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Volumn 13, Issue 4, 2009, Pages 649-665

Lifestyle Modification as the Primary Treatment of NASH

Author keywords

Exercise; High fructose corn syrup; Insulin resistance; Lipotoxicity; Obesity; Trans fatty acids

Indexed keywords

CERAMIDE DERIVATIVE; DIACYLGLYCEROL; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDYLCHOLINE; PHOSPHATIDIC ACID; SWEETENING AGENT;

EID: 70349765667     PISSN: 10893261     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cld.2009.07.006     Document Type: Review
Times cited : (56)

References (97)
  • 1
    • 0027947379 scopus 로고
    • Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships
    • Lee Y., Hirose H., Ohneda M., et al. Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. Proc Natl Acad Sci U S A 91 23 (1994) 10878-10882
    • (1994) Proc Natl Acad Sci U S A , vol.91 , Issue.23 , pp. 10878-10882
    • Lee, Y.1    Hirose, H.2    Ohneda, M.3
  • 2
    • 66149088144 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease in type 2 diabetes mellitus
    • Cusi K. Nonalcoholic fatty liver disease in type 2 diabetes mellitus. Curr Opin Endocrinol Diabetes Obes 16 2 (2009) 141-149
    • (2009) Curr Opin Endocrinol Diabetes Obes , vol.16 , Issue.2 , pp. 141-149
    • Cusi, K.1
  • 3
    • 38049186666 scopus 로고    scopus 로고
    • Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes
    • Han M.S., Park S.Y., Shinzawa K., et al. Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes. J Lipid Res 49 1 (2008) 84-97
    • (2008) J Lipid Res , vol.49 , Issue.1 , pp. 84-97
    • Han, M.S.1    Park, S.Y.2    Shinzawa, K.3
  • 4
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: a tale of two "hits"
    • Day C.P., and James O.F. Steatohepatitis: a tale of two "hits". Gastroenterology 114 4 (1998) 842-845
    • (1998) Gastroenterology , vol.114 , Issue.4 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 5
    • 4344589923 scopus 로고    scopus 로고
    • Lipid metabolism in hepatic steatosis
    • Bradbury M.W., and Berk P.D. Lipid metabolism in hepatic steatosis. Clin Liver Dis 8 3 (2004) 639-671
    • (2004) Clin Liver Dis , vol.8 , Issue.3 , pp. 639-671
    • Bradbury, M.W.1    Berk, P.D.2
  • 6
    • 34250356015 scopus 로고    scopus 로고
    • Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
    • Yamaguchi K., Yang L., McCall S., et al. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology 45 6 (2007) 1366-1374
    • (2007) Hepatology , vol.45 , Issue.6 , pp. 1366-1374
    • Yamaguchi, K.1    Yang, L.2    McCall, S.3
  • 7
    • 30044431801 scopus 로고    scopus 로고
    • From fat to inflammation
    • Day C.P. From fat to inflammation. Gastroenterology 130 1 (2006) 207-210
    • (2006) Gastroenterology , vol.130 , Issue.1 , pp. 207-210
    • Day, C.P.1
  • 8
    • 56649094325 scopus 로고    scopus 로고
    • Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease
    • Malhi H., and Gores G.J. Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease. Semin Liver Dis 28 4 (2008) 360-369
    • (2008) Semin Liver Dis , vol.28 , Issue.4 , pp. 360-369
    • Malhi, H.1    Gores, G.J.2
  • 9
    • 54049150442 scopus 로고    scopus 로고
    • Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis
    • Anderson N., and Borlak J. Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis. Pharmacol Rev 60 3 (2008) 311-357
    • (2008) Pharmacol Rev , vol.60 , Issue.3 , pp. 311-357
    • Anderson, N.1    Borlak, J.2
  • 10
    • 51349156218 scopus 로고    scopus 로고
    • Insulin sensitivity: modulation by nutrients and inflammation
    • Schenk S., Saberi M., and Olefsky J.M. Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest 118 9 (2008) 2992-3002
    • (2008) J Clin Invest , vol.118 , Issue.9 , pp. 2992-3002
    • Schenk, S.1    Saberi, M.2    Olefsky, J.M.3
  • 11
    • 0031799747 scopus 로고    scopus 로고
    • Hepatic steatosis: innocent bystander or guilty party?
