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Volumn 43, Issue 6, 2005, Pages 1021-1030

Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat

Author keywords

Bile acids; Glutathione; Glutathione conjugates; Isolated rat liver perfusion; Organic anion transport; Steatosis

Indexed keywords

BILE ACID; BILE SALT; GLUTATHIONE DERIVATIVE; GLUTATHIONE DISULFIDE; HEPATOCYTE NUCLEAR FACTOR 3; HEPATOCYTE NUCLEAR FACTOR 3BETA; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 4; NUCLEAR FACTOR; ORGANIC ANION TRANSPORTER; S (2,4 DINITROPHENYL)GLUTATHIONE; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

EID: 27744507313     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2005.05.031     Document Type: Article
Times cited : (50)

References (58)
  • 1
    • 0038142845 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: An underrecognized cause of cryptogenic cirrhosis
    • J.M. Clark, and A.M. Diehl Nonalcoholic fatty liver disease: an underrecognized cause of cryptogenic cirrhosis J Am Med Assoc 289 2003 3000 3004
    • (2003) J Am Med Assoc , vol.289 , pp. 3000-3004
    • Clark, J.M.1    Diehl, A.M.2
  • 3
    • 0022657320 scopus 로고
    • Liver investigation in 149 asymptomatic patients with moderately elevated activities of serum aminotransferases
    • R. Hultcrantz, H. Glaumann, G. Lindberg, and L.H. Nilsson Liver investigation in 149 asymptomatic patients with moderately elevated activities of serum aminotransferases Scand J Gastroenterol 21 1986 109 113
    • (1986) Scand J Gastroenterol , vol.21 , pp. 109-113
    • Hultcrantz, R.1    Glaumann, H.2    Lindberg, G.3    Nilsson, L.H.4
  • 6
    • 0035078599 scopus 로고    scopus 로고
    • Animal models of steatosis
    • A. Koteish, and A.M. Diehl Animal models of steatosis Semin Liver Dis 21 2001 89 104
    • (2001) Semin Liver Dis , vol.21 , pp. 89-104
    • Koteish, A.1    Diehl, A.M.2
  • 7
    • 0034682474 scopus 로고    scopus 로고
    • Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets
    • T. Kakuma, Y. Lee, M. Higa, Z. Wang, W. Pan, and I. Shimomura Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets Proc Natl Acad Sci USA 97 2000 8536 8541
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 8536-8541
    • Kakuma, T.1    Lee, Y.2    Higa, M.3    Wang, Z.4    Pan, W.5    Shimomura, I.6
  • 9
    • 0037379362 scopus 로고    scopus 로고
    • Bile salt transporters: Molecular characterization, function, and regulation
    • M. Trauner, and J.L. Boyer Bile salt transporters: molecular characterization, function, and regulation Physiol Rev 83 2003 633 671
    • (2003) Physiol Rev , vol.83 , pp. 633-671
    • Trauner, M.1    Boyer, J.L.2
  • 10
    • 0344665555 scopus 로고    scopus 로고
    • ABC of oral bioavailability: Transporters as gatekeepers in the gut
    • C.G. Dietrich, A. Geier, and R.P. Oude Elferink ABC of oral bioavailability: transporters as gatekeepers in the gut Gut 52 2003 1788 1795
    • (2003) Gut , vol.52 , pp. 1788-1795
    • Dietrich, C.G.1    Geier, A.2    Oude Elferink, R.P.3
  • 11
    • 0028987020 scopus 로고
    • Prolonged antagonism of alpha 1-adrenergic vasoconstriction in the rat liver by atrial natriuretic peptide
    • M. Bilzer, G. Paumgartner, and A.L. Gerbes Prolonged antagonism of alpha 1-adrenergic vasoconstriction in the rat liver by atrial natriuretic peptide Gastroenterology 108 1995 803 811
    • (1995) Gastroenterology , vol.108 , pp. 803-811
    • Bilzer, M.1    Paumgartner, G.2    Gerbes, A.L.3
  • 12
    • 0018256781 scopus 로고
    • Glutathione S-conjugate formation from 1-chloro-2,4-dinitrobenzene and biliary S-conjugate excretion in the perfused rat liver
