-
1
-
-
84055193535
-
TCM: made in China
-
Cheung F. TCM: made in China. Nature 2011;480:S82-S83.
-
(2011)
Nature
, vol.480
, pp. S82-S83
-
-
Cheung, F.1
-
2
-
-
33750935268
-
New concepts and approaches for drug discovery based on traditional Chinese medicine
-
Xu X. New concepts and approaches for drug discovery based on traditional Chinese medicine. Drug DiscovToday Technol 2006;3:247-253.
-
(2006)
Drug DiscovToday Technol
, vol.3
, pp. 247-253
-
-
Xu, X.1
-
3
-
-
79958290393
-
ADME properties of herbal medicines in humans: evidence, challenges and strategies
-
He S-M, Chan E, Zhou S-F. ADME properties of herbal medicines in humans: evidence, challenges and strategies. Curr PharmDes 2011;17:357-407.
-
(2011)
Curr PharmDes
, vol.17
, pp. 357-407
-
-
He, S.-M.1
Chan, E.2
Zhou, S.-F.3
-
4
-
-
84055190704
-
Perspective: all systems go
-
Van der Greef J. Perspective: all systems go. Nature 2011; 480:S87-S87.
-
(2011)
Nature
, vol.480
, pp. S87-S87
-
-
Van der Greef, J.1
-
5
-
-
67650488269
-
Synergistic drug combinations tend to improve therapeutically relevant selectivity
-
Lehár J, Krueger AS, Avery W, et al. Synergistic drug combinations tend to improve therapeutically relevant selectivity. Nat Biotechnol 2009;27:659-666.
-
(2009)
Nat Biotechnol
, vol.27
, pp. 659-666
-
-
Lehár, J.1
Krueger, A.S.2
Avery, W.3
-
6
-
-
84055184876
-
Convergence: where west meets east
-
Tian P. Convergence: where west meets east. Nature 2011; 480:S84-S86.
-
(2011)
Nature
, vol.480
, pp. S84-S86
-
-
Tian, P.1
-
7
-
-
33846091184
-
Biological fingerprinting analysis of traditional Chinese medicines with targeting ADME/ Tox property for screening of bioactive compounds by chromatographic and MS methods
-
Su X, Kong L, Lei X, et al. Biological fingerprinting analysis of traditional Chinese medicines with targeting ADME/ Tox property for screening of bioactive compounds by chromatographic and MS methods. Mini Rev Med Chem 2007;7:87-98.
-
(2007)
Mini Rev Med Chem
, vol.7
, pp. 87-98
-
-
Su, X.1
Kong, L.2
Lei, X.3
-
8
-
-
0037364162
-
ADMET in silico modelling:towards prediction paradise?
-
Van de Waterbeemd H, Gifford E. ADMET in silico modelling:towards prediction paradise? Nat Rev Drug Discov 2003;2:192-204.
-
(2003)
Nat Rev Drug Discov
, vol.2
, pp. 192-204
-
-
Van de Waterbeemd, H.1
Gifford, E.2
-
9
-
-
0036891062
-
In silico prediction of ADME and pharmacokinetics: Report of an expert meeting organised by COST B15
-
Boobis A, Gundert-Remy U, Kremers P, et al. In silico prediction of ADME and pharmacokinetics: Report of an expert meeting organised by COST B15. Eur J Pharm Sci 2002;17:183-193.
-
(2002)
Eur J Pharm Sci
, vol.17
, pp. 183-193
-
-
Boobis, A.1
Gundert-Remy, U.2
Kremers, P.3
-
10
-
-
84866040675
-
A system-level investigation into the mechanisms of Chinese traditional medicine: compound danshen formula for cardiovascular disease treatment
-
Li X, Xu X, Wang J, et al. A system-level investigation into the mechanisms of Chinese traditional medicine: compound danshen formula for cardiovascular disease treatment. PLoS One 2012;7:e43918.
-
(2012)
PLoS One
, vol.7
, pp. e43918
-
-
Li, X.1
Xu, X.2
Wang, J.3
-
11
-
-
84871281143
-
Network pharmacologybased prediction of the active ingredients and potential targets of Chinese herbal Radix Curcumae formula for application to cardiovascular disease
-
Tao W, Xu X, Wang X, et al. Network pharmacologybased prediction of the active ingredients and potential targets of Chinese herbal Radix Curcumae formula for application to cardiovascular disease. J Ethnopharmacol 2012;145:1-10.
-
(2012)
J Ethnopharmacol
, vol.145
, pp. 1-10
-
-
Tao, W.1
Xu, X.2
Wang, X.3
-
13
-
-
48549086653
-
Estimation of ADME properties in drug discovery:Predicting Caco-2 cell permeability using atom-based stochastic and non-stochastic linear indices
-
Castillo-Garit JA, Marrero-Ponce Y, Torrens F, et al. Estimation of ADME properties in drug discovery:Predicting Caco-2 cell permeability using atom-based stochastic and non-stochastic linear indices. J Pharm Sci 2008;97:1946-1976.
-
(2008)
J Pharm Sci
, vol.97
, pp. 1946-1976
-
-
Castillo-Garit, J.A.1
Marrero-Ponce, Y.2
Torrens, F.3
-
14
-
-
0030787532
-
A human colonic cell line sharing similarities with enterocytes as a model to examine oral absorption: advantages and limitations of the Caco-2 model
-
Delie F, Rubas W. A human colonic cell line sharing similarities with enterocytes as a model to examine oral absorption: advantages and limitations of the Caco-2 model. Crit RevTher Drug Carrier Syst 1997;14:221.
-
(1997)
Crit RevTher Drug Carrier Syst
, vol.14
, pp. 221
-
-
Delie, F.1
Rubas, W.2
-
15
-
-
0031834404
-
P-glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: the influence of culturing conditions and drug exposure on P-gp expression levels
-
Anderle P, Niederer E, Rubas W, et al. P-glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: the influence of culturing conditions and drug exposure on P-gp expression levels. J Pharm Sci 1998;87:757-762.
-
(1998)
J Pharm Sci
, vol.87
, pp. 757-762
-
-
Anderle, P.1
Niederer, E.2
Rubas, W.3
-
16
-
-
0035286778
-
Caco-2 monolayers in experimental and theoretical predictions of drug transport
-
Artursson P, Palm K, Luthman K. Caco-2 monolayers in experimental and theoretical predictions of drug transport. AdvDrugDeliv Rev 2001;46:27-43.
-
(2001)
AdvDrugDeliv Rev
, vol.46
, pp. 27-43
-
-
Artursson, P.1
Palm, K.2
Luthman, K.3
-
17
-
-
0042330313
-
ADME-Tox in drug discovery: integration of experimental and computational technologies
-
Yu H, Adedoyin A. ADME-Tox in drug discovery: integration of experimental and computational technologies. Drug DiscovToday 2003;8:852-861.