    • Day C.P., and James O.F. Hepatic steatosis: innocent bystander or guilty party?. Hepatology 27 6 (1998) 1463-1466
    • (1998) Hepatology , vol.27 , Issue.6 , pp. 1463-1466
    • Day, C.P.1    James, O.F.2
  • 12
    • 0035084699 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
    • Sanyal A.J., Campbell-Sargent C., Mirshahi F., et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 120 5 (2001) 1183-1192
    • (2001) Gastroenterology , vol.120 , Issue.5 , pp. 1183-1192
    • Sanyal, A.J.1    Campbell-Sargent, C.2    Mirshahi, F.3
  • 13
    • 56149127703 scopus 로고    scopus 로고
    • Regulatable fatty acid transport mechanisms are central to the pathophysiology of obesity, fatty liver, and metabolic syndrome
    • Berk P.D. Regulatable fatty acid transport mechanisms are central to the pathophysiology of obesity, fatty liver, and metabolic syndrome. Hepatology 48 5 (2008) 1362-1376
    • (2008) Hepatology , vol.48 , Issue.5 , pp. 1362-1376
    • Berk, P.D.1
  • 15
    • 33847613579 scopus 로고    scopus 로고
    • Habitual physical activity is associated with intrahepatic fat content in humans
    • Perseghin G., Lattuada G., De Cobelli F., et al. Habitual physical activity is associated with intrahepatic fat content in humans. Diabetes Care 30 3 (2007) 683-688
    • (2007) Diabetes Care , vol.30 , Issue.3 , pp. 683-688
    • Perseghin, G.1    Lattuada, G.2    De Cobelli, F.3
  • 16
    • 22644445633 scopus 로고    scopus 로고
    • Changes in liver tests during 1-year treatment of patients with type 2 diabetes with pioglitazone, metformin or gliclazide
    • Belcher G., and Schernthaner G. Changes in liver tests during 1-year treatment of patients with type 2 diabetes with pioglitazone, metformin or gliclazide. Diabet Med 22 8 (2005) 973-979
    • (2005) Diabet Med , vol.22 , Issue.8 , pp. 973-979
    • Belcher, G.1    Schernthaner, G.2
  • 17
    • 57649229536 scopus 로고    scopus 로고
    • Clinical trial: pilot study of metformin for the treatment of nonalcoholic steatohepatitis
    • Loomba R., Lutchman G., Kleiner D.E., et al. Clinical trial: pilot study of metformin for the treatment of nonalcoholic steatohepatitis. Aliment Pharmacol Ther 29 (2008) 172-182
    • (2008) Aliment Pharmacol Ther , vol.29 , pp. 172-182
    • Loomba, R.1    Lutchman, G.2    Kleiner, D.E.3
  • 18
    • 34548626600 scopus 로고    scopus 로고
    • Effects of pioglitazone and metformin on intracellular lipid content in liver and skeletal muscle of individuals with type 2 diabetes mellitus
    • Teranishi T., Ohara T., Maeda K., et al. Effects of pioglitazone and metformin on intracellular lipid content in liver and skeletal muscle of individuals with type 2 diabetes mellitus. Metabolism 56 10 (2007) 1418-1424
    • (2007) Metabolism , vol.56 , Issue.10 , pp. 1418-1424
    • Teranishi, T.1    Ohara, T.2    Maeda, K.3
  • 19
    • 3142670354 scopus 로고    scopus 로고
    • Metformin in the treatment of nonalcoholic steatohepatitis: a pilot open label trial
    • Nair S., Diehl A.M., Wiseman M., et al. Metformin in the treatment of nonalcoholic steatohepatitis: a pilot open label trial. Aliment Pharmacol Ther 20 1 (2004) 23-28
    • (2004) Aliment Pharmacol Ther , vol.20 , Issue.1 , pp. 23-28
    • Nair, S.1    Diehl, A.M.2    Wiseman, M.3
  • 20
    • 16444378976 scopus 로고    scopus 로고
    • A phase 2 clinical trial of metformin as a treatment for non-diabetic paediatric nonalcoholic steatohepatitis
    • Schwimmer J.B., Middleton M.S., Deutsch R., et al. A phase 2 clinical trial of metformin as a treatment for non-diabetic paediatric nonalcoholic steatohepatitis. Aliment Pharmacol Ther 21 7 (2005) 871-879
    • (2005) Aliment Pharmacol Ther , vol.21 , Issue.7 , pp. 871-879
    • Schwimmer, J.B.1    Middleton, M.S.2    Deutsch, R.3
  • 21
    • 0035883890 scopus 로고    scopus 로고
    • Metformin in nonalcoholic steatohepatitis (letter)
    • Marchesini G., Brizi M., Bianchi G., et al. Metformin in nonalcoholic steatohepatitis (letter). Lancet 358 9285 (2001) 893-894
    • (2001) Lancet , vol.358 , Issue.9285 , pp. 893-894
    • Marchesini, G.1    Brizi, M.2    Bianchi, G.3
  • 22
    • 19144365586 scopus 로고    scopus 로고
    • A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease
    • Bugianesi E., Gentilcore E., Manini R., et al. A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease. Am J Gastroenterol 100 5 (2005) 1082-1090
    • (2005) Am J Gastroenterol , vol.100 , Issue.5 , pp. 1082-1090
    • Bugianesi, E.1    Gentilcore, E.2    Manini, R.3
  • 23
    • 0033635205 scopus 로고    scopus 로고
    • Focal fatty infiltration in the posterior aspect of hepatic segment IV: relationship to pancreaticoduodenal venous drainage
    • Fukukura Y., Fujiyoshi F., Inoue H., et al. Focal fatty infiltration in the posterior aspect of hepatic segment IV: relationship to pancreaticoduodenal venous drainage. Am J Gastroenterol 95 12 (2000) 3590-3595
    • (2000) Am J Gastroenterol , vol.95 , Issue.12 , pp. 3590-3595
