-
1
-
-
0037379362
-
Bile salt transporters: Molecular characterization, function, and regulation
-
Trauner M., Boyer J. L. Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev: 2003; 83 2 633 671
-
(2003)
Physiol Rev
, vol.83
, Issue.2
, pp. 633-671
-
-
Trauner, M.1
Boyer, J.L.2
-
3
-
-
0028231206
-
Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter
-
Hagenbuch B., Meier P. J. Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter. J Clin Invest: 1994; 93 3 1326 1331
-
(1994)
J Clin Invest
, vol.93
, Issue.3
, pp. 1326-1331
-
-
Hagenbuch, B.1
Meier, P.J.2
-
4
-
-
0028108370
-
Functional characterization of the basolateral rat liver organic anion transporting polypeptide
-
Kullak-Ublick G. A., Hagenbuch B., Stieger B., Wolkoff A. W., Meier P. J. Functional characterization of the basolateral rat liver organic anion transporting polypeptide. Hepatology: 1994; 20 2 411 416
-
(1994)
Hepatology
, vol.20
, Issue.2
, pp. 411-416
-
-
Kullak-Ublick, G.A.1
Hagenbuch, B.2
Stieger, B.3
Wolkoff, A.W.4
Meier, P.J.5
-
5
-
-
0033611305
-
The continuing importance of bile acids in liver and intestinal disease
-
Hofmann A. F. The continuing importance of bile acids in liver and intestinal disease. Arch Intern Med: 1999; 159 22 2647 2658
-
(1999)
Arch Intern Med
, vol.159
, Issue.22
, pp. 2647-2658
-
-
Hofmann, A.F.1
-
6
-
-
0037790917
-
The enzymes, regulation, and genetics of bile acid synthesis
-
Russell D. W. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem: 2003; 72 137 174
-
(2003)
Annu Rev Biochem
, vol.72
, pp. 137-174
-
-
Russell, D.W.1
-
7
-
-
0019995346
-
Different effects of chenodeoxycholic acid and ursodeoxycholic acid on serum lipoprotein concentrations in patients with radiolucent gallstones
-
Leiss O., von Bergmann K. Different effects of chenodeoxycholic acid and ursodeoxycholic acid on serum lipoprotein concentrations in patients with radiolucent gallstones. Scand J Gastroenterol: 1982; 17 5 587 592
-
(1982)
Scand J Gastroenterol
, vol.17
, Issue.5
, pp. 587-592
-
-
Leiss, O.1
Von Bergmann, K.2
-
8
-
-
0028798367
-
Abnormal bile acid absorption in familial hypertriglyceridemia
-
Duane W. C. Abnormal bile acid absorption in familial hypertriglyceridemia. J Lipid Res: 1995; 36 1 96 107
-
(1995)
J Lipid Res
, vol.36
, Issue.1
, pp. 96-107
-
-
Duane, W.C.1
-
9
-
-
0033797032
-
Diminished gene expression of ileal apical sodium bile acid transporter explains impaired absorption of bile acid in patients with hypertriglyceridemia
-
Duane W. C., Hartich L. A., Bartman A. E., Ho S. B. Diminished gene expression of ileal apical sodium bile acid transporter explains impaired absorption of bile acid in patients with hypertriglyceridemia. J Lipid Res: 2000; 41 9 1384 1389
-
(2000)
J Lipid Res
, vol.41
, Issue.9
, pp. 1384-1389
-
-
Duane, W.C.1
Hartich, L.A.2
Bartman, A.E.3
Ho, S.B.4
-
10
-
-
0028919931
-
1994 Mack-Forster Award Lecture. Review. Studies on the regulation of hepatic cholesterol metabolism in humans
-
Angelin B. 1994 Mack-Forster Award Lecture. Review. Studies on the regulation of hepatic cholesterol metabolism in humans. Eur J Clin Invest: 1995; 25 4 215 224
-
(1995)
Eur J Clin Invest
, vol.25
, Issue.4
, pp. 215-224
-
-
Angelin, B.1
-
11
-
-
0018132578
-
Effects of cholestyramine and chenodeoxycholic acid on the metabolism of endogenous triglyceride in hyperlipoproteinemia
-
Angelin B., Einarsson K., Hellström K., Leijd B. Effects of cholestyramine and chenodeoxycholic acid on the metabolism of endogenous triglyceride in hyperlipoproteinemia. J Lipid Res: 1978; 19 8 1017 1024
-
(1978)
J Lipid Res
, vol.19
, Issue.8
, pp. 1017-1024
-
-
Angelin, B.1
Einarsson, K.2
Hellström, K.3
Leijd, B.4
-
12
-
-
0024307596
-
Comparative effects of simvastatin and cholestyramine in treatment of patients with hypercholesterolaemia
-
Mölgaard J., von Schenck H., Olsson A. G. Comparative effects of simvastatin and cholestyramine in treatment of patients with hypercholesterolaemia. Eur J Clin Pharmacol: 1989; 36 5 455 460
-
(1989)
Eur J Clin Pharmacol
, vol.36
, Issue.5
, pp. 455-460
-
-
Mölgaard, J.1
Von Schenck, H.2
Olsson, A.G.3
-
13
-
-
0025086998
-
Effect of partial ileal bypass surgery on mortality and morbidity from coronary heart disease in patients with hypercholesterolemia. Report of the Program on the Surgical Control of the Hyperlipidemias (POSCH)
-
Buchwald H., Varco R. L., Matts J. P., et al. Effect of partial ileal bypass surgery on mortality and morbidity from coronary heart disease in patients with hypercholesterolemia. Report of the Program on the Surgical Control of the Hyperlipidemias (POSCH). N Engl J Med: 1990; 323 14 946 955
-
(1990)
N Engl J Med
, vol.323
, Issue.14
, pp. 946-955
-
-
Buchwald, H.1
Varco, R.L.2
Matts, J.P.3
-
14
-
-
18244382304
-
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
-
Donnelly K. L., Smith C. I., Schwarzenberg S. J., Jessurun J., Boldt M. D., Parks E. J. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest: 2005; 115 5 1343 1351
-
(2005)
J Clin Invest
, vol.115
, Issue.5
, pp. 1343-1351
-
-
Donnelly, K.L.1
Smith, C.I.2
Schwarzenberg, S.J.3
Jessurun, J.4
Boldt, M.D.5
Parks, E.J.6
-
15
-
-
79959517565
-
Human fatty liver disease: Old questions and new insights
-
Cohen J. C., Horton J. D., Hobbs H. H. Human fatty liver disease: old questions and new insights. Science: 2011; 332 6037 1519 1523
-
(2011)
Science
, vol.332
, Issue.6037
, pp. 1519-1523
-
-
Cohen, J.C.1
Horton, J.D.2
Hobbs, H.H.3
-
16
-
-
0036251153
-
SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
-
Horton J. D., Goldstein J. L., Brown M. S. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest: 2002; 109 9 1125 1131
-
(2002)
J Clin Invest
, vol.109
, Issue.9
, pp. 1125-1131
-
-
Horton, J.D.1
Goldstein, J.L.2
Brown, M.S.3
-
18
-
-
84860197759
-
Intracellular trafficking and secretion of VLDL
-
Tiwari S., Siddiqi S. A. Intracellular trafficking and secretion of VLDL. Arterioscler Thromb Vasc Biol: 2012; 32 5 1079 1086
-
(2012)
Arterioscler Thromb Vasc Biol
, vol.32
, Issue.5
, pp. 1079-1086
-
-
Tiwari, S.1
Siddiqi, S.A.2
-
19
-
-
33645738747
-
Endocrine functions of bile acids
-
Houten S. M., Watanabe M., Auwerx J. Endocrine functions of bile acids. EMBO J: 2006; 25 7 1419 1425
-
(2006)
EMBO J
, vol.25
, Issue.7
, pp. 1419-1425
-
-
Houten, S.M.1
Watanabe, M.2
Auwerx, J.3
-
20
-
-
69449095892
-
Bile acids as regulatory molecules
-
Hylemon P. B., Zhou H., Pandak W. M., Ren S., Gil G., Dent P. Bile acids as regulatory molecules. J Lipid Res: 2009; 50 8 1509 1520
-
(2009)
J Lipid Res
, vol.50
, Issue.8
, pp. 1509-1520
-
-
Hylemon, P.B.1
Zhou, H.2
Pandak, W.M.3
Ren, S.4
Gil, G.5
Dent, P.6
-
21
-
-
25444530047
-
Transcriptional regulation of hepatobiliary transport systems in health and disease: Implications for a rationale approach to the treatment of intrahepatic cholestasis
-
Wagner M., Trauner M. Transcriptional regulation of hepatobiliary transport systems in health and disease: implications for a rationale approach to the treatment of intrahepatic cholestasis. Ann Hepatol: 2005; 4 2 77 99
-
(2005)
Ann Hepatol
, vol.4
, Issue.2
, pp. 77-99
-
-
Wagner, M.1
Trauner, M.2
-
22
-
-
26244441014
-
The farnesoid X receptor: A molecular link between bile acid and lipid and glucose metabolism
-
