Peroxynitrite production and activation of poly (adenosine diphosphate ribose) synthetase in spinal cord injury

Annals of Neurology

Volumn 45, Issue 1, 1999, Pages 120-124

  Scott, G S ^a   Jakeman, L B ^b   Stokes, B T ^b   Szabo C ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PEROXYNITRITE; POLY(ADENOSINE DIPHOSPHATE RIBOSE);

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME ACTIVATION; FEMALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY;

ADENOSINE DIPHOSPHATE; ANIMALS; CONTUSIONS; FEMALE; LAMINECTOMY; NITRATES; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; SPINAL CORD INJURIES; TYROSINE;

EID: 0032947547     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/1531-8249(199901)45:1<120::AID-ART18>3.0.CO;2-I     Document Type: Article

References (20)

1. Wu W, Liuzzi FJ, Schinco FP, et al. Neuronal nitric oxide synthase is induced in spinal neurons by traumatic injury. Neuroscience 1994;61:719-726
2. Demopoulos HB, Flamm ES, Pietronigro DD, Seligman ML. The free radical pathology and the microcirculation in the major central nervous system disorders. Acta Physiol Scand Suppl 1980:492:91-119
3. Hall ED, Braughler JM. Role of lipid peroxidation in post traumatic spinal cord degeneration: a review. J Neurotrauma 1986; 3:281-294
4. Lipton SA, Choi Y-B, Pan Z-H, et al. A redox-based mechanism for the neuroprotective and neuro-destructive effects of nitric oxide and related nitroso-compounds. Nature 1993;364: 626-632
5. Szabó C. Role of poly (ADP-ribose) synthetase in inflammation. Eur J Pharmacol 1998;350:1-19
6. Schraufstatter JB, Hinshaw D, Hyslop P, et al. Oxidant injury of cells. DNA strand breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide. J Clin Invest 1986;77:1312-1330
7. Cosi C, Suzuki H, Skaper SD, et al. Poly (ADP-ribose) polymerase revisited. A new role for an old enzyme: PARP involvement in neurodegeneration and PARS inhibitors as possible neuroprotective agents. Ann N Y Acad Sci 1997;825:366-379
8. Endres M, Scott G, Naumra S, et al. Role of peroxynitrite and neuronal nitric oxide synthase in the activation of poly (ADP-ribose) synthetase in a murine model of cerebral ischemia-reperfusion. Neurosci Lett 1998;248:41-44
9. Stokes BT, Noyes DH, Behrmann DL. An electromechanical spinal injury device with dynamic sensitivity. J Neurotrauma 1992;9:187-195
10. Cookson MR, Ince PG, Shaw PJ. Peroxynitrite and hydrogen peroxide induced cell death in the NSC34 neuroblastoma X spinal cord cell line: role of poly (ADP-ribose) polymerase. J Neurochem 1998;70:501-508
11. Eliasson MJL, Sampei K, Mandir AS, et al. Poly(ADP-ribose)polymerase gene disruption renders mice resistant to cerebral ischemia. Nature Medicine 1997;3:1089-1095
12. Endres M, Wang Z-Q, Naumra S, et al. Ischemic brain injury is mediated by the activation of poly (ADP-ribose) polymerase. J Cereb Blood Flow Metab 1997;17:1143-1151
13. Scott GS, Hake P, Salzman AL, Szabó C. Inhibition of poly (ADP-ribose) synthetase prevents the neurological development of experimental allergic encephalomyelitis. FASEB J 1998;12: A753 (Abstract)
14. Wallis RA, Panizzon KL, Girard JM. Traumatic neuroprotection with inhibitors of nitric oxide and ADP-ribosylation. Brain Res 1996;710:169-177
15. Beckman JS. Oxidative damage and tyrosine nitration from peroxynitrite. Chem Res Toxicol 1996;9:836-844
16. Eiserich JP, Hristova M, Cross CE, et al. Formation of nitric oxide derivatives catalysed by myeloperoxidase in neutrophils. Nature 1998;391:393-397
17. Satoh MS, Lindahl T. Role of poly (ADP-ribose) formation in DNA repair. Nature 1992;356:356-358
18. Wallis RA, Panizzon KL, Henry D, Wasterlain CG. Neuroprotection against nitric oxide injury with inhibitors of ADP-ribosylation. Neuroreport 1993;5:245-248
19. Zhang J, Dawson VL, Dawson TM, Snyder SH. Nitric oxide activation of poly (ADP-ribose) synthetase in neurotoxicity. Science 1994;263:687-689
20. Virág L, Scott GS, Cuzzocrea S, et al. Peroxynitrite-induced thymocyte apoptosis: the role of caspases and poly-(ADP-ribose) synthetase (PARS) activation. Immunology 1998;94: 345-355