    • Fukukura, Y.1    Fujiyoshi, F.2    Inoue, H.3
  • 24
    • 48349135916 scopus 로고    scopus 로고
    • Peritumoral steatosis associated with insulinomas: appearance at imaging
    • Atwell T.D., Lloyd R.V., Nagorney D.M., et al. Peritumoral steatosis associated with insulinomas: appearance at imaging. Abdom Imaging 33 5 (2008) 571-574
    • (2008) Abdom Imaging , vol.33 , Issue.5 , pp. 571-574
    • Atwell, T.D.1    Lloyd, R.V.2    Nagorney, D.M.3
  • 25
    • 27744565732 scopus 로고    scopus 로고
    • Metastatic insulinoma and glucagonoma from the pancreas responsible for specific peritumoral patterns of hepatic steatosis secondary to local effects of insulin and glucagon on hepatocytes
    • 365
    • Fregeville A., Couvelard A., Paradis V., et al. Metastatic insulinoma and glucagonoma from the pancreas responsible for specific peritumoral patterns of hepatic steatosis secondary to local effects of insulin and glucagon on hepatocytes. Gastroenterology 129 4 (2005) 1150 365
    • (2005) Gastroenterology , vol.129 , Issue.4 , pp. 1150
    • Fregeville, A.1    Couvelard, A.2    Paradis, V.3
  • 26
    • 0035091166 scopus 로고    scopus 로고
    • Acute hepatic steatosis complicating massive insulin overdose and excessive glucose administration
    • Jolliet P., Leverve X., and Pichard C. Acute hepatic steatosis complicating massive insulin overdose and excessive glucose administration. Intensive Care Med 27 1 (2001) 313-316
    • (2001) Intensive Care Med , vol.27 , Issue.1 , pp. 313-316
    • Jolliet, P.1    Leverve, X.2    Pichard, C.3
  • 27
    • 42249114813 scopus 로고    scopus 로고
    • Health-related fitness and physical activity in patients with nonalcoholic fatty liver disease
    • Krasnoff J.B., Painter P.L., Wallace J.P., et al. Health-related fitness and physical activity in patients with nonalcoholic fatty liver disease. Hepatology 47 4 (2008) 1158-1166
    • (2008) Hepatology , vol.47 , Issue.4 , pp. 1158-1166
    • Krasnoff, J.B.1    Painter, P.L.2    Wallace, J.P.3
  • 28
    • 21244490885 scopus 로고    scopus 로고
    • Effects of diet and exercise on muscle and liver intracellular lipid contents and insulin sensitivity in type 2 diabetic patients
    • Tamura Y., Tanaka Y., Sato F., et al. Effects of diet and exercise on muscle and liver intracellular lipid contents and insulin sensitivity in type 2 diabetic patients. J Clin Endocrinol Metab 90 6 (2005) 3191-3196
    • (2005) J Clin Endocrinol Metab , vol.90 , Issue.6 , pp. 3191-3196
    • Tamura, Y.1    Tanaka, Y.2    Sato, F.3
  • 29
    • 28044447611 scopus 로고    scopus 로고
    • Improved insulin action following short-term exercise training: role of energy and carbohydrate balance
    • Black S.E., Mitchell E., Freedson P.S., et al. Improved insulin action following short-term exercise training: role of energy and carbohydrate balance. J Appl Phys 99 6 (2005) 2285-2293
    • (2005) J Appl Phys , vol.99 , Issue.6 , pp. 2285-2293
    • Black, S.E.1    Mitchell, E.2    Freedson, P.S.3
  • 30
    • 0038517194 scopus 로고    scopus 로고
    • Concurrent exercise prevents high-fat-diet-induced macrovesicular hepatic steatosis
    • Gauthier M.S., Couturier K., Latour J.G., et al. Concurrent exercise prevents high-fat-diet-induced macrovesicular hepatic steatosis. J Appl Phys 94 6 (2003) 2127-2134
    • (2003) J Appl Phys , vol.94 , Issue.6 , pp. 2127-2134
    • Gauthier, M.S.1    Couturier, K.2    Latour, J.G.3
  • 31
    • 85047690933 scopus 로고    scopus 로고
    • Splanchnic lipolysis in human obesity
    • Nielsen S., Guo Z., Johnson C.M., et al. Splanchnic lipolysis in human obesity. J Clin Invest 113 11 (2004) 1582-1588
    • (2004) J Clin Invest , vol.113 , Issue.11 , pp. 1582-1588
    • Nielsen, S.1    Guo, Z.2    Johnson, C.M.3
  • 32
    • 33744532392 scopus 로고    scopus 로고
    • Association of cardiorespiratory fitness, body mass index, and waist circumference to nonalcoholic fatty liver disease
    • Church T.S., Kuk J.L., Ross R., et al. Association of cardiorespiratory fitness, body mass index, and waist circumference to nonalcoholic fatty liver disease. Gastroenterology 130 7 (2006) 2023-2030
    • (2006) Gastroenterology , vol.130 , Issue.7 , pp. 2023-2030
    • Church, T.S.1    Kuk, J.L.2    Ross, R.3
  • 33
    • 58149396950 scopus 로고    scopus 로고
    • Role of leisure-time physical activity in nonalcoholic fatty liver disease: a population-based study
    • Zelber-Sagi S., Nitzan-Kaluski D., Goldsmith R., et al. Role of leisure-time physical activity in nonalcoholic fatty liver disease: a population-based study. Hepatology 48 6 (2008) 1791-1798
    • (2008) Hepatology , vol.48 , Issue.6 , pp. 1791-1798
    • Zelber-Sagi, S.1    Nitzan-Kaluski, D.2    Goldsmith, R.3
  • 34
    • 4344610502 scopus 로고    scopus 로고
    • Mitochondria in nonalcoholic fatty liver disease
    • Caldwell S.H., Chang C.Y., Nakamoto R.K., et al. Mitochondria in nonalcoholic fatty liver disease. Clin Liver Dis 8 3 (2004) 595-617