-
(2003)
Drug DiscovToday
, vol.8
, pp. 852-861
-
-
Yu, H.1
Adedoyin, A.2
-
18
-
-
0028307188
-
Intestinal drug absorption during induced net water absorption in man; a mechanistic study using antipyrine, atenolol and enalaprilat
-
Lennernas H, Ahrenstedt Ö, Ungell A. Intestinal drug absorption during induced net water absorption in man; a mechanistic study using antipyrine, atenolol and enalaprilat. BrJClin Pharmacol 1994;37:589-596.
-
(1994)
BrJClin Pharmacol
, vol.37
, pp. 589-596
-
-
Lennernas, H.1
Ahrenstedt, Ö2
Ungell, A.3
-
19
-
-
69349087126
-
Recent advances on in silico ADME modeling
-
Wang J, Hou T. Recent advances on in silico ADME modeling. Annu Rep Comput Chem 2009;5:101-127.
-
(2009)
Annu Rep Comput Chem
, vol.5
, pp. 101-127
-
-
Wang, J.1
Hou, T.2
-
21
-
-
33749596971
-
Moving in silico screening into practice: A minimalist approach to guide permeability screening
-
Stoner CL, Troutman M, Gao H, et al. Moving in silico screening into practice: A minimalist approach to guide permeability screening. LettDrug DesDiscov 2006;3:575-581.
-
(2006)
LettDrug DesDiscov
, vol.3
, pp. 575-581
-
-
Stoner, C.L.1
Troutman, M.2
Gao, H.3
-
22
-
-
34548358826
-
Artificial neural network models for prediction of intestinal permeability of oligopeptides
-
Jung E, Kim J, Kim M, et al. Artificial neural network models for prediction of intestinal permeability of oligopeptides. BMC Bioinformatics 2007;8:245.
-
(2007)
BMC Bioinformatics
, vol.8
, pp. 245
-
-
Jung, E.1
Kim, J.2
Kim, M.3
-
23
-
-
84925548062
-
Predicting Caco-2 permeability using support vector machine and chemistry development kit
-
Guangli M, Yiyu C. Predicting Caco-2 permeability using support vector machine and chemistry development kit. J Pharm Pharm Sci 2006;9:210-221.
-
(2006)
J Pharm Pharm Sci
, vol.9
, pp. 210-221
-
-
Guangli, M.1
Yiyu, C.2
-
24
-
-
0035498340
-
Development of quantitative structure-property relationship models for early ADME evaluation in drug discovery. 1. Aqueous solubility
-
Liu R, So S-S. Development of quantitative structure-property relationship models for early ADME evaluation in drug discovery. 1. Aqueous solubility. J Chem Inform Comput Sci 2001;41:1633-1639.
-
(2001)
J Chem Inform Comput Sci
, vol.41
, pp. 1633-1639
-
-
Liu, R.1
So, S.-S.2
-
25
-
-
67649394120
-
A prediction model for blood-brain barrier permeation and analysis on its parameter biologically
-
Chen Y, Zhu Q-J, Pan J, et al. A prediction model for blood-brain barrier permeation and analysis on its parameter biologically. Comput Methods Programs Biomed 2009;95:280-287.
-
(2009)
Comput Methods Programs Biomed
, vol.95
, pp. 280-287
-
-
Chen, Y.1
Zhu, Q.-J.2
Pan, J.3
-
26
-
-
33746874714
-
A data base for partition of volatile organic compounds and drugs from blood/plasma/serum to brain, and an LFER analysis of the data
-
Abraham MH, Ibrahim A, Zhao Y, et al. A data base for partition of volatile organic compounds and drugs from blood/plasma/serum to brain, and an LFER analysis of the data. J Pharm Sci 2006;95:2091-2100.
-
(2006)
J Pharm Sci
, vol.95
, pp. 2091-2100
-
-
Abraham, M.H.1
Ibrahim, A.2
Zhao, Y.3
-
27
-
-
46749152924
-
QSAR modeling of the blood-brain barrier permeability for diverse organic compounds
-
Zhang L, Zhu H, Oprea TI, et al. QSAR modeling of the blood-brain barrier permeability for diverse organic compounds. Pharm Res 2008;25:1902-1914.
-
(2008)
Pharm Res
, vol.25
, pp. 1902-1914
-
-
Zhang, L.1
Zhu, H.2
Oprea, T.I.3
-
28
-
-
0037204545
-
Computational approaches to the prediction of the blood-brain distribution
-
Norinder U, Haeberlein M. Computational approaches to the prediction of the blood-brain distribution. Adv Drug Deliv Rev 2002;54:291-313.
-
(2002)
Adv Drug Deliv Rev
, vol.54
, pp. 291-313
-
-
Norinder, U.1
Haeberlein, M.2
-
29
-
-
70350397386
-
Brain drug targeting: a computational approach for overcoming blood-brain barrier
-
Mehdipour AR, Hamidi M. Brain drug targeting: a computational approach for overcoming blood-brain barrier. Drug DiscovToday 2009;14:1030-1036.
-
(2009)
Drug DiscovToday
, vol.14
, pp. 1030-1036
-
-
Mehdipour, A.R.1
Hamidi, M.2
-
30
-
-
77956344034
-
Looking at the blood- brain barrier: molecular anatomy and possible investigation approaches
-
Cardoso FL, Brites D, Brito MA. Looking at the blood- brain barrier: molecular anatomy and possible investigation approaches. Brain Res Rev 2010;64:328-363.
-
(2010)
Brain Res Rev
, vol.64
, pp. 328-363
-
-
Cardoso, F.L.1
Brites, D.2
Brito, M.A.3
-
32
-
-
79959742759
-
P-glycoprotein substrate models using support vector machines based on a comprehensive data set
-
Wang Z, Chen Y, Liang H, et al. P-glycoprotein substrate models using support vector machines based on a comprehensive data set. J Chem InformModel 2011;51:1447-1456.
-
(2011)
J Chem InformModel
, vol.51
, pp. 1447-1456
-
-
Wang, Z.1
Chen, Y.2
Liang, H.3
-
33
-
-
4043091303
-
Prediction of P-glycoprotein substrates by a support vector machine approach
-
Xue Y, Yap CW, Sun L, et al. Prediction of P-glycoprotein substrates by a support vector machine approach. J Chem Inform Comput Sci 2004;44:1497-1505.
-
(2004)
J Chem Inform Comput Sci
, vol.44
, pp. 1497-1505
-
-
Xue, Y.1
Yap, C.W.2
Sun, L.3
-
34
-
-
22144463182
-
An in silico approach for screening flavonoids as P-glycoprotein inhibitors based on a Bayesian-regularized neural network
-
Wang Y-H, Li Y, Yang S-L, et al. An in silico approach for screening flavonoids as P-glycoprotein inhibitors based on a Bayesian-regularized neural network. J Comput Aided Mol Des 2005;19:137-147.
-
(2005)
J Comput Aided Mol Des
, vol.19
, pp. 137-147
-
-
Wang, Y.-H.1
Li, Y.2
Yang, S.-L.3
-
35
-
-
84899487696
-
Mechanism of the plant cytochrome P450 for herbicide resistance: a modelling study
-
Li Q, Fang Y, Li X, et al. Mechanism of the plant cytochrome P450 for herbicide resistance: a modelling study. J Enzyme InhibMed Chem 2012;1-10.
