A systems biology approach to uncovering pharmacological synergy in herbal medicines with applications to cardiovascular disease

Evidence-based Complementary and Alternative Medicine

Volumn 2012, Issue , 2012, Pages

  Wang, Xia ^a   Xu, Xue ^a   Tao, Weiyang ^a,c   Li, Yan ^b   Wang, Yonghua ^a   Yang, Ling ^d  

^a NORTHWEST A F UNIVERSITY   (China)

^b DALIAN UNIVERSITY OF TECHNOLOGY   (China)

^c INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^d DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOVASCULAR AGENT; HERBACEOUS AGENT; RADIX ASTRAGALI MONGOLICI; RADIX OPHIOPOGONIS JAPONICI; RADIX PUERARIAE LOBATAE,; RADIX SALVIAE MILTIORRHIZA; UNCLASSIFIED DRUG;

ARTICLE; CARDIOVASCULAR DISEASE; DRUG POTENTIATION; HUMAN; PLANT ROOT; PRIORITY JOURNAL; SYSTEMS BIOLOGY;

EID: 84871391448     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2012/519031     Document Type: Article

References (75)

1. Cheung F., TCM: made in China. Nature 2011 480 S82 S83
2. Adams J. D., Wang R., Yang J., Lien E. J., Preclinical and clinical examinations of Salvia miltiorrhiza and its tanshinones in ischemic conditions. Chinese Medicine 2006 1, article 3 2-s2.0-34250810703 10.1186/1749-8546-1-3
3. Fava M., Alpert J., Nierenberg A. A., Mischoulon D., Otto M. W., Zajecka J., Murck H., Rosenbaum J. F., A double-blind, randomized trial of St John's wort, fluoxetine, and placebo in major depressive disorder. Journal of Clinical Psychopharmacology 2005 25 5 441 447 2-s2.0-25444520063 10.1097/01.jcp. 0000178416.60426.29 (Pubitemid 41368366)
4. Spinella M., The importance of pharmacological synergy in psychoactive herbal medicines. Alternative Medicine Review 2002 7 2 130 137 2-s2.0-0036241566 (Pubitemid 34461524)
5. Ma X. H., Zheng C. J., Han L. Y., Xie B., Jia J., Cao Z. W., Li Y. X., Chen Y. Z., Synergistic therapeutic actions of herbal ingredients and their mechanisms from molecular interaction and network perspectives. Drug Discovery Today 2009 14 11-12 579 588 2-s2.0-67349094548 10.1016/j.drudis.2009.03.012
6. Yata N., Sugihara N., Yamajo R., Enhanced small intestinal absorption of β -lactam antibiotics in rats in the presence of monodesmosides isolated from pericarps of Sapindus mukurossi (ENMEI-HI). Journal of Pharmacobio-Dynamics 1986 9 2 211 217 2-s2.0-0022602605 (Pubitemid 16131873)
7. Butterweck V., Petereit F., Winterhoff H., Nahrstedt A., Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test. Planta Medica 1998 64 4 291 294 2-s2.0-0031830782 10.1055/s-2006-957437 (Pubitemid 28234262)
8. Butterweck V., Liefländer-Wulf U., Winterhoff H., Nahrstedt A., Plasma levels of hypericin in presence of procyanidin B2 and hyperoside: a pharmacokinetic study in rats. Planta Medica 2003 69 3 189 192 2-s2.0-0344670186 10.1055/s-2003-38495 (Pubitemid 36470120)
9. Berenbaum M. C., George K., Sidney W., Criteria for analyzing interactions between biologically active agents. Advances in Cancer Research 1981 Academic Press 269 335
10. Wiesner J., Henschker D., Hutchinson D. B., Beck E., Jomaa H., In vitro and in vivo synergy of fosmidomycin, a novel antimalarial drug, with clindamycin. Antimicrobial Agents and Chemotherapy 2002 46 9 2889 2894 2-s2.0-0036720273 10.1128/AAC.46.9.2889-2894.2002
11. Nguyen J. T., Hoopes J. D., Le M. H., Smee D. F., Patick A. K., Faix D. J., Blair P. J., De Jong M. D., Prichard M. N., Went G. T., Triple combination of amantadine, ribavirin, and oseltamivir is highly active and synergistic against drug resistant influenza virus strains in vitro. PLoS One 2010 5 2 2-s2.0-77949639846 10.1371/journal.pone.0009332 e9332
12. Lock E. F., Abdo N., Huang R., Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model. Toxicological Sciences 2012 126 578 588