    • (2004) Clin Liver Dis , vol.8 , Issue.3 , pp. 595-617
    • Caldwell, S.H.1    Chang, C.Y.2    Nakamoto, R.K.3
  • 35
    • 34249792393 scopus 로고    scopus 로고
    • Role of mitochondria in nonalcoholic fatty liver disease
    • Pessayre D. Role of mitochondria in nonalcoholic fatty liver disease. J Gastroenterol Hepatol 22 Suppl 1 (2007) S20-S27
    • (2007) J Gastroenterol Hepatol , vol.22 , Issue.SUPPL. 1
    • Pessayre, D.1
  • 36
    • 1642377274 scopus 로고    scopus 로고
    • Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
    • Petersen K.F., Dufour S., Befroy D., et al. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med 350 (2004) 664-671
    • (2004) N Engl J Med , vol.350 , pp. 664-671
    • Petersen, K.F.1    Dufour, S.2    Befroy, D.3
  • 37
    • 25644448096 scopus 로고    scopus 로고
    • Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents
    • Petersen K.F., Dufour S., and Shulman G.I. Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents. PLoS Med 2 9 (2005) e233
    • (2005) PLoS Med , vol.2 , Issue.9
    • Petersen, K.F.1    Dufour, S.2    Shulman, G.I.3
  • 38
    • 58149394230 scopus 로고    scopus 로고
    • Regulation of skeletal muscle mitochondrial fatty acid metabolism in lean and obese individuals
    • Holloway G.P., Bonen A., and Spriet L.L. Regulation of skeletal muscle mitochondrial fatty acid metabolism in lean and obese individuals. Am J Clin Nutr 89 1 (2009) 455S-462S
    • (2009) Am J Clin Nutr , vol.89 , Issue.1
    • Holloway, G.P.1    Bonen, A.2    Spriet, L.L.3
  • 39
    • 40449094269 scopus 로고    scopus 로고
    • Insulin-resistant muscle is exercise resistant: evidence for reduced response of nuclear-encoded mitochondrial genes to exercise
    • De Filippis E., Alvarez G., Berria R., et al. Insulin-resistant muscle is exercise resistant: evidence for reduced response of nuclear-encoded mitochondrial genes to exercise. Am J Physiol Endocrinol Metab 294 3 (2008) E607-E614
    • (2008) Am J Physiol Endocrinol Metab , vol.294 , Issue.3
    • De Filippis, E.1    Alvarez, G.2    Berria, R.3
  • 40
    • 34249852535 scopus 로고    scopus 로고
    • Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention
    • Stefan N., Thamer C., Staiger H., et al. Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention. J Clin Endocrinol Metab 92 5 (2007) 1827-1833
    • (2007) J Clin Endocrinol Metab , vol.92 , Issue.5 , pp. 1827-1833
    • Stefan, N.1    Thamer, C.2    Staiger, H.3
  • 41
    • 12344305124 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and type 2 diabetes
    • Lowell B.B., and Shulman G.I. Mitochondrial dysfunction and type 2 diabetes. Science 307 5708 (2005) 384-387
    • (2005) Science , vol.307 , Issue.5708 , pp. 384-387
    • Lowell, B.B.1    Shulman, G.I.2
  • 42
    • 33747032052 scopus 로고    scopus 로고
    • Deletion of nicotinamide nucleotide transhydrogenase: a new quantitative trait locus accounting for glucose intolerance in C57BL/6J mice
    • Freeman H.C., Hugill A., Dear N.T., et al. Deletion of nicotinamide nucleotide transhydrogenase: a new quantitative trait locus accounting for glucose intolerance in C57BL/6J mice. Diabetes 55 7 (2006) 2153-2156
    • (2006) Diabetes , vol.55 , Issue.7 , pp. 2153-2156
    • Freeman, H.C.1    Hugill, A.2    Dear, N.T.3
  • 43
    • 20944448234 scopus 로고    scopus 로고
    • A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice
    • Toye A.A., Lippiat J.D., Proks P., et al. A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice. Diabetologia 48 4 (2005) 675-686
    • (2005) Diabetologia , vol.48 , Issue.4 , pp. 675-686
    • Toye, A.A.1    Lippiat, J.D.2    Proks, P.3
  • 44
    • 0030017181 scopus 로고    scopus 로고
    • Distinct effects of aerobic exercise training and weight loss on glucose homeostasis in obese sedentary men
    • Dengel D.R., Pratley R.E., Hagberg J.M., et al. Distinct effects of aerobic exercise training and weight loss on glucose homeostasis in obese sedentary men. J Appl Phys 81 1 (1996) 318-325
    • (1996) J Appl Phys , vol.81 , Issue.1 , pp. 318-325
    • Dengel, D.R.1    Pratley, R.E.2    Hagberg, J.M.3
  • 45
    • 17144389303 scopus 로고    scopus 로고
    • The effect of metformin and intensive lifestyle intervention on the metabolic syndrome: the Diabetes Prevention Program randomized trial
    • Orchard T.J., Temprosa M., Goldberg R., et al. The effect of metformin and intensive lifestyle intervention on the metabolic syndrome: the Diabetes Prevention Program randomized trial. Ann Intern Med 142 8 (2005) 611-619
    • (2005) Ann Intern Med , vol.142 , Issue.8 , pp. 611-619
    • Orchard, T.J.1    Temprosa, M.2    Goldberg, R.3
  • 46
    • 33751366229 scopus 로고    scopus 로고
    • Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study
    • Lindström J., Ilanne-Parikka P., Peltonen M., et al. Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study. Lancet 368 9548 (2006) 1673-1679
