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Volumn 157, Issue 13-14, 2007, Pages 356-361

St. John's wort: Role of active compounds for its mechanism of action and efficacy

Author keywords

Active constituents; Clinical efficacy; Hypericum perforatum; Pharmacology

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); ANTIDEPRESSANT AGENT; FLAVONOID; HYPERFORIN; HYPERICIN; HYPERICUM PERFORATUM EXTRACT; NAPHTHODIANTHRONE DERIVATIVE; NEUROTRANSMITTER; PSEUDOHYPERICIN; UNCLASSIFIED DRUG;

EID: 34548442151     PISSN: 00435341     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10354-007-0440-8     Document Type: Article
Times cited : (151)

References (61)
  • 1
    • 55049121475 scopus 로고    scopus 로고
    • Linde K, Mulrow CD, Egger M (2005) St. John's Wort for depression. Cochrane Database Syst Rev: CD000448
    • Linde K, Mulrow CD, Egger M (2005) St. John's Wort for depression. Cochrane Database Syst Rev: CD000448
  • 2
    • 33749428693 scopus 로고    scopus 로고
    • St. John's wort and the treatment of mild to moderate depression: A systematic review
    • Clement K, Covertson CR, Johnson MJ, Dearing K (2006) St. John's wort and the treatment of mild to moderate depression: a systematic review. Holist Nurs Pract 20: 197-203
    • (2006) Holist Nurs Pract , vol.20 , pp. 197-203
    • Clement, K.1    Covertson, C.R.2    Johnson, M.J.3    Dearing, K.4
  • 3
    • 0037698961 scopus 로고    scopus 로고
    • Mechanism of action of St John's wort in depression: What is known?
    • Butterweck V (2003) Mechanism of action of St John's wort in depression: what is known? CNS Drugs 17: 539-562
    • (2003) CNS Drugs , vol.17 , pp. 539-562
    • Butterweck, V.1
  • 4
    • 0035106685 scopus 로고    scopus 로고
    • St. John's wort (Hypericum perforatum): A review of the current pharmacological, toxicological, and clinical literature
    • Greeson JM, Sanford B, Monti DA (2001) St. John's wort (Hypericum perforatum): a review of the current pharmacological, toxicological, and clinical literature. Psychopharmacology (Berl) 153: 402-414
    • (2001) Psychopharmacology (Berl) , vol.153 , pp. 402-414
    • Greeson, J.M.1    Sanford, B.2    Monti, D.A.3
  • 5
    • 2942682962 scopus 로고    scopus 로고
    • The antidepressant mechanism of Hypericum perforatum
    • Mennini T, Gobbi M (2004) The antidepressant mechanism of Hypericum perforatum. Life Sci 75: 1021-1027
    • (2004) Life Sci , vol.75 , pp. 1021-1027
    • Mennini, T.1    Gobbi, M.2
  • 6
    • 0035081368 scopus 로고    scopus 로고
    • Hypericum perforatum (St John's Wort): A non-selective reuptake inhibitor? A review of the recent advances in its pharmacology
    • Nathan PJ (2001) Hypericum perforatum (St John's Wort): a non-selective reuptake inhibitor? A review of the recent advances in its pharmacology. J Psychopharmacol 15: 47-54
    • (2001) J Psychopharmacol , vol.15 , pp. 47-54
    • Nathan, P.J.1
  • 7
    • 0027171295 scopus 로고
    • Untersuchungen über antidepressive Wirkstoffe von Johanniskraut
    • Sparenberg B, Demisch L, Hölzl J (1993) Untersuchungen über antidepressive Wirkstoffe von Johanniskraut. Pharm Z Wiss 138: 50-54
    • (1993) Pharm Z Wiss , vol.138 , pp. 50-54
    • Sparenberg, B.1    Demisch, L.2    Hölzl, J.3
  • 8
    • 0023009595 scopus 로고
    • Johanniskraut (Hypericum perforatum L.) - Prüfung auf Verfälschung
    • Berghöfer R, Hölzl J (1986) Johanniskraut (Hypericum perforatum L.) - Prüfung auf Verfälschung. Dtsch Apoth Ztg 47: 2569-2573
