Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations

Diabetologia

Volumn 53, Issue 2, 2010, Pages 299-308

  Takeuchi, F ^a   Katsuya, T ^b   Chakrewarthy, S ^c   Yamamoto, K ^d   Fujioka, A ^e   Serizawa, M ^a   Fujisawa, T ^b   Nakashima, E ^f,g   Ohnaka, K ^h   Ikegami, H ⁱ   Sugiyama, T ^j   Nabika, T ^k   Kasturiratne, A ^c   Yamaguchi, S ^k   Kono, S ^h   Takayanagi, R ^h   Yamori, Y ^l   Kobayashi, S ^m   Ogihara, T ⁿ   De Silva, A ^c   Wickremasinghe, R ^c   Kato, N ^a   more..

^a NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF KELANIYA   (Sri Lanka)

^d KYUSHU UNIVERSITY   (Japan)

^e Amagasaki Health Medical Foundation   (Japan)

^f NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^g CHUBU ROSAI HOSPITAL   (Japan)

^h KYUSHU UNIVERSITY   (Japan)

ⁱ KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^j INSTITUTE FOR ADULT DISEASES   (Japan)

^k SHIMANE UNIVERSITY FACULTY OF MEDICINE   (Japan)

^l MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

^m SHIMANE UNIVERSITY HOSPITAL   (Japan)

ⁿ OSAKA GENERAL MEDICAL CENTER   (Japan)

more..

Author keywords

Asians; Association study; Ethnicity; Fasting plasma glucose; Polymorphisms

Indexed keywords

GLUCOSE;

ARTICLE; ASIAN; DIABETES MELLITUS; FASTING PLASMA GLUCOSE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE MAPPING; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC IDENTIFICATION; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; HUMAN; JAPANESE; MAJOR CLINICAL STUDY; MTNR1B GENE; NON INSULIN DEPENDENT DIABETES MELLITUS; POPULATION RESEARCH; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SOUTH ASIA; SRI LANKA;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; ATP-BINDING CASSETTE TRANSPORTERS; BLOOD GLUCOSE; CHROMOSOME MAPPING; ETHNIC GROUPS; FASTING; GENETIC VARIATION; GLUCOSE-6-PHOSPHATASE; HAPLOTYPES; HUMANS; JAPAN; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN-SERINE-THREONINE KINASES; RECEPTOR, MELATONIN, MT2; REGRESSION ANALYSIS; SRI LANKA;

EID: 77949300137     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1595-1     Document Type: Article

References (37)