    • (2006) Lancet , vol.368 , Issue.9548 , pp. 1673-1679
    • Lindström, J.1    Ilanne-Parikka, P.2    Peltonen, M.3
  • 47
    • 34249915334 scopus 로고    scopus 로고
    • Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid-induced insulin resistance
    • Schenk S., and Horowitz J.F. Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid-induced insulin resistance. J Clin Invest 117 6 (2007) 1690-1698
    • (2007) J Clin Invest , vol.117 , Issue.6 , pp. 1690-1698
    • Schenk, S.1    Horowitz, J.F.2
  • 48
    • 0037342842 scopus 로고    scopus 로고
    • Effects of identical weight loss on body composition and features of insulin resistance in obese women with high and low liver fat content
    • Tiikkainen M., Bergholm R., Vehkavaara S., et al. Effects of identical weight loss on body composition and features of insulin resistance in obese women with high and low liver fat content. Diabetes 52 3 (2003) 701-707
    • (2003) Diabetes , vol.52 , Issue.3 , pp. 701-707
    • Tiikkainen, M.1    Bergholm, R.2    Vehkavaara, S.3
  • 49
    • 27744490794 scopus 로고    scopus 로고
    • Effect of changes on body weight and lifestyle in nonalcoholic fatty liver disease
    • Suzuki A., Lindor K., St Saver J., et al. Effect of changes on body weight and lifestyle in nonalcoholic fatty liver disease. J Hepatol 43 6 (2005) 1060-1066
    • (2005) J Hepatol , vol.43 , Issue.6 , pp. 1060-1066
    • Suzuki, A.1    Lindor, K.2    St Saver, J.3
  • 50
    • 58949102847 scopus 로고    scopus 로고
    • Orlistat for overweight subjects with nonalcoholic steatohepatitis: a randomized, prospective trial
    • Harrison S.A., Fecht W., Brunt E.M., et al. Orlistat for overweight subjects with nonalcoholic steatohepatitis: a randomized, prospective trial. Hepatology 49 1 (2009) 80-86
    • (2009) Hepatology , vol.49 , Issue.1 , pp. 80-86
    • Harrison, S.A.1    Fecht, W.2    Brunt, E.M.3
  • 51
    • 27644544209 scopus 로고    scopus 로고
    • Review article: the treatment of fatty liver disease associated with the metabolic syndrome
    • Marchesini G., Natale S., Manini R., et al. Review article: the treatment of fatty liver disease associated with the metabolic syndrome. Aliment Pharmacol Ther 22 Suppl 2 (2005) 37-39
    • (2005) Aliment Pharmacol Ther , vol.22 , Issue.SUPPL. 2 , pp. 37-39
    • Marchesini, G.1    Natale, S.2    Manini, R.3
  • 52
    • 56649117397 scopus 로고    scopus 로고
    • Current and emerging therapies in nonalcoholic fatty liver disease
    • Kashi M.R., Torres D.M., and Harrison S.A. Current and emerging therapies in nonalcoholic fatty liver disease. Semin Liver Dis 28 4 (2008) 396-406
    • (2008) Semin Liver Dis , vol.28 , Issue.4 , pp. 396-406
    • Kashi, M.R.1    Torres, D.M.2    Harrison, S.A.3
  • 53
    • 56649106415 scopus 로고    scopus 로고
    • Effects of weight loss on nonalcoholic fatty liver disease
    • Rafiq N., and Younossi Z.M. Effects of weight loss on nonalcoholic fatty liver disease. Semin Liver Dis 28 4 (2008) 427-433
    • (2008) Semin Liver Dis , vol.28 , Issue.4 , pp. 427-433
    • Rafiq, N.1    Younossi, Z.M.2
  • 54
    • 47149086771 scopus 로고    scopus 로고
    • Lifestyle intervention and antioxidant therapy in children with nonalcoholic fatty liver disease: a randomized, controlled trial
    • Nobili V., Manco M., Devito R., et al. Lifestyle intervention and antioxidant therapy in children with nonalcoholic fatty liver disease: a randomized, controlled trial. Hepatology 48 1 (2008) 119-128
    • (2008) Hepatology , vol.48 , Issue.1 , pp. 119-128
    • Nobili, V.1    Manco, M.2    Devito, R.3
  • 55
    • 0031913573 scopus 로고    scopus 로고
    • Liver abnormalities in severely obese subjects: effect of drastic weight loss after gastroplasty
    • Luyckx F.H., Desaive C., Thiry A., et al. Liver abnormalities in severely obese subjects: effect of drastic weight loss after gastroplasty. Int J Obes Relat Metab Disord 22 3 (1998) 222-226
    • (1998) Int J Obes Relat Metab Disord , vol.22 , Issue.3 , pp. 222-226
    • Luyckx, F.H.1    Desaive, C.2    Thiry, A.3
  • 56
    • 0348047323 scopus 로고    scopus 로고
    • Effects of surgical treatment of the metabolic syndrome on liver fibrosis and cirrhosis
    • Kral J.G., Thung S.N., Biron S., et al. Effects of surgical treatment of the metabolic syndrome on liver fibrosis and cirrhosis. Surgery 135 1 (2004) 48-58
    • (2004) Surgery , vol.135 , Issue.1 , pp. 48-58
    • Kral, J.G.1    Thung, S.N.2    Biron, S.3
  • 57
    • 0014051568 scopus 로고
    • Liver morphology and function tests in obesity and during total starvation
    • Rozental P., Biava C., Spencer H., et al. Liver morphology and function tests in obesity and during total starvation. Am J Dig Dis 12 (1967) 198-208
    • (1967) Am J Dig Dis , vol.12 , pp. 198-208
    • Rozental, P.1    Biava, C.2    Spencer, H.3
  • 58
    • 0020040615 scopus 로고
    • Fasting in obesity: another cause of liver injury with alcoholic hyaline?