    • (1986) Dtsch Apoth Ztg , vol.47 , pp. 2569-2573
    • Berghöfer, R.1    Hölzl, J.2
  • 9
    • 0028103890 scopus 로고
    • The variability of the hypericin content in the regenerants of Hypericum perforatum
    • Cellarova E, Daxnerova Z, Kimakova K, Haluskova J (1994) The variability of the hypericin content in the regenerants of Hypericum perforatum. Acta Biotechnologica 14: 267-274
    • (1994) Acta Biotechnologica , vol.14 , pp. 267-274
    • Cellarova, E.1    Daxnerova, Z.2    Kimakova, K.3    Haluskova, J.4
  • 10
    • 0027985032 scopus 로고
    • Vergleichende phytochemische Untersuchungen an Hypericum perforatum L. und Hypericum maculatum Crantz
    • Brantner A, Kartnig TH, Quehenberger F (1994) Vergleichende phytochemische Untersuchungen an Hypericum perforatum L. und Hypericum maculatum Crantz. Scient Pharm 62: 261-276
    • (1994) Scient Pharm , vol.62 , pp. 261-276
    • Brantner, A.1    Kartnig, T.H.2    Quehenberger, F.3
  • 11
    • 33748788822 scopus 로고    scopus 로고
    • Hyperforin
    • Beerhues L (2006) Hyperforin. Phytochemistry 67: 2201-2207
    • (2006) Phytochemistry , vol.67 , pp. 2201-2207
    • Beerhues, L.1
  • 12
    • 0003056209 scopus 로고    scopus 로고
    • Hyperforin im Johanniskraut. Hauptwirkstoff oder nur Leitsubstanz?
    • Melzer M, Fuhrken D, Kolkmann R (1998) Hyperforin im Johanniskraut. Hauptwirkstoff oder nur Leitsubstanz? Dtsch Apoth Ztg 13: 4754-4760
    • (1998) Dtsch Apoth Ztg , vol.13 , pp. 4754-4760
    • Melzer, M.1    Fuhrken, D.2    Kolkmann, R.3
  • 13
    • 0036156993 scopus 로고    scopus 로고
    • Phenolic compounds from Hypericum perforatum
    • Jürgenliemk G, Nahrstedt A (2002) Phenolic compounds from Hypericum perforatum. Planta Med 68: 88-91
    • (2002) Planta Med , vol.68 , pp. 88-91
    • Jürgenliemk, G.1    Nahrstedt, A.2
  • 15
    • 0028154811 scopus 로고
    • Inhibition of MAO by fractions and constituents of hypericum extract
    • Bladt S, Wagner H (1994) Inhibition of MAO by fractions and constituents of hypericum extract. J Geriatr Psychiatry Neurol 7(Suppl 1): 57-59
    • (1994) J Geriatr Psychiatry Neurol , vol.7 , Issue.SUPPL. 1 , pp. 57-59
    • Bladt, S.1    Wagner, H.2
  • 16
    • 0030881089 scopus 로고    scopus 로고
    • In vitro receptor binding and enzyme inhibition by Hypericum perforatum extract
    • Cott JM (1997) In vitro receptor binding and enzyme inhibition by Hypericum perforatum extract. Pharmacopsychiatry 30(Suppl 2): 108-112
    • (1997) Pharmacopsychiatry , vol.30 , Issue.SUPPL. 2 , pp. 108-112
    • Cott, J.M.1
  • 17
    • 0027994755 scopus 로고
    • Inhibition of MAO and COMT by hypericum extracts and hypericin
    • Thiede H-M, Walper A (1994) Inhibition of MAO and COMT by hypericum extracts and hypericin. J Geriatr Psychiatry Neurol 7: 54-56
    • (1994) J Geriatr Psychiatry Neurol , vol.7 , pp. 54-56
    • Thiede, H.-M.1    Walper, A.2
  • 18
    • 0023732498 scopus 로고
    • High affinity of the naturally-occurring biflavonoid, amentoflavon, to brain benzodiazepine receptors in vitro
    • Nielsen M, Frokjaer S, Braestrup C (1988) High affinity of the naturally-occurring biflavonoid, amentoflavon, to brain benzodiazepine receptors in vitro. Biochem Pharmacol 37: 3285-3287
    • (1988) Biochem Pharmacol , vol.37 , pp. 3285-3287
    • Nielsen, M.1    Frokjaer, S.2    Braestrup, C.3
  • 19
    • 0343035701 scopus 로고    scopus 로고
