of fracture dislocation of spinal column. JAMA 1911, 57:878-880.
    • (1911) JAMA , vol.57 , pp. 878-880
    • Allen, A.R.1
  • 46
    • 0032404088 scopus 로고    scopus 로고
    • Lumbar motor neuron size and number is affected by age in male F344 rats
    • Jacob JM. Lumbar motor neuron size and number is affected by age in male F344 rats. Mech Ageing Dev 1998, 106:205-216.
    • (1998) Mech Ageing Dev , vol.106 , pp. 205-216
    • Jacob, J.M.1
  • 48
    • 0018406568 scopus 로고
    • Rapid isolation of carcinogen-bound DNA and RNA by hydroxyapatite chromatography
    • Beland FA, Dooley KL, Casciano DA. Rapid isolation of carcinogen-bound DNA and RNA by hydroxyapatite chromatography. J Chromatogr 1979, 174:177-186.
    • (1979) J Chromatogr , vol.174 , pp. 177-186
    • Beland, F.A.1    Dooley, K.L.2    Casciano, D.A.3
  • 51
    • 57349179914 scopus 로고    scopus 로고
    • Local inhibition of Rho signaling by cell-permeable recombinant protein BA-210 prevents secondary damage and promotes functional recovery following acute spinal cord injury
    • Lord-Fontaine S, Yang F, Diep Q, Dergham P, Munzer S, Tremblay P, McKerracher LJ. Local inhibition of Rho signaling by cell-permeable recombinant protein BA-210 prevents secondary damage and promotes functional recovery following acute spinal cord injury. J Neurotrauma 2008, 25:1309-1322.
    • (2008) J Neurotrauma , vol.25 , pp. 1309-1322
    • Lord-Fontaine, S.1    Yang, F.2    Diep, Q.3    Dergham, P.4    Munzer, S.5    Tremblay, P.6    McKerracher, L.J.7
  • 52
    • 70450195811 scopus 로고    scopus 로고
    • Molecular, anatomical, physiological, and behavioral studies of rats treated with buprenorphine after spinal cord injury
    • Santiago JM, Rosas O, Torrado AI, González MM, Kalyan-Masih PO, Miranda JD. Molecular, anatomical, physiological, and behavioral studies of rats treated with buprenorphine after spinal cord injury. J Neurotrauma 2009, 26:1783-93.
    • (2009) J Neurotrauma , vol.26 , pp. 1783-1793
    • Santiago, J.M.1    Rosas, O.2    Torrado, A.I.3    González, M.M.4    Kalyan-Masih, P.O.5    Miranda, J.D.6
  • 53
    • 48249117463 scopus 로고    scopus 로고
    • Intraspinal MDL28170 microinjection improves functional and pathological outcome following spinal cord injury
    • Yu CG, Joshi A, Geddes JW. Intraspinal MDL28170 microinjection improves functional and pathological outcome following spinal cord injury. J Neurotrauma 2008, 25:833-40.
    • (2008) J Neurotrauma , vol.25 , pp. 833-840
    • Yu, C.G.1    Joshi, A.2    Geddes, J.W.3
  • 54
    • 76349090715 scopus 로고    scopus 로고
    • The functional and neuroprotective actions of Neu 2000, a dual-acting pharmacological agent, in the treatment of acute spinal cord injury
    • Springer JE, Rao RR, Lim HR, Cho SI, Moon GJ, Lee HY, Park EJ, Noh JS, Gwag BJ. The functional and neuroprotective actions of Neu 2000, a dual-acting pharmacological agent, in the treatment of acute spinal cord injury. J Neurotrauma 2010, 27:139-49.
    • (2010) J Neurotrauma , vol.27 , pp. 139-149
    • Springer, J.E.1    Rao, R.R.2    Lim, H.R.3    Cho, S.I.4    Moon, G.J.5    Lee, H.Y.6    Park, E.J.7    Noh, J.S.8    Gwag, B.J.9
  • 56
    • 0028919411 scopus 로고
    • A sensitive and reliable locomotor rating scale for open field testing in rats
    • Basso DM, Beattie MS, Bresnahan JC. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 1995, 12:1-21.
