A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads

Diabetologia

Volumn 52, Issue 10, 2009, Pages 2122-2129

  Rose, C S ^a   Grarup, N ^a   Krarup, N T ^a   Poulsen, P ^g   Wegner, L ^a   Nielsen, T ^a   Banasik, K ^a   Faerch K ^g   Andersen, G ^a   Albrechtsen, A ^b   Borch Johnsen, K ^d,g   Clausen, J O ^g   Jorgensen T ^c,e   Vaag, A ^g   Pedersen, O ^a,d,e   Hansen, T ^a,f  

^a HAGEDORN RESEARCH INSTITUTE   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^d AARHUS UNIVERSITY   (Denmark)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

^f UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^g STENO DIABETES CENTER   (Denmark)

Author keywords

ABCB11; Association study; G6PC2; Genetic variants; Glucose production; Hepatic; Insulin release; Type 2 diabetes

Indexed keywords

GLUCOSE; INSULIN;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; FEMALE; G6PC2 GENE; GENE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GROUPS BY AGE; HETEROZYGOTE; HUMAN; HUMAN EXPERIMENT; HYPERINSULINEMIA; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESPONSE; INTRAVENOUS GLUCOSE TOLERANCE TEST; MALE; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL;

ADULT; ATP-BINDING CASSETTE TRANSPORTERS; BLOOD GLUCOSE; FASTING; FEMALE; GENOTYPE; GLUCOSE; GLUCOSE TOLERANCE TEST; GLUCOSE-6-PHOSPHATASE; HUMANS; INSULIN; LIVER; MALE; MIDDLE AGED;

EID: 69949172422     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1463-z     Document Type: Article

References (27)

1. CS Rose J Ek SA Urhammer, et al. 2005 A -30G>A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites Diabetes 54 3026 3031
2. MN Weedon VJ Clark Y Qian, et al. 2006 A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses Am J Hum Genet 79 991 1001
3. T Sparsø G Andersen T Nielsen, et al. 2008 The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes Diabetologia 51 70 75
4. V Lyssenko CL Nagorny MR Erdos, et al. 2009 Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion Nat Genet 41 82 88
5. N Bouatia-Naji A Bonnefond C Cavalcanti-Proença, et al. 2009 A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk Nat Genet 41 89 94
6. I Prokopenko C Langenberg JC Florez, et al. 2009 Variants in MTNR1B influence fasting glucose levels Nat Genet 41 77 81
7. WM Chen MR Erdos AU Jackson, et al. 2008 Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels J Clin Invest 118 2620 2628
8. T Jørgensen K Borch-Johnsen TF Thomsen H Ibsen C Glümer C Pisinger 2003 A randomized non-pharmacological intervention study for prevention of ischaemic heart disease: baseline results Inter99 Eur J Cardiovasc Prev Rehabil 10 377 386
9. C Glümer T Jørgensen K Borch-Johnsen Inter99 study 2003 Prevalences of diabetes and impaired glucose regulation in a Danish population: the Inter99 study Diabetes Care 26 2335 2340
10. N Bouatia-Naji G Rocheleau L Van-Lommel, et al. 2008 A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels Science 320 1085 1088
11. JO Clausen K Borch-Johnsen H Ibsen, et al. 1996 Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians. Analysis of the impact of gender, body fat, physical fitness, and life-style factors J Clin Invest 98 1195 1209
12. T Hansen L Ambye N Grarup, et al. 2001 Genetic variability of the SUR1 promoter in relation to beta-cell function and Type II diabetes mellitus Diabetologia 44 1330 1334 (Pubitemid 33010511)
13. P Poulsen K Levin I Petersen K Christensen H Beck-Nielsen A Vaag 2005 Heritability of insulin secretion, peripheral and hepatic insulin action, and intracellular glucose partitioning in young and old Danish twins Diabetes 54 275 283
14. World Health Organization Study Group (1999) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus. World Health Organization, Geneva
15. CC Martin LJ Bischof B Bergman, et al. 2001 Cloning and characterization of the human and rat islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) genes J Biol Chem 276 25197 25207
16. AJ Petrolonis Q Yang PJ Tummino, et al. 2004 Enzymatic characterization of the pancreatic islet-specific glucose-6-phosphatase-related protein (IGRP) J Biol Chem 279 13976 13983
17. JJ Shieh CJ Pan BC Mansfield JY Chou 2005 In islet-specific glucose-6-phosphatase-related protein, the beta cell antigenic sequence that is targeted in diabetes is not responsible for the loss of phosphohydrolase activity Diabetologia 48 1851 1859
18. SD Arden T Zahn S Steegers, et al. 1999 Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein Diabetes 48 531 542
19. JJ Shieh CJ Pan BC Mansfield JY Chou 2004 The islet-specific glucose-6-phosphatase-related protein, implicated in diabetes, is a glycoprotein embedded in the endoplasmic reticulum membrane FEBS Lett 562 160 164
20. Y Wang CC Martin JK Oeser, et al. 2007 Deletion of the gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen results in a mild metabolic phenotype Diabetologia 50 774 778
21. C Dos-Santos P Bougnéres D Fradin 2009 A single-nucleotide polymorphism in a methylatable Foxa2 binding site of the G6PC2 promoter is associated with insulin secretion in vivo and increased promoter activity in vitro Diabetes 58 489 492
22. P Lam CL Pearson CJ Soroka S Xu A Mennone JL Boyer 2007 Levels of plasma membrane expression in progressive and benign mutations of the bile salt export pump (Bsep/Abcb11) correlate with severity of cholestatic diseases Am J Physiol Cell Physiol 293 C1709 C1716
23. SS Strautnieks LN Bull AS Knisely, et al. 1998 A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis Nat Genet 20 233 238
24. T Gerloff B Stieger B Hagenbuch, et al. 1998 The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver J Biol Chem 273 10046 10050
25. PL Jansen SS Strautnieks E Jacquemin, et al. 1999 Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis Gastroenterology 117 1370 1379
26. B Staels F Kuipers 2007 Bile acid sequestrants and the treatment of type 2 diabetes mellitus Drugs 67 1383 1392
27. M Coutinho HC Gerstein Y Wang S Yusuf 1999 The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95, 783 individuals followed for 12.4 years Diabetes Care 22 233 240