Temporal profile and cell subtype distribution of activated caspase-3 following experimental traumatic brain injury

Journal of Neurochemistry

Volumn 75, Issue 3, 2000, Pages 1264-1273

  Beer, R ^a,b,c,d   Franz, G ^a,b,c,d   Srinivasan, A ^a,b,c,d   Hayes, R L ^a,b,c,d   Pike, B R ^a,b,c,d   Newcomb, J K ^a,b,c,d   Zhao, X ^a,b,c,d   Schmutzhard, E ^a,b,c,d   Poewe, W ^a,b,c,d   Kampfl, A ^a,b,c,d  

^a UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

^b PFIZER INC   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

^d UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Spectrin; Astrocyte; Caspase 3; Neuron; Oligodendrocyte; Traumatic brain injury

Indexed keywords

CASPASE 3;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INJURY; CELLULAR DISTRIBUTION; ENZYME ACTIVATION; ENZYME ACTIVITY; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ASTROCYTES; BRAIN INJURIES; CASPASE 3; CASPASES; CEREBRAL CORTEX; ENZYME ACTIVATION; FUNCTIONAL LATERALITY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; NEURONS; OLIGODENDROGLIA; RATS; RATS, SPRAGUE-DAWLEY; SPECTRIN; TIME FACTORS;

EID: 0033836364     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0751264.x     Document Type: Article

References (68)

1. Combined mechanical trauma and metabolic impairment in vitro induces NMDA receptor-dependent neuronal cell death and caspase-3-dependent apoptosis
2. Human ICE/CED-3 protease nomenclature
3. Activation of the CED3/ICE-related protease CPP32 in cerebellar granule neurons undergoing apoptosis but not necrosis
4. Expression of Fas and Fas ligand following experimental traumatic brain injury in the rat
5. Apoptosis: Pathophysiology of programmed cell death
6. Regional cerebral blood flow after controlled cortical impact injury in rats
7. The biochemistry of cell death by apoptosis
8. Fas/Apo (apoptosis)-1 and associated proteins in the differentiating cortex: Induction of caspase dependent cell death and induction of NF-kappa B
9. Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia
10. Increases in Bcl-2 and cleavage of caspase-1 and caspase-3 in human after head injury
11. Caspase-3 mediated neuronal death after traumatic brain injury in rats
12. Apoptosis
13. Apoptotic morphology of dentate gyms granule cells following experimental cortical impact injury in rats: Possible role in spatial memory deficits
14. Delayed selective neuronal death following experimental cortical impact injury in rats: Possible role in spatial memory deficits
15. A biochemical hallmark of apoptosis: Internucleosomal degradation of the genome
16. Experimental brain injury induces regionally distinct apoptosis during the acute and delayed post-traumatic period
17. Monoclonal antibodies specific for glial fibriliary acidic (GFA) protein and for each of the neurofilament triplet polypeptides
18. A controlled cortical impact model of traumatic brain injury in the rat
19. Activation of caspase-3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons
20. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis
21. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
22. Pharmacological treatment of central nervous system trauma
23. The role of excitatory amino acids and NMDA receptors in traumatic brain injury
24. Increased expression of apolipoprotein D following experimental traumatic brain injury
25. Cleavage of poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7
26. Glutamate release and free radical production following brain injury: Effects of posttraumatic hypothermia
27. New expression of myelomonocytic antigens by microglia and perivascular cells following lethal motor neuron injury
28. Oligodendrocyte apoptosis mediated by caspase activation
29. Neurotransmitter mediated mechanisms of traumatic brain injury: Acetylcholine and excitatory amino acids
30. Caspase-3 is required for α-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis
31. Poly(ADP ribose) polymerase cleavage precedes neuronal death in the hippocampus and cerebellum following injury to the developing rat forebrain
32. Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury
33. Apoptosis and expression of p53 response proteins and cyclin D1 after cortical impact in rat brain
34. Activation of CPP32 during apoptosis of neurons and astrocytes
35. Reduction of ischemic brain injury by topical application of glia cell line-derived factor after permanent middle cerebral artery occlusion in rats
36. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
37. Temporal patterns of poly(ADP-ribose) polymerase activation following experimental brain injury in the rat
38. Activation of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease). Oligomerization and direct interaction with historic H1
39. The Dorothy Russell Memorial Lecture: The molecular and cellular sequelae of experimental traumatic brain injury: Pathogenetic mechanisms
40. Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia
41. Non-erythroid alpha spectrin breakdown by calpain and interleukin 1 beta-converting-enzyme-like protease(s) in apoptotic cells: Contributory roles of both protease families in neuronal apoptosis
42. Effects of ICE-like protease and calpain inhibitors on neuronal apoptosis
43. Evidence for activation of caspase-3-like protease in excitotoxin-and hypoxia/hypoglycemia-injured neurons
44. Immunohistochemical study of calpain-mediated breakdown products to α-spectrin following controlled cortical impact injury in the rat
45. Temporal profile of apoptotic-like changes in neurons and astrocytes following controlled cortical impact injury in the rat
46. Transient global forebrain ischemia induces a prolonged expression of the caspase-3 mRNA in rat hippocampal CA1 pyramidal neurons
47. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
48. Changes in cortical extracellular levels of energy-related metabolites and amino acids following concussive brain injury in rats
49. Traumatic brain injury-induced excitotoxicity assessed in a controlled cortical impact model
50. Temporal relationships between de novo protein synthesis calpain and caspase-3-like protein activation, and DNA fragmentation during apoptosis in septo-hippocampal cultures
51. Regional calpain and caspase-3 proteolysis of alpha-spectrin after traumatic brain injury
52. Emerging roles of caspase-3 in apoptosis
53. Evidence of apoptotic cell death after experimental traumatic brain injury in the rat
54. Glutamate and the pathophysiology of hypoxic-ischemic brain damage
55. Apoptosis: The biochemistry and molecular biology of programmed cell death
56. In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system
57. Death by a thousand cuts: An ever increasing list of caspase substrates
58. Cleavage of DFF-45/ICAD by multiple caspases is essential for its function during apoptosis
59. Caspase-8 and caspase-3 are expressed by different populations of cortical neurons undergoing delayed cell death after focal stroke in the rat
60. Caspases and caspase inhibitors
61. Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: A (p20/p10)2 homodimer
62. Simultaneous degradation of alphaII- and betaII-spectrin by caspase-3 (CPP32) in apoptotic cells
63. Reduction of cognitive and motor deficits alter traumatic brain injury in mice deficient in poly(ADP-ribose) polymerase
64. NeuN: A useful neuronal marker for diagnostic histopathology
65. Apoptosis: Cell death in tissue regulation
66. Cell death: The significance of apoptosis
67. Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury
68. Regional and temporal alterations in DNA fragmentation factor (DFF)-like proteins following experimental brain trauma in the rat