    • Inhibition of benzodiazepine binding in vitro by amentoflavone, a constituent of various species of Hypericum
    • Baureithel KH, Buter KB, Engesser A, Burkard W, Schaffner W (1997) Inhibition of benzodiazepine binding in vitro by amentoflavone, a constituent of various species of Hypericum. Pharm Acta Helv 72: 153-157
    • (1997) Pharm Acta Helv , vol.72 , pp. 153-157
    • Baureithel, K.H.1    Buter, K.B.2    Engesser, A.3    Burkard, W.4    Schaffner, W.5
  • 20
    • 0036019551 scopus 로고    scopus 로고
    • In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRs
    • Butterweck V, Nahrstedt A, Evans J, Hufeisen S, Rauser L, Savage J et al (2002) In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRs. Psychopharmacology (Berl) 162: 193-202
    • (2002) Psychopharmacology (Berl) , vol.162 , pp. 193-202
    • Butterweck, V.1    Nahrstedt, A.2    Evans, J.3    Hufeisen, S.4    Rauser, L.5    Savage, J.6
  • 21
    • 0034926582 scopus 로고    scopus 로고
    • In vitro binding studies with two hypericum perforatum extracts - hyperforin, hypericin and biapigenin - on 5-HT6, 5-HT7, GABA(A)/benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters
    • Gobbi M, Moia M, Pirona L, Morizzoni P, Mennini T (2001) In vitro binding studies with two hypericum perforatum extracts - hyperforin, hypericin and biapigenin - on 5-HT6, 5-HT7, GABA(A)/benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters. Pharmacopsychiatry 34(Suppl 1): 45-48
    • (2001) Pharmacopsychiatry , vol.34 , Issue.SUPPL. 1 , pp. 45-48
    • Gobbi, M.1    Moia, M.2    Pirona, L.3    Morizzoni, P.4    Mennini, T.5
  • 22
    • 0032513119 scopus 로고    scopus 로고
    • Screen of receptor and uptake-site activity of hypericin component of St. John's wort reveals sigma receptor binding
    • Raffa RB (1998) Screen of receptor and uptake-site activity of hypericin component of St. John's wort reveals sigma receptor binding. Life Sci 62: L265-L270
    • (1998) Life Sci , vol.62
    • Raffa, R.B.1
  • 23
    • 0032998772 scopus 로고    scopus 로고
    • Extracts and constituents of Hypericum perforatum inhibit the binding of various ligands to recombinant receptors expressed with the Semliki Forest virus system
    • Simmen U, Burkard W, Berger K, Schaffner W, Lundstrom K (1999) Extracts and constituents of Hypericum perforatum inhibit the binding of various ligands to recombinant receptors expressed with the Semliki Forest virus system. J Recept Signal Transduct Res 19: 59-74
    • (1999) J Recept Signal Transduct Res , vol.19 , pp. 59-74
    • Simmen, U.1    Burkard, W.2    Berger, K.3    Schaffner, W.4    Lundstrom, K.5
  • 26
    • 0031748869 scopus 로고    scopus 로고
    • Antidepressant activity of hypericum perforatum and hyperforin: The neglected possibility
    • Chatterjee SS, Noldner M, Koch E, Erdelmeier C (1998) Antidepressant activity of hypericum perforatum and hyperforin: the neglected possibility. Pharmacopsychiatry 31(Suppl 1): 7-15
    • (1998) Pharmacopsychiatry , vol.31 , Issue.SUPPL. 1 , pp. 7-15
    • Chatterjee, S.S.1    Noldner, M.2    Koch, E.3    Erdelmeier, C.4
  • 27
    • 0031780096 scopus 로고    scopus 로고
    • Hyperforin represents the neurotransmitter reuptake inhibiting constituent of hypericum extract
    • Müller WE, Singer A, Wonnemann M, Hafner U, Rolli M, Schäfer C (1998) Hyperforin represents the neurotransmitter reuptake inhibiting constituent of hypericum extract. Pharmacopsychiatry 31(Suppl 1): 16-21
