Mitochondrial superoxide production in kainate-induced hippocampal damage

Neuroscience

Volumn 101, Issue 3, 2000, Pages 563-570

  Liang, L P ^a   Ho, Y S ^b   Patel, M ^a,c  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

Antioxidant; Epilepsy; Excitotoxicity; Free radical; Mitochondria; Seizures

Indexed keywords

ANTIOXIDANT; KAINIC ACID; MITOCHONDRIAL DNA; SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CELL DEATH; CONTROLLED STUDY; DNA DAMAGE; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE, EPILEPSY AND CONVULSION;

ACONITATE HYDRATASE; ANIMALS; CELL DEATH; DEOXYGUANOSINE; DNA DAMAGE; EPILEPSY; FREE RADICAL SCAVENGERS; HIPPOCAMPUS; KAINIC ACID; MALE; METALLOPORPHYRINS; MITOCHONDRIA; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES; SUPEROXIDE DISMUTASE; SUPEROXIDES;

EID: 0034669186     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(00)00397-3     Document Type: Article

References (59)

1. Genotoxicity of ribo- and deoxyribonucleosides of 8-hydroxyguanine 5-hydroxycytosine and 2-hydroxyadenine: induction of SCE in human lymphocytes and mutagenicity in Salmonella typhirium TA100
2. Effect of mannitol treatment on brain neurotransmitter markers in kainic acid-induced epilepsy
3. Aconitase, a two-faced protein:enzyme and iron regulatory factor
4. Electrographic, clinical and pathological alterations following systemic administration of kainic acid, bicuculline or pentetrazole: metabolic mapping using the deoxyglucose method with special reference to the pathology of epilepsy
5. Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine
6. Novel role of phosphorylation in Fe-S cluster stability revealed by phosphomimetic mutations at Ser-138 of iron regulatory protein 1
7. Mammalian cytochrome-c oxidase: characterization of enzyme and immunological detection of subunits in tissue extracts and whole cells
8. Oxidative stress, glutamate, and neurodegenerative disorders
9. Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate
10. Mechanism of kainate toxicity to cerebellar neurons in vitro is analogous to reperfusion tissue injury
11. -), superoxide dismutases and related matters
12. Nitric oxide sensitivity of the aconitase
13. Inactivation-reactivation of aconitase in Escherichia coli. A sensitive measure of superoxide radical
14. Superoxide radical and iron modulate aconitase activity in mammalian cells
15. Hydroxyl radical generation during mitochondrial electron transfer and formation of 8-hydroxydeoxyguanosine in mitochondrial DNA
16. Manganese superoxide dismutase protects nNOS neurons from NMDA and nitric oxide-mediated neurotoxicity
17. Cellular regulation of the iron-responsive element binding protein: disassembly of the cubane iron-sulfur cluster results in high affinity RNA binding
18. Status epilepticus: frequency, etiology, and neurological sequelae
19. Superoxide and peroxynitrite inactivate aconitase, but nitric oxide does not
20. Transgenic models for the study of lung antioxidant defense: enhanced manganese-containing superoxide dismutase activity gives partial protection to B6C3 hybrid mice exposed to hyperoxia
21. Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair
22. Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction
23. Manganese superoxide dismutase overexpression attenuates MPTP toxicity
24. DNA fragmentation and prolonged expression of c-fos, c-jun, and hsp70 in kainic acid-induced neuronal cell death in transgenic mice overexpressing human CuZn-superoxide dismutase
25. The conversion of citrate into cis-aconitate and isocitrate in the presence of aconitase
26. Formation of base modification 8-hydroxyl-2'-deoxyguanosine and DNA fragmentation following seizures induced by systemic kainic acid in the rat
27. Ascorbate attenuates the systemic kainate-induced neurotoxicity in the rat hippocampus
28. Endogenous DNA adducts: potential and paradox
29. Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain
30. Mitochondrial disease in superoxide dismutase-2 mutant mice
31. A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase
32. A catalytic antioxidant metalloporphyrin blocks hydrogen peroxide-induced mitochondrial DNA damage
33. Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death
34. Kainic acid: neurophysiology and neurotoxic actions
35. Inhibition of neuronal apoptosis by a metalloporphyrin SOD mimetic
36. Metalloporphyrin class of therapeutic catalytic antioxidants
37. Requirement for superoxide in excitotoxic cell death
38. Kainate-induced apoptotic cell death in hippocampal neurons
39. Kainic acid-induced lipid peroxidation: protection with butylated hydroxytoluene and U78517F in primary cultures of cerebellar granule cells
40. Mitochondrial damage by the 'pro-oxidant' peroxisomal proliferator clofibrate
41. Spectrophotometric measurements of the enzymatic formation of fumaric and cis-aconitic acids
42. Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation
43. Oxidative damage to mitochondrial DNA and its relationship to ageing
44. Normal oxidative damage to mitochondrial and nuclear DNA is extensive
45. EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology
46. Involvement of free radicals in excitotoxicity in vivo
47. The role of mitochondrial dysfunction and neuronal nitric oxide in animal models of neurodegenerative diseases
48. Effects of over- and under-expression of Cu, Zn-superoxide dismutase on the toxicity of glutamate analogs in transgenic mouse striatum
49. In vivo DNA damage: measurement of 8-hydroxy-2'-deoxyguanosine in DNA and urine by high-performance liquid chromatography with electrochemical detection
50. 'Epileptic' brain damage in rats induced by sustained electrical stimulation of the perforant path. I. Acute electrophysiological and light microscopic studies
51. Apoptosis and necrosis induced in different hippocampal neuron populations by repetitive perforant path stimulation in the rat
52. 'Epileptic' brain damage is replicated qualitatively in the rat hippocampus by central injection of glutamate or aspartate but not by GABA or acetylcholine
53. Isolation of subcellular organelles
54. Melatonin protects hippocampal neurons in vivo against kainic acid-induced damage in mice
55. Endogenous oxidative damage of deoxycytidine in DNA
56. Increased oxidative damage is correlated to altered mitochondrial function in heterozygous manganese superoxide dismutase knockout mice