    • A. Wahllander, and H. Sies Glutathione S-conjugate formation from 1-chloro-2,4-dinitrobenzene and biliary S-conjugate excretion in the perfused rat liver Eur J Biochem 96 1979 441 446
    • (1979) Eur J Biochem , vol.96 , pp. 441-446
    • Wahllander, A.1    Sies, H.2
  • 13
    • 0023038417 scopus 로고
    • Intrabiliary glutathione hydrolysis. a source of glutamate in bile
    • N. Ballatori, R. Jacob, and J.L. Boyer Intrabiliary glutathione hydrolysis. A source of glutamate in bile J Biol Chem 261 1986 7860 7865
    • (1986) J Biol Chem , vol.261 , pp. 7860-7865
    • Ballatori, N.1    Jacob, R.2    Boyer, J.L.3
  • 14
    • 0019741605 scopus 로고
    • Assays for differentiation of glutathione S-transferase
    • W.H. Habig, and W.B. Jakoby Assays for differentiation of glutathione S-transferase Methods Enzymol 77 1981 398 405
    • (1981) Methods Enzymol , vol.77 , pp. 398-405
    • Habig, W.H.1    Jakoby, W.B.2
  • 16
    • 0025150602 scopus 로고
    • Use of isolated perfused organs in hypoxia and ischemia/reperfusion oxidant stress
    • H. Jaeschke, and J.R. Mitchell Use of isolated perfused organs in hypoxia and ischemia/reperfusion oxidant stress Methods Enzymol 186 1990 752 759
    • (1990) Methods Enzymol , vol.186 , pp. 752-759
    • Jaeschke, H.1    Mitchell, J.R.2
  • 17
    • 0021670950 scopus 로고
    • Simultaneous determination of cholic acid and chenodeoxycholic acid pool sizes and fractional turnover rates in human serum using 13C-labeled bile acids
    • F. Stellaard, M. Sackmann, T. Sauerbruch, and G. Paumgartner Simultaneous determination of cholic acid and chenodeoxycholic acid pool sizes and fractional turnover rates in human serum using 13C-labeled bile acids J Lipid Res 25 1984 1313 1319
    • (1984) J Lipid Res , vol.25 , pp. 1313-1319
    • Stellaard, F.1    Sackmann, M.2    Sauerbruch, T.3    Paumgartner, G.4
  • 18
    • 84920357266 scopus 로고    scopus 로고
    • Differential expression of basolateral and canalicular organic anion transporters during regeneration of rat liver
    • T. Gerloff, A. Geier, B. Stieger, B. Hagenbuch, P.J. Meier, and S. Matern Differential expression of basolateral and canalicular organic anion transporters during regeneration of rat liver Gastroenterology 117 1999 1408 1415
    • (1999) Gastroenterology , vol.117 , pp. 1408-1415
    • Gerloff, T.1    Geier, A.2    Stieger, B.3    Hagenbuch, B.4    Meier, P.J.5    Matern, S.6
  • 19
    • 0042766885 scopus 로고    scopus 로고
    • Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis
    • A. Geier, C.G. Dietrich, S. Voigt, S.K. Kim, T. Gerloff, and G.A. Kullak-Ublick Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis Hepatology 38 2003 345 354
    • (2003) Hepatology , vol.38 , pp. 345-354
    • Geier, A.1    Dietrich, C.G.2    Voigt, S.3    Kim, S.K.4    Gerloff, T.5    Kullak-Ublick, G.A.6
  • 20
    • 0034928631 scopus 로고    scopus 로고
    • Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver
    • M.G. Donner, and D. Keppler Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver Hepatology 34 2001 351 359
    • (2001) Hepatology , vol.34 , pp. 351-359
    • Donner, M.G.1    Keppler, D.2
  • 21
    • 0042766881 scopus 로고    scopus 로고
    • Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane
    • M. Rius, A.T. Nies, J. Hummel-Eisenbeiss, G. Jedlitschky, and D. Keppler Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane Hepatology 38 2003 374 384
    • (2003) Hepatology , vol.38 , pp. 374-384
    • Rius, M.1    Nies, A.T.2    Hummel-Eisenbeiss, J.3    Jedlitschky, G.4    Keppler, D.5
  • 22
    • 0036890295 scopus 로고    scopus 로고
    • Increase in renal glutathione in cholestatic liver disease is due to a direct effect of bile acids