Claudel T., Staels B., Kuipers F. The farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism. Arterioscler Thromb Vasc Biol: 2005; 25 10 2020 2030
-
(2005)
Arterioscler Thromb Vasc Biol
, vol.25
, Issue.10
, pp. 2020-2030
-
-
Claudel, T.1
Staels, B.2
Kuipers, F.3
-
23
-
-
0033591387
-
Bile acids: Natural ligands for an orphan nuclear receptor
-
Parks D. J., Blanchard S. G., Bledsoe R. K., et al. Bile acids: natural ligands for an orphan nuclear receptor. Science: 1999; 284 5418 1365 1368
-
(1999)
Science
, vol.284
, Issue.5418
, pp. 1365-1368
-
-
Parks, D.J.1
Blanchard, S.G.2
Bledsoe, R.K.3
-
24
-
-
0033591297
-
Identification of a nuclear receptor for bile acids
-
Makishima M., Okamoto A. Y., Repa J. J., et al. Identification of a nuclear receptor for bile acids. Science: 1999; 284 5418 1362 1365
-
(1999)
Science
, vol.284
, Issue.5418
, pp. 1362-1365
-
-
Makishima, M.1
Okamoto, A.Y.2
Repa, J.J.3
-
25
-
-
0033026760
-
Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
-
Wang H., Chen J., Hollister K., Sowers L. C., Forman B. M. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell: 1999; 3 5 543 553
-
(1999)
Mol Cell
, vol.3
, Issue.5
, pp. 543-553
-
-
Wang, H.1
Chen, J.2
Hollister, K.3
Sowers, L.C.4
Forman, B.M.5
-
26
-
-
84873342775
-
Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist
-
Sayin S. I., Wahlström A., Felin J., et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab: 2013; 17 2 225 235
-
(2013)
Cell Metab
, vol.17
, Issue.2
, pp. 225-235
-
-
Sayin, S.I.1
Wahlström, A.2
Felin, J.3
-
27
-
-
0036668184
-
Bile acid regulation of gene expression: Roles of nuclear hormone receptors
-
Chiang J. Y. Bile acid regulation of gene expression: roles of nuclear hormone receptors. Endocr Rev: 2002; 23 4 443 463
-
(2002)
Endocr Rev
, vol.23
, Issue.4
, pp. 443-463
-
-
Chiang, J.Y.1
-
28
-
-
70349430938
-
Bile acids: Regulation of synthesis
-
Chiang J. Y. Bile acids: regulation of synthesis. J Lipid Res: 2009; 50 10 1955 1966
-
(2009)
J Lipid Res
, vol.50
, Issue.10
, pp. 1955-1966
-
-
Chiang, J.Y.1
-
29
-
-
31444454037
-
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
-
Watanabe M., Houten S. M., Mataki C., et al. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature: 2006; 439 7075 484 489
-
(2006)
Nature
, vol.439
, Issue.7075
, pp. 484-489
-
-
Watanabe, M.1
Houten, S.M.2
Mataki, C.3
-
30
-
-
48749113401
-
Targeting bile-acid signalling for metabolic diseases
-
Thomas C., Pellicciari R., Pruzanski M., Auwerx J., Schoonjans K. Targeting bile-acid signalling for metabolic diseases. Nat Rev Drug Discov: 2008; 7 8 678 693
-
(2008)
Nat Rev Drug Discov
, vol.7
, Issue.8
, pp. 678-693
-
-
Thomas, C.1
Pellicciari, R.2
Pruzanski, M.3
Auwerx, J.4
Schoonjans, K.5
-
31
-
-
58249110568
-
Role of bile acids and bile acid receptors in metabolic regulation
-
Lefebvre P., Cariou B., Lien F., Kuipers F., Staels B. Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev: 2009; 89 1 147 191
-
(2009)
Physiol Rev
, vol.89
, Issue.1
, pp. 147-191
-
-
Lefebvre, P.1
Cariou, B.2
Lien, F.3
Kuipers, F.4
Staels, B.5
-
32
-
-
27544448347
-
Nuclear receptor regulation of lipid metabolism: Potential therapeutics for dyslipidemia, diabetes, and chronic heart and liver diseases
-
Chiang J. Y. Nuclear receptor regulation of lipid metabolism: potential therapeutics for dyslipidemia, diabetes, and chronic heart and liver diseases. Curr Opin Investig Drugs: 2005; 6 10 994 1001
-
(2005)
Curr Opin Investig Drugs
, vol.6
, Issue.10
, pp. 994-1001
-
-
Chiang, J.Y.1
-
33
-
-
0036218724
-
Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element
-
Claudel T., Sturm E., Duez H., et al. Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element. J Clin Invest: 2002; 109 7 961 971
-
(2002)
J Clin Invest
, vol.109
, Issue.7
, pp. 961-971
-
-
Claudel, T.1
Sturm, E.2
Duez, H.3
-
34
-
-
0038281429
-
FXR induces the UGT2B4 enzyme in hepatocytes: A potential mechanism of negative feedback control of FXR activity
-
Barbier O., Torra I. P., Sirvent A., et al. FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity. Gastroenterology: 2003; 124 7 1926 1940
-
(2003)
Gastroenterology
, vol.124
, Issue.7
, pp. 1926-1940
-
-
Barbier, O.1
Torra, I.P.2
Sirvent, A.3
-
35
-
-
0034616147
-
Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor
-
Laffitte B. A., Kast H. R., Nguyen C. M., Zavacki A. M., Moore D. D., Edwards P. A. Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor. J Biol Chem: 2000; 275 14 10638 10647
-
(2000)
J Biol Chem
, vol.275
, Issue.14
, pp. 10638-10647
-
-
Laffitte, B.A.1
Kast, H.R.2
Nguyen, C.M.3
Zavacki, A.M.4
Moore, D.D.5
Edwards, P.A.6
-
36
-
-
0042666932
-
Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression
-
Claudel T., Inoue Y., Barbier O., et al. Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression. Gastroenterology: 2003; 125 2 544 555
-
(2003)
Gastroenterology
, vol.125
, Issue.2
, pp. 544-555
-
-
Claudel, T.1
Inoue, Y.2
Barbier, O.3
-
37
-
-
33745774784
-
Role of nuclear receptors in the adaptive response to bile acids and cholestasis: Pathogenetic and therapeutic considerations
-
Zollner G., Marschall H. U., Wagner M., Trauner M. Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations. Mol Pharm: 2006; 3 3 231 251
-
(2006)
Mol Pharm
, vol.3
, Issue.3
, pp. 231-251
-
-
Zollner, G.1
Marschall, H.U.2
Wagner, M.3
Trauner, M.4
-
38
-
-
9944247695
-
Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism
-
Eloranta J. J., Kullak-Ublick G. A. Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism. Arch Biochem Biophys: 2005; 433 2 397 412
-
(2005)
Arch Biochem Biophys
, vol.433
, Issue.2
, pp. 397-412
-
-
Eloranta, J.J.1
Kullak-Ublick, G.A.2
-
39
-
-
33644979579
-
The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes
-
Landrier J. F., Eloranta J. J., Vavricka S. R., Kullak-Ublick G. A. The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes. Am J Physiol Gastrointest Liver Physiol: 2006; 290 3 G476 G485
-
(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.290
, Issue.3
-
-
Landrier, J.F.1
Eloranta, J.J.2
Vavricka, S.R.3
Kullak-Ublick, G.A.4
-
40
-
-
30844445030
-
FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine
-
Lee H., Zhang Y., Lee F. Y., Nelson S. F., Gonzalez F. J., Edwards P. A. FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine. J Lipid Res: 2006; 47 1 201 214
-
(2006)
J Lipid Res
, vol.47
, Issue.1
, pp. 201-214
-
-
Lee, H.1
Zhang, Y.2
Lee, F.Y.3
Nelson, S.F.4
Gonzalez, F.J.5
Edwards, P.A.6
-
41
-
-
0037663483
-
Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis
-
Holt J. A., Luo G., Billin A. N., et al. Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. Genes Dev: 2003; 17 13 1581 1591
-
(2003)
Genes Dev
, vol.17
, Issue.13
, pp. 1581-1591
-
-
Holt, J.A.1
Luo, G.2
Billin, A.N.3
-
42
-
-
27844546989
-
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
-
Inagaki T., Choi M., Moschetta A., et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab: 2005; 2 4 217 225
-
(2005)
Cell Metab
, vol.2
, Issue.4
, pp. 217-225
-
-
Inagaki, T.1
Choi, M.2
Moschetta, A.3
-
43
-
-
0034664729
-
Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
-
Sinal C. J., Tohkin M., Miyata M., Ward J. M., Lambert G., Gonzalez F. J. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell: 2000; 102 6 731 744
-
(2000)
Cell
, vol.102
, Issue.6
, pp. 731-744
-
-
Sinal, C.J.1
Tohkin, M.2
