A human colonic cell line sharing similarities with enterocytes as a model to examine oral absorption: Advantages and limitations of the Caco-2 model

Critical Reviews in Therapeutic Drug Carrier Systems

Volumn 14, Issue 3, 1997, Pages 221-286

  Delie, Florence ^a   Rubas, Werner ^a  

^a GENENTECH INC   (United States)

Author keywords

Caco 2 culture; Drug screening; In vitro; Oral absorption; Permeability

Indexed keywords

ALKALINE PHOSPHATASE; ALPRENOLOL; ANTIBIOTIC AGENT; ATENOLOL; CARRIER PROTEIN; CEFACLOR; CEFALEXIN; CEFRADINE; CEFTIBUTEN; CELL ENZYME; CEPHALOSPORIN DERIVATIVE; CYANOCOBALAMIN; DEXAMETHASONE; GLUCOSE; GLUCOSE TRANSPORTER; GROWTH FACTOR; HIPPURIC ACID; HYDROCORTISONE; LORACARBEF; MACROGOL 4000; MANNITOL; MICROSOMAL AMINOPEPTIDASE; PROPRANOLOL; SALICYLIC ACID; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN C; TESTOSTERONE; UNINDEXED DRUG; UREA; WARFARIN;

APICAL MEMBRANE; BASOLATERAL MEMBRANE; CELL MEMBRANE PERMEABILITY; CELL POLARITY; CELL STRAIN CACO 2; CELL ULTRASTRUCTURE; COLON ABSORPTION; DRUG ABSORPTION; DRUG SCREENING; ENZYME ACTIVITY; GLUCOSE TRANSPORT; GOLGI COMPLEX; HUMAN; INTESTINE EPITHELIUM CELL; INTRACELLULAR TRANSPORT; LIPID METABOLISM; MOLECULAR DYNAMICS; NONHUMAN; REVIEW; SCANNING ELECTRON MICROSCOPY; SMALL INTESTINE ABSORPTION; TRANSMISSION ELECTRON MICROSCOPY; TRANSPORT KINETICS;

EID: 0030787532     PISSN: 07434863     EISSN: None     Source Type: Journal    
DOI: 10.1615/critrevtherdrugcarriersyst.v14.i3.20     Document Type: Review

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