    • E. Purucker, H.U. Marschall, A. Geier, C. Gartung, and S. Matern Increase in renal glutathione in cholestatic liver disease is due to a direct effect of bile acids Am J Physiol Renal Physiol 283 2002 F1281 F1289
    • (2002) Am J Physiol Renal Physiol , vol.283
    • Purucker, E.1    Marschall, H.U.2    Geier, A.3    Gartung, C.4    Matern, S.5
  • 23
    • 0036022841 scopus 로고    scopus 로고
    • Hepatobiliary organic anion transporters are differentially regulated in acute toxic liver injury induced by carbon tetrachloride
    • A. Geier, S.K. Kim, T. Gerloff, C.G. Dietrich, F. Lammert, and S.J. Karpen Hepatobiliary organic anion transporters are differentially regulated in acute toxic liver injury induced by carbon tetrachloride J Hepatol 37 2002 198 205
    • (2002) J Hepatol , vol.37 , pp. 198-205
    • Geier, A.1    Kim, S.K.2    Gerloff, T.3    Dietrich, C.G.4    Lammert, F.5    Karpen, S.J.6
  • 24
    • 15844426563 scopus 로고    scopus 로고
    • Multiple factors regulate the rat liver basolateral sodium-dependent bile acid co-transporter gene promotor
    • S.J. Karpen, A.-Q. Sun, B. Kudish, B. Hagenbuch, P.J. Meier, and M. Ananthanarayanan Multiple factors regulate the rat liver basolateral sodium-dependent bile acid co-transporter gene promotor J Biol Chem 271 1996 15211 15221
    • (1996) J Biol Chem , vol.271 , pp. 15211-15221
    • Karpen, S.J.1    Sun, A.-Q.2    Kudish, B.3    Hagenbuch, B.4    Meier, P.J.5    Ananthanarayanan, M.6
  • 25
    • 0036178073 scopus 로고    scopus 로고
    • Postnatal expression and induction by pregnenolone-16alpha-carbonitrile of the organic anion-transporting polypeptide 2 in rat liver
    • G.L. Guo, D.R. Johnson, and C.D. Klaassen Postnatal expression and induction by pregnenolone-16alpha-carbonitrile of the organic anion-transporting polypeptide 2 in rat liver Drug Metab Dispos 30 2002 283 288
    • (2002) Drug Metab Dispos , vol.30 , pp. 283-288
    • Guo, G.L.1    Johnson, D.R.2    Klaassen, C.D.3
  • 27
    • 0032524012 scopus 로고    scopus 로고
    • Endotoxin down-regulates rat hepatic ntcp gene expression by decreased activity of critical transcription factors
    • M. Trauner, M. Arrese, H. Lee, J.L. Boyer, and S.J. Karpen Endotoxin down-regulates rat hepatic ntcp gene expression by decreased activity of critical transcription factors J Clin Invest 101 1998 2092 2100
    • (1998) J Clin Invest , vol.101 , pp. 2092-2100
    • Trauner, M.1    Arrese, M.2    Lee, H.3    Boyer, J.L.4    Karpen, S.J.5
  • 28
    • 0034708264 scopus 로고    scopus 로고
    • Interleukin-1beta suppresses retinoid transactivation of two hepatic transporter genes involved in bile formation
    • L.A. Denson, K.L. Auld, D.S. Schiek, M.H. McClure, D.J. Mangelsdorf, and S.J. Karpen Interleukin-1beta suppresses retinoid transactivation of two hepatic transporter genes involved in bile formation J Biol Chem 275 2000 8835 8843
    • (2000) J Biol Chem , vol.275 , pp. 8835-8843
    • Denson, L.A.1    Auld, K.L.2    Schiek, D.S.3    McClure, M.H.4    Mangelsdorf, D.J.5    Karpen, S.J.6
  • 29
    • 0037169551 scopus 로고    scopus 로고
    • Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor
    • H.R. Kast, B. Goodwin, P.T. Tarr, S.A. Jones, A.M. Anisfeld, and C.M. Stoltz Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor J Biol Chem 277 2002 2908 2915
    • (2002) J Biol Chem , vol.277 , pp. 2908-2915
    • Kast, H.R.1    Goodwin, B.2    Tarr, P.T.3    Jones, S.A.4    Anisfeld, A.M.5    Stoltz, C.M.6
  • 30
    • 0033776792 scopus 로고    scopus 로고
    • Elevated levels of hepatocyte nuclear factor 3beta in mouse hepatocytes influence expression of genes involved in bile acid and glucose homeostasis