Miyata, M.3
Ward, J.M.4
Lambert, G.5
Gonzalez, F.J.6
-
44
-
-
85047694456
-
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
-
Watanabe M., Houten S. M., Wang L., et al. Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest: 2004; 113 10 1408 1418
-
(2004)
J Clin Invest
, vol.113
, Issue.10
, pp. 1408-1418
-
-
Watanabe, M.1
Houten, S.M.2
Wang, L.3
-
45
-
-
0037315190
-
Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor
-
Pineda Torra I., Claudel T., Duval C., Kosykh V., Fruchart J. C., Staels B. Bile acids induce the expression of the human peroxisome proliferator- activated receptor alpha gene via activation of the farnesoid X receptor. Mol Endocrinol: 2003; 17 2 259 272
-
(2003)
Mol Endocrinol
, vol.17
, Issue.2
, pp. 259-272
-
-
Pineda Torra, I.1
Claudel, T.2
Duval, C.3
Kosykh, V.4
Fruchart, J.C.5
Staels, B.6
-
46
-
-
8544256355
-
Bile acid reduces the secretion of very low density lipoprotein by repressing microsomal triglyceride transfer protein gene expression mediated by hepatocyte nuclear factor-4
-
Hirokane H., Nakahara M., Tachibana S., Shimizu M., Sato R. Bile acid reduces the secretion of very low density lipoprotein by repressing microsomal triglyceride transfer protein gene expression mediated by hepatocyte nuclear factor-4. J Biol Chem: 2004; 279 44 45685 45692
-
(2004)
J Biol Chem
, vol.279
, Issue.44
, pp. 45685-45692
-
-
Hirokane, H.1
Nakahara, M.2
Tachibana, S.3
Shimizu, M.4
Sato, R.5
-
47
-
-
0034791544
-
Farnesoid X-activated receptor induces apolipoprotein C-II transcription: A molecular mechanism linking plasma triglyceride levels to bile acids
-
Kast H. R., Nguyen C. M., Sinal C. J., et al. Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids. Mol Endocrinol: 2001; 15 10 1720 1728
-
(2001)
Mol Endocrinol
, vol.15
, Issue.10
, pp. 1720-1728
-
-
Kast, H.R.1
Nguyen, C.M.2
Sinal, C.J.3
-
48
-
-
0038491484
-
The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor-alpha and contains a novel farnesoid X-activated receptor response element
-
Prieur X., Coste H., Rodriguez J. C. The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor-alpha and contains a novel farnesoid X-activated receptor response element. J Biol Chem: 2003; 278 28 25468 25480
-
(2003)
J Biol Chem
, vol.278
, Issue.28
, pp. 25468-25480
-
-
Prieur, X.1
Coste, H.2
Rodriguez, J.C.3
-
49
-
-
0037462815
-
The farnesoid X-receptor is an essential regulator of cholesterol homeostasis
-
Lambert G., Amar M. J., Guo G., Brewer H. B. Jr, Gonzalez F. J., Sinal C. J. The farnesoid X-receptor is an essential regulator of cholesterol homeostasis. J Biol Chem: 2003; 278 4 2563 2570
-
(2003)
J Biol Chem
, vol.278
, Issue.4
, pp. 2563-2570
-
-
Lambert, G.1
Amar, M.J.2
Guo, G.3
Brewer Jr., H.B.4
Gonzalez, F.J.5
Sinal, C.J.6
-
50
-
-
33748940093
-
The farnesoid X receptor promotes adipocyte differentiation and regulates adipose cell function in vivo
-
Rizzo G., Disante M., Mencarelli A., et al. The farnesoid X receptor promotes adipocyte differentiation and regulates adipose cell function in vivo. Mol Pharmacol: 2006; 70 4 1164 1173
-
(2006)
Mol Pharmacol
, vol.70
, Issue.4
, pp. 1164-1173
-
-
Rizzo, G.1
Disante, M.2
Mencarelli, A.3
-
51
-
-
78449258535
-
The farnesoid X receptor regulates adipocyte differentiation and function by promoting peroxisome proliferator-activated receptor-gamma and interfering with the Wnt/beta-catenin pathways
-
Abdelkarim M., Caron S., Duhem C., et al. The farnesoid X receptor regulates adipocyte differentiation and function by promoting peroxisome proliferator-activated receptor-gamma and interfering with the Wnt/beta-catenin pathways. J Biol Chem: 2010; 285 47 36759 36767
-
(2010)
J Biol Chem
, vol.285
, Issue.47
, pp. 36759-36767
-
-
Abdelkarim, M.1
Caron, S.2
Duhem, C.3
-
52
-
-
33645509321
-
Farnesoid X receptor is essential for normal glucose homeostasis
-
Ma K., Saha P. K., Chan L., Moore D. D. Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest: 2006; 116 4 1102 1109
-
(2006)
J Clin Invest
, vol.116
, Issue.4
, pp. 1102-1109
-
-
Ma, K.1
Saha, P.K.2
Chan, L.3
Moore, D.D.4
-
53
-
-
84861880073
-
Bile acids acutely stimulate insulin secretion of mouse β-cells via farnesoid X receptor activation and K(ATP) channel inhibition
-
Düfer M., Hörth K., Wagner R., et al. Bile acids acutely stimulate insulin secretion of mouse β-cells via farnesoid X receptor activation and K(ATP) channel inhibition. Diabetes: 2012; 61 6 1479 1489
-
(2012)
Diabetes
, vol.61
, Issue.6
, pp. 1479-1489
-
-
Düfer, M.1
Hörth, K.2
Wagner, R.3
-
54
-
-
14244264780
-
Regulation of carbohydrate metabolism by the farnesoid X receptor
-
Stayrook K. R., Bramlett K. S., Savkur R. S., et al. Regulation of carbohydrate metabolism by the farnesoid X receptor. Endocrinology: 2005; 146 3 984 991
-
(2005)
Endocrinology
, vol.146
, Issue.3
, pp. 984-991
-
-
Stayrook, K.R.1
Bramlett, K.S.2
Savkur, R.S.3
-
55
-
-
32244447570
-
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
-
Zhang Y., Lee F. Y., Barrera G., et al. Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Proc Natl Acad Sci U S A: 2006; 103 4 1006 1011
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.4
, pp. 1006-1011
-
-
Zhang, Y.1
Lee, F.Y.2
Barrera, G.3
-
56
-
-
79953129095
-
FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis
-
Kir S., Beddow S. A., Samuel V. T., et al. FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Science: 2011; 331 6024 1621 1624
-
(2011)
Science
, vol.331
, Issue.6024
, pp. 1621-1624
-
-
Kir, S.1
Beddow, S.A.2
Samuel, V.T.3
-
57
-
-
33645531297
-
The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice
-
Cariou B., van Harmelen K., Duran-Sandoval D., et al. The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice. J Biol Chem: 2006; 281 16 11039 11049
-
(2006)
J Biol Chem
, vol.281
, Issue.16
, pp. 11039-11049
-
-
Cariou, B.1
Van Harmelen, K.2
Duran-Sandoval, D.3
-
58
-
-
22544474215
-
Transient impairment of the adaptive response to fasting in FXR-deficient mice
-
Cariou B., van Harmelen K., Duran-Sandoval D., et al. Transient impairment of the adaptive response to fasting in FXR-deficient mice. FEBS Lett: 2005; 579 19 4076 4080
-
(2005)
FEBS Lett
, vol.579
, Issue.19
, pp. 4076-4080
-
-
Cariou, B.1
Van Harmelen, K.2
Duran-Sandoval, D.3
-
59
-
-
0033579972
-
Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain
-
Nishimura T., Utsunomiya Y., Hoshikawa M., Ohuchi H., Itoh N. Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain. Biochim Biophys Acta: 1999; 1444 1 148 151
-
(1999)
Biochim Biophys Acta
, vol.1444
, Issue.1
, pp. 148-151
-
-
Nishimura, T.1
Utsunomiya, Y.2
Hoshikawa, M.3
Ohuchi, H.4
Itoh, N.5
-
60
-
-
18344394556
-
Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity
-
Tomlinson E., Fu L., John L., et al. Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity. Endocrinology: 2002; 143 5 1741 1747
-
(2002)
Endocrinology
, vol.143
, Issue.5
, pp. 1741-1747
-
-
Tomlinson, E.1
Fu, L.2
John, L.3
-
61
-
-
0029961359
-
Cloning of human acetyl-CoA carboxylase-beta and its unique features
-
Ha J., Lee J. K., Kim K. S., Witters L. A., Kim K. H. Cloning of human acetyl-CoA carboxylase-beta and its unique features. Proc Natl Acad Sci U S A: 1996; 93 21 11466 11470
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, Issue.21
, pp. 11466-11470
-
-
Ha, J.1
Lee, J.K.2
