Vagal hepatopancreatic reflex effect evoked by intraportal appearance of tGLP-1

American Journal of Physiology - Endocrinology and Metabolism

Volumn 271, Issue 5 34-5, 1996, Pages

  Nakabayashi, Hajime ^a   Nishizawa, Makoto ^b   Nakagawa, Atsushi ^b   Takeda, Ryoyu ^b   Niijima, Akira ^b  

^a KANAZAWA UNIVERSITY   (Japan)

^b NONE

Author keywords

enteroinsular axis; portal vein; proglucagon derived peptide; rat; truncated glucagon like peptide 1; vagal hormone reception

Indexed keywords

GLUCAGON; GLUCAGON LIKE PEPTIDE; INSULIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; INSULIN BLOOD LEVEL; MALE; NONHUMAN; PANCREAS ISLET CELL FUNCTION; PEPTIDE ANALYSIS; PORTAL VEIN; PRIORITY JOURNAL; RAT; REFLEX; SENSORY NERVE; VAGOTOMY; VAGUS NERVE;

EID: 0029829821     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1996.271.5.e808     Document Type: Article

References (32)

1. Berthoud, H.-R., M. Kressel, and W. L. Neuhuber. An anterograde tracing study of the vagal innervation or rat liver, portal vein and biliary system. Anat. Embryol. 186: 431-442, 1992.
2. Blackmore, P., S. Mojsov, J. H. Exton, and J. F. Habener. Absence of insulinotropic glucagon-like peptide-I (7-37) receptors on isolated rat liver hepatocytes. FEBS Lett. 283: 7-10, 1991.
3. Campos, R. V., Y. C. Lee, and D. J. Drucker. Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-I in the mouse. Endocrinology 134: 2156-2164, 1994.
4. D'Alessio, D., R. Thirlby, E. Laschansky, H. Zebroski, and J. Ensinck. Response of tGLP-1 to nutrients in humans. Digestion 54: 377-379, 1993.
5. Dupre, J. Influences of the gut on the endocrine pancreas: an overview of established and potential physiological mechanisms. In: The Endocrine Pancreas, edited by E. Samols. New York: Raven, 1991, p. 253-281
6. Dupre, J., S. A. Ross, D. Watson, and J. C. Brown. Stimulation of insulin secretion by gastric inhibitory polypeptide in man. J. Clin. Endocrinol. Metab. 37: 826-828, 1973.
7. Elliot, R. M., L. M. Morgan, J. A. Tredger, S. Deacon, J. Wright, and V. Marks. Glucagon-like peptide-1 (7-36)amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24-h secretion patterns. J. Endocrinol. 138: 159-166, 1993.
8. Fehmann, H.-C., R. Göke, and B. Göke. Cell and molecular biology of the incretin hormones glucagon-like peptide-I and glucose-dependent insulin releasing polypeptide. Endocr. Rev. 16: 390-410, 1995.
9. Göke, R., P. J. Larsen, J. D. Mikkelsen, and S. P. Sheikh. Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sites. Eur. J. Neurosci. 7: 2294-2300, 1995.
10. Gutniak, M., C. Ørskov, J. J. Holst, B. Ahren, and S. Efendic. Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus. N. Engl. J. Med. 326: 1316-1322, 1992.
11. Hendrick, G. K., A. Gjinovci, L. A. Baxter, S. Mojsov, C. B. Wollheim, J. F. Habener, and G. C. Weir. Glucagon-like peptide-1-(7-37) suppresses hyperglycemia in rats. Metab. Clin. Exp. 42: 1-6, 1993.
12. Holst, J. J., C. Ørskov, O. V. Nielsen, and T. W. Schwartz. Truncated glucagon-like peptide 1, an insulin-releasing hormone from the distal gut. FEBS Lett. 211: 169-174, 1987.
13. Kreymann, B., G. Williams, M. A. Ghatei, and S. R. Bloom. Glucagon-like peptide 1 7-36: a physiological incretin in man. Lancet 2: 1300-1304, 1987.
14. Miller, R. E. Pancreatic neuroendocrinology: peripheral neural mechanisms in the regulation of the islet of Langerhans. Endocr. Rev. 2: 471-494, 1981.
15. Mojsov, S., G. C. Weir, and J. F. Habener. Insulinotropin: glucagon-like peptide 1 (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J. Clin. Invest. 79: 616-619, 1987.