13. Cho C. R., Labow M., Reinhardt M., van Oostrum J., Peitsch M. C., The application of systems biology to drug discovery. Current Opinion in Chemical Biology 2006 10 4 294 302 2-s2.0-33746075170 10.1016/j.cbpa.2006.06.025 (Pubitemid 44080655)
14. Wu Z., Zhao X. M., Chen L., A systems biology approach to identify effective cocktail drugs. BMC Systems Biology 2010 4 supplement 2, article 7 2-s2.0-77956836440 10.1186/1752-0509-4-7
15. Li S., Zhang B., Zhang N., Network target for screening synergistic drug combinations with application to traditional Chinese medicine. BMC Systems Biology 2011 5 supplement 1, article S10 2-s2.0-79959199033 10.1186/1752-0509-5- S1-S10
16. Campillos M., Kuhn M., Gavin A.-C., Jensen L. J., Bork P., Drug target identification using side-effect similarity. Science 2008 321 5886 263 266 2-s2.0-47249146126 10.1126/science.1158140 (Pubitemid 351989100)
17. Chinese Pharmacopoeia Commission, Pharmacopoeia of the People's Republic of China 2011 Beijing, China China Medical Science Press
18. Lei X. L., Chiou G. C., Studies on cardiovascular actions of Salvia miltiorrhiza. The American Journal of Chinese Medicine 1986 14 1-2 26 32 2-s2.0-0022612112
19. Kang D. G., Oh H., Chung H. T., Lee H. S., Inhibition of angiotensin converting enzyme by lithospermic acid B isolated from radix Salviae miltiorrhiza bunge. Phytotherapy Research 2003 17 8 917 920 2-s2.0-0141849855 10.1002/ptr.1250 (Pubitemid 37152758)
20. Makino T., Wakushima H., Okamoto T., Okukubo Y., Saito K. I., Kano Y., Effects of Kangen-karyu on coagulation system and platelet aggregation in mice. Biological and Pharmaceutical Bulletin 2002 25 4 523 525 2-s2.0-0036547862 10.1248/bpb.25.523 (Pubitemid 40036747)
21. Liu X., Min W., Protective effects of astragaloside against ultraviolet A-induced photoaging in human fibroblasts. Zhong Xi Yi Jie He Xue Bao 2011 9 3 328 332 2-s2.0-79952916294 10.3736/jcim20110315
22. Deng Y., Chen H. F., Effects of Astragalus injection and its ingredients on proliferation and Akt phosphorylation of breast cancer cell lines. Zhong Xi Yi Jie He Xue Bao 2009 7 12 1174 1180 2-s2.0-74949085718 10.3736/jcim20091216
23. Lin Y.-J., Hou Y. C., Lin C.-H., Hsu Y. A., Sheu J. J. C., Lai C. H., Chen B. H., Lee Chao P. D., Wan L., Tsai F. J., Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells. Biochemical and Biophysical Research Communications 2009 378 4 683 688 2-s2.0-57849109804 10.1016/j.bbrc.2008.10.178
24. Zhang J., Hu Y., Wang D., The optimization of sulfation modification conditions for ophiopogonpolysaccharide based on antiviral activity. International Journal of Biological Macromolecules 2012 51 657 662
25. Deaton C., Froelicher E. S., Wu L. H., Ho C., Shishani K., Jaarsma T., The global burden of cardiovascular disease. European Journal of Cardiovascular Nursing 2011 10 supplement 2 S5 S13 2-s2.0-79960322798 10.1016/S1474-5151(11) 00111-3
26. Yu H., Chen J., Xu X., A systematic prediction of multiple drug-target interactions from chemical, genomic, and pharmacological data. PLoS One 2012 7 e37608
27. Xu X., Zhang W., Huang C., A novel chemometric method for the prediction of human oral bioavailability. International Journal of Molecular Sciences 2012 13 6964 6982
28. Németh K., Plumb G. W., Berrin J. G., Juge N., Jacob R., Naim H. Y., Williamson G., Swallow D. M., Kroon P. A., Deglycosylation by small intestinal epithelial cell β -glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans. European Journal of Nutrition 2003 42 1 29 42 2-s2.0-0037219688 10.1007/s00394-003-0397-3 (Pubitemid 36286303)
29. Vistoli G., Pedretti A., Testa B., Assessing drug-likeness-what are we missing? Drug Discovery Today 2008 13 7-8 285 294 2-s2.0-41549115075 10.1016/j.drudis.2007.11.007