    • Capron J.P., Delamarre J., Dupas J.L., et al. Fasting in obesity: another cause of liver injury with alcoholic hyaline?. Dig Dis Sci 27 (1982) 265-268
    • (1982) Dig Dis Sci , vol.27 , pp. 265-268
    • Capron, J.P.1    Delamarre, J.2    Dupas, J.L.3
  • 59
    • 56649115813 scopus 로고    scopus 로고
    • Role of fatty acids in the pathogenesis of obesity and fatty liver: impact of bariatric surgery
    • Verna E.C., and Berk P.D. Role of fatty acids in the pathogenesis of obesity and fatty liver: impact of bariatric surgery. Semin Liver Dis 28 4 (2008) 407-426
    • (2008) Semin Liver Dis , vol.28 , Issue.4 , pp. 407-426
    • Verna, E.C.1    Berk, P.D.2
  • 60
    • 0037502809 scopus 로고    scopus 로고
    • Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women
    • Hu F.B., Li T.Y., Colditz G.A., et al. Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women. JAMA 289 14 (2003) 1785-1791
    • (2003) JAMA , vol.289 , Issue.14 , pp. 1785-1791
    • Hu, F.B.1    Li, T.Y.2    Colditz, G.A.3
  • 61
    • 34250347736 scopus 로고    scopus 로고
    • Lifestyle intervention in individuals with normal versus impaired glucose tolerance
    • Schäfer S., Kantartzis K., Machann J., et al. Lifestyle intervention in individuals with normal versus impaired glucose tolerance. Eur J Clin Invest 37 7 (2007) 535-543
    • (2007) Eur J Clin Invest , vol.37 , Issue.7 , pp. 535-543
    • Schäfer, S.1    Kantartzis, K.2    Machann, J.3
  • 62
    • 0036828347 scopus 로고    scopus 로고
    • Fructose, weight gain, and the insulin resistance syndrome
    • Elliott S.S., Keim N.L., Stern J.S., et al. Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr 76 5 (2002) 911-922
    • (2002) Am J Clin Nutr , vol.76 , Issue.5 , pp. 911-922
    • Elliott, S.S.1    Keim, N.L.2    Stern, J.S.3
  • 63
    • 2142815151 scopus 로고    scopus 로고
    • Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity
    • Bray G.A., Nielsen S.J., and Popkin B.M. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr 79 4 (2004) 537-543
    • (2004) Am J Clin Nutr , vol.79 , Issue.4 , pp. 537-543
    • Bray, G.A.1    Nielsen, S.J.2    Popkin, B.M.3
  • 64
    • 43049170503 scopus 로고    scopus 로고
    • Fructose consumption as a risk factor for nonalcoholic fatty liver disease
    • Ouyang X., Cirillo P., Sautin Y., et al. Fructose consumption as a risk factor for nonalcoholic fatty liver disease. J Hepatol 48 6 (2008) 993-999
    • (2008) J Hepatol , vol.48 , Issue.6 , pp. 993-999
    • Ouyang, X.1    Cirillo, P.2    Sautin, Y.3
  • 66
    • 0024565530 scopus 로고
    • Effect of intravenous fructose on the P-31 MR spectrum of the liver: dose response in healthy volunteers
    • Terrier F., Vock P., Cotting J., et al. Effect of intravenous fructose on the P-31 MR spectrum of the liver: dose response in healthy volunteers. Radiology 171 2 (1989) 557-563
    • (1989) Radiology , vol.171 , Issue.2 , pp. 557-563
    • Terrier, F.1    Vock, P.2    Cotting, J.3
  • 67
    • 2942638040 scopus 로고    scopus 로고
    • Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women
    • Teff K.L., Elliott S.S., Tschop M., et al. Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. J Clin Endocrinol Metab 89 6 (2004) 2963-2972
    • (2004) J Clin Endocrinol Metab , vol.89 , Issue.6 , pp. 2963-2972
    • Teff, K.L.1    Elliott, S.S.2    Tschop, M.3
  • 68
    • 55849114189 scopus 로고    scopus 로고
    • Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding
    • Shapiro A., Mu W., Roncal C., et al. Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding. Am J Physiol Regul Integr Comp Physiol 295 5 (2008) R1370-R1375
    • (2008) Am J Physiol Regul Integr Comp Physiol , vol.295 , Issue.5
    • Shapiro, A.1    Mu, W.2    Roncal, C.3
  • 70
    • 12944278731 scopus 로고    scopus 로고
    • Dietary trans-fatty acids alter adipocyte plasma membrane fatty acid composition and insulin sensitivity in rats
    • Ibrahim A., Natrajan S., and Ghafoorunissa R. Dietary trans-fatty acids alter adipocyte plasma membrane fatty acid composition and insulin sensitivity in rats. Metabolism 54 2 (2005) 240-246
    • (2005) Metabolism , vol.54 , Issue.2 , pp. 240-246
    • Ibrahim, A.1    Natrajan, S.2    Ghafoorunissa, R.3
  • 71
    • 33744815896 scopus 로고    scopus 로고
    • Should trans fatty acids be viewed as membrane-active drugs?
    • Katz A.M. Should trans fatty acids be viewed as membrane-active drugs?. Atheroscler Suppl 7 2 (2006) 41-42
    • (2006) Atheroscler Suppl , vol.7 , Issue.2 , pp. 41-42
    • Katz, A.M.1
  • 72
    • 33645757846 scopus 로고    scopus 로고
    • Trans fatty acids and cardiovascular disease
    • Mozaffarian D., Katan M.B., Ascherio A., et al. Trans fatty acids and cardiovascular disease. N Engl J Med 354 15 (2006) 1601-1613
    • (2006) N Engl J Med , vol.354 , Issue.15 , pp. 1601-1613
    • Mozaffarian, D.1    Katan, M.B.2    Ascherio, A.3
  • 73
    • 42549164262 scopus 로고    scopus 로고
    • Fast-food-based hyper-alimentation can induce rapid and profound elevation of serum alanine aminotransferase in healthy subjects
    • Kechagias S., Ernersson Å D.O., et al. Fast-food-based hyper-alimentation can induce rapid and profound elevation of serum alanine aminotransferase in healthy subjects. Gut 57 5 (2008) 649-654