Kim, K.S.3
Witters, L.A.4
Kim, K.H.5
-
62
-
-
0035970805
-
Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2
-
Abu-Elheiga L., Matzuk M. M., Abo-Hashema K. A., Wakil S. J. Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science: 2001; 291 5513 2613 2616
-
(2001)
Science
, vol.291
, Issue.5513
, pp. 2613-2616
-
-
Abu-Elheiga, L.1
Matzuk, M.M.2
Abo-Hashema, K.A.3
Wakil, S.J.4
-
63
-
-
34948821192
-
FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver
-
Huang X., Yang C., Luo Y., Jin C., Wang F., McKeehan W. L. FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver. Diabetes: 2007; 56 10 2501 2510
-
(2007)
Diabetes
, vol.56
, Issue.10
, pp. 2501-2510
-
-
Huang, X.1
Yang, C.2
Luo, Y.3
Jin, C.4
Wang, F.5
McKeehan, W.L.6
-
64
-
-
0037143752
-
Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity
-
Ntambi J. M., Miyazaki M., Stoehr J. P., et al. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci U S A: 2002; 99 17 11482 11486
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, Issue.17
, pp. 11482-11486
-
-
Ntambi, J.M.1
Miyazaki, M.2
Stoehr, J.P.3
-
65
-
-
33751115468
-
Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man
-
Lundåsen T., Gälman C., Angelin B., Rudling M. Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man. J Intern Med: 2006; 260 6 530 536
-
(2006)
J Intern Med
, vol.260
, Issue.6
, pp. 530-536
-
-
Lundåsen, T.1
Gälman, C.2
Angelin, B.3
Rudling, M.4
-
66
-
-
84857775690
-
Bile acid signaling in liver metabolism and diseases
-
Li T., Chiang J. Y. Bile acid signaling in liver metabolism and diseases. J Lipids: 2012; 2012 754067
-
(2012)
J Lipids
, vol.2012
, pp. 754067
-
-
Li, T.1
Chiang, J.Y.2
-
67
-
-
77249102583
-
The hepatic response to FGF19 is impaired in patients with nonalcoholic fatty liver disease and insulin resistance
-
Schreuder T. C., Marsman H. A., Lenicek M., et al. The hepatic response to FGF19 is impaired in patients with nonalcoholic fatty liver disease and insulin resistance. Am J Physiol Gastrointest Liver Physiol: 2010; 298 3 G440 G445
-
(2010)
Am J Physiol Gastrointest Liver Physiol
, vol.298
, Issue.3
-
-
Schreuder, T.C.1
Marsman, H.A.2
Lenicek, M.3
-
68
-
-
0036468871
-
Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele
-
Bange J., Prechtl D., Cheburkin Y., et al. Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele. Cancer Res: 2002; 62 3 840 847
-
(2002)
Cancer Res
, vol.62
, Issue.3
, pp. 840-847
-
-
Bange, J.1
Prechtl, D.2
Cheburkin, Y.3
-
69
-
-
32944455535
-
Ectopic activity of fibroblast growth factor receptor 1 in hepatocytes accelerates hepatocarcinogenesis by driving proliferation and vascular endothelial growth factor-induced angiogenesis
-
Huang X., Yu C., Jin C., et al. Ectopic activity of fibroblast growth factor receptor 1 in hepatocytes accelerates hepatocarcinogenesis by driving proliferation and vascular endothelial growth factor-induced angiogenesis. Cancer Res: 2006; 66 3 1481 1490
-
(2006)
Cancer Res
, vol.66
, Issue.3
, pp. 1481-1490
-
-
Huang, X.1
Yu, C.2
Jin, C.3
-
70
-
-
0034697846
-
Identification of a novel FGF, FGF-21, preferentially expressed in the liver
-
Nishimura T., Nakatake Y., Konishi M., Itoh N. Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Biochim Biophys Acta: 2000; 1492 1 203 206
-
(2000)
Biochim Biophys Acta
, vol.1492
, Issue.1
, pp. 203-206
-
-
Nishimura, T.1
Nakatake, Y.2
Konishi, M.3
Itoh, N.4
-
71
-
-
34848869695
-
Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21
-
Kurosu H., Choi M., Ogawa Y., et al. Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J Biol Chem: 2007; 282 37 26687 26695
-
(2007)
J Biol Chem
, vol.282
, Issue.37
, pp. 26687-26695
-
-
Kurosu, H.1
Choi, M.2
Ogawa, Y.3
-
72
-
-
34249697012
-
BetaKlotho is required for metabolic activity of fibroblast growth factor 21
-
Ogawa Y., Kurosu H., Yamamoto M., et al. BetaKlotho is required for metabolic activity of fibroblast growth factor 21. Proc Natl Acad Sci U S A: 2007; 104 18 7432 7437
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, Issue.18
, pp. 7432-7437
-
-
Ogawa, Y.1
Kurosu, H.2
Yamamoto, M.3
-
73
-
-
41649109108
-
BetaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c
-
Suzuki M., Uehara Y., Motomura-Matsuzaka K., et al. betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol Endocrinol: 2008; 22 4 1006 1014
-
(2008)
Mol Endocrinol
, vol.22
, Issue.4
, pp. 1006-1014
-
-
Suzuki, M.1
Uehara, Y.2
Motomura-Matsuzaka, K.3
-
75
-
-
33845380799
-
Forced expression of hepatocyte-specific fibroblast growth factor 21 delays initiation of chemically induced hepatocarcinogenesis
-
Huang X., Yu C., Jin C., et al. Forced expression of hepatocyte-specific fibroblast growth factor 21 delays initiation of chemically induced hepatocarcinogenesis. Mol Carcinog: 2006; 45 12 934 942
-
(2006)
Mol Carcinog
, vol.45
, Issue.12
, pp. 934-942
-
-
Huang, X.1
Yu, C.2
Jin, C.3
-
76
-
-
33750587755
-
Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways
-
Wente W., Efanov A. M., Brenner M., et al. Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways. Diabetes: 2006; 55 9 2470 2478
-
(2006)
Diabetes
, vol.55
, Issue.9
, pp. 2470-2478
-
-
Wente, W.1
Efanov, A.M.2
Brenner, M.3
-
77
-
-
34249711964
-
Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states
-
Badman M. K., Pissios P., Kennedy A. R., Koukos G., Flier J. S., Maratos-Flier E. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab: 2007; 5 6 426 437
-
(2007)
Cell Metab
, vol.5
, Issue.6
, pp. 426-437
-
-
Badman, M.K.1
Pissios, P.2
Kennedy, A.R.3
Koukos, G.4
Flier, J.S.5
Maratos-Flier, E.6
-
78
-
-
34249686631
-
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
-
Inagaki T., Dutchak P., Zhao G., et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab: 2007; 5 6 415 425
-
(2007)
Cell Metab
, vol.5
, Issue.6
, pp. 415-425
-
-
Inagaki, T.1
Dutchak, P.2
Zhao, G.3
-
79
-
-
84864105994
-
Activation of the farnesoid X receptor induces hepatic expression and secretion of fibroblast growth factor 21
-
Cyphert H. A., Ge X., Kohan A. B., Salati L. M., Zhang Y., Hillgartner F. B. Activation of the farnesoid X receptor induces hepatic expression and secretion of fibroblast growth factor 21. J Biol Chem: 2012; 287 30 25123 25138
-
(2012)
J Biol Chem
, vol.287
, Issue.30
, pp. 25123-25138
-
-
Cyphert, H.A.1
Ge, X.2
Kohan, A.B.3
Salati, L.M.4
Zhang, Y.5
Hillgartner, F.B.6
-
80
-
-
48349146527
-
Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans
-
Zhang X., Yeung D. C., Karpisek M., et al. Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes: 2008; 57 5 1246 1253
-
(2008)
Diabetes
, vol.57
, Issue.5
, pp. 1246-1253
-
-
Zhang, X.1
Yeung, D.C.2
Karpisek, M.3
-
81
-
-
39449127028
-
Circulating FGF-21 levels in normal subjects and in newly diagnosed patients with type 2 diabetes mellitus
-
Chen W. W., Li L., Yang G. Y., et al. Circulating FGF-21 levels in normal subjects and in newly diagnosed patients with type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes: 2008; 116 1 65 68
-
(2008)
Exp Clin Endocrinol Diabetes
, vol.116
, Issue.1
, pp. 65-68
-
-
Chen, W.W.1
Li, L.2
Yang, G.Y.3
-
82
-
-
74849119709
-
Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: Potential impact in diabetes
-
Genet C., Strehle A., Schmidt C., et al. Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. J Med Chem: 2010; 53 1 178 190