    • F.M. Rausa, Y. Tan, H. Zhou, K.W. Yoo, D.B. Stolz, and S.C. Watkins Elevated levels of hepatocyte nuclear factor 3beta in mouse hepatocytes influence expression of genes involved in bile acid and glucose homeostasis Mol Cell Biol 20 2000 8264 8282
    • (2000) Mol Cell Biol , vol.20 , pp. 8264-8282
    • Rausa, F.M.1    Tan, Y.2    Zhou, H.3    Yoo, K.W.4    Stolz, D.B.5    Watkins, S.C.6
  • 31
    • 4944226211 scopus 로고    scopus 로고
    • Role of Liver-Enriched Transcription Factors in the Down-Regulation of organic anion transporting polypeptide 4 (Oatp4; Oatplb2; Slc21a10) by lipopolysaccharide
    • N. Li, and C.D. Klaassen Role of Liver-Enriched Transcription Factors in the Down-Regulation of organic anion transporting polypeptide 4 (Oatp4; Oatplb2; Slc21a10) by lipopolysaccharide Mol Pharmacol 66 2004 694 701
    • (2004) Mol Pharmacol , vol.66 , pp. 694-701
    • Li, N.1    Klaassen, C.D.2
  • 32
    • 0029615982 scopus 로고
    • Molecular mechanisms of hepatic bile salt transport from sinusoidal blood into bile
    • P.J. Meier Molecular mechanisms of hepatic bile salt transport from sinusoidal blood into bile Am J Physiol 269 1995 G801 G812
    • (1995) Am J Physiol , vol.269
    • Meier, P.J.1
  • 33
    • 0035040534 scopus 로고    scopus 로고
    • Characterization of the mouse bile salt export pump overexpressed in the baculovirus system
    • J. Noe, B. Hagenbuch, P.J. Meier, and M.V. St-Pierre Characterization of the mouse bile salt export pump overexpressed in the baculovirus system Hepatology 33 2001 1223 1231
    • (2001) Hepatology , vol.33 , pp. 1223-1231
    • Noe, J.1    Hagenbuch, B.2    Meier, P.J.3    St-Pierre, M.V.4
  • 34
    • 0032500601 scopus 로고    scopus 로고
    • The role of phosphoinositide 3-kinase in taurocholate-induced trafficking of ATP-dependent canalicular transporters in rat liver
    • S. Misra, P. Ujhazy, Z. Gatmaitan, L. Varticovski, and I.M. Arias The role of phosphoinositide 3-kinase in taurocholate-induced trafficking of ATP-dependent canalicular transporters in rat liver J Biol Chem 273 1998 26638 26644
    • (1998) J Biol Chem , vol.273 , pp. 26638-26644
    • Misra, S.1    Ujhazy, P.2    Gatmaitan, Z.3    Varticovski, L.4    Arias, I.M.5
  • 35
    • 0033104810 scopus 로고    scopus 로고
    • Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione
    • C.C. Paulusma, M.A. van Geer, R. Evers, M. Heijn, R. Ottenhoff, and P. Borst Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione Biochem J 338 1999 393 401
    • (1999) Biochem J , vol.338 , pp. 393-401
    • Paulusma, C.C.1    Van Geer, M.A.2    Evers, R.3    Heijn, M.4    Ottenhoff, R.5    Borst, P.6
  • 36
    • 0033745088 scopus 로고    scopus 로고
    • Hepatic secretion of conjugated drugs and endogenous substances
    • D. Keppler, and J. Konig Hepatic secretion of conjugated drugs and endogenous substances Semin Liver Dis 20 2000 265 272
    • (2000) Semin Liver Dis , vol.20 , pp. 265-272
    • Keppler, D.1    Konig, J.2
  • 37
    • 0032434272 scopus 로고    scopus 로고
    • Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2
    • H. Suzuki, and Y. Sugiyama Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2 Semin Liver Dis 18 1998 359 376
    • (1998) Semin Liver Dis , vol.18 , pp. 359-376
    • Suzuki, H.1    Sugiyama, Y.2
  • 38
    • 0036329226 scopus 로고    scopus 로고
    • Organ-specific alterations in RAR alpha: RXR alpha abundance regulate rat Mrp2 (Abcc2) expression in obstructive cholestasis
    • L.A. Denson, A. Bohan, M.A. Held, and J.L. Boyer Organ-specific alterations in RAR alpha: RXR alpha abundance regulate rat Mrp2 (Abcc2) expression in obstructive cholestasis Gastroenterology 123 2002 599 607