    • (2008) Gut , vol.57 , Issue.5 , pp. 649-654
    • Kechagias, S.1    Ernersson Å, D.O.2
  • 74
    • 33645772260 scopus 로고    scopus 로고
    • High levels of industrially produced trans fat in popular fast foods
    • Stender S., Dyerberg J., and Astrup A. High levels of industrially produced trans fat in popular fast foods. N Engl J Med 354 15 (2006) 1650-1652
    • (2006) N Engl J Med , vol.354 , Issue.15 , pp. 1650-1652
    • Stender, S.1    Dyerberg, J.2    Astrup, A.3
  • 75
    • 2942706241 scopus 로고    scopus 로고
    • Increase in long-chain polyunsaturated fatty acid n - 6/n - 3 ratio in relation to hepatic steatosis in patients with nonalcoholic fatty liver disease
    • Araya J., Rodrigo R., Videla L.A., et al. Increase in long-chain polyunsaturated fatty acid n - 6/n - 3 ratio in relation to hepatic steatosis in patients with nonalcoholic fatty liver disease. Clin Sci (Lond) 106 6 (2004) 635-643
    • (2004) Clin Sci (Lond) , vol.106 , Issue.6 , pp. 635-643
    • Araya, J.1    Rodrigo, R.2    Videla, L.A.3
  • 76
    • 57349137214 scopus 로고    scopus 로고
    • Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent
    • Tetri L.H., Basaranoglu M., Brunt E.M., et al. Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent. Am J Physiol Gastrointest Liver Physiol 295 5 (2008) G987-G995
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.295 , Issue.5
    • Tetri, L.H.1    Basaranoglu, M.2    Brunt, E.M.3
  • 77
    • 1542303721 scopus 로고    scopus 로고
    • Trans, saturated, and unsaturated fat in foods in the United States prior to mandatory trans-fat labeling
    • Satchithanandam S., Oles C.J., Spease C.J., et al. Trans, saturated, and unsaturated fat in foods in the United States prior to mandatory trans-fat labeling. Lipids 39 1 (2004) 11-18
    • (2004) Lipids , vol.39 , Issue.1 , pp. 11-18
    • Satchithanandam, S.1    Oles, C.J.2    Spease, C.J.3
  • 78
    • 34247489673 scopus 로고    scopus 로고
    • Understanding the complexity of trans fatty acid reduction in the American diet: American Heart Association Trans Fat Conference 2006: report of the Trans Fat Conference Planning Group
    • Eckel R.H., Borra S., Lichtenstein A.H., et al. Understanding the complexity of trans fatty acid reduction in the American diet: American Heart Association Trans Fat Conference 2006: report of the Trans Fat Conference Planning Group. Circulation 115 16 (2007) 2231-2246
    • (2007) Circulation , vol.115 , Issue.16 , pp. 2231-2246
    • Eckel, R.H.1    Borra, S.2    Lichtenstein, A.H.3
  • 79
    • 38349109916 scopus 로고    scopus 로고
    • 2006 marketplace survey of trans-fatty acid content of margarines and butters, cookies and snack cakes, and savory snacks
    • Albers M.J., Harnack L.J., Steffen L.M., et al. 2006 marketplace survey of trans-fatty acid content of margarines and butters, cookies and snack cakes, and savory snacks. J Am Diet Assoc 108 2 (2008) 367-370
    • (2008) J Am Diet Assoc , vol.108 , Issue.2 , pp. 367-370
    • Albers, M.J.1    Harnack, L.J.2    Steffen, L.M.3
  • 80
    • 70349757896 scopus 로고    scopus 로고
    • Trans fats in cardiac and diabetes risk: an overview
    • Willett W.C., and Mozaffarian D. Trans fats in cardiac and diabetes risk: an overview. Curr Cardiovasc Risk Rep 1 (2007) 16-23
    • (2007) Curr Cardiovasc Risk Rep , vol.1 , pp. 16-23
    • Willett, W.C.1    Mozaffarian, D.2
  • 81
    • 62149099611 scopus 로고    scopus 로고
    • Americans' awareness, knowledge, and behaviors regarding fats: 2006-2007
    • Eckel R.H., Kris-Etherton P., Lichtenstein A.H., et al. Americans' awareness, knowledge, and behaviors regarding fats: 2006-2007. J Am Diet Assoc 109 2 (2009) 288-296
    • (2009) J Am Diet Assoc , vol.109 , Issue.2 , pp. 288-296
    • Eckel, R.H.1    Kris-Etherton, P.2    Lichtenstein, A.H.3
  • 82
    • 36448956884 scopus 로고    scopus 로고
    • An update of trans-fat reduction in the American diet
    • Borra S., Kris-Etherton P.M., Dausch J.G., et al. An update of trans-fat reduction in the American diet. J Am Diet Assoc 107 12 (2007) 2048-2050
    • (2007) J Am Diet Assoc , vol.107 , Issue.12 , pp. 2048-2050
    • Borra, S.1    Kris-Etherton, P.M.2    Dausch, J.G.3
  • 83
    • 0034738904 scopus 로고    scopus 로고
    • Exercise limitation in health and disease
    • Jones N.L., and Killian K.J. Exercise limitation in health and disease. N Engl J Med 343 9 (2000) 632-641
    • (2000) N Engl J Med , vol.343 , Issue.9 , pp. 632-641
    • Jones, N.L.1    Killian, K.J.2
  • 84
    • 4344684844 scopus 로고    scopus 로고
    • Management of nonalcoholic fatty liver disease: weight control
    • Bouneva I., and Kirby D.F. Management of nonalcoholic fatty liver disease: weight control. Clin Liver Dis 8 3 (2004) 693-713
    • (2004) Clin Liver Dis , vol.8 , Issue.3 , pp. 693-713
    • Bouneva, I.1    Kirby, D.F.2
  • 85
    • 0037031308 scopus 로고    scopus 로고
    • Does counseling by clinicians improve physical activity? A summary of the evidence for the U.S. Preventive Services Task Force
    • Eden K.B., Orleans C.T., Mulrow C.D., et al. Does counseling by clinicians improve physical activity? A summary of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med 137 3 (2002) 208-215