-
(2010)
J Med Chem
, vol.53
, Issue.1
, pp. 178-190
-
-
Genet, C.1
Strehle, A.2
Schmidt, C.3
-
83
-
-
0003269455
-
A G protein-coupled receptor responsive to bile acids
-
Kawamata Y., Fujii R., Hosoya M., et al. A G protein-coupled receptor responsive to bile acids. J Biol Chem: 2003; 278 11 9435 9440
-
(2003)
J Biol Chem
, vol.278
, Issue.11
, pp. 9435-9440
-
-
Kawamata, Y.1
Fujii, R.2
Hosoya, M.3
-
84
-
-
33748757234
-
Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation
-
Vassileva G., Golovko A., Markowitz L., et al. Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation. Biochem J: 2006; 398 3 423 430
-
(2006)
Biochem J
, vol.398
, Issue.3
, pp. 423-430
-
-
Vassileva, G.1
Golovko, A.2
Markowitz, L.3
-
85
-
-
70349255713
-
The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders
-
Keitel V., Cupisti K., Ullmer C., Knoefel W. T., Kubitz R., Häussinger D. The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders. Hepatology: 2009; 50 3 861 870
-
(2009)
Hepatology
, vol.50
, Issue.3
, pp. 861-870
-
-
Keitel, V.1
Cupisti, K.2
Ullmer, C.3
Knoefel, W.T.4
Kubitz, R.5
Häussinger, D.6
-
86
-
-
0036432845
-
Identification of membrane-type receptor for bile acids (M-BAR)
-
Maruyama T., Miyamoto Y., Nakamura T., et al. Identification of membrane-type receptor for bile acids (M-BAR). Biochem Biophys Res Commun: 2002; 298 5 714 719
-
(2002)
Biochem Biophys Res Commun
, vol.298
, Issue.5
, pp. 714-719
-
-
Maruyama, T.1
Miyamoto, Y.2
Nakamura, T.3
-
87
-
-
33947383769
-
The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells
-
Keitel V., Reinehr R., Gatsios P., et al. The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells. Hepatology: 2007; 45 3 695 704
-
(2007)
Hepatology
, vol.45
, Issue.3
, pp. 695-704
-
-
Keitel, V.1
Reinehr, R.2
Gatsios, P.3
-
88
-
-
44649092024
-
Expression and function of the bile acid receptor TGR5 in Kupffer cells
-
Keitel V., Donner M., Winandy S., Kubitz R., Häussinger D. Expression and function of the bile acid receptor TGR5 in Kupffer cells. Biochem Biophys Res Commun: 2008; 372 1 78 84
-
(2008)
Biochem Biophys Res Commun
, vol.372
, Issue.1
, pp. 78-84
-
-
Keitel, V.1
Donner, M.2
Winandy, S.3
Kubitz, R.4
Häussinger, D.5
-
89
-
-
77954569180
-
The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes
-
Keitel V., Ullmer C., Häussinger D. The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes. Biol Chem: 2010; 391 7 785 789
-
(2010)
Biol Chem
, vol.391
, Issue.7
, pp. 785-789
-
-
Keitel, V.1
Ullmer, C.2
Häussinger, D.3
-
90
-
-
55049094158
-
Bile acids and signal transduction: Role in glucose homeostasis
-
Nguyen A., Bouscarel B. Bile acids and signal transduction: role in glucose homeostasis. Cell Signal: 2008; 20 12 2180 2197
-
(2008)
Cell Signal
, vol.20
, Issue.12
, pp. 2180-2197
-
-
Nguyen, A.1
Bouscarel, B.2
-
91
-
-
70350292362
-
Bile-acid-activated receptors: Targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders
-
Fiorucci S., Mencarelli A., Palladino G., Cipriani S. Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders. Trends Pharmacol Sci: 2009; 30 11 570 580
-
(2009)
Trends Pharmacol Sci
, vol.30
, Issue.11
, pp. 570-580
-
-
Fiorucci, S.1
Mencarelli, A.2
Palladino, G.3
Cipriani, S.4
-
92
-
-
0344357096
-
Glucagon-like peptide i stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line
-
Drucker D. J., Philippe J., Mojsov S., Chick W. L., Habener J. F. Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line. Proc Natl Acad Sci U S A: 1987; 84 10 3434 3438
-
(1987)
Proc Natl Acad Sci U S A
, vol.84
, Issue.10
, pp. 3434-3438
-
-
Drucker, D.J.1
Philippe, J.2
Mojsov, S.3
Chick, W.L.4
Habener, J.F.5
-
93
-
-
0023638829
-
Glucagon-like peptide-1 7-36: A physiological incretin in man
-
Kreymann B., Williams G., Ghatei M. A., Bloom S. R. Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet: 1987; 2 8571 1300 1304
-
(1987)
Lancet
, vol.2
, Issue.8571
, pp. 1300-1304
-
-
Kreymann, B.1
Williams, G.2
Ghatei, M.A.3
Bloom, S.R.4
-
94
-
-
0029829821
-
Vagal hepatopancreatic reflex effect evoked by intraportal appearance of tGLP-1
-
Nakabayashi H., Nishizawa M., Nakagawa A., Takeda R., Niijima A. Vagal hepatopancreatic reflex effect evoked by intraportal appearance of tGLP-1. Am J Physiol: 1996; 271 5 Pt 1 E808 E813
-
(1996)
Am J Physiol
, vol.271
, Issue.PART 1
-
-
Nakabayashi, H.1
Nishizawa, M.2
Nakagawa, A.3
Takeda, R.4
Niijima, A.5
-
95
-
-
35748957503
-
The physiology of glucagon-like peptide 1
-
Holst J. J. The physiology of glucagon-like peptide 1. Physiol Rev: 2007; 87 4 1409 1439
-
(2007)
Physiol Rev
, vol.87
, Issue.4
, pp. 1409-1439
-
-
Holst, J.J.1
-
96
-
-
84874031840
-
Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice
-
Potthoff M. J., Potts A., He T., et al. Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice. Am J Physiol Gastrointest Liver Physiol: 2013; 304 4 G371 G380
-
(2013)
Am J Physiol Gastrointest Liver Physiol
, vol.304
, Issue.4
-
-
Potthoff, M.J.1
Potts, A.2
He, T.3
-
97
-
-
0037129380
-
Nonalcoholic fatty liver disease
-
Angulo P. Nonalcoholic fatty liver disease. N Engl J Med: 2002; 346 16 1221 1231
-
(2002)
N Engl J Med
, vol.346
, Issue.16
, pp. 1221-1231
-
-
Angulo, P.1
-
98
-
-
77957375969
-
Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease
-
Targher G., Day C. P., Bonora E. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med: 2010; 363 14 1341 1350
-
(2010)
N Engl J Med
, vol.363
, Issue.14
, pp. 1341-1350
-
-
Targher, G.1
Day, C.P.2
Bonora, E.3
-
99
-
-
0034680309
-
VLDL, apolipoproteins B, CIII, and E, and risk of recurrent coronary events in the Cholesterol and Recurrent Events (CARE) trial
-
Sacks F. M., Alaupovic P., Moye L. A., et al. VLDL, apolipoproteins B, CIII, and E, and risk of recurrent coronary events in the Cholesterol and Recurrent Events (CARE) trial. Circulation: 2000; 102 16 1886 1892
-
(2000)
Circulation
, vol.102
, Issue.16
, pp. 1886-1892
-
-
Sacks, F.M.1
Alaupovic, P.2
Moye, L.A.3
-
100
-
-
84878261341
-
Fatty liver: A link to cardiovascular disease-its natural history, pathogenesis, and treatment
-
Monsour H. P. Jr, Frenette C. T., Wyne K. Fatty liver: a link to cardiovascular disease-its natural history, pathogenesis, and treatment. Methodist Debakey Cardiovasc J: 2012; 8 3 21 25
-
(2012)
Methodist Debakey Cardiovasc J
, vol.8
, Issue.3
, pp. 21-25
-
-
Monsour Jr., H.P.1
Frenette, C.T.2
Wyne, K.3
-
101
-
-
77955690182
-
Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites
-
Neuschwander-Tetri B. A. Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites. Hepatology: 2010; 52 2 774 788
-
(2010)
Hepatology
, vol.52
, Issue.2
, pp. 774-788
-
-
Neuschwander-Tetri, B.A.1
-
102
-
-
76049091112
-
Lipid homeostasis, lipotoxicity and the metabolic syndrome
-
Unger R. H., Clark G. O., Scherer P. E., Orci L. Lipid homeostasis, lipotoxicity and the metabolic syndrome. Biochim Biophys Acta: 2010; 1801 3 209 214
-
(2010)
Biochim Biophys Acta
, vol.1801
, Issue.3
, pp. 209-214
-
-
Unger, R.H.1
Clark, G.O.2
Scherer, P.E.3
Orci, L.4
-
103
-
-
84858020291
-
FAT SIGNALS-lipases and lipolysis in lipid metabolism and signaling
-
Zechner R., Zimmermann R., Eichmann T. O., et al. FAT SIGNALS-lipases and lipolysis in lipid metabolism and signaling. Cell Metab: 2012; 15 3 279 291
-
(2012)
Cell Metab
, vol.15
, Issue.3
, pp. 279-291
-
-