    • (1995) J Neurotrauma , vol.12 , pp. 1-21
    • Basso, D.M.1    Beattie, M.S.2    Bresnahan, J.C.3
  • 57
    • 0030157694 scopus 로고    scopus 로고
    • Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection
    • Basso DM, Beattie MS, Bresnahan JC. Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp Neurol 1996, 139:244-256.
    • (1996) Exp Neurol , vol.139 , pp. 244-256
    • Basso, D.M.1    Beattie, M.S.2    Bresnahan, J.C.3
  • 58
    • 0017992470 scopus 로고
    • Effect of duration of acute spinal cord compression in a new acute cord injury model in the rat
    • Rivlin AS, Tator CH. Effect of duration of acute spinal cord compression in a new acute cord injury model in the rat. Surg Neurol 1978, 10:38-43.
    • (1978) Surg Neurol , vol.10 , pp. 38-43
    • Rivlin, A.S.1    Tator, C.H.2
  • 59
    • 0018349240 scopus 로고
    • Effect of vasodilators and myelotomy on recovery after acute spinal cord injury in rats
    • Rivlin AS, Tator CH. Effect of vasodilators and myelotomy on recovery after acute spinal cord injury in rats. J Neurosurg 1979, 50:349-352.
    • (1979) J Neurosurg , vol.50 , pp. 349-352
    • Rivlin, A.S.1    Tator, C.H.2
  • 60
    • 0029988766 scopus 로고    scopus 로고
    • Motor performance score: a new algorithm for accurate behavioral testing of spinal cord injury in rats
    • Von Euler M, Akesson E, Samuelsson EB, Seiger A, Sundstrom E. Motor performance score: a new algorithm for accurate behavioral testing of spinal cord injury in rats. Exp Neurol 1996, 137:242-254.
    • (1996) Exp Neurol , vol.137 , pp. 242-254
    • Von Euler, M.1    Akesson, E.2    Samuelsson, E.B.3    Seiger, A.4    Sundstrom, E.5
  • 61
    • 0035074297 scopus 로고    scopus 로고
    • Temporal-spatial pattern of acute neuronal and glial loss after spinal cord contusion
    • Grossman SD, Rosenberg LJ, Wrathall JR. Temporal-spatial pattern of acute neuronal and glial loss after spinal cord contusion. Exp Neurol 2001, 168:273-282.
    • (2001) Exp Neurol , vol.168 , pp. 273-282
    • Grossman, S.D.1    Rosenberg, L.J.2    Wrathall, J.R.3
  • 62
    • 0025796753 scopus 로고
    • Three-dimensional computer-assisted analysis of graded contusion lesions in the spinal cord of the rat
    • Bresnahan JC, Beattie MS, Stokes BT, Conway KM. Three-dimensional computer-assisted analysis of graded contusion lesions in the spinal cord of the rat. J Neurotrauma 1991, 8:91-101.
    • (1991) J Neurotrauma , vol.8 , pp. 91-101
    • Bresnahan, J.C.1    Beattie, M.S.2    Stokes, B.T.3    Conway, K.M.4
  • 63
    • 70450198892 scopus 로고    scopus 로고
    • Serial changes in bladder, locomotion, and levels of neurotrophic factors in rats with spinal cord contusion
    • Hyun JK, Lee YI, Son YJ, Park JS. Serial changes in bladder, locomotion, and levels of neurotrophic factors in rats with spinal cord contusion. J Neurotrauma 2009, 26:1773-1782.
    • (2009) J Neurotrauma , vol.26 , pp. 1773-1782
    • Hyun, J.K.1    Lee, Y.I.2    Son, Y.J.3    Park, J.S.4
  • 64
    • 0028641248 scopus 로고
    • Apoptosis and free radicals
    • Wood KA, Youle RJ. Apoptosis and free radicals. Ann NY Acad Sci 1994, 738:400-407.