    • (2002) Ann Intern Med , vol.137 , Issue.3 , pp. 208-215
    • Eden, K.B.1    Orleans, C.T.2    Mulrow, C.D.3
  • 86
    • 61449183682 scopus 로고    scopus 로고
    • Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates
    • Sacks F.M., Bray G.A., Carey V.J., et al. Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Engl J Med 360 9 (2009) 859-873
    • (2009) N Engl J Med , vol.360 , Issue.9 , pp. 859-873
    • Sacks, F.M.1    Bray, G.A.2    Carey, V.J.3
  • 87
    • 65249179010 scopus 로고    scopus 로고
    • Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction
    • Kirk E., Reeds D.N., Finck B.N., et al. Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction. Gastroenterology 136 5 (2009) 1552-1560
    • (2009) Gastroenterology , vol.136 , Issue.5 , pp. 1552-1560
    • Kirk, E.1    Reeds, D.N.2    Finck, B.N.3
  • 88
    • 0038284646 scopus 로고    scopus 로고
    • Diet, obesity, and cardiovascular risk
    • Bonow R.O., and Eckel R.H. Diet, obesity, and cardiovascular risk. N Engl J Med 348 (2003) 2057-2058
    • (2003) N Engl J Med , vol.348 , pp. 2057-2058
    • Bonow, R.O.1    Eckel, R.H.2
  • 89
    • 36749033063 scopus 로고    scopus 로고
    • Benefits of lifestyle modification in NAFLD
    • Harrison S.A., and Day C.P. Benefits of lifestyle modification in NAFLD. Gut 56 12 (2007) 1760-1769
    • (2007) Gut , vol.56 , Issue.12 , pp. 1760-1769
    • Harrison, S.A.1    Day, C.P.2
  • 90
    • 0025186310 scopus 로고
    • Effect of weight reduction on hepatic abnormalities in overweight patients
    • Palmer M., and Schaffner F. Effect of weight reduction on hepatic abnormalities in overweight patients. Gastroenterology 99 5 (1990) 1408-1413
    • (1990) Gastroenterology , vol.99 , Issue.5 , pp. 1408-1413
    • Palmer, M.1    Schaffner, F.2
  • 91
    • 0030740659 scopus 로고    scopus 로고
    • Therapeutic effects of restricted diet and exercise in obese patients with fatty liver
    • Ueno T., Sugawara H., Sujaku K., et al. Therapeutic effects of restricted diet and exercise in obese patients with fatty liver. J Hepatol 27 1 (1997) 103-107
    • (1997) J Hepatol , vol.27 , Issue.1 , pp. 103-107
    • Ueno, T.1    Sugawara, H.2    Sujaku, K.3
  • 92
    • 0042265627 scopus 로고    scopus 로고
    • Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E
    • Kugelmas M., Hill D.B., Vivian B., et al. Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E. Hepatology 38 (2003) 413-419
    • (2003) Hepatology , vol.38 , pp. 413-419
    • Kugelmas, M.1    Hill, D.B.2    Vivian, B.3
  • 93
    • 1242340436 scopus 로고    scopus 로고
    • Modest weight loss and physical activity in overweight patients with chronic liver disease results in sustained improvements in alanine aminotransferase, fasting insulin, and quality of life
    • Hickman I.J., Jonsson J.R., Prins J.B., et al. Modest weight loss and physical activity in overweight patients with chronic liver disease results in sustained improvements in alanine aminotransferase, fasting insulin, and quality of life. Gut 53 3 (2004) 413-419
    • (2004) Gut , vol.53 , Issue.3 , pp. 413-419
    • Hickman, I.J.1    Jonsson, J.R.2    Prins, J.B.3
  • 94
    • 3142634597 scopus 로고    scopus 로고
    • Vitamin E treatment in pediatric obesity-related liver disease: a randomized study
    • Vajro P., Mandato C., Franzese A., et al. Vitamin E treatment in pediatric obesity-related liver disease: a randomized study. J Pediatr Gastroenterol Nutr 38 1 (2004) 48-55
    • (2004) J Pediatr Gastroenterol Nutr , vol.38 , Issue.1 , pp. 48-55
    • Vajro, P.1    Mandato, C.2    Franzese, A.3
  • 95
    • 19144372447 scopus 로고    scopus 로고
    • One-year intense nutritional counseling results in histological improvement in patients with nonalcoholic steatohepatitis: a pilot study
    • Huang M.A., Greenson J.K., Chao C., et al. One-year intense nutritional counseling results in histological improvement in patients with nonalcoholic steatohepatitis: a pilot study. Am J Gastroenterol 100 5 (2005) 1072-1081
    • (2005) Am J Gastroenterol , vol.100 , Issue.5 , pp. 1072-1081
    • Huang, M.A.1    Greenson, J.K.2    Chao, C.3
  • 96
    • 41549108440 scopus 로고    scopus 로고
    • Effect of lifestyle intervention on nonalcoholic fatty liver disease in Chinese obese children
    • Wang C.-L., Liang L., Fu J.-F., et al. Effect of lifestyle intervention on nonalcoholic fatty liver disease in Chinese obese children. World J Gastroenterol 14 10 (2008) 1598-1602
    • (2008) World J Gastroenterol , vol.14 , Issue.10 , pp. 1598-1602
    • Wang, C.-L.1    Liang, L.2    Fu, J.-F.3
  • 97
    • 33845491494 scopus 로고    scopus 로고
    • Effect of vitamin E on aminotransferase levels and insulin resistance in children with nonalcoholic fatty liver disease
    • Nobili V., Manco M., Devito R., et al. Effect of vitamin E on aminotransferase levels and insulin resistance in children with nonalcoholic fatty liver disease. Aliment Pharmacol Ther 24 11-12 (2006) 1553-1561
    • (2006) Aliment Pharmacol Ther , vol.24 , Issue.11-12 , pp. 1553-1561
    • Nobili, V.1    Manco, M.2    Devito, R.3


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