16. Nakabayashi, H., K. Kobayashi, I. O. Nakabayashi, and Y. Kurata. Somatostatin receptor on the afferent nerve terminals in the rat hepatoportal area. Neurosci. Lett. 183: 46-49, 1995.
17. Nakabayashi, H., A. Niijima, Y. Kurata, Z.-Y. Jiang, N. Usukura, and R. Takeda. Pancreatic vagal nerve is receptive to somatostatin in rats. Am. J. Physiol. 253 (Regulatory Integrative Comp. Physiol. 22): R200-R203, 1987.
18. Nakabayashi, H., A. Niijima, Y. Kurata, N. Usukura, and R. Takeda. Somatostatin-sensitive neural system in the liver. Neurosci. Lett. 67: 78-81, 1986.
19. Nakabayashi, H., A. Niijima, M. Nishizawa, I. O. Nakabayashi, and R. Takeda. A unique receptor-mediated mechanism in vagal chemoreception of somatostatin in the hepatoportal area. J. Auton. Nerv. Syst. 50: 45-50, 1994.
20. Nakabayashi, H., H. Sagara, N. Usukura, K. Yoshimitsu, T. Imamura, T. Seta, E. Yanase, M. Kawato, Y. Hiraiwa, S. Sakato, and R. Takeda. Effect of somatostatin on the flow rate and triglyceride levels of thoracic duct lymph in normal and vagotomized dogs. Diabetes 30: 440-445, 1981.
21. Nakabayashi, I. O., and H. Nakabayashi. Monoclonal antibodies to somatostatin receptor of rat brain. Hybridoma 11: 789-794, 1992.
22. Nathan, D. M., E. Schreiber, H. Fogel, S. Mojsov, and J. F. Habener. Insulinotropic action of glucagonlike peptide-1-(7-37) in diabetic and nondiabetic subjects. Diabetes Care 15: 270-276, 1992.
23. Nauck, M., W. E. Schmidt, R. Ebert, J. Strietzel, P. Cantor, G. Hoffmann, and W. Creutzfeldt. Insulinotropic properties of synthetic human gastric inhibitory polypeptide in man: interactions with glucose, phenylalanine, and cholecystokinin-8. J. Clin. Endocrinol. Metab. 69: 654-662, 1989.
24. Nauck, M. A., M. M. Heimesaat, C. Ørskov, J. J. Holst, R. Ebert, and W. Creutzfeldt. Preserved incretin activity of glucagon-like peptide 1(GLP-1)(7-36 amide) but not of synthetic human gastric inhibitory polypeptide (GIP) in patients with type 2 diabetes mellitus. J. Clin. Invest. 91: 301-307, 1993.
25. Niijima, A. Glucose-sensitive afferent nerve fibers in the hepatic branch of the vagus nerve in the guinea pig. J. Physiol. Lond. 332. 315-323, 1982.
26. Niijima, A. Neural control of blood glucose level. Jpn. J. Physiol. 36: 827-841, 1986.
27. Ørskov, C., M. Bersani, A. H. Johnsen, P. Hojrup, and J. J. Holst. Complete sequences of glucagon-like peptide-1 from human and pig small intestine. J. Biol. Chem. 264: 12826-12829, 1989.
28. Ørskov, C., J. Jeppensen, S. Madsbad, and J. J. Holst. Proglucagon products in plasma of noninsulin-dependent diabetics and nondiabetic controls in the fasting state and after oral glucose and intravenous arginine. J. Clin. Invest. 87: 415-425, 1991.
29. Ørskov, C., L. Rabenhoj, H. Kofod, A. Wettergren, and J. J. Holst. Production and secretion of amidated and glycine-extended glucagon-like peptide-1 (GLP-1) in man. Diabetes 43: 535-539, 1994.
30. Suzuki, S., K. Kawai, S. Ohashi, H. Mukai, and K. Yamashita. Comparison of the effects of various C-terminal and N-terminal fragment peptides of glucagon-like peptide-1 on insulin and glucagon release from the isolated perfused rat pancreas. Endocrinology 125: 3109-3114, 1989.
31. Unger, R. H., and A. M. Eisentraut. Entero-insular axis. Arch. Intern. Med. 123: 261-266, 1969.
32. Wang, Z., R. M. Wang, A. A. Owji, D. M. Smith, M. A. Ghatei, and S. R. Bloom. Glucagon-like peptide-1 is a physiological incretin in rat. J. Clin. Invest. 95: 417-421, 1995.