    • (1998) Pharmacopsychiatry , vol.31 , Issue.SUPPL. 1 , pp. 16-21
    • Müller, W.E.1    Singer, A.2    Wonnemann, M.3    Hafner, U.4    Rolli, M.5    Schäfer, C.6
  • 28
    • 0036225284 scopus 로고    scopus 로고
    • Dual modulation of striatal acetylcholine release by hyperforin, a constituent of St. John's wort
    • Buchholzer ML, Dvorak C, Chatterjee SS, Klein J (2002) Dual modulation of striatal acetylcholine release by hyperforin, a constituent of St. John's wort. J Pharmacol Exp Ther 301: 714-719
    • (2002) J Pharmacol Exp Ther , vol.301 , pp. 714-719
    • Buchholzer, M.L.1    Dvorak, C.2    Chatterjee, S.S.3    Klein, J.4
  • 29
    • 0035936726 scopus 로고    scopus 로고
    • Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity
    • Jensen AG, Hansen SH, Nielsen EO (2001) Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity. Life Sci 68: 1593-1605
    • (2001) Life Sci , vol.68 , pp. 1593-1605
    • Jensen, A.G.1    Hansen, S.H.2    Nielsen, E.O.3
  • 31
    • 0034919810 scopus 로고    scopus 로고
    • Biochemical mechanisms of action of Hypericum LI 160 in glial and neuronal cells: Inhibition of neurotransmitter uptake and stimulation of extracellular signal regulated protein kinase
    • Neary JT, Whittemore SR, Bu Y, Mehta H, Shi YF (2001) Biochemical mechanisms of action of Hypericum LI 160 in glial and neuronal cells: inhibition of neurotransmitter uptake and stimulation of extracellular signal regulated protein kinase. Pharmacopsychiatry 34(Suppl 1): 103-107
    • (2001) Pharmacopsychiatry , vol.34 , Issue.SUPPL. 1 , pp. 103-107
    • Neary, J.T.1    Whittemore, S.R.2    Bu, Y.3    Mehta, H.4    Shi, Y.F.5
  • 32
    • 0032797512 scopus 로고    scopus 로고
    • Hyperforin, a major antidepressant constituent of St. John's wort, inhibits serotonin uptake by elevating free intracellular Na+
    • Singer A, Wonnemann M, Müller WE (1999) Hyperforin, a major antidepressant constituent of St. John's wort, inhibits serotonin uptake by elevating free intracellular Na+. J Pharmacol Exp Ther 290: 1363-1368
    • (1999) J Pharmacol Exp Ther , vol.290 , pp. 1363-1368
    • Singer, A.1    Wonnemann, M.2    Müller, W.E.3
  • 33
    • 0034131070 scopus 로고    scopus 로고
    • Inhibition of synaptosomal uptake of 3H-L-glutamate and 3H-GABA by hyperforin, a major constituent of St. John's wort: The role of amiloride sensitive sodium conductive pathways
    • Wonnemann M, Singer A, Müller WE (2000) Inhibition of synaptosomal uptake of 3H-L-glutamate and 3H-GABA by hyperforin, a major constituent of St. John's wort: the role of amiloride sensitive sodium conductive pathways. Neuropsychopharmacology 23: 188-197
    • (2000) Neuropsychopharmacology , vol.23 , pp. 188-197
    • Wonnemann, M.1    Singer, A.2    Müller, W.E.3
  • 34
    • 0034928466 scopus 로고    scopus 로고
    • Evaluation of synaptosomal uptake inhibition of most relevant constituents of St. John's wort
    • Wonnemann M, Singer A, Siebert B, Müller WE (2001) Evaluation of synaptosomal uptake inhibition of most relevant constituents of St. John's wort. Pharmacopsychiatry 34: 148-151
    • (2001) Pharmacopsychiatry , vol.34 , pp. 148-151
    • Wonnemann, M.1    Singer, A.2    Siebert, B.3    Müller, W.E.4
  • 36
    • 0033595771 scopus 로고    scopus 로고
    • Hyperforin attenuates various ionic conductance mechanisms in the isolated hippocampal neurons of rat