30. Talete S., Dragon for Windows (Software for Molecular Descriptor Calculations), Version 5.4 2011. http://www.talete.mi.it/
31. Li X., Xu X., Wang J., A system-level investigation into the mechanisms of Chinese traditional medicine: compound danshen formula for cardiovascular disease treatment. PLoS One 2012 7 e43918
32. Thorn C. F., Klein T. E., Altman R. B., PharmGKB: the pharmacogenetics and pharmacogenomics knowledge base. Methods in Molecular Biology 2005 311 179 191 2-s2.0-27744460659
33. Zhu F., Shi Z., Qin C., Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Research 2012 40 1128 1136
34. Smoot M. E., Ono K., Ruscheinski J., Wang P. L., Ideker T., Cytoscape 2.8: new features for data integration and network visualization. Bioinformatics 2011 27 3 431 432 2-s2.0-79551587720 10.1093/bioinformatics/btq675
35. Zimmermann G. R., Lehár J., Keith C. T., Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discovery Today 2007 12 1-2 34 42 2-s2.0-33845762340 10.1016/j.drudis.2006.11. 008 (Pubitemid 46014485)
36. Sun J., Huang S. H., Tan B. K. H., Whiteman M., Zhu Y. C., Wu Y. J., Ng Y., Duan W., Zhu Y. Z., Effects of purified herbal extract of Salvia miltiorrhiza on ischemic rat myocardium after acute myocardial infarction. Life Sciences 2005 76 24 2849 2860 2-s2.0-16244371762 10.1016/j.lfs.2004.11.016 (Pubitemid 40460330)
37. Chang H. M., Chui K. Y., Tan F. W. L., Yang Y., Zhong Z. P., Lee C. M., Sham H. L., Wong H. N. C., Structure-activity relationship of miltirone, an active central benzodiazepine receptor ligand isolated from Salvia miltiorrhiza bunge (Danshen). Journal of Medicinal Chemistry 1991 34 5 1675 1692 2-s2.0-0025850650
38. Yagi A., Fujimoto K., Tanonaka K., Hirai K., Takeo S., Possible active components of Tan-Shen (Salvia miltiorrhiza) for protection of the myocardium against ischemia-induced derangements. Planta Medica 1989 55 1 51 54 2-s2.0-0024502823 (Pubitemid 19058361)
39. Zhao Q.-T., Guo Q.-M., Wang P., Wang Q., Salvianic acid A inhibits lipopolysaccharide-induced apoptosis through regulating glutathione peroxidase activity and malondialdehyde level in vascular endothelial cells. Chinese Journal of Natural Medicines 2012 10 53 57
40. Yu X. Q., Xue C. C., Zhou Z. W., Li C. G., Zhou S. F., Tanshinone IIB, a primary active constituent from Salvia miltiorrhiza, exerts neuroprotective effect via inhibition of neuronal apoptosis in vitro. Phytotherapy Research 2008 22 6 846 850 2-s2.0-46849117754 10.1002/ptr.2404 (Pubitemid 351955587)
41. Perez-Vizcaino F., Duarte J., Andriantsitohaina R., Endothelial function and cardiovascular disease: effects of quercetin and wine polyphenols. Free Radical Research 2006 40 10 1054 1065 2-s2.0-33749246068 10.1080/ 10715760600823128 (Pubitemid 44480546)
42. Shirataki Y., Takao M., Yoshida S., Toda S., Antioxidative components isolated from the roots of Astragalus membranaceus Bunge (Astragali Radix). Phytotherapy Research 1997 11 603 605 (Pubitemid 28053644)
43. Teede H. J., McGrath B. P., DeSilva L., Cehun M., Fassoulakis A., Nestel P. J., Isoflavones reduce arterial stiffness: a placebo-controlled study in men and postmenopausal women. Arteriosclerosis, Thrombosis, and Vascular Biology 2003 23 6 1066 1071 2-s2.0-0037783250 10.1161/01.ATV.0000072967.97296.4A (Pubitemid 36713562)
44. Hertog M. G. L., Feskens E. J. M., Hollman P. C. H., Katan M. B., Kromhout D., Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen Elderly Study. The Lancet 1993 342 8878 1007 1011 2-s2.0-0027504187 10.1016/0140-6736(93)92876-U (Pubitemid 23314801)