-
(2012)
J Enzyme InhibMed Chem
, pp. 1-10
-
-
Li, Q.1
Fang, Y.2
Li, X.3
-
36
-
-
77953207457
-
Investigation of binding features:effects on the interaction between CYP2A6 and inhibitors
-
Ai C, Li Y, Wang Y, et al. Investigation of binding features:effects on the interaction between CYP2A6 and inhibitors. JComputChem 2010;31:1822-1831.
-
(2010)
JComputChem
, vol.31
, pp. 1822-1831
-
-
Ai, C.1
Li, Y.2
Wang, Y.3
-
37
-
-
33947326090
-
An in silico method for screening nicotine derivatives as cytochrome P450 2A6 selective inhibitors based on kernel partial least squares
-
Wang Y, Li Y, Wang B. An in silico method for screening nicotine derivatives as cytochrome P450 2A6 selective inhibitors based on kernel partial least squares. Int J Mol Sci 2007;8:166-179.
-
(2007)
Int J Mol Sci
, vol.8
, pp. 166-179
-
-
Wang, Y.1
Li, Y.2
Wang, B.3
-
38
-
-
23644443521
-
Modeling Km values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism
-
Wang Y, Li Y, Li Y, et al. Modeling Km values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism. Bioorg Med Chem Lett 2005;15:4076-4084.
-
(2005)
Bioorg Med Chem Lett
, vol.15
, pp. 4076-4084
-
-
Wang, Y.1
Li, Y.2
Li, Y.3
-
39
-
-
0036319482
-
Comparison of the computer programs DEREK and TOPKAT to predict bacterial mutagenicity
-
Cariello NF, Wilson JD, Britt BH, et al. Comparison of the computer programs DEREK and TOPKAT to predict bacterial mutagenicity. Mutagenesis 2002;17:321-329.
-
(2002)
Mutagenesis
, vol.17
, pp. 321-329
-
-
Cariello, N.F.1
Wilson, J.D.2
Britt, B.H.3
-
40
-
-
34548562171
-
Quantum chemical simulation of cytochrome P450 catalyzed aromatic oxidation: metabolism, toxicity, and biodegradation of benzene derivatives
-
D'yachkov P, Kharchevnikova N, Dmitriev A, et al. Quantum chemical simulation of cytochrome P450 catalyzed aromatic oxidation: metabolism, toxicity, and biodegradation of benzene derivatives. Int J Quantum Chem 2007; 107:2454-2478.
-
(2007)
Int J Quantum Chem
, vol.107
, pp. 2454-2478
-
-
D'yachkov, P.1
Kharchevnikova, N.2
Dmitriev, A.3
-
41
-
-
0032849040
-
Three and four dimensional- quantitative structure activity relationship (3D/4DQSAR) analyses of CYP2D6 inhibitors
-
Ekins S, Bravi G, Binkley S, et al. Three and four dimensional- quantitative structure activity relationship (3D/4DQSAR) analyses of CYP2D6 inhibitors. Pharmacogenet Genomics 1999;9:477-489.
-
(1999)
Pharmacogenet Genomics
, vol.9
, pp. 477-489
-
-
Ekins, S.1
Bravi, G.2
Binkley, S.3
-
43
-
-
0037286803
-
Interactions of herbs with cytochrome P450
-
Zhou S, Gao Y, Jiang W, et al. Interactions of herbs with cytochrome P450. DrugMetab Rev 2003;35:35-98.
-
(2003)
DrugMetab Rev
, vol.35
, pp. 35-98
-
-
Zhou, S.1
Gao, Y.2
Jiang, W.3
-
45
-
-
84866053048
-
Application of systems biology to absorption, distribution, metabolism and excretion in Traditional Chinese Medicine
-
Yang L, Liu H, Ma H, et al. Application of systems biology to absorption, distribution, metabolism and excretion in Traditional Chinese Medicine. World Sci Tech ModernTrad ChinMed 2007;9:98-104.
-
(2007)
World Sci Tech ModernTrad ChinMed
, vol.9
, pp. 98-104
-
-
Yang, L.1
Liu, H.2
Ma, H.3
-
46
-
-
84873297322
-
Systems pharmacology uncovers Janus functions of botanical drugs: activation of host defense system and inhibition of influenza virus replication
-
Wang X, Xu X, Li Y, et al. Systems pharmacology uncovers Janus functions of botanical drugs: activation of host defense system and inhibition of influenza virus replication. Integ Biol 2013;5:351-371.
-
(2013)
Integ Biol
, vol.5
, pp. 351-371
-
-
Wang, X.1
Xu, X.2
Li, Y.3
-
47
-
-
84871391448
-
A systems biology approach to uncovering pharmacological synergy in herbal medicines with applications to cardiovascular disease
-
Wang X, Xu X, Tao W, et al. A systems biology approach to uncovering pharmacological synergy in herbal medicines with applications to cardiovascular disease. Evid Based ComplementAlternatMed 2012;2012:519031.
-
(2012)
Evid Based ComplementAlternatMed
, vol.2012
, pp. 519031
-
-
Wang, X.1
Xu, X.2
Tao, W.3
-
48
-
-
84875507557
-
Systems approaches and polypharmacology for drug discovery from herbal medicines:an example using Licorice
-
Liu H, Wang J, Zhou W, et al. Systems approaches and polypharmacology for drug discovery from herbal medicines:an example using Licorice. J Ethnopharmacol 2013; 146:773-793.
-
(2013)
J Ethnopharmacol
, vol.146
, pp. 773-793
-
-
Liu, H.1
Wang, J.2
Zhou, W.3
-
49
-
-
0037061492
-
Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays
-
Kuruvilla FG, Shamji AF, Sternson SM, et al. Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays. Nature 2002;416:653-657.
-
(2002)
Nature
, vol.416
, pp. 653-657
-
-
Kuruvilla, F.G.1
Shamji, A.F.2
Sternson, S.M.3
-
50
-
-
31144432293
-
Literature mining for the biologist:from information retrieval to biological discovery
-
Jensen LJ, Saric J, Bork P. Literature mining for the biologist:from information retrieval to biological discovery. Nat Rev Genet 2006;7:119-129.
-
(2006)
Nat Rev Genet
, vol.7
, pp. 119-129
-
-
Jensen, L.J.1
Saric, J.2
Bork, P.3
-
51
-
-
46249127253
-
Identifying gene-disease associations using centrality on a literature mined gene-interaction network
-
Özgür A, Vu T, Erkan G, et al. Identifying gene-disease associations using centrality on a literature mined gene-interaction network. Bioinformatics 2008;24:i277-i285.
-
(2008)
Bioinformatics
, vol.24
, pp. i277-i285
-
-
Özgür, A.1
Vu, T.2
Erkan, G.3
-
52
-
-
33748196408
-
A combined approach to data mining of textual and structured data to identify cancer-related targets
-
Pospisil P, Iyer LK, Adelstein SJ, et al. A combined approach to data mining of textual and structured data to identify cancer-related targets. BMC Bioinformatics 2006;7:354.