    • Chatterjee S, Filippov V, Lishko P, Maximyuk O, Noldner M, Krishtal O (1999) Hyperforin attenuates various ionic conductance mechanisms in the isolated hippocampal neurons of rat. Life Sci 65: 2395-2405
    • (1999) Life Sci , vol.65 , pp. 2395-2405
    • Chatterjee, S.1    Filippov, V.2    Lishko, P.3    Maximyuk, O.4    Noldner, M.5    Krishtal, O.6
  • 38
    • 0031779971 scopus 로고    scopus 로고
    • Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers
    • Biber A, Fischer H, Römer A, Chatterjee SS (1998) Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers. Pharmacopsychiatry 31(Suppl 1): 36-43
    • (1998) Pharmacopsychiatry , vol.31 , Issue.SUPPL. 1 , pp. 36-43
    • Biber, A.1    Fischer, H.2    Römer, A.3    Chatterjee, S.S.4
  • 39
    • 0030821595 scopus 로고    scopus 로고
    • Effects of the total extract and fractions of Hypericum perforatum in animal assays for antidepressant activity
    • Butterweck V, Wall A, Liefländer-Wulf U, Winterhoff H, Nahrstedt A (1997) Effects of the total extract and fractions of Hypericum perforatum in animal assays for antidepressant activity. Pharmacopsychiatry 30(Suppl 2): 117-124
    • (1997) Pharmacopsychiatry , vol.30 , Issue.SUPPL. 2 , pp. 117-124
    • Butterweck, V.1    Wall, A.2    Liefländer-Wulf, U.3    Winterhoff, H.4    Nahrstedt, A.5
  • 40
    • 0036968302 scopus 로고    scopus 로고
    • Pharmacological activity of hyperforin acetate in rats
    • Zanoli P, Rivasi M, Baraldi C, Baraldi M (2002) Pharmacological activity of hyperforin acetate in rats. Behav Pharmacol 13: 645-651
    • (2002) Behav Pharmacol , vol.13 , pp. 645-651
    • Zanoli, P.1    Rivasi, M.2    Baraldi, C.3    Baraldi, M.4
  • 41
    • 0037721068 scopus 로고    scopus 로고
    • Step by step removal of hyperforin and hypericin: Activity profile of different Hypericum preparations in behavioral models
    • Butterweck V, Christoffel V, Nahrstedt A, Petereit F, Spengler B, Winterhoff H (2003) Step by step removal of hyperforin and hypericin: activity profile of different Hypericum preparations in behavioral models. Life Sei 73: 627-639
    • (2003) Life Sei , vol.73 , pp. 627-639
    • Butterweck, V.1    Christoffel, V.2    Nahrstedt, A.3    Petereit, F.4    Spengler, B.5    Winterhoff, H.6
  • 42
    • 0033963119 scopus 로고    scopus 로고
    • Flavonoids from Hypericum perforatum show antidepressant activity in the forced swimming test
    • Butterweck V, Jürgenliemk G, Nahrstedt A, Winterhoff H (2000) Flavonoids from Hypericum perforatum show antidepressant activity in the forced swimming test. Planta Med 66: 3-6
    • (2000) Planta Med , vol.66 , pp. 3-6
    • Butterweck, V.1    Jürgenliemk, G.2    Nahrstedt, A.3    Winterhoff, H.4
  • 43
    • 0034922417 scopus 로고    scopus 로고
    • Pharmacological and endocrine effects of Hypericum perforatum and hypericin after repeated treatment
    • Butterweck V, Korte B, Winterhoff H (2001) Pharmacological and endocrine effects of Hypericum perforatum and hypericin after repeated treatment. Pharmacopsychiatry 34(Suppl 1): 2-7
    • (2001) Pharmacopsychiatry , vol.34 , Issue.SUPPL. 1 , pp. 2-7
    • Butterweck, V.1    Korte, B.2    Winterhoff, H.3
  • 44
    • 7644232422 scopus 로고    scopus 로고
    • Flavonoids of St. John's wort reduce HPA axis function in the rat
    • Butterweck V, Hegger M, Winterhoff H (2004) Flavonoids of St. John's wort reduce HPA axis function in the rat. Planta Med 70: 1008-1011
    • (2004) Planta Med , vol.70 , pp. 1008-1011
    • Butterweck, V.1    Hegger, M.2    Winterhoff, H.3
  • 45