Zechner, R.1
Zimmermann, R.2
Eichmann, T.O.3
-
104
-
-
56149085041
-
Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response
-
Wang Y. D., Chen W. D., Wang M., Yu D., Forman B. M., Huang W. Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response. Hepatology: 2008; 48 5 1632 1643
-
(2008)
Hepatology
, vol.48
, Issue.5
, pp. 1632-1643
-
-
Wang, Y.D.1
Chen, W.D.2
Wang, M.3
Yu, D.4
Forman, B.M.5
Huang, W.6
-
105
-
-
34547411540
-
Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver
-
Huang J., Iqbal J., Saha P. K., et al. Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver. Hepatology: 2007; 46 1 147 157
-
(2007)
Hepatology
, vol.46
, Issue.1
, pp. 147-157
-
-
Huang, J.1
Iqbal, J.2
Saha, P.K.3
-
106
-
-
55549144718
-
FXR: A metabolic regulator and cell protector
-
Wang Y. D., Chen W. D., Moore D. D., Huang W. FXR: a metabolic regulator and cell protector. Cell Res: 2008; 18 11 1087 1095
-
(2008)
Cell Res
, vol.18
, Issue.11
, pp. 1087-1095
-
-
Wang, Y.D.1
Chen, W.D.2
Moore, D.D.3
Huang, W.4
-
107
-
-
39749198581
-
Epigenetic inhibition of nuclear receptor small heterodimer partner is associated with and regulates hepatocellular carcinoma growth
-
He N., Park K., Zhang Y., Huang J., Lu S., Wang L. Epigenetic inhibition of nuclear receptor small heterodimer partner is associated with and regulates hepatocellular carcinoma growth. Gastroenterology: 2008; 134 3 793 802
-
(2008)
Gastroenterology
, vol.134
, Issue.3
, pp. 793-802
-
-
He, N.1
Park, K.2
Zhang, Y.3
Huang, J.4
Lu, S.5
Wang, L.6
-
108
-
-
34547476712
-
A little orphan runs to fat: The orphan receptor small heterodimer partner as a key player in the regulation of hepatic lipid metabolism
-
Trauner M. A little orphan runs to fat: the orphan receptor small heterodimer partner as a key player in the regulation of hepatic lipid metabolism. Hepatology: 2007; 46 1 1 5
-
(2007)
Hepatology
, vol.46
, Issue.1
, pp. 1-5
-
-
Trauner, M.1
-
109
-
-
77952562273
-
Gender-dependent effect of Gpbar1 genetic deletion on the metabolic profiles of diet-induced obese mice
-
Vassileva G., Hu W., Hoos L., et al. Gender-dependent effect of Gpbar1 genetic deletion on the metabolic profiles of diet-induced obese mice. J Endocrinol: 2010; 205 3 225 232
-
(2010)
J Endocrinol
, vol.205
, Issue.3
, pp. 225-232
-
-
Vassileva, G.1
Hu, W.2
Hoos, L.3
-
110
-
-
69149083245
-
TGR5-mediated bile acid sensing controls glucose homeostasis
-
Thomas C., Gioiello A., Noriega L., et al. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab: 2009; 10 3 167 177
-
(2009)
Cell Metab
, vol.10
, Issue.3
, pp. 167-177
-
-
Thomas, C.1
Gioiello, A.2
Noriega, L.3
-
111
-
-
84879110184
-
Hepatic fat loss in advanced nonalcoholic steatohepatitis: Are alterations in serum adiponectin the cause
-
van der Poorten D., Samer C. F., Ramezani-Moghadam M., et al. Hepatic fat loss in advanced nonalcoholic steatohepatitis: are alterations in serum adiponectin the cause? Hepatology: 2013; 57 6 2180 2188
-
(2013)
Hepatology
, vol.57
, Issue.6
, pp. 2180-2188
-
-
Van Der Poorten, D.1
Samer, C.F.2
Ramezani-Moghadam, M.3
-
112
-
-
33745901941
-
Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver
-
Meier Y., Pauli-Magnus C., Zanger U. M., et al. Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver. Hepatology: 2006; 44 1 62 74
-
(2006)
Hepatology
, vol.44
, Issue.1
, pp. 62-74
-
-
Meier, Y.1
Pauli-Magnus, C.2
Zanger, U.M.3
-
113
-
-
73449101426
-
Genetic determinants of serum lipid levels in Chinese subjects: A population-based study in Shanghai, China
-
Andreotti G., Menashe I., Chen J., et al. Genetic determinants of serum lipid levels in Chinese subjects: a population-based study in Shanghai, China. Eur J Epidemiol: 2009; 24 12 763 774
-
(2009)
Eur J Epidemiol
, vol.24
, Issue.12
, pp. 763-774
-
-
Andreotti, G.1
Menashe, I.2
Chen, J.3
-
114
-
-
66549091098
-
Common variants of ABCB4 and ABCB11 and plasma lipid levels: A study in sib pairs with gallstones, and controls
-
Acalovschi M., Tirziu S., Chiorean E., Krawczyk M., Grünhage F., Lammert F. Common variants of ABCB4 and ABCB11 and plasma lipid levels: a study in sib pairs with gallstones, and controls. Lipids: 2009; 44 6 521 526
-
(2009)
Lipids
, vol.44
, Issue.6
, pp. 521-526
-
-
Acalovschi, M.1
Tirziu, S.2
Chiorean, E.3
Krawczyk, M.4
Grünhage, F.5
Lammert, F.6
-
115
-
-
80053590797
-
Body mass index in the general population is associated with the common p.A444V variant of the ABC transporter for bile salts
-
(4, Suppl)
-
Krawczyk M., Rusticeanu M., Grunhage F., Lammert F. Body mass index in the general population is associated with the common p.A444V variant of the ABC transporter for bile salts. Hepatology: 2009; 50 (4, Suppl): 1016A
-
(2009)
Hepatology
, vol.50
-
-
Krawczyk, M.1
Rusticeanu, M.2
Grunhage, F.3
Lammert, F.4
-
116
-
-
79951780069
-
A common polymorphism in the ABCB11 gene is associated with advanced fibrosis in hepatitis C but not in non-alcoholic fatty liver disease
-
et al; Swiss Hepatitis C Cohort Study Group.
-
Iwata R., Baur K., Stieger B., et al. Swiss Hepatitis C Cohort Study Group. A common polymorphism in the ABCB11 gene is associated with advanced fibrosis in hepatitis C but not in non-alcoholic fatty liver disease. Clin Sci (Lond): 2011; 120 7 287 296
-
(2011)
Clin Sci (Lond)
, vol.120
, Issue.7
, pp. 287-296
-
-
Iwata, R.1
Baur, K.2
Stieger, B.3
-
117
-
-
84863788678
-
Abcb11 deficiency induces cholestasis coupled to impaired β-fatty acid oxidation in mice
-
Zhang Y., Li F., Patterson A. D., et al. Abcb11 deficiency induces cholestasis coupled to impaired β-fatty acid oxidation in mice. J Biol Chem: 2012; 287 29 24784 24794
-
(2012)
J Biol Chem
, vol.287
, Issue.29
, pp. 24784-24794
-
-
Zhang, Y.1
Li, F.2
Patterson, A.D.3
-
118
-
-
77949300137
-
Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations
-
Takeuchi F., Katsuya T., Chakrewarthy S., et al. Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations. Diabetologia: 2010; 53 2 299 308
-
(2010)
Diabetologia
, vol.53
, Issue.2
, pp. 299-308
-
-
Takeuchi, F.1
Katsuya, T.2
Chakrewarthy, S.3
-
119
-
-
69949172422
-
A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads
-
Rose C. S., Grarup N., Krarup N. T., et al. A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads. Diabetologia: 2009; 52 10 2122 2129
-
(2009)
Diabetologia
, vol.52
, Issue.10
, pp. 2122-2129
-
-
Rose, C.S.1
Grarup, N.2
Krarup, N.T.3
-
120
-
-
78650913170
-
A new role for a metabolic star: AMP-activated protein kinase stimulates fat absorption
-
Ferré P., Foufelle F. A new role for a metabolic star: AMP-activated protein kinase stimulates fat absorption. Cell Metab: 2011; 13 1 1 2
-
(2011)
Cell Metab
, vol.13
, Issue.1
, pp. 1-2
-
-
Ferré, P.1
Foufelle, F.2
-
121
-
-
78650911273
-
Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption
-
Chopra A. R., Kommagani R., Saha P., et al. Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption. Cell Metab: 2011; 13 1 35 43
-
(2011)
Cell Metab
, vol.13
, Issue.1
, pp. 35-43
-
-
Chopra, A.R.1
Kommagani, R.2
Saha, P.3
-
122
-
-
0036324142
-
The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism
-
Hawley S. A., Gadalla A. E., Olsen G. S., Hardie D. G. The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism. Diabetes: 2002; 51 8 2420 2425
-
(2002)
Diabetes
, vol.51
, Issue.8
, pp. 2420-2425