-
(2006)
BMC Bioinformatics
, vol.7
, pp. 354
-
-
Pospisil, P.1
Iyer, L.K.2
Adelstein, S.J.3
-
53
-
-
78651326779
-
HIT: linking herbal active ingredients to targets
-
Ye H, Ye L, Kang H, et al. HIT: linking herbal active ingredients to targets. Nucleic Acids Res 2011;39:D1055-D1059.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. D1055-D1059
-
-
Ye, H.1
Ye, L.2
Kang, H.3
-
54
-
-
77954264038
-
PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach
-
Liu X, Ouyang S, Yu B, et al. PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach. Nucleic Acids Res 2010;38:W609-W614.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. W609-W614
-
-
Liu, X.1
Ouyang, S.2
Yu, B.3
-
55
-
-
84855225473
-
A classification study of human b 3-adrenergic receptor agonists using BCUT descriptors
-
Hao M, Li Y, Wang Y, et al. A classification study of human b 3-adrenergic receptor agonists using BCUT descriptors. Mol Divers 2011;15:877-887.
-
(2011)
Mol Divers
, vol.15
, pp. 877-887
-
-
Hao, M.1
Li, Y.2
Wang, Y.3
-
56
-
-
84861610134
-
A systematic prediction of multiple drug-target interactions from chemical, genomic, and pharmacological data
-
Yu H, Chen J, Xu X, et al. A systematic prediction of multiple drug-target interactions from chemical, genomic, and pharmacological data. PLoS One 2012;7:e37608.
-
(2012)
PLoS One
, vol.7
, pp. e37608
-
-
Yu, H.1
Chen, J.2
Xu, X.3
-
57
-
-
84872711545
-
A systematic identification of multiple toxin-target interactions based on chemical, genomic and toxicological data
-
Zhou W, Huang C, Li Y, et al. A systematic identification of multiple toxin-target interactions based on chemical, genomic and toxicological data. Toxicology 2013;304:173-184.
-
(2013)
Toxicology
, vol.304
, pp. 173-184
-
-
Zhou, W.1
Huang, C.2
Li, Y.3
-
58
-
-
33846876695
-
Relating protein pharmacology by ligand chemistry
-
Keiser MJ, Roth BL, Armbruster BN, et al. Relating protein pharmacology by ligand chemistry. Nat Biotechnol 2007;25:197-206.
-
(2007)
Nat Biotechnol
, vol.25
, pp. 197-206
-
-
Keiser, M.J.1
Roth, B.L.2
Armbruster, B.N.3
-
59
-
-
33748189789
-
Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation
-
Cai J, Han C, Hu T, et al. Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation. Protein Sci 2006;15:2071-2081.
-
(2006)
Protein Sci
, vol.15
, pp. 2071-2081
-
-
Cai, J.1
Han, C.2
Hu, T.3
-
60
-
-
0035342428
-
Ligand-protein inverse docking and its potential use in the computer search of protein targets of a small molecule
-
Chen Y, Zhi D. Ligand-protein inverse docking and its potential use in the computer search of protein targets of a small molecule. Proteins 2001;43:217-226.
-
(2001)
Proteins
, vol.43
, pp. 217-226
-
-
Chen, Y.1
Zhi, D.2
-
61
-
-
1542286205
-
Recovering the true targets of specific ligands by virtual screening of the protein data bank
-
Paul N, Kellenberger E, Bret G, et al. Recovering the true targets of specific ligands by virtual screening of the protein data bank. Proteins 2004;54:671-680.
-
(2004)
Proteins
, vol.54
, pp. 671-680
-
-
Paul, N.1
Kellenberger, E.2
Bret, G.3
-
62
-
-
84870701834
-
A systems biology approach to understanding the mechanisms of action of Chinese herbs for treatment of cardiovascular disease
-
Li B, Xu X, Wang X, et al. A systems biology approach to understanding the mechanisms of action of Chinese herbs for treatment of cardiovascular disease. IntJMol Sci 2012;13:13501-13520.
-
(2012)
IntJMol Sci
, vol.13
, pp. 13501-13520
-
-
Li, B.1
Xu, X.2
Wang, X.3
-
64
-
-
78651287426
-
DrugBank 3.0: a comprehensive resource for 'omics' research on drugs
-
Knox C, Law V, Jewison T, et al. DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res 2011;39:D1035-D1041.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. D1035-D1041
-
-
Knox, C.1
Law, V.2
Jewison, T.3
-
65
-
-
84928178884
-
Traditional Chinese Medicine Systems Pharmacology Database
-
October 30, date last accessed
-
Traditional Chinese Medicine Systems Pharmacology Database. http://tcmspnw.com/login_clearSession (October 30, 2012, date last accessed.)
-
(2012)
-
-
-
66
-
-
79251561193
-
TCM Database@ Taiwan: the world's largest Traditional Chinese Medicine database for drug screening in silico
-
Chen CY-C. TCM Database@ Taiwan: the world's largest Traditional Chinese Medicine database for drug screening in silico. PLoS One 2011;6:e15939.
-
(2011)
PLoS One
, vol.6
, pp. e15939
-
-
Chen, C.-C.1
-
67
-
-
54249155522
-
Network pharmacology: the next paradigm in drug discovery
-
Hopkins AL. Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol 2008;4:682-690.
-
(2008)
Nat Chem Biol
, vol.4
, pp. 682-690
-
-
Hopkins, A.L.1
-
68
-
-
79951512210
-
Strategies to discover unexpected targets for drugs active at G protein-coupled receptors
-
Allen JA, Roth BL. Strategies to discover unexpected targets for drugs active at G protein-coupled receptors. Annu Rev PharmacolToxicol 2011;51:117-144.
-
(2011)
Annu Rev PharmacolToxicol
, vol.51
, pp. 117-144
-
-
Allen, J.A.1
Roth, B.L.2
-
69
-
-
51349085387
-
Data completeness- the Achilles heel of drug-target networks
-
Mestres J, Gregori-Puigjané E, Valverde S, et al. Data completeness- the Achilles heel of drug-target networks. Nat Biotechnol 2008;26:983-984.
-
(2008)
Nat Biotechnol
, vol.26
, pp. 983-984
-
-
Mestres, J.1
Gregori-Puigjané, E.2
Valverde, S.3
-
70
-
-
84855906454
-
Systems pharmacology: network analysis to identify multiscale mechanisms of drug action
-
Zhao S, Iyengar R. Systems pharmacology: network analysis to identify multiscale mechanisms of drug action. Ann Rev PharmacolToxicol 2012;52:505-521.
-
(2012)
Ann Rev PharmacolToxicol
, vol.52
, pp. 505-521
-
-
Zhao, S.1
Iyengar, R.2
-
71
-
-
80053447047
-
Computational prediction of heme-binding residues by exploiting residue interaction network
-
Liu R, Hu J. Computational prediction of heme-binding residues by exploiting residue interaction network. PLoS One 2011;6:e25560.