    • 0034886177 scopus 로고    scopus 로고
    • St John's wort, hypericin, and imipramine: A comparative analysis of mRNA levels in brain areas involved in HPA axis control following short-term and long-term administration in normal and stressed rats
    • Butterweck V, Winterhoff H, Herkenham M (2001) St John's wort, hypericin, and imipramine: a comparative analysis of mRNA levels in brain areas involved in HPA axis control following short-term and long-term administration in normal and stressed rats. Mol Psychiatry 6: 547-564
    • (2001) Mol Psychiatry , vol.6 , pp. 547-564
    • Butterweck, V.1    Winterhoff, H.2    Herkenham, M.3
  • 46
    • 0033013398 scopus 로고    scopus 로고
    • Efficacy of an Hypericum perforatum (St. John's wort) extract in preventing and reverting a condition of escape deficit in rats
    • Gambarana C, Ghiglieri O, Tolu P, De Mentis MG, Giachetti D, Bombardelli E et al (1999) Efficacy of an Hypericum perforatum (St. John's wort) extract in preventing and reverting a condition of escape deficit in rats. Neuropsychopharmacology 21: 247-257
    • (1999) Neuropsychopharmacology , vol.21 , pp. 247-257
    • Gambarana, C.1    Ghiglieri, O.2    Tolu, P.3    De Mentis, M.G.4    Giachetti, D.5    Bombardelli, E.6
  • 47
    • 0031830782 scopus 로고    scopus 로고
    • Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test
    • Butterweck V, Petereit F, Winterhoff H, Nahrstedt A (1998) Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test. Planta Med 64: 291-294
    • (1998) Planta Med , vol.64 , pp. 291-294
    • Butterweck, V.1    Petereit, F.2    Winterhoff, H.3    Nahrstedt, A.4
  • 48
    • 0037346647 scopus 로고    scopus 로고
    • Dissolution, solubility and cooperativity of phenolic compounds from Hypericum perforatum L. in aqueous systems
    • Jürgenliemk G, Nahrstedt A (2003) Dissolution, solubility and cooperativity of phenolic compounds from Hypericum perforatum L. in aqueous systems. Pharmazie 58: 200-203
    • (2003) Pharmazie , vol.58 , pp. 200-203
    • Jürgenliemk, G.1    Nahrstedt, A.2
  • 49
    • 0036315755 scopus 로고    scopus 로고
    • Rutin is essential for the antidepressant activity of Hypericum perforatum extracts in the forced swimming test
    • Nöldner M, Schötz K (2002) Rutin is essential for the antidepressant activity of Hypericum perforatum extracts in the forced swimming test. Planta Med 68: 577-580
    • (2002) Planta Med , vol.68 , pp. 577-580
    • Nöldner, M.1    Schötz, K.2
  • 50
    • 0344670186 scopus 로고    scopus 로고
    • Plasma levels of hypericin in presence of procyanidin B2 and hyperoside: A pharmacokinetic study in rats
    • Butterweck V, Liefländer-Wulf U, Winterhoff H, Nahrstedt A (2003) Plasma levels of hypericin in presence of procyanidin B2 and hyperoside: a pharmacokinetic study in rats. Planta Med 69: 189-192
    • (2003) Planta Med , vol.69 , pp. 189-192
    • Butterweck, V.1    Liefländer-Wulf, U.2    Winterhoff, H.3    Nahrstedt, A.4
  • 51
    • 12944296601 scopus 로고    scopus 로고
    • Investigation of the bioavailability of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin following single and multipe oral dosing of a Hypericum extract containing tablet
    • Schulz HU, Schürer M, Bässler D, Weiser D (2005) Investigation of the bioavailability of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin following single and multipe oral dosing of a Hypericum extract containing tablet. Arzneim-Forsch/Drug Res 55: 15-22
