-
1
-
-
73149086369
-
An outline of general system theory
-
von Bertalanfy, L. An outline of general system theory. Br. J. Philos. Sci. 1, 139-164 (1950).
-
(1950)
Br. J. Philos. Sci.
, vol.1
, pp. 139-164
-
-
Von Bertalanfy, L.1
-
2
-
-
35649001607
-
A quantitative description of membrane current and its application to conduction and excitation in nerve
-
Hodgkin, A.L. & Huxley, A.F. A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. (Lond.) 117, 500-544 (1952).
-
(1952)
J. Physiol. (Lond.)
, vol.117
, pp. 500-544
-
-
Hodgkin, A.L.1
Huxley, A.F.2
-
3
-
-
36949064203
-
Cardiac action and pacemaker potentials based on the Hodgkin-Huxley equations
-
Noble, D. Cardiac action and pacemaker potentials based on the Hodgkin-Huxley equations. Nature 188, 495-497 (1960)
-
(1960)
Nature
, vol.188
, pp. 495-497
-
-
Noble, D.1
-
7
-
-
4644335402
-
Systems biology, proteomics, and the future of health care: Toward predictive, preventative, and personalized medicine
-
Weston, A.D. & Hood, L. Systems biology, proteomics, and the future of health care: toward predictive, preventative, and personalized medicine. J. Proteome Res. 3, 179-196 (2004).
-
(2004)
J. Proteome Res.
, vol.3
, pp. 179-196
-
-
Weston, A.D.1
Hood, L.2
-
8
-
-
5044229321
-
The impact of systems approaches on biological problems in drug discovery
-
Hood, L. & Perlmutter, R.M. The impact of systems approaches on biological problems in drug discovery. Nat. Biotechnol. 22, 1215-1217 (2004).
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 1215-1217
-
-
Hood, L.1
Perlmutter, R.M.2
-
9
-
-
68749116325
-
Systems biology and the virtual physiological human
-
Kohl, P. & Noble, D. Systems biology and the virtual physiological human. Mol. Syst. Biol. 5, 292 (2009).
-
(2009)
Mol. Syst. Biol.
, vol.5
, pp. 292
-
-
Kohl, P.1
Noble, D.2
-
10
-
-
35449004951
-
Molecular systems biology in drug development
-
Silver, P.A. & Way, J.C. Molecular systems biology in drug development. Clin. Pharmacol. Ther. 82, 586-590 (2007).
-
(2007)
Clin. Pharmacol. Ther.
, vol.82
, pp. 586-590
-
-
Silver, P.A.1
Way, J.C.2
-
11
-
-
70349972372
-
ATP-sensitive K+ channel knockout induces cardiac proteome remodeling predictive of heart disease susceptibility
-
Arrell, D.K., Zlatkovic, J., Kane, G.C., yamada, S. & Terzic, A. ATP-sensitive K+ channel knockout induces cardiac proteome remodeling predictive of heart disease susceptibility. J. Proteome Res. 8, 4823-4834 (2009).
-
(2009)
J. Proteome Res.
, vol.8
, pp. 4823-4834
-
-
Arrell, D.K.1
Zlatkovic, J.2
Kane, G.C.3
Yamada, S.4
Terzic, A.5
-
12
-
-
54249108861
-
Stem cells: Biologics for regeneration
-
Nelson, T., Behfar, A. & Terzic, A. Stem cells: biologics for regeneration. Clin. Pharmacol. Ther. 84, 620-623 (2008).
-
(2008)
Clin. Pharmacol. Ther.
, vol.84
, pp. 620-623
-
-
Nelson, T.1
Behfar, A.2
Terzic, A.3
-
13
-
-
67349247807
-
Delivery of biologics in cardiovascular regenerative medicine
-
Bartunek, J., Sherman, W., Vanderheyden, M., Fernandez-Aviles, F., Wijns, W. & Terzic, A. Delivery of biologics in cardiovascular regenerative medicine. Clin. Pharmacol. Ther. 85, 548-552 (2009).
-
(2009)
Clin. Pharmacol. Ther.
, vol.85
, pp. 548-552
-
-
Bartunek, J.1
Sherman, W.2
Vanderheyden, M.3
Fernandez-Aviles, F.4
Wijns, W.5
Terzic, A.6
-
14
-
-
42349105273
-
Therapeutic targeting: A crucible for individualized medicine
-
Waldman, S.A. & Terzic, A. Therapeutic targeting: a crucible for individualized medicine. Clin. Pharmacol. Ther. 83, 651-654 (2008).
-
(2008)
Clin. Pharmacol. Ther.
, vol.83
, pp. 651-654
-
-
Waldman, S.A.1
Terzic, A.2
-
15
-
-
0038483826
-
Emergence of scaling in random networks
-
Barabasi, A.L. & Albert, R. Emergence of scaling in random networks. Science 286, 509-512 (1999).
-
(1999)
Science
, vol.286
, pp. 509-512
-
-
Barabasi, A.L.1
Albert, R.2
-
16
-
-
67749140118
-
Scale-free networks: A decade and beyond
-
Barabási, A.L. Scale-free networks: a decade and beyond. Science 325, 412-413 (2009).
