Systemic administration of PEP-1-SOD1 fusion protein improves functional recovery by inhibition of neuronal cell death after spinal cord injury

Free Radical Biology and Medicine

Volumn 45, Issue 8, 2008, Pages 1190-1200

  Yune, Tae Young ^a   Lee, Jee Youn ^a   Jiang, Mei Hua ^a   Kim, Dae Won ^b   Choi, Soo Young ^b   Oh, Tae Hwan ^a  

^a Kyung Hee University   (South Korea)

^b Hallym University   (South Korea)

Author keywords

Antioxidant enzymes; Motor neuron death; Neuroprotection; Peptide carrier; Reactive oxygen species; Spinal cord injury

Indexed keywords

CASPASE 3; CASPASE 9; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOCHROME C; HYBRID PROTEIN; MITOCHONDRIAL PROTEIN; PEP 1 COPPER ZINC SUPEROXIDE DISMUTASE FUSION PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DETOXIFICATION; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; EXPRESSION VECTOR; FUNCTIONAL STATUS; GENE; GENETIC TRANSFECTION; MOTONEURON; NERVE CELL NECROSIS; NEUROPROTECTION; NITRATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CARBONYLATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PURIFICATION; PROTEIN SECRETION; RAT; SOD1 GENE; SPINAL CORD INJURY; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BLOTTING, WESTERN; CYSTEAMINE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; NEURONS; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RECOMBINANT FUSION PROTEINS; RECOVERY OF FUNCTION; SPINAL CORD INJURIES; SUPEROXIDE DISMUTASE;

BACTERIA (MICROORGANISMS);

EID: 53049092441     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2008.07.016     Document Type: Article

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