45. Xu X. L., Ji H., Gu S. Y., Shao Q., Huang Q. J., Cheng Y. P., Modification of alterations in cardiac function and sarcoplasmic reticulum by astragaloside IV in myocardial injury in vivo. European Journal of Pharmacology 2007 568 1-3 203 212 2-s2.0-34250835018 10.1016/j.ejphar.2007.04.007 (Pubitemid 46976897)
46. Hikino H., Funayama S., Endo K., Hypotensive principle of Astragalus and Hedysarum roots. Planta Medica 1976 30 4 297 302 2-s2.0-0017142175
47. Rong H., Stevens J. F., Deinzer M. L., Cooman L. D., Keukeleire D. D., Identification of isoflavones in the roots of Pueraria lobata. Planta Medica 1998 64 7 620 627 2-s2.0-0031754945 10.1055/s-2006-957534 (Pubitemid 28481474)
48. Keung W. M., Vallee B. L., Daidzin: a potent, selective inhibitor of human mitochondrial aldehyde dehydrogenase. Proceedings of the National Academy of Sciences of the United States of America 1993 90 4 1247 1251 2-s2.0-0027466340 10.1073/pnas.90.4.1247 (Pubitemid 23058148)
49. Peluso M. R., Flavonoids attenuate cardiovascular disease, inhibit phosphodiesterase, and modulate lipid homeostasis in adipose tissue and liver. Experimental Biology and Medicine 2006 231 8 1287 1299 2-s2.0-33748324543 (Pubitemid 44330564)
50. Wang L. Y., Zhao A. P., Chai X. S., Effects of puerarin on cat vascular smooth muscle in vitro. Zhongguo Yao Li Xue Bao 1994 15 2 180 182 2-s2.0-0028326989
51. Lin Y., Zhu D., Qi J., Qin M., Yu B., Characterization of homoisoflavonoids in different cultivation regions of Ophiopogon japonicus and related antioxidant activity. Journal of Pharmaceutical and Biomedical Analysis 2010 52 5 757 762 2-s2.0-77950865976 10.1016/j.jpba.2010.02.016
52. Wang K. W., Zhang H., Shen L. Q., Wang W., Novel steroidal saponins from Liriope graminifolia (Linn.) Baker with anti-tumor activities. Carbohydrate Research 2011 346 2 253 258 2-s2.0-78651374878 10.1016/j.carres.2010.11.015
53. Hasebe Y., Egawa K., Yamazaki Y., Kunimoto S., Hirai Y., Ida Y., Nose K., Specific inhibition of hypoxia-inducible factor (HIF)-1 α activation and of vascular endothelial growth factor (VEGF) production by flavonoids. Biological and Pharmaceutical Bulletin 2003 26 10 1379 1383 2-s2.0-1542541381 10.1248/bpb.26.1379 (Pubitemid 41685384)
54. 2-induced injury in primary human umbilical vein endothelial cells. Journal of Ethnopharmacology 2010 128 2 438 445 2-s2.0-77649189826 10.1016/j.jep.2010.01.031
55. Morecroft I., Heeley R. P., Prentice H. M., Kirk A., MacLean M. R., 5-Hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT(1B) receptor. British Journal of Pharmacology 1999 128 3 730 734 2-s2.0-0032751507 10.1038/sj.bjp.0702841 (Pubitemid 29504766)
56. Emilien G., Maloteaux J. M., Current therapeutic uses and potential of β -adrenoceptor agonists and antagonists. European Journal of Clinical Pharmacology 1998 53 6 389 404 2-s2.0-0031978010 10.1007/s002280050399 (Pubitemid 28154739)
57. Ibarra M., Pardo J. P., López-Guerrero J. J., Villalobos-Molina R., Differential response to chloroethylclonidine in blood vessels of normotensive and spontaneously hypertensive rats: role of α (1D)- and α (1A)-adrenoceptors in contraction. British Journal of Pharmacology 2000 129 4 653 660 2-s2.0-0034059529 (Pubitemid 30153848)
58. Shimizu W., Antzelevitch C., Suyama K., Kurita T., Taguchi A., Aihara N., Takaki H., Sunagawa K., Kamakura S., Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada Syndrome. Journal of Cardiovascular Electrophysiology 2000 11 12 1320 1329 2-s2.0-0034548068 (Pubitemid 32016854)
59. Vandenberg J. I., Walker B. D., Campbell T. J., HERG K+ channels: friend and foe. Trends in Pharmacological Sciences 2001 22 5 240 246 2-s2.0-0035337145 10.1016/S0165-6147(00)01662-X (Pubitemid 32411525)
60. Ridker P. M., Hennekens C. H., Miletich J. P., G20210A mutation in prothrombin gene and risk of myocardial infarction, stroke, and venous thrombosis in a large cohort of US men. Circulation 1999 99 8 999 1004 2-s2.0-0033515068 (Pubitemid 29104487)