-
(2009)
Science
, vol.325
, pp. 412-413
-
-
Barabási, A.L.1
-
17
-
-
0742305866
-
Network biology: Understanding the cell's functional organization
-
Barabási, A.L. & Oltvai, Z.N. Network biology: understanding the cell's functional organization. Nat. Rev. Genet. 5, 101-113 (2004).
-
(2004)
Nat. Rev. Genet.
, vol.5
, pp. 101-113
-
-
Barabási, A.L.1
Oltvai, Z.N.2
-
18
-
-
70349948795
-
How to visually interpret biological data using networks
-
Merico, D., Gfeller, D. & Bader, G.D. How to visually interpret biological data using networks. Nat. Biotechnol. 27, 921-924 (2009).
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 921-924
-
-
Merico, D.1
Gfeller, D.2
Bader, G.D.3
-
19
-
-
73949145041
-
The potential of biologic network models in understanding the etiopathogenesis of ovarian cancer
-
Khalil, I., Brewer, M.A., Neyarapally, T. & Runowicz, C.D. The potential of biologic network models in understanding the etiopathogenesis of ovarian cancer. Gynecol. Oncol. 116, 282-285 (2010).
-
(2010)
Gynecol. Oncol.
, vol.116
, pp. 282-285
-
-
Khalil, I.1
Brewer, M.A.2
Neyarapally, T.3
Runowicz, C.D.4
-
20
-
-
34247587012
-
Genetics. Getting closer to the whole picture
-
Sauer, U., Heinemann, M. & Zamboni, N. Genetics. Getting closer to the whole picture. Science 316, 550-551 (2007).
-
(2007)
Science
, vol.316
, pp. 550-551
-
-
Sauer, U.1
Heinemann, M.2
Zamboni, N.3
-
21
-
-
19444365485
-
ATP-sensitive K+ channel channel/enzyme multimer: Metabolic gating in the heart
-
Alekseev, A.E., Hodgson, D.M., Karger, A.B., Park, S., Zingman, L.V. & Terzic, A. ATP-sensitive K+ channel channel/enzyme multimer: metabolic gating in the heart. J. Mol. Cell. Cardiol. 38, 895-905 (2005).
-
(2005)
J. Mol. Cell. Cardiol.
, vol.38
, pp. 895-905
-
-
Alekseev, A.E.1
Hodgson, D.M.2
Karger, A.B.3
Park, S.4
Zingman, L.V.5
Terzic, A.6
-
22
-
-
40949164677
-
Cardioinductive network guiding stem cell diferentiation revealed by proteomic cartography of tumor necrosis factor alpha-primed endodermal secretome
-
Arrell, D.K., Niederländer, N.J., Faustino, R.S., Behfar, A. & Terzic, A. Cardioinductive network guiding stem cell diferentiation revealed by proteomic cartography of tumor necrosis factor alpha-primed endodermal secretome. Stem Cells 26, 387-400 (2008).
-
(2008)
Stem Cells
, vol.26
, pp. 387-400
-
-
Arrell, D.K.1
Niederländer, N.J.2
Faustino, R.S.3
Behfar, A.4
Terzic, A.5
-
23
-
-
0034721164
-
Error and attack tolerance of complex networks
-
Albert, R., Jeong, H. & Barabasi, A.L. Error and attack tolerance of complex networks. Nature 406, 378-382 (2000).
-
(2000)
Nature
, vol.406
, pp. 378-382
-
-
Albert, R.1
Jeong, H.2
Barabasi, A.L.3
-
24
-
-
54349093738
-
Identifcation of information fow-modulating drug targets: A novel bridging paradigm for drug discovery
-
Hwang, W.C., Zhang, A. & Ramanathan, M. Identifcation of information fow-modulating drug targets: a novel bridging paradigm for drug discovery. Clin. Pharmacol. Ther. 84, 563-572 (2008).
-
(2008)
Clin. Pharmacol. Ther.
, vol.84
, pp. 563-572
-
-
Hwang, W.C.1
Zhang, A.2
Ramanathan, M.3
-
25
-
-
24044504447
-
Functional essentiality from topology features in metabolic networks: A case study in yeast
-
Palumbo, M.C., Colosimo, A., Giuliani, A. & Farina, L. Functional essentiality from topology features in metabolic networks: a case study in yeast. FEBS Lett. 579, 4642-4646 (2005).
-
(2005)
FEBS Lett.
, vol.579
, pp. 4642-4646
-
-
Palumbo, M.C.1
Colosimo, A.2
Giuliani, A.3
Farina, L.4
-
26
-
-
72849142731
-
Edgetic perturbation models of human inherited disorders
-
Zhong, Q. et al. Edgetic perturbation models of human inherited disorders. Mol. Syst. Biol. 5, 321 (2009).
-
(2009)
Mol. Syst. Biol.
, vol.5
, pp. 321
-
-
Zhong, Q.1
-
27
-
-
41149167511
-
Network medicine
-
Pawson, T. & Linding, R. Network medicine. FEBS Lett. 582, 1266-1270 (2008).