-
(2011)
PLoS One
, vol.6
, pp. e25560
-
-
Liu, R.1
Hu, J.2
-
72
-
-
34247622363
-
The importance of bottlenecks in protein networks: correlation with gene essentiality and expression dynamics
-
Yu H, Kim PM, Sprecher E, et al. The importance of bottlenecks in protein networks: correlation with gene essentiality and expression dynamics. PLoS Comput Biol 2007;3:e59.
-
(2007)
PLoS Comput Biol
, vol.3
, pp. e59
-
-
Yu, H.1
Kim, P.M.2
Sprecher, E.3
-
73
-
-
74349098658
-
Network analysis for international relations
-
Emilie M, Hafner-Burton MK. Network analysis for international relations. IntOrg 2009;63:559-592.
-
(2009)
IntOrg
, vol.63
, pp. 559-592
-
-
Emilie, M.1
Hafner-Burton, M.K.2
-
74
-
-
84867896997
-
Current progress in static and dynamic modeling of biological networks
-
Daigle BJJr, Srinivasan BS, Flannick JA, et al. Current progress in static and dynamic modeling of biological networks. Syst Biol SignalNetw 2010;1:13-73.
-
(2010)
Syst Biol SignalNetw
, vol.1
, pp. 13-73
-
-
Daigle, B.J.1
Srinivasan, B.S.2
Flannick, J.A.3
-
75
-
-
80052607334
-
MiR-206-mediated dynamic mechanism of the mammalian circadian clock
-
Zhou W, Li Y, Wang X, et al. MiR-206-mediated dynamic mechanism of the mammalian circadian clock. BMC Syst Biol 2011;5:141.
-
(2011)
BMC Syst Biol
, vol.5
, pp. 141
-
-
Zhou, W.1
Li, Y.2
Wang, X.3
-
76
-
-
17444430052
-
Dynamic network reconstruction from gene expression data applied to immune response during bacterial infection
-
Guthke R, Möller U, Hoffmann M, et al. Dynamic network reconstruction from gene expression data applied to immune response during bacterial infection. Bioinformatics 2005;21:1626-1634.
-
(2005)
Bioinformatics
, vol.21
, pp. 1626-1634
-
-
Guthke, R.1
Möller, U.2
Hoffmann, M.3
-
77
-
-
0033879735
-
An integrated SOFC plant dynamic model for power systems simulation
-
Padulles J, Ault G, McDonald J. An integrated SOFC plant dynamic model for power systems simulation. JPowerSources 2000;86:495-500.
-
(2000)
JPowerSources
, vol.86
, pp. 495-500
-
-
Padulles, J.1
Ault, G.2
McDonald, J.3
-
78
-
-
34248347907
-
Stochastic simulations of the cytochrome P450 catalytic cycle
-
Wang Y, Li Y, Wang B. Stochastic simulations of the cytochrome P450 catalytic cycle. J Phys Chem B 2007;111:4251-4260.
-
(2007)
J Phys Chem B
, vol.111
, pp. 4251-4260
-
-
Wang, Y.1
Li, Y.2
Wang, B.3
-
79
-
-
67651163400
-
Multivariate global sensitivity analysis for dynamic crop models
-
Lamboni M, Makowski D, Lehuger S, et al. Multivariate global sensitivity analysis for dynamic crop models. Field Crops Res 2009;113:312-320.
-
(2009)
Field Crops Res
, vol.113
, pp. 312-320
-
-
Lamboni, M.1
Makowski, D.2
Lehuger, S.3
-
80
-
-
0036500993
-
Systems biology: a brief overview
-
Kitano H. Systems biology: a brief overview. Science 2002; 295:1662-1664.
-
(2002)
Science
, vol.295
, pp. 1662-1664
-
-
Kitano, H.1
-
81
-
-
66249129037
-
A dynamic network approach for the study of human phenotypes
-
Hidalgo CA, Blumm N, Barabási A-L, et al. A dynamic network approach for the study of human phenotypes. PLoSComput Biol 2009;5:e1000353.
-
(2009)
PLoSComput Biol
, vol.5
, pp. e1000353
-
-
Hidalgo, C.A.1
Blumm, N.2
Barabási, A.-L.3
-
82
-
-
71749104303
-
Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies
-
Strazzullo P, D'Elia L, Kandala N-B, et al. Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies. BrMedJ 2009;339:b4567.
-
(2009)
BrMedJ
, vol.339
, pp. b4567
-
-
Strazzullo, P.1
D'Elia, L.2
Kandala, N.-B.3
-
83
-
-
67650220754
-
All systems go
-
Werner E. All systems go. Nature 2007;446:493-494.
-
(2007)
Nature
, vol.446
, pp. 493-494
-
-
Werner, E.1
-
84
-
-
84928183384
-
Depression facts and stats
-
22 May, date last accessed
-
Murray B, Fortinberry A, Statistics D, et al. 'Depression facts and stats'. http://www.upliftprogram.com/depression_stats. html#recovery2005 (22 May 2013, date last accessed).
-
(2013)
-
-
Murray, B.1
Fortinberry, A.2
Statistics, D.3
-
85
-
-
12944260429
-
Evidence-based decision making:global evidence, local decisions
-
Clancy CM, Cronin K. Evidence-based decision making:global evidence, local decisions. Health Affairs 2005;24:151-162.
-
(2005)
Health Affairs
, vol.24
, pp. 151-162
-
-
Clancy, C.M.1
Cronin, K.2
-
86
-
-
1542619848
-
Cancer as a robust system: implications for anticancer therapy
-
Kitano H. Cancer as a robust system: implications for anticancer therapy. Nat Rev Cancer 2004;4:227-235.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 227-235
-
-
Kitano, H.1
-
87
-
-
0033028596
-
Systematic determination of genetic network architecture
-
Tavazoie S, Hughes JD, Campbell MJ, et al. Systematic determination of genetic network architecture. Nat Genet 1999;22:281-285.
-
(1999)
Nat Genet
, vol.22
, pp. 281-285
-
-
Tavazoie, S.1
Hughes, J.D.2
Campbell, M.J.3
-
88
-
-
33646124719
-
Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients
-
Wurglics M, Schubert-Zsilavecz M. Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. Clin Pharmacokinet 2006;45:449-468.
-
(2006)
Clin Pharmacokinet
, vol.45
, pp. 449-468
-
-
Wurglics, M.1
Schubert-Zsilavecz, M.2
-
89
-
-
84862502609
-
A novel chemometric method for the prediction of human oral bioavailability
-
Xu X, Zhang W, Huang C, et al. A novel chemometric method for the prediction of human oral bioavailability. IntJMol Sci 2012;13:6964-6982.
-
(2012)
IntJMol Sci
, vol.13
, pp. 6964-6982
-
-
Xu, X.1
Zhang, W.2
Huang, C.3
-
90
-
-
84905511660
-
Prediction of human intestinal absorption based on molecular indices
-
Li L, Li Y, Wang Y, et al. Prediction of human intestinal absorption based on molecular indices. J Mol Sci 2007;23:286-291.