-
-
Hawley, S.A.1
Gadalla, A.E.2
Olsen, G.S.3
Hardie, D.G.4
-
123
-
-
9144241623
-
Hepatic overexpression of murine Abcb11 increases hepatobiliary lipid secretion and reduces hepatic steatosis
-
Figge A., Lammert F., Paigen B., et al. Hepatic overexpression of murine Abcb11 increases hepatobiliary lipid secretion and reduces hepatic steatosis. J Biol Chem: 2004; 279 4 2790 2799
-
(2004)
J Biol Chem
, vol.279
, Issue.4
, pp. 2790-2799
-
-
Figge, A.1
Lammert, F.2
Paigen, B.3
-
124
-
-
19644375041
-
Steatohepatitis develops rapidly in transgenic mice overexpressing Abcb11 and fed a methionine-choline-deficient diet
-
Sundaram S. S., Whitington P. F., Green R. M. Steatohepatitis develops rapidly in transgenic mice overexpressing Abcb11 and fed a methionine-choline- deficient diet. Am J Physiol Gastrointest Liver Physiol: 2005; 288 6 G1321 G1327
-
(2005)
Am J Physiol Gastrointest Liver Physiol
, vol.288
, Issue.6
-
-
Sundaram, S.S.1
Whitington, P.F.2
Green, R.M.3
-
125
-
-
33646121972
-
The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis
-
Li Z., Agellon L. B., Allen T. M., et al. The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis. Cell Metab: 2006; 3 5 321 331
-
(2006)
Cell Metab
, vol.3
, Issue.5
, pp. 321-331
-
-
Li, Z.1
Agellon, L.B.2
Allen, T.M.3
-
126
-
-
84887603268
-
Intrahepatic changes in bile acid composition protects bsep (abcb11) KO mice from hepatic inflammation in methionine choline deficient diet induced NASH
-
et al
-
Fuchs C., Claudel T., Hallibasic E., et al Intrahepatic changes in bile acid composition protects bsep (abcb11) KO mice from hepatic inflammation in methionine choline deficient diet induced NASH. J Hepatol: 2013; 58 S1 S32
-
(2013)
J Hepatol
, vol.58
, Issue.S1
-
-
Fuchs, C.1
Claudel, T.2
Hallibasic, E.3
-
127
-
-
27744507313
-
Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat
-
Geier A., Dietrich C. G., Grote T., et al. Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat. J Hepatol: 2005; 43 6 1021 1030
-
(2005)
J Hepatol
, vol.43
, Issue.6
, pp. 1021-1030
-
-
Geier, A.1
Dietrich, C.G.2
Grote, T.3
-
128
-
-
9344262376
-
Bile secretory function in the obese Zucker rat: Evidence of cholestasis and altered canalicular transport function
-
Pizarro M., Balasubramaniyan N., Solís N., et al. Bile secretory function in the obese Zucker rat: evidence of cholestasis and altered canalicular transport function. Gut: 2004; 53 12 1837 1843
-
(2004)
Gut
, vol.53
, Issue.12
, pp. 1837-1843
-
-
Pizarro, M.1
Balasubramaniyan, N.2
Solís, N.3
-
129
-
-
84876146580
-
Free fatty acids repress small heterodimer partner (SHP) activation and adiponectin counteracts bile acid-induced liver injury in superobese patients with nonalcoholic steatohepatitis
-
Bechmann L. P., Kocabayoglu P., Sowa J. P., et al. Free fatty acids repress small heterodimer partner (SHP) activation and adiponectin counteracts bile acid-induced liver injury in superobese patients with nonalcoholic steatohepatitis. Hepatology: 2013; 57 4 1394 1406
-
(2013)
Hepatology
, vol.57
, Issue.4
, pp. 1394-1406
-
-
Bechmann, L.P.1
Kocabayoglu, P.2
Sowa, J.P.3
-
130
-
-
84875506641
-
Gut microbiota and non-alcoholic fatty liver disease: New insights
-
Aron-Wisnewsky J., Gaborit B., Dutour A., Clement K. Gut microbiota and non-alcoholic fatty liver disease: new insights. Clin Microbiol Infect: 2013; 19 4 338 348
-
(2013)
Clin Microbiol Infect
, vol.19
, Issue.4
, pp. 338-348
-
-
Aron-Wisnewsky, J.1
Gaborit, B.2
Dutour, A.3
Clement, K.4
-
131
-
-
0020065283
-
Hepatic steatosis after intestinal bypass-prevention and reversal by metronidazole, irrespective of protein-calorie malnutrition
-
Drenick E. J., Fisler J., Johnson D. Hepatic steatosis after intestinal bypass-prevention and reversal by metronidazole, irrespective of protein-calorie malnutrition. Gastroenterology: 1982; 82 3 535 548
-
(1982)
Gastroenterology
, vol.82
, Issue.3
, pp. 535-548
-
-
Drenick, E.J.1
Fisler, J.2
Johnson, D.3
-
132
-
-
78049522194
-
Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis
-
Tilg H., Moschen A. R. Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology: 2010; 52 5 1836 1846
-
(2010)
Hepatology
, vol.52
, Issue.5
, pp. 1836-1846
-
-
Tilg, H.1
Moschen, A.R.2
-
133
-
-
33644867569
-
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
-
Inagaki T., Moschetta A., Lee Y. K., et al. Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc Natl Acad Sci U S A: 2006; 103 10 3920 3925
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.10
, pp. 3920-3925
-
-
Inagaki, T.1
Moschetta, A.2
Lee, Y.K.3
-
134
-
-
70349765667
-
Lifestyle modification as the primary treatment of NASH
-
Neuschwander-Tetri B. A. Lifestyle modification as the primary treatment of NASH. Clin Liver Dis: 2009; 13 4 649 665
-
(2009)
Clin Liver Dis
, vol.13
, Issue.4
, pp. 649-665
-
-
Neuschwander-Tetri, B.A.1
-
135
-
-
79954792488
-
UDCA for NASH: End of the story
-
Haedrich M., Dufour J. F. UDCA for NASH: end of the story? J Hepatol: 2011; 54 5 856 858
-
(2011)
J Hepatol
, vol.54
, Issue.5
, pp. 856-858
-
-
Haedrich, M.1
Dufour, J.F.2
-
136
-
-
0036725044
-
Ursodeoxycholic acid in cholestatic liver disease: Mechanisms of action and therapeutic use revisited
-
Paumgartner G., Beuers U. Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisited. Hepatology: 2002; 36 3 525 531
-
(2002)
Hepatology
, vol.36
, Issue.3
, pp. 525-531
-
-
Paumgartner, G.1
Beuers, U.2
-
137
-
-
79954764140
-
A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis
-
et al; FRESGUN.
-
Ratziu V., de Ledinghen V., Oberti F., et al. FRESGUN. A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis. J Hepatol: 2011; 54 5 1011 1019
-
(2011)
J Hepatol
, vol.54
, Issue.5
, pp. 1011-1019
-
-
Ratziu, V.1
De Ledinghen, V.2
Oberti, F.3
-
138
-
-
0032525819
-
A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation
-
Rodrigues C. M., Fan G., Ma X., Kren B. T., Steer C. J. A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation. J Clin Invest: 1998; 101 12 2790 2799
-
(1998)
J Clin Invest
, vol.101
, Issue.12
, pp. 2790-2799
-
-
Rodrigues, C.M.1
Fan, G.2
Ma, X.3
Kren, B.T.4
Steer, C.J.5
-
139
-
-
33748069813
-
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
-
Ozcan U., Yilmaz E., Ozcan L., et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science: 2006; 313 5790 1137 1140
-
(2006)
Science
, vol.313
, Issue.5790
, pp. 1137-1140
-
-
Ozcan, U.1
Yilmaz, E.2
Ozcan, L.3
-
140
-
-
77955411159
-
Tauroursodeoxycholic acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women
-
Kars M., Yang L., Gregor M. F., et al. Tauroursodeoxycholic acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes: 2010; 59 8 1899 1905
-
(2010)
Diabetes
, vol.59
, Issue.8
, pp. 1899-1905
-
-
Kars, M.1
Yang, L.2
Gregor, M.F.3
-
141
-
-
1542515099
-
Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: Results of a randomized trial
-
Lindor K. D., Kowdley K. V., Heathcote E. J., et al. Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: results of a randomized trial. Hepatology: 2004; 39 3 770 778
-
(2004)
Hepatology
, vol.39
, Issue.3
, pp. 770-778
-
-
Lindor, K.D.1
Kowdley, K.V.2
Heathcote, E.J.3
-
142
-
-
77955699301
-
High-dose ursodeoxycholic acid therapy for nonalcoholic steatohepatitis: A double-blind, randomized, placebo-controlled trial
-
et al; NASH Study Group.