61. Hsueh W. A., Bruemmer D., Peroxisome proliferator-activated receptor gamma: implications for cardiovascular disease. Hypertension 2004 43 2 297 305 2-s2.0-0842311509 10.1161/01.HYP.0000113626.76571.5b (Pubitemid 38174129)
62. Veikkola T., Karkkainen M., Claesson-Welsh L., Alitalo K., Regulation of angiogenesis via vascular endothelial growth factor receptors. Cancer Research 2000 60 2 203 212 2-s2.0-0034650802 (Pubitemid 30070735)
63. Wang D., Liu Y., Han J., Puerarin suppresses invasion and vascularization of endometriosis tissue stimulated by 17beta-estradiol. PLoS One 2011 6 e25011
64. Zhang S., Chen S., Shen Y., Yang D., Liu X., Sun-Chi A. C., Xu H., Puerarin induces angiogenesis in myocardium of rat with myocardial infarction. Biological and Pharmaceutical Bulletin 2006 29 5 945 950 2-s2.0-33646449792 10.1248/bpb.29.945
65. Wong K. H., Li G. Q., Li K. M., Razmovski-Naumovski V., Chan K., Kudzu root: traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases. Journal of Ethnopharmacology 2011 134 3 584 607 2-s2.0-79954422522 10.1016/j.jep.2011.02.001
66. Feher M., Schmidt J. M., Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry. Journal of Chemical Information and Computer Sciences 2003 43 1 218 227 2-s2.0-0037208308 10.1021/ci0200467
67. Martin Y. C., A bioavailability score. Journal of Medicinal Chemistry 2005 48 9 3164 3170 2-s2.0-18244370266 10.1021/jm0492002 (Pubitemid 40628036)
68. Chan E., Tan M., Xin J., Sudarsanam S., Johnson D. E., Interactions between traditional Chinese medicines and Western therapeutics. Current Opinion in Drug Discovery and Development 2010 13 1 50 65 2-s2.0-73849123558
69. Tomaszewski M., Brain N. J. R., Charchar F. J., Wang W. Y. S., Lacka B., Padmanabahn S., Clark J. S., Anderson N. H., Edwards H. V., Zukowska- Szczechowska E., Grzeszczak W., Dominiczak A. F., Essential hypertension and β 2-adrenergic receptor gene: linkage and association analysis. Hypertension 2002 40 3 286 291 2-s2.0-0036707448 10.1161/01.HYP.0000029105. 21202.FE (Pubitemid 35006712)
70. Verstraete M., Synthetic inhibitors of platelet glycoprotein IIb/IIIa in clinical development. Circulation 2000 101 6 E76 E80 2-s2.0-0034651322
71. Mestres J., Gregori-Puigjané E., Valverde S., Solé R. V., The topology of drug-target interaction networks: implicit dependence on drug properties and target families. Molecular BioSystems 2009 5 9 1051 1057 2-s2.0-68949119585 10.1039/b905821b
72. Förstermann U., Münzel T., Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation 2006 113 13 1708 1714 2-s2.0-33645780634 10.1161/CIRCULATIONAHA.105.602532
73. Guo K., Andres V., Walsh K., Nitric oxide-induced downregulation of cdk2 activity and cyclin A gene transcription in vascular smooth muscle cells. Circulation 1998 97 20 2066 2072 2-s2.0-0032568481 (Pubitemid 28243670)
74. Suzuki J. I., Isobe M., Morishita R., Aoki M., Horie S., Okubo Y., Kaneda Y., Sawa Y., Matsuda H., Ogihara T., Sekiguchi M., Prevention of graft coronary arteriosclerosis by antisense cdk2 kinase oligonucleotide. Nature Medicine 1997 3 8 900 903 2-s2.0-0030877852 10.1038/nm0897-900 (Pubitemid 27353451)
75. Nishida K., Yamaguchi O., Hirotani S., Hikoso S., Higuchi Y., Watanabe T., Takeda T., Osuka S., Morita T., Kondoh G., Uno Y., Kashiwase K., Taniike M., Nakai A., Matsumura Y., Miyazaki J. I., Sudo T., Hongo K., Kusakari Y., Kurihara S., Chien K. R., Takeda J., Hori M., Otsu K., P38 α mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload. Molecular and Cellular Biology 2004 24 24 10611 10620 2-s2.0-10044261073 10.1128/MCB.24.24.10611-10620.2004 (Pubitemid 39603120)