    • (2002) Gastroenterology , vol.123 , pp. 599-607
    • Denson, L.A.1    Bohan, A.2    Held, M.A.3    Boyer, J.L.4
  • 39
    • 1842479142 scopus 로고    scopus 로고
    • Consequences of bile duct obstruction on intestinal expression and function of Multidrug-resistance associated protein 2
    • C.G. Dietrich, A. Geier, N. Salein, F. Lammert, E. Roeb, and R.P.J. Oude Elferink Consequences of bile duct obstruction on intestinal expression and function of Multidrug-resistance associated protein 2 Gastroenterology 126 2004 1044 1053
    • (2004) Gastroenterology , vol.126 , pp. 1044-1053
    • Dietrich, C.G.1    Geier, A.2    Salein, N.3    Lammert, F.4    Roeb, E.5    Oude Elferink, R.P.J.6
  • 40
    • 0035072875 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism
    • D.Q. Shih, M. Bussen, E. Sehayek, M. Ananthanarayanan, B.L. Shneider, and F.J. Suchy Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism Nat Genet 27 2001 375 382
    • (2001) Nat Genet , vol.27 , pp. 375-382
    • Shih, D.Q.1    Bussen, M.2    Sehayek, E.3    Ananthanarayanan, M.4    Shneider, B.L.5    Suchy, F.J.6
  • 41
    • 0033199592 scopus 로고    scopus 로고
    • Regulation of organic anion and drug transporters of the sinusoidal membrane
    • G.A. Kullak-Ublick Regulation of organic anion and drug transporters of the sinusoidal membrane J Hepatol 31 1999 563 573
    • (1999) J Hepatol , vol.31 , pp. 563-573
    • Kullak-Ublick, G.A.1
  • 42
    • 0031136586 scopus 로고    scopus 로고
    • Differences in binding of hepatic nuclear proteins from lean and obese rats to the 5′-upstream region of tyrosine aminotransferase
    • H. Dong, Y. Wang, M. Jenson, H.D. Braymer, and D.A. York Differences in binding of hepatic nuclear proteins from lean and obese rats to the 5′-upstream region of tyrosine aminotransferase Obes Res 5 1997 208 217
    • (1997) Obes Res , vol.5 , pp. 208-217
    • Dong, H.1    Wang, Y.2    Jenson, M.3    Braymer, H.D.4    York, D.A.5
  • 43
    • 0030886124 scopus 로고    scopus 로고
    • Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain
    • B. Noe, B. Hagenbuch, B. Stieger, and P.J. Meier Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain Proc Natl Acad Sci USA 94 1997 10346 10350
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 10346-10350
    • Noe, B.1    Hagenbuch, B.2    Stieger, B.3    Meier, P.J.4
  • 44
    • 0035188883 scopus 로고    scopus 로고
    • Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3
    • V. Cattori, J.E. van Montfoort, B. Stieger, L. Landmann, D.K. Meijer, and K.H. Winterhalter Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3 Pflugers Arch 443 2001 188 195
    • (2001) Pflugers Arch , vol.443 , pp. 188-195
    • Cattori, V.1    Van Montfoort, J.E.2    Stieger, B.3    Landmann, L.4    Meijer, D.K.5    Winterhalter, K.H.6
  • 45
    • 0032407040 scopus 로고    scopus 로고
    • Roles of MRP2 and oatp1 in hepatocellular export of reduced glutathione
    • N. Ballatori, and J.F. Rebbeor Roles of MRP2 and oatp1 in hepatocellular export of reduced glutathione Semin Liver Dis 18 1998 377 387
    • (1998) Semin Liver Dis , vol.18 , pp. 377-387
    • Ballatori, N.1    Rebbeor, J.F.2
  • 46
    • 0033943874 scopus 로고    scopus 로고
    • Oatp2 mediates bidirectional organic solute transport: A role for intracellular glutathione
    • L. Li, P.J. Meier, and N. Ballatori Oatp2 mediates bidirectional organic solute transport: a role for intracellular glutathione Mol Pharmacol 58 2000 335 340
    • (2000) Mol Pharmacol , vol.58 , pp. 335-340
    • Li, L.1    Meier, P.J.2    Ballatori, N.3