-
Leuschner U. F., Lindenthal B., Herrmann G., et al. NASH Study Group. High-dose ursodeoxycholic acid therapy for nonalcoholic steatohepatitis: a double-blind, randomized, placebo-controlled trial. Hepatology: 2010; 52 2 472 479
-
(2010)
Hepatology
, vol.52
, Issue.2
, pp. 472-479
-
-
Leuschner, U.F.1
Lindenthal, B.2
Herrmann, G.3
-
143
-
-
84865840207
-
Combined rifampicin and ursodeoxycholic acid treatment does not amplify rifampicin effects on hepatic detoxification and transport systems in humans
-
Marschall H. U., Wagner M., Zollner G., et al. Combined rifampicin and ursodeoxycholic acid treatment does not amplify rifampicin effects on hepatic detoxification and transport systems in humans. Digestion: 2012; 86 3 244 249
-
(2012)
Digestion
, vol.86
, Issue.3
, pp. 244-249
-
-
Marschall, H.U.1
Wagner, M.2
Zollner, G.3
-
144
-
-
79952227694
-
Nuclear receptors in liver disease
-
Wagner M., Zollner G., Trauner M. Nuclear receptors in liver disease. Hepatology: 2011; 53 3 1023 1034
-
(2011)
Hepatology
, vol.53
, Issue.3
, pp. 1023-1034
-
-
Wagner, M.1
Zollner, G.2
Trauner, M.3
-
145
-
-
2542505481
-
Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes
-
Fu L., John L. M., Adams S. H., et al. Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes. Endocrinology: 2004; 145 6 2594 2603
-
(2004)
Endocrinology
, vol.145
, Issue.6
, pp. 2594-2603
-
-
Fu, L.1
John, L.M.2
Adams, S.H.3
-
146
-
-
67649210759
-
Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis
-
Zhang S., Wang J., Liu Q., Harnish D. C. Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis. J Hepatol: 2009; 51 2 380 388
-
(2009)
J Hepatol
, vol.51
, Issue.2
, pp. 380-388
-
-
Zhang, S.1
Wang, J.2
Liu, Q.3
Harnish, D.C.4
-
147
-
-
84865499656
-
Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis
-
Adorini L., Pruzanski M., Shapiro D. Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis. Drug Discov Today: 2012; 17 17-18 988 997
-
(2012)
Drug Discov Today
, vol.17
, Issue.1718
, pp. 988-997
-
-
Adorini, L.1
Pruzanski, M.2
Shapiro, D.3
-
148
-
-
84880664792
-
Efficacy and safety of the farnesoid x receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease
-
Mudaliar S., Henry R. R., Sanyal A. J., et al. Efficacy and safety of the farnesoid x receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease. Gastroenterology: 2013; 145 3 574, e1
-
(2013)
Gastroenterology
, vol.145
, Issue.3
, pp. 574
-
-
Mudaliar, S.1
Henry, R.R.2
Sanyal, A.J.3
-
150
-
-
67650566600
-
Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR-/- and apoE-/- mice
-
Hartman H. B., Gardell S. J., Petucci C. J., Wang S., Krueger J. A., Evans M. J. Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR-/- and apoE-/- mice. J Lipid Res: 2009; 50 6 1090 1100
-
(2009)
J Lipid Res
, vol.50
, Issue.6
, pp. 1090-1100
-
-
Hartman, H.B.1
Gardell, S.J.2
Petucci, C.J.3
Wang, S.4
Krueger, J.A.5
Evans, M.J.6
-
151
-
-
84869205703
-
Synthetic farnesoid X receptor agonists induce high-density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys and prevent atherosclerosis in cholesteryl ester transfer protein transgenic low-density lipoprotein receptor (-/-) mice
-
Hambruch E., Miyazaki-Anzai S., Hahn U., et al. Synthetic farnesoid X receptor agonists induce high-density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys and prevent atherosclerosis in cholesteryl ester transfer protein transgenic low-density lipoprotein receptor (-/-) mice. J Pharmacol Exp Ther: 2012; 343 3 556 567
-
(2012)
J Pharmacol Exp Ther
, vol.343
, Issue.3
, pp. 556-567
-
-
Hambruch, E.1
Miyazaki-Anzai, S.2
Hahn, U.3
-
152
-
-
84863427742
-
Non-alcoholic fatty liver disease: The bile acid-activated farnesoid x receptor as an emerging treatment target
-
Fuchs M. Non-alcoholic fatty liver disease: the bile acid-activated farnesoid x receptor as an emerging treatment target. J Lipids: 2012; 2012 934396
-
(2012)
J Lipids
, vol.2012
, pp. 934396
-
-
Fuchs, M.1
-
153
-
-
80052380574
-
Farnesoid X receptor represses hepatic human APOA gene expression
-
Chennamsetty I., Claudel T., Kostner K. M., et al. Farnesoid X receptor represses hepatic human APOA gene expression. J Clin Invest: 2011; 121 9 3724 3734
-
(2011)
J Clin Invest
, vol.121
, Issue.9
, pp. 3724-3734
-
-
Chennamsetty, I.1
Claudel, T.2
Kostner, K.M.3
-
154
-
-
84876896348
-
Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease
-
McMahan R. H., Wang X. X., Cheng L. L., et al. Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease. J Biol Chem: 2013; 288 17 11761 11770
-
(2013)
J Biol Chem
, vol.288
, Issue.17
, pp. 11761-11770
-
-
McMahan, R.H.1
Wang, X.X.2
Cheng, L.L.3
-
155
-
-
77953268611
-
Alternative activation of macrophages: Mechanism and functions
-
Gordon S., Martinez F. O. Alternative activation of macrophages: mechanism and functions. Immunity: 2010; 32 5 593 604
-
(2010)
Immunity
, vol.32
, Issue.5
, pp. 593-604
-
-
Gordon, S.1
Martinez, F.O.2
-
156
-
-
0028575639
-
Cholestyramine therapy for dyslipidemia in non-insulin-dependent diabetes mellitus. A short-term, double-blind, crossover trial
-
Garg A., Grundy S. M. Cholestyramine therapy for dyslipidemia in non-insulin-dependent diabetes mellitus. A short-term, double-blind, crossover trial. Ann Intern Med: 1994; 121 6 416 422
-
(1994)
Ann Intern Med
, vol.121
, Issue.6
, pp. 416-422
-
-
Garg, A.1
Grundy, S.M.2
-
157
-
-
33750522053
-
Blood glucose-lowering activity of colestimide in patients with type 2 diabetes and hypercholesterolemia: A case-control study comparing colestimide with acarbose
-
Suzuki T., Oba K., Futami S., et al. Blood glucose-lowering activity of colestimide in patients with type 2 diabetes and hypercholesterolemia: a case-control study comparing colestimide with acarbose. J Nippon Med Sch: 2006; 73 5 277 284
-
(2006)
J Nippon Med Sch
, vol.73
, Issue.5
, pp. 277-284
-
-
Suzuki, T.1
Oba, K.2
Futami, S.3
-
158
-
-
49449087092
-
Efficacy and safety of colesevelam in patients with type 2 diabetes mellitus and inadequate glycemic control receiving insulin-based therapy
-
Goldberg R. B., Fonseca V. A., Truitt K. E., Jones M. R. Efficacy and safety of colesevelam in patients with type 2 diabetes mellitus and inadequate glycemic control receiving insulin-based therapy. Arch Intern Med: 2008; 168 14 1531 1540
-
(2008)
Arch Intern Med
, vol.168
, Issue.14
, pp. 1531-1540
-
-
Goldberg, R.B.1
Fonseca, V.A.2
Truitt, K.E.3
Jones, M.R.4
-
159
-
-
77950620903
-
The effect of colesevelam hydrochloride on insulin sensitivity and secretion in patients with type 2 diabetes: A pilot study
-
Schwartz S. L., Lai Y. L., Xu J., et al. The effect of colesevelam hydrochloride on insulin sensitivity and secretion in patients with type 2 diabetes: a pilot study. Metab Syndr Relat Disord: 2010; 8 2 179 188
-
(2010)
Metab Syndr Relat Disord
, vol.8
, Issue.2
, pp. 179-188
-
-
Schwartz, S.L.1
Lai, Y.L.2
Xu, J.3
-
160
-
-
0021349709
-
The Lipid Research Clinics Coronary Primary Prevention Trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering
-
The Lipid Research Clinics Coronary Primary Prevention Trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering. JAMA: 1984; 251 3 365 374
-
(1984)
JAMA
, vol.251
, Issue.3
, pp. 365-374
-
-
-
161
-
-
0021350001
-
The Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in incidence of coronary heart disease
-
The Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in incidence of coronary heart disease. JAMA: 1984; 251 3 351 364
-
(1984)
JAMA
, vol.251
, Issue.3
, pp. 351-364
-
-
-
162
-
-
67649604526
-
Treatment of nonalcoholic steatohepatitis with colestimide
-
Taniai M., Hashimoto E., Tobari M., et al. Treatment of nonalcoholic steatohepatitis with colestimide. Hepatol Res: 2009; 39 7 685 693
-
(2009)
Hepatol Res
, vol.39
, Issue.7
, pp. 685-693
-
-
Taniai, M.1
Hashimoto, E.2
Tobari, M.3
-
163
-
-
84865569519
-
Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: A randomized controlled trial
-
et al; San Diego Integrated NAFLD Research Consortium (SINC).
-
Le T. A., Chen J., Changchien C., et al. San Diego Integrated NAFLD Research Consortium (SINC). Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. Hepatology: 2012; 56 3 922 932
-
(2012)
Hepatology
, vol.56
, Issue.3
, pp. 922-932
-
-
Le, T.A.1
Chen, J.2
Changchien, C.3
-
164
-
-
70149108533
-
Serum bile acid along with plasma incretins and serum high-molecular weight adiponectin levels are increased after bariatric surgery
-
Nakatani H., Kasama K., Oshiro T., Watanabe M., Hirose H., Itoh H. Serum bile acid along with plasma incretins and serum high-molecular weight adiponectin levels are increased after bariatric surgery. Metabolism: 2009; 58 10 1400 1407
-
(2009)
Metabolism
, vol.58
, Issue.10
, pp. 1400-1407
-
-
Nakatani, H.1
Kasama, K.2
Oshiro, T.3
Watanabe, M.4
Hirose, H.5
Itoh, H.6
-
165
-
-
13844299425
-
Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1
-
Katsuma S,Hirasawa A, TsujimotoG. Bile acids promote glucagonlike peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1. BiochemBiophys Res Commun 2005;329(1): 386-390
-
(2005)
Biochem Biophys Res Commun
, vol.329
, Issue.1
, pp. 386-390
-
-
Katsuma, S.1
Hirasawa, A.2
Tsujimoto, G.3
|