-
(2008)
FEBS Lett.
, vol.582
, pp. 1266-1270
-
-
Pawson, T.1
Linding, R.2
-
28
-
-
69849115198
-
Therapeutically targeting ErbB3: A key node in ligand-induced activation of the ErbB receptor-PI3K axis
-
Schoeberl, B. et al. Therapeutically targeting ErbB3: a key node in ligand-induced activation of the ErbB receptor-PI3K axis. Sci. Signal. 2, ra31 (2009).
-
(2009)
Sci. Signal.
, vol.2
-
-
Schoeberl, B.1
-
29
-
-
34247612307
-
Multiple high-throughput analyses monitor the response of E. coli to perturbations
-
Ishii, N. et al. Multiple high-throughput analyses monitor the response of E. coli to perturbations. Science 316, 593-597 (2007).
-
(2007)
Science
, vol.316
, pp. 593-597
-
-
Ishii, N.1
-
30
-
-
70450160004
-
Systems-level dynamic analyses of fate change in murine embryonic stem cells
-
Lu, R. et al. Systems-level dynamic analyses of fate change in murine embryonic stem cells. Nature 462, 358-362 (2009)
-
(2009)
Nature
, vol.462
, pp. 358-362
-
-
Lu, R.1
-
31
-
-
35148838537
-
Drug-target network
-
yildirim, M.A., Goh, K.I., Cusick, M.E., Barabási, A.L. & Vidal, M. Drug-target network. Nat. Biotechnol. 25, 1119-1126 (2007).
-
(2007)
Nat. Biotechnol.
, vol.25
, pp. 1119-1126
-
-
Yildirim, M.A.1
-
32
-
-
70350227039
-
Systematic evaluation of drug-disease relationships to identify leads for novel drug uses
-
Chiang, A.P. & Butte, A.J. Systematic evaluation of drug-disease relationships to identify leads for novel drug uses. Clin. Pharmacol. Ther. 86, 507-510 (2009).
-
(2009)
Clin. Pharmacol. Ther.
, vol.86
, pp. 507-510
-
-
Chiang, A.P.1
Butte, A.J.2
-
33
-
-
33846876695
-
Relating protein pharmacology by ligand chemistry
-
Keiser, M.J., Roth, B.L., Armbruster, B.N., Ernsberger, P., Irwin, J.J. & Shoichet, B.K. Relating protein pharmacology by ligand chemistry. Nat. Biotechnol. 25, 197-206 (2007).
-
(2007)
Nat. Biotechnol.
, vol.25
, pp. 197-206
-
-
Keiser, M.J.1
Roth, B.L.2
Armbruster, B.N.3
Ernsberger, P.4
Irwin, J.J.5
Shoichet, B.K.6
-
34
-
-
54249155522
-
Network pharmacology: The next paradigm in drug discovery
-
Hopkins, A.L. Network pharmacology: the next paradigm in drug discovery. Nat. Chem. Biol. 4, 682-690 (2008).
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 682-690
-
-
Hopkins, A.L.1
-
35
-
-
70449634957
-
Predicting new molecular targets for known drugs
-
Keiser, M.J. et al. Predicting new molecular targets for known drugs. Nature 462, 175-181 (2009).
-
(2009)
Nature
, vol.462
, pp. 175-181
-
-
Keiser, M.J.1
-
36
-
-
33746156959
-
Global mapping of pharmacological space
-
Paolini, G.V., Shapland, R.H., van Hoorn, W.P., Mason, J.S. & Hopkins, A.L. Global mapping of pharmacological space. Nat. Biotechnol. 24, 805-815 (2006).
-
(2006)
Nat. Biotechnol.
, vol.24
, pp. 805-815
-
-
Paolini, G.V.1
Shapland, R.H.2
Van Hoorn, W.P.3
Mason, J.S.4
Hopkins, A.L.5
-
37
-
-
34547913421
-
Pharmacoproteomics: advancing the efcacy and safety of regenerative therapeutics
-
Arrell, D.K., Niederländer, N.J., Perez-Terzic, C., Chung, S., Behfar, A. & Terzic, A. Pharmacoproteomics: advancing the efcacy and safety of regenerative therapeutics. Clin. Pharmacol. Ther. 82, 316-319 (2007).
-
(2007)
Clin. Pharmacol. Ther.
, vol.82
, pp. 316-319
-
-
Arrell, D.K.1
Niederländer, N.J.2
Perez-Terzic, C.3
Chung, S.4
Behfar, A.5
Terzic, A.6
-
38
-
-
54249135797
-
Bioinformatic networks: Molecular reticles for pinpointing pharmacological target selection
-
Faustino, R.S. & Terzic, A. Bioinformatic networks: molecular reticles for pinpointing pharmacological target selection. Clin. Pharmacol. Ther. 84, 543-545 (2008).
-
(2008)
Clin. Pharmacol. Ther.
, vol.84
, pp. 543-545
-
-
Faustino, R.S.1
Terzic, A.2
|