-
(2007)
J Mol Sci
, vol.23
, pp. 286-291
-
-
Li, L.1
Li, Y.2
Wang, Y.3
-
91
-
-
84887021927
-
Prediction of BBB permeation based on molecular indices
-
Li L, Li Y,Wang Y, et al. Prediction of BBB permeation based on molecular indices. ChinJMedChem 2007;17:221-228.
-
(2007)
ChinJMedChem
, vol.17
, pp. 221-228
-
-
Li, L.1
Li, Y.2
Wang, Y.3
-
92
-
-
84861186793
-
Hyperforin as a natural antidepressant: an overview
-
Gharge D, Pavan T, Sunil B, et al. Hyperforin as a natural antidepressant: an overview. JPharmRes 2009;2:1373-1375.
-
(2009)
JPharmRes
, vol.2
, pp. 1373-1375
-
-
Gharge, D.1
Pavan, T.2
Sunil, B.3
-
93
-
-
79251598311
-
Metabolism of hyperforin, the active constituent of St. John's wort, in human liver microsomes
-
Hokkanen J, Tolonen A, Mattila S, et al. Metabolism of hyperforin, the active constituent of St. John's wort, in human liver microsomes. Eur J Pharm Sci 2011;42:273-284.
-
(2011)
Eur J Pharm Sci
, vol.42
, pp. 273-284
-
-
Hokkanen, J.1
Tolonen, A.2
Mattila, S.3
-
94
-
-
34548616031
-
Antidepressant effect of kaempferol, a constituent of saffron (Crocus sativus) petal, in mice and rats
-
Hosseinzadeh H, Motamedshariaty V, Hadizadeh F. Antidepressant effect of kaempferol, a constituent of saffron (Crocus sativus) petal, in mice and rats. Pharmacologyonline 2007;2:367-370.
-
(2007)
Pharmacologyonline
, vol.2
, pp. 367-370
-
-
Hosseinzadeh, H.1
Motamedshariaty, V.2
Hadizadeh, F.3
-
95
-
-
34548442151
-
St. John's wort: role of active compounds for its mechanism of action and efficacy
-
Butterweck V, Schmidt M. St. John's wort: role of active compounds for its mechanism of action and efficacy. Wien MedWochenschr 2007;157:356-361.
-
(2007)
Wien MedWochenschr
, vol.157
, pp. 356-361
-
-
Butterweck, V.1
Schmidt, M.2
-
96
-
-
59449108915
-
Pharmacological in vivo test to evaluate the bioavailability of some St John's Wort innovative oral preparations
-
Isacchi B, Galeotti N, Bergonzi M, et al. Pharmacological in vivo test to evaluate the bioavailability of some St John's Wort innovative oral preparations. Phytother Res 2009;23:197-205.
-
(2009)
Phytother Res
, vol.23
, pp. 197-205
-
-
Isacchi, B.1
Galeotti, N.2
Bergonzi, M.3
-
97
-
-
11844287615
-
Hypericin-the facts about a controversial agent
-
Kubin A, Wierrani F, Burner U, et al. Hypericin-the facts about a controversial agent. Curr Pharm Des 2005;11:233-253.
-
(2005)
Curr Pharm Des
, vol.11
, pp. 233-253
-
-
Kubin, A.1
Wierrani, F.2
Burner, U.3
-
99
-
-
7644232422
-
Flavonoids of St. John's Wort reduce HPA axis function in the rat
-
Butterweck V, Hegger M, Winterhoff H. Flavonoids of St. John's Wort reduce HPA axis function in the rat. Planta Med 2004;70:1008-1011.
-
(2004)
Planta Med
, vol.70
, pp. 1008-1011
-
-
Butterweck, V.1
Hegger, M.2
Winterhoff, H.3
-
100
-
-
0023373608
-
Asimilobine and lirinidine, serotonergic receptor antagonists, from Nelumbo nucifera
-
Shoji N, Umeyama A, Saito N, et al. Asimilobine and lirinidine, serotonergic receptor antagonists, from Nelumbo nucifera. JNat Prod 1987;50:773-774.
-
(1987)
JNat Prod
, vol.50
, pp. 773-774
-
-
Shoji, N.1
Umeyama, A.2
Saito, N.3
-
101
-
-
0029562769
-
Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes
-
Protais P, Arbaoui J, Bakkali E-H, et al. Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes. J Nat Prod 1995;58:1475-1484.
-
(1995)
J Nat Prod
, vol.58
, pp. 1475-1484
-
-
Protais, P.1
Arbaoui, J.2
Bakkali, E.-H.3
-
102
-
-
79955620175
-
Second-tier natural antidepressants: review and critique
-
Iovieno N, Dalton ED, Fava M, et al. Second-tier natural antidepressants: review and critique. J Affect Disord 2011; 130:343-357.
-
(2011)
J Affect Disord
, vol.130
, pp. 343-357
-
-
Iovieno, N.1
Dalton, E.D.2
Fava, M.3
-
103
-
-
37449014659
-
Comparative study of Rhodiola preparations on behavioral despair of rats
-
Panossian A, Nikoyan N, Ohanyan N, et al. Comparative study of Rhodiola preparations on behavioral despair of rats. Phytomedicine 2008;15:84-91.
-
(2008)
Phytomedicine
, vol.15
, pp. 84-91
-
-
Panossian, A.1
Nikoyan, N.2
Ohanyan, N.3
-
104
-
-
0029194010
-
Reversible and selective inhibitors of monoamine oxidase A in mental and other disorders
-
Priest R, Gimbrett R, Roberts M, et al. Reversible and selective inhibitors of monoamine oxidase A in mental and other disorders. Acta Psychiatr Scand 1995;91:40-43.
-
(1995)
Acta Psychiatr Scand
, vol.91
, pp. 40-43
-
-
Priest, R.1
Gimbrett, R.2
Roberts, M.3
-
105
-
-
60849112548
-
Monoamine oxidase inhibition by Rhodiola rosea L. roots
-
Van Diermen D, Marston A, Bravo J, et al. Monoamine oxidase inhibition by Rhodiola rosea L. roots. J Ethnopharmacol 2009;122:397-401.
-
(2009)
J Ethnopharmacol
, vol.122
, pp. 397-401
-
-
Van Diermen, D.1
Marston, A.2
Bravo, J.3
-
106
-
-
33644873213
-
The Universal Protein Resource (UniProt): an expanding universe of protein information
-
Wu CH, Apweiler R, Bairoch A, et al. The Universal Protein Resource (UniProt): an expanding universe of protein information. NucleicAcidsRes 2006;34:D187-D191.
-
(2006)
NucleicAcidsRes
, vol.34
, pp. D187-D191
-
-
Wu, C.H.1
Apweiler, R.2
Bairoch, A.3
-
107
-
-
34047182529
-
PharmGKB: a logical home for knowledge relating genotype to drug response phenotype
-
Altman RB. PharmGKB: a logical home for knowledge relating genotype to drug response phenotype. Nat Genet 2007;39:426.