    • (2005) Arzneim-Forsch/Drug Res , vol.55 , pp. 15-22
    • Schulz, H.U.1    Schürer, M.2    Bässler, D.3    Weiser, D.4
  • 53
    • 0031747773 scopus 로고    scopus 로고
    • St. John's wort in mild to moderate depression: The relevance of hyperforin for the clinical efficacy
    • Laakmann G, Schüle C, Baghai T, Kieser M (1998) St. John's wort in mild to moderate depression: the relevance of hyperforin for the clinical efficacy. Pharmacopsychiatry 31(Suppl 1): 54-59
    • (1998) Pharmacopsychiatry , vol.31 , Issue.SUPPL. 1 , pp. 54-59
    • Laakmann, G.1    Schüle, C.2    Baghai, T.3    Kieser, M.4
  • 54
    • 0018764647 scopus 로고
    • Therapie von depressiven Zuständen mit Hypericin
    • Hoffmann J, Kühl ED (1979) Therapie von depressiven Zuständen mit Hypericin. ZFA (Stuttgart) 55: 776-782
    • (1979) ZFA (Stuttgart) , vol.55 , pp. 776-782
    • Hoffmann, J.1    Kühl, E.D.2
  • 55
    • 0001588759 scopus 로고
    • Behandlung depressiver Zustandsbilder mit Hypericinum
    • Schlich D, Braukmann F, Schenk N (1987) Behandlung depressiver Zustandsbilder mit Hypericinum. Psycho 13: 440-447
    • (1987) Psycho , vol.13 , pp. 440-447
    • Schlich, D.1    Braukmann, F.2    Schenk, N.3
  • 56
    • 0001159635 scopus 로고
    • Hypericin-Applikation. Zur Therapie depressiver Verstimmungen
    • Schmidt U, Schenk N, Schwarz I, Vorberg G (1989) Hypericin-Applikation. Zur Therapie depressiver Verstimmungen. Psycho 15: 665-671
    • (1989) Psycho , vol.15 , pp. 665-671
    • Schmidt, U.1    Schenk, N.2    Schwarz, I.3    Vorberg, G.4
  • 57
    • 0031966728 scopus 로고    scopus 로고
    • Hypericum treatment of mild-moderate depression in a placebo-controlled study. A prospective, double-blind, randomized, placebo-controlled, multicentre study
    • Schrader E, Meier B, Brattström A (1998) Hypericum treatment of mild-moderate depression in a placebo-controlled study. A prospective, double-blind, randomized, placebo-controlled, multicentre study. Hum Psychopharmacol 13: 163-169
    • (1998) Hum Psychopharmacol , vol.13 , pp. 163-169
    • Schrader, E.1    Meier, B.2    Brattström, A.3
  • 58
    • 0034008572 scopus 로고    scopus 로고
    • Equivalence of St John's wort extract (Ze 117) and fluoxetine: A randomized, controlled study in mild-moderate depression
    • Schrader E (2000) Equivalence of St John's wort extract (Ze 117) and fluoxetine: a randomized, controlled study in mild-moderate depression. Int Clin Psychopharmacol 15: 61-68
    • (2000) Int Clin Psychopharmacol , vol.15 , pp. 61-68
    • Schrader, E.1
  • 59
    • 0034596545 scopus 로고    scopus 로고
    • Comparison of St. John's wort and imipramine for treating depression: Randomised controlled trial
    • Woelk H (2000) Comparison of St. John's wort and imipramine for treating depression: randomised controlled trial. Br Med J 321: 536-539
    • (2000) Br Med J , vol.321 , pp. 536-539
    • Woelk, H.1
  • 61
    • 33746043341 scopus 로고    scopus 로고
    • Hypericum perforatum: Which constituents may induce intestinal MDR1 and CYP3A4 mRNA expression?
    • Gutmann H, Poller B, Buter KB, Pfrunder A, Schaffner W, Drewe J (2006) Hypericum perforatum: which constituents may induce intestinal MDR1 and CYP3A4 mRNA expression? Planta Med 72: 685-690
    • (2006) Planta Med , vol.72 , pp. 685-690
    • Gutmann, H.1    Poller, B.2    Buter, K.B.3    Pfrunder, A.4    Schaffner, W.5    Drewe, J.6


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