  • 47
    • 0344927562 scopus 로고    scopus 로고
    • Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity, and MRP2-mediated drug resistance
    • J. Konig, A.T. Nies, Y. Cui, I. Leier, and D. Keppler Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance Biochim Biophys Acta 1461 1999 377 394
    • (1999) Biochim Biophys Acta , vol.1461 , pp. 377-394
    • Konig, J.1    Nies, A.T.2    Cui, Y.3    Leier, I.4    Keppler, D.5
  • 48
    • 0036074018 scopus 로고    scopus 로고
    • Mammalian ABC transporters in health and disease
    • P. Borst, and R.O. Elferink Mammalian ABC transporters in health and disease Annu Rev Biochem 71 2002 537 592
    • (2002) Annu Rev Biochem , vol.71 , pp. 537-592
    • Borst, P.1    Elferink, R.O.2
  • 49
    • 0033545984 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase lipid products regulate ATP-dependent transport by sister of P-glycoprotein and multidrug resistance associated protein 2 in bile canalicular membrane vesicles
    • S. Misra, P. Ujhazy, L. Varticovski, and I.M. Arias Phosphoinositide 3-kinase lipid products regulate ATP-dependent transport by sister of P-glycoprotein and multidrug resistance associated protein 2 in bile canalicular membrane vesicles Proc Natl Acad Sci USA 96 1999 5814 5819
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 5814-5819
    • Misra, S.1    Ujhazy, P.2    Varticovski, L.3    Arias, I.M.4
  • 51
    • 0028148189 scopus 로고
    • Identification and characterization of high and low affinity transport systems for reduced glutathione in liver cell canalicular membranes
    • N. Ballatori, and W.J. Dutczak Identification and characterization of high and low affinity transport systems for reduced glutathione in liver cell canalicular membranes J Biol Chem 269 1994 19731 19737
    • (1994) J Biol Chem , vol.269 , pp. 19731-19737
    • Ballatori, N.1    Dutczak, W.J.2
  • 52
    • 0034803328 scopus 로고    scopus 로고
    • Nifedipine modulation of biliary GSH and GSSG/conjugate efflux in normal and regenerating rat liver
    • B. Yang, and C.E. Hill Nifedipine modulation of biliary GSH and GSSG/conjugate efflux in normal and regenerating rat liver Am J Physiol Gastrointest Liver Physiol 281 2001 G85 G94
    • (2001) Am J Physiol Gastrointest Liver Physiol , vol.281
    • Yang, B.1    Hill, C.E.2
  • 53
    • 0344927562 scopus 로고    scopus 로고
    • Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity and MRP2-mediated drug resistance
    • J. Konig, A.T. Nies, Y. Cui, I. Leier, and D. Keppler Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity and MRP2-mediated drug resistance Biochim Biophys Acta 1461 1999 377 394
    • (1999) Biochim Biophys Acta , vol.1461 , pp. 377-394
    • Konig, J.1    Nies, A.T.2    Cui, Y.3    Leier, I.4    Keppler, D.5
  • 54
    • 0032407040 scopus 로고    scopus 로고
    • Roles of MRP2 and oatp1 in hepatocellular export of reduced glutathione
    • N. Ballatori, and J.F. Rebbeor Roles of MRP2 and oatp1 in hepatocellular export of reduced glutathione Semin Liver Dis 18 1998 377 387
    • (1998) Semin Liver Dis , vol.18 , pp. 377-387
    • Ballatori, N.1    Rebbeor, J.F.2
  • 57
    • 0037084149 scopus 로고    scopus 로고
    • Inhibition of Mrp2- and Ycflp-mediated. Transport by reducing agents: Evidence for GSH transport on rat Mrp2
    • J.F. Rebbeor, G.C. Connolly, and N. Ballatori Inhibition of Mrp2- and Ycflp-mediated. Transport by reducing agents: evidence for GSH transport on rat Mrp2 Biochim Biophys Acta 1559 2002 171 178
    • (2002) Biochim Biophys Acta , vol.1559 , pp. 171-178
    • Rebbeor, J.F.1    Connolly, G.C.2    Ballatori, N.3


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