-
(2007)
Nat Genet
, vol.39
, pp. 426
-
-
Altman, R.B.1
-
108
-
-
84876467333
-
The comparative toxicogenomics Database: update 2013
-
Davis AP, Murphy CG, Johnson R, et al. The comparative toxicogenomics Database: update 2013. Nucleic Acids Res 2013;41:D1104-D1114.
-
(2013)
Nucleic Acids Res
, vol.41
, pp. D1104-D1114
-
-
Davis, A.P.1
Murphy, C.G.2
Johnson, R.3
-
109
-
-
0030941119
-
Depression and coronary heart disease: a review for cardiologists
-
Carney RM, Freedland KE, Sheline YI, et al. Depression and coronary heart disease: a review for cardiologists. Clin Cardiol 1997;20:196-200.
-
(1997)
Clin Cardiol
, vol.20
, pp. 196-200
-
-
Carney, R.M.1
Freedland, K.E.2
Sheline, Y.I.3
-
110
-
-
0036185840
-
Are anxiety and depression related to gastrointestinal symptoms in the general population?
-
Haug TT, Mykletun A, Dahl A. Are anxiety and depression related to gastrointestinal symptoms in the general population? ScandJGastroenterol 2002;37:294-298.
-
(2002)
ScandJGastroenterol
, vol.37
, pp. 294-298
-
-
Haug, T.T.1
Mykletun, A.2
Dahl, A.3
-
111
-
-
50649087691
-
Depression in the patient with COPD
-
Wilson I. Depression in the patient with COPD. IntJChron Obstruct Pulmon Dis 2006;1:61-64.
-
(2006)
IntJChron Obstruct Pulmon Dis
, vol.1
, pp. 61-64
-
-
Wilson, I.1
-
112
-
-
34447559701
-
Substance-related disorders in adults
-
Leikin JB. Substance-related disorders in adults. DisMonth 2007;53:313-335.
-
(2007)
DisMonth
, vol.53
, pp. 313-335
-
-
Leikin, J.B.1
-
113
-
-
0036947656
-
Biological mechanisms in the relationship between depression and heart disease
-
Grippo AJ, Johnson AK. Biological mechanisms in the relationship between depression and heart disease. Neurosci Biobehav Rev 2002;26:941-962.
-
(2002)
Neurosci Biobehav Rev
, vol.26
, pp. 941-962
-
-
Grippo, A.J.1
Johnson, A.K.2
-
114
-
-
84863695857
-
Rapid cloning and functional characterization of hypericin synthase gene
-
Shi Y, Zhi X, Zheng H, et al. Rapid cloning and functional characterization of hypericin synthase gene. Acta Pharm Sin 2012;47:670-676.
-
(2012)
Acta Pharm Sin
, vol.47
, pp. 670-676
-
-
Shi, Y.1
Zhi, X.2
Zheng, H.3
-
115
-
-
33745617042
-
The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine
-
Müller N, Schwarz M, Dehning S, et al. The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine. MolPsychiatry 2006;11:680-684.
-
(2006)
MolPsychiatry
, vol.11
, pp. 680-684
-
-
Müller, N.1
Schwarz, M.2
Dehning, S.3
-
116
-
-
74549220751
-
COX-2 inhibitors as antidepressants and antipsychotics:clinical evidence
-
Müller N. COX-2 inhibitors as antidepressants and antipsychotics:clinical evidence. CurrOpin InvestigDrugs 2010; 11:31-42.
-
(2010)
CurrOpin InvestigDrugs
, vol.11
, pp. 31-42
-
-
Müller, N.1
-
117
-
-
47249109433
-
COX-2 inhibition in schizophrenia and major depression
-
Muller N, Schwarz MJ. COX-2 inhibition in schizophrenia and major depression. Curr Pharm Des 2008;14:1452-1465.
-
(2008)
Curr Pharm Des
, vol.14
, pp. 1452-1465
-
-
Muller, N.1
Schwarz, M.J.2
-
118
-
-
79955997133
-
No influence of PTGS2 polymorphisms on response and remission to antidepressants in major depression
-
Serretti A, Chiesa A, Calati R, et al. No influence of PTGS2 polymorphisms on response and remission to antidepressants in major depression. Psychiatry Res 2011;188:166-169.
-
(2011)
Psychiatry Res
, vol.188
, pp. 166-169
-
-
Serretti, A.1
Chiesa, A.2
Calati, R.3
-
119
-
-
3342903485
-
Slow actions of neuroactive steroids at GABAA receptors
-
Shu H-J, Eisenman LN, Jinadasa D, et al. Slow actions of neuroactive steroids at GABAA receptors. J Neurosci 2004; 24:6667-6675.
-
(2004)
J Neurosci
, vol.24
, pp. 6667-6675
-
-
Shu, H.-J.1
Eisenman, L.N.2
Jinadasa, D.3
-
121
-
-
0024319401
-
Major depression in Parkinson's disease and the mood response to intravenous methylphenidate: possible role of the'' hedonic'' dopamine synapse
-
Cantello R, Aguggia M, Gilli M, et al. Major depression in Parkinson's disease and the mood response to intravenous methylphenidate: possible role of the'' hedonic'' dopamine synapse. J Neurol Neurosurg Psychiatry 1989;52:724-731.
-
(1989)
J Neurol Neurosurg Psychiatry
, vol.52
, pp. 724-731
-
-
Cantello, R.1
Aguggia, M.2
Gilli, M.3
-
122
-
-
40349114504
-
Role of the brainderived neurotrophic factor at glutamatergic synapses
-
Carvalho A, Caldeira M, Santos S, et al. Role of the brainderived neurotrophic factor at glutamatergic synapses. BrJ Pharmacol 2008;153:S310-S324.
-
(2008)
BrJ Pharmacol
, vol.153
, pp. S310-S324
-
-
Carvalho, A.1
Caldeira, M.2
Santos, S.3
-
123
-
-
33644553074
-
AMPA signalling in nascent glutamatergic synapses: there and not there!
-
Groc L, Gustafsson B, Hanse E. AMPA signalling in nascent glutamatergic synapses: there and not there!. Trends Neurosci 2006;29:132-139.
-
(2006)
Trends Neurosci
, vol.29
, pp. 132-139
-
-
Groc, L.1
Gustafsson, B.2
Hanse, E.3
-
124
-
-
0033533787
-
Polyamine-dependent facilitation of postsynaptic AMPA receptors counteracts paired-pulse depression
-
Rozov A, Burnashev N. Polyamine-dependent facilitation of postsynaptic AMPA receptors counteracts paired-pulse depression. Nature 1999;401:594-598.
-
(1999)
Nature
, vol.401
, pp. 594-598
-
-
Rozov, A.1
Burnashev, N.2
-
125
-
-
74049087828
-
Selective serotonin reuptake inhibitors (SSRI) pathway
-
Sangkuhl K, Klein T, Altman R. Selective serotonin reuptake inhibitors (SSRI) pathway. Pharmacogenet Genomics 2009;19:907-909.