1. Tirosh A, Shai I, Tekes-Manova D et al (2005) Normal fasting plasma glucose levels and type 2 diabetes in young men. N Engl J Med 353:1454-1462
2. Coutinho M, Gerstein HC, Wang Y, Yusuf S (1999) The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years. Diabetes Care 22:233-240
3. Xiang AH, Wang C, Peters RK, Trigo E, Kjos SL, Buchanan TA (2006) Coordinate changes in plasma glucose and pancreatic betacell function in Latino women at high risk for type 2 diabetes. Diabetes 55:1074-1079
4. Pilia G, Chen WM, Scuteri A et al (2006) Heritability of cardiovascular and personality traits in 6, 148 Sardinians. PLoS Genet 2:e132
5. Weedon MN, Frayling TM, Shields B et al (2005) Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene. Diabetes 54:576-581
6. Rose CS, Ek J, Urhammer SA et al (2005) A -30G>A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites. Diabetes 54:3026-3031
7. Weedon MN, Clark VJ, Qian Y et al (2006) A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses. Am J Hum Genet 79:991-1001
8. Vaxillaire M, Cavalcanti-Proenca C, Dechaume A et al (2008) The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population. Diabetes 57:2253-2257
9. Orho-Melander M, Melander O, Guiducci C et al (2008) Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations. Diabetes 57:3112-3121
10. Sparso T, Andersen G, Nielsen T et al (2008) The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes. Diabetologia 51:70-75
11. Tam CH, Ma RC, So WYet al (2009) Interaction effect of genetic polymorphisms in glucokinase (GCK) and glucokinase regulatory protein (GCKR) on metabolic traits in healthy Chinese adults and adolescents. Diabetes 58:765-769
12. Qi Q,Wu Y, Li H et al (2009) Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population. Diabetologia 52:834-843
13. Saxena R, Voight BF, Lyssenko V et al (2007) Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316:1331-1336
14. Bouatia-Naji N, Rocheleau G, van Lommel L et al (2008) A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels. Science 320:1085-1088
15. Chen WM, Erdos MR, Jackson AU et al (2008) Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. J Clin Invest 118:2620-2628
16. Sabatti C, Service SK, Hartikainen AL et al (2009) Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet 41:35-46
17. Prokopenko I, Langenberg C, Florez JC et al (2009) Variants in MTNR1B influence fasting glucose levels. Nat Genet 41:77-81
18. Bouatia-Naji N, Bonnefond A, Cavalcanti-Proenca C et al (2009) A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet 41:89-94
19. Hu C, Zhang R, Wang C et al (2009) A genetic variant of G6PC2 is associated with type 2 diabetes and fasting plasma glucose level in the Chinese population. Diabetologia 52:451-456
20. Rönn T, Wen J, Yang Z et al (2009) A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals. Diabetologia 52:830-833
21. McCarthy MI, Hirschhorn JN (2008) Genome-wide association studies: potential next steps on a genetic journey. Hum Mol Genet 17:R156-R165
22. Saccone NL, Saccone SF, Goate AM et al (2008) In search of causal variants: refining disease association signals using crosspopulation contrasts. BMC Genet 9:58
23. Waters KM, Le Marchand L, Kolonel LN et al (2009) Generalizability of associations from prostate cancer genome-wide association studies in multiple populations. Cancer Epidemiol Biomarkers Prev 18:1285-1289
24. Helgason A, Palsson S, Thorleifsson G et al (2007) Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet 39:218-225
25. Tsuchihashi-Makaya M, Serizawa M, Yanai K et al (2009) Geneenvironmental interaction regarding alcohol-metabolizing enzymes in the Japanese general population. Hypertens Res 32:207-213
26. Dassanayake A, Kasturiratne A, Rajindrajith S et al (2009) Prevalence and risk factors for non-alcoholic fatty liver disease (NAFLD) among adults in an urban Sri Lankan population.J Gastroenterol Hepatol 24:1284-1288
27. Takeuchi F, Serizawa M, Yamamoto K et al (2009) Confirmation of multiple risk loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Diabetes 58:1690-1699
28. Purcell S, Neale B, Todd-Brown K et al (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81:559-575
29. Stephens M, Smith NJ, Donnelly P (2001) A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68:978-989
30. Barrett JC, Fry B,Maller J, DalyMJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263-265
31. Li JZ, Absher DM, Tang H et al (2008) Worldwide human relationships inferred from genome-wide patterns of variation. Science 319:1100-1104
32. Petrolonis AJ, Yang Q, Tummino PJ et al (2004) Enzymatic characterization of the pancreatic islet-specific glucose-6-phosphatase-related protein (IGRP). J Biol Chem 279:13976-13983
33. Lang T, Haberl M, Jung D et al (2006) Genetic variability, haplotype structures, and ethnic diversity of hepatic transporters MDR3 (ABCB4) and bile salt export pump (ABCB11). Drug Metab Dispos 34:1582-1599
34. Ramaraj R, Chellappa P (2008) Cardiovascular risk in South Asians. Postgrad Med J 84:518-523
35. Reiling E, van't Riet E, Groenewoud MJ et al (2009) Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk. Diabetologia 52:1866-1870
36. Ge D, Zhang K, Need AC et al (2008) WGAViewer: software for genomic annotation of whole genome association studies. Genome Res 18:640-643
37. Zeggini E, Scott LJ, Saxena R et al (2008) Meta-analysis of genomewide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 40:638-645