    • (1994) Ann NY Acad Sci , vol.738 , pp. 400-407
    • Wood, K.A.1    Youle, R.J.2
  • 66
    • 0033985183 scopus 로고    scopus 로고
    • Apoptosis and the nervous system
    • Sastry PS, Rao KS. Apoptosis and the nervous system. J Neurochem 2000, 74:1-20.
    • (2000) J Neurochem , vol.74 , pp. 1-20
    • Sastry, P.S.1    Rao, K.S.2
  • 67
    • 0033782260 scopus 로고    scopus 로고
    • Caspase pathways, neuronal apoptosis, and CNS injury
    • Eldadah BA, Faden AI. Caspase pathways, neuronal apoptosis, and CNS injury. J Neurotrauma 2000, 17:811-829.
    • (2000) J Neurotrauma , vol.17 , pp. 811-829
    • Eldadah, B.A.1    Faden, A.I.2
  • 68
    • 0032790541 scopus 로고    scopus 로고
    • Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury
    • Springer JE, Azbill RD, Knapp PE. Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury. Nat Med 1999, 5:943-946.
    • (1999) Nat Med , vol.5 , pp. 943-946
    • Springer, J.E.1    Azbill, R.D.2    Knapp, P.E.3
  • 69
    • 17444427385 scopus 로고    scopus 로고
    • Increased production of reactive oxygen species contributes to motor neuron death in a compression mouse model of spinal cord injury
    • Xu W, Chi L, Xu R, Ke Y, Luo C, Cai J, Qiu M, Gozal D, Liu R. Increased production of reactive oxygen species contributes to motor neuron death in a compression mouse model of spinal cord injury. Spinal cord 2005, 43:204-213.
    • (2005) Spinal cord , vol.43 , pp. 204-213
    • Xu, W.1    Chi, L.2    Xu, R.3    Ke, Y.4    Luo, C.5    Cai, J.6    Qiu, M.7    Gozal, D.8    Liu, R.9
  • 71
    • 78751704214 scopus 로고    scopus 로고
    • Recombinant human erythropoietin prevents motor neuron apoptosis in a rat model of cervical sub-acute spinal cord compression
    • Ning B, Zhang A, Song H, Gong W, Ding Y, Guo S, Zhao Y, Jiang J, Jia T. Recombinant human erythropoietin prevents motor neuron apoptosis in a rat model of cervical sub-acute spinal cord compression. Neurosci Lett 2011, 490:57-62.
    • (2011) Neurosci Lett , vol.490 , pp. 57-62
    • Ning, B.1    Zhang, A.2    Song, H.3    Gong, W.4    Ding, Y.5    Guo, S.6    Zhao, Y.7    Jiang, J.8    Jia, T.9
  • 74
    • 78651267346 scopus 로고    scopus 로고
    • Effect of Apocynin, an inhibitor of NADPH oxidase, in the inflammatory process induced by an experimental model of spinal cord injury
    • Impellizzeri D, Mazzon E, Esposito E, Paterniti I, Bramanti P, Cuzzocrea S. Effect of Apocynin, an inhibitor of NADPH oxidase, in the inflammatory process induced by an experimental model of spinal cord injury. Free Radic Res 2011, 45:221-236.
    • (2011) Free Radic Res , vol.45 , pp. 221-236
    • Impellizzeri, D.1    Mazzon, E.2    Esposito, E.3    Paterniti, I.4    Bramanti, P.5    Cuzzocrea, S.6
  • 76
    • 33644663413 scopus 로고    scopus 로고
    • Metalloporphyrin-based superoxide dismutase mimic attenuates the nuclear translocation of apoptosis-inducing factor and the subsequent DNA fragmentation after permanent focal cerebral ischemia in mice
    • Lee BI, Chan PH, Kim GW. Metalloporphyrin-based superoxide dismutase mimic attenuates the nuclear translocation of apoptosis-inducing factor and the subsequent DNA fragmentation after permanent focal cerebral ischemia in mice. Stroke 2005, 36:2712-2717.
    • (2005) Stroke , vol.36 , pp. 2712-2717
    • Lee, B.I.1    Chan, P.H.2    Kim, G.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.