-
(2009)
Pharmacogenet Genomics
, vol.19
, pp. 907-909
-
-
Sangkuhl, K.1
Klein, T.2
Altman, R.3
-
128
-
-
84855974464
-
The roles of neurotrophic factor and wnt signaling in depression
-
Voleti B, Duman R. The roles of neurotrophic factor and wnt signaling in depression. Clin PharmacolTher 2011;91:333-338.
-
(2011)
Clin PharmacolTher
, vol.91
, pp. 333-338
-
-
Voleti, B.1
Duman, R.2
-
129
-
-
67650470151
-
'Killing the Blues': a role for cellular suicide (apoptosis) in depression and the antidepressant response?
-
McKernan DP, Dinan TG, Cryan JF. 'Killing the Blues': a role for cellular suicide (apoptosis) in depression and the antidepressant response? ProgNeurobiol 2009;88:246-263.
-
(2009)
ProgNeurobiol
, vol.88
, pp. 246-263
-
-
McKernan, D.P.1
Dinan, T.G.2
Cryan, J.F.3
-
130
-
-
0037245913
-
BIND: the biomolecular interaction network database
-
Bader GD, Betel D, Hogue CW. BIND: the biomolecular interaction network database. Nucleic Acids Res 2003;31:248-250.
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 248-250
-
-
Bader, G.D.1
Betel, D.2
Hogue, C.W.3
-
131
-
-
33644873184
-
BioGRID: a general repository for interaction datasets
-
Stark C, Breitkreutz B-J, Reguly T, et al. BioGRID: a general repository for interaction datasets. Nucleic Acids Res 2006;34:D535-D539.
-
(2006)
Nucleic Acids Res
, vol.34
, pp. D535-D539
-
-
Stark, C.1
Breitkreutz, B.-J.2
Reguly, T.3
-
132
-
-
0347755535
-
The database of interacting proteins: 2004 update
-
Salwinski L, Miller CS, Smith AJ, et al. The database of interacting proteins: 2004 update. Nucleic Acids Res 2004; 32:D449-D451.
-
(2004)
Nucleic Acids Res
, vol.32
, pp. D449-D451
-
-
Salwinski, L.1
Miller, C.S.2
Smith, A.J.3
-
133
-
-
10744224197
-
Development of human protein reference database as an initial platform for approaching systems biology in humans
-
Peri S, Navarro JD, Amanchy R, et al. Development of human protein reference database as an initial platform for approaching systems biology in humans. Genome Res 2003;13:2363-2371.
-
(2003)
Genome Res
, vol.13
, pp. 2363-2371
-
-
Peri, S.1
Navarro, J.D.2
Amanchy, R.3
-
136
-
-
20144387067
-
The MIPS mammalian protein-protein interaction database
-
Pagel P, Kovac S, Oesterheld M, et al. The MIPS mammalian protein-protein interaction database. Bioinformatics 2005;21:832-834.
-
(2005)
Bioinformatics
, vol.21
, pp. 832-834
-
-
Pagel, P.1
Kovac, S.2
Oesterheld, M.3
-
137
-
-
15944375458
-
PDZBase: a protein- protein interaction database for PDZ-domains
-
Beuming T, Skrabanek L, Niv MY, et al. PDZBase: a protein- protein interaction database for PDZ-domains. Bioinformatics 2005;21:827-828.
-
(2005)
Bioinformatics
, vol.21
, pp. 827-828
-
-
Beuming, T.1
Skrabanek, L.2
Niv, M.Y.3
-
138
-
-
34250191844
-
Reactome: a knowledge base of biologic pathways and processes
-
Vastrik I, D'Eustachio P, Schmidt E, et al. Reactome: a knowledge base of biologic pathways and processes. Genome Biol 2007;8:R39.
-
(2007)
Genome Biol
, vol.8
, pp. R39
-
-
Vastrik, I.1
D'Eustachio, P.2
Schmidt, E.3
-
139
-
-
84878485512
-
Towards a bioinformatics analysis of anti-Alzheimer's herbal medicines from a target network perspective
-
Sun Y, Zhu R, Ye H, et al. Towards a bioinformatics analysis of anti-Alzheimer's herbal medicines from a target network perspective. Brief Bioinformatics 2013;14:327-43.
-
(2013)
Brief Bioinformatics
, vol.14
, pp. 327-343
-
-
Sun, Y.1
Zhu, R.2
Ye, H.3
-
140
-
-
1842529218
-
Proteomic analysis of integral plasma membrane proteins
-
Zhao Y, Zhang W, Kho Y, et al. Proteomic analysis of integral plasma membrane proteins. Anal Chem 2004;76:1817-1823.
-
(2004)
Anal Chem
, vol.76
, pp. 1817-1823
-
-
Zhao, Y.1
Zhang, W.2
Kho, Y.3
-
141
-
-
79955988456
-
Protein kinase A-dependent neuronal nitric oxide synthase activation mediates the enhancement of baroreflex response by adrenomedullin in the nucleus tractus solitarii of rats
-
David Y, Lih-Chi C, Yuh-Chiang S, et al. Protein kinase A-dependent neuronal nitric oxide synthase activation mediates the enhancement of baroreflex response by adrenomedullin in the nucleus tractus solitarii of rats. J Biomed Sci 2011;18:32-40.
-
(2011)
J Biomed Sci
, vol.18
, pp. 32-40
-
-
David, Y.1
Lih-Chi, C.2
Yuh-Chiang, S.3
-
142
-
-
36249009890
-
Neuronal nitric oxide synthase contributes to chronic stress-induced depression by suppressing hippocampal neurogenesis
-
Zhou QG, Hu Y, Hua Y, et al. Neuronal nitric oxide synthase contributes to chronic stress-induced depression by suppressing hippocampal neurogenesis. J Neurochem 2007;103:1843-1854.
-
(2007)
J Neurochem
, vol.103
, pp. 1843-1854
-
-
Zhou, Q.G.1
Hu, Y.2
Hua, Y.3
-
143
-
-
0141957372
-
Treatment of depression with the CRH-1-receptor antagonist R121919:endocrine changes and side effects
-
Künzel HE, Zobel AW, Nickel T, et al. Treatment of depression with the CRH-1-receptor antagonist R121919:endocrine changes and side effects. J Psychiatr Res 2003;37:525-533.
-
(2003)
J Psychiatr Res
, vol.37
, pp. 525-533
-
-
Künzel, H.E.1
Zobel, A.W.2
Nickel, T.3
-
145
-
-
70349847876
-
Network analyses in systems pharmacology
-
Berger SI, Iyengar R. Network analyses in systems pharmacology. Bioinformatics 2009;25:2466-2472.
-
(2009)
Bioinformatics
, vol.25
, pp. 2466-2472
-
-
Berger, S.I.1
Iyengar, R.2
-
146
-
-
77953811662
-
Network systems biology for drug discovery
-
Arrell D, Terzic A. Network systems biology for drug discovery. Clin PharmacolTher 2010;88:120-125.
-
(2010)
Clin PharmacolTher
, vol.88
, pp. 120-125
-
-
Arrell, D.1
Terzic, A.2
|