메뉴 건너뛰기




Volumn 45, Issue 5, 2006, Pages 449-468

Hypericum perforatum: A 'modern' herbal antidepressant - Pharmacokinetics of active ingredients

Author keywords

[No Author keywords available]

Indexed keywords

ALPRAZOLAM; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; CYCLOSPORIN A; DIGOXIN; ETHINYLESTRADIOL; FEXOFENADINE; FLAVONOID; FLAVONOL DERIVATIVE; HYPERFORIN; HYPERICIN; HYPERICUM PERFORATUM EXTRACT; HYPERIN; IMMUNOSUPPRESSIVE AGENT; ISOQUERCITRIN; LAIF; NAPHTHODIANTHRONE DERIVATIVE; ORAL CONTRACEPTIVE AGENT; PHLOROGLUCINOL DERIVATIVE; PROANTHOCYANIDIN DERIVATIVE; PROCYANIDIN DERIVATIVE; PROTEINASE INHIBITOR; PSEUDOHYPERICIN; QUERCETIN; QUERCITRIN; RUTOSIDE; STW 3; THEOPHYLLINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; WARFARIN; WS 5572; XANTHONE DERIVATIVE;

EID: 33646124719     PISSN: 03125963     EISSN: 03125963     Source Type: Journal    
DOI: 10.2165/00003088-200645050-00002     Document Type: Review
Times cited : (112)

References (130)
  • 1
    • 33646123478 scopus 로고    scopus 로고
    • WHO. Depression: what is depression [online]? Available from URL: http://www.who.int/mental_health/management/depression/definition/en/ [Accessed 2006 Feb 28]
    • Depression: What Is Depression [Online]?
  • 2
    • 0034780546 scopus 로고    scopus 로고
    • Depressive disorders in Europe: Prevalence figures from the ODIN study
    • Ayuso-Mateos JL, Vazquez-Barquero JL, Dowrick C, et al. Depressive disorders in Europe: prevalence figures from the ODIN study. Br J Psychiatry 2001; 179: 308-16
    • (2001) Br J Psychiatry , vol.179 , pp. 308-316
    • Ayuso-Mateos, J.L.1    Vazquez-Barquero, J.L.2    Dowrick, C.3
  • 3
    • 0031554516 scopus 로고    scopus 로고
    • ABC of mental health: Depression
    • Hale AS. ABC of mental health: depression. BMJ 1997; 315 (7099): 43-6
    • (1997) BMJ , vol.315 , Issue.7099 , pp. 43-46
    • Hale, A.S.1
  • 4
    • 0346622392 scopus 로고    scopus 로고
    • Cost of depression among adults in England in 2000
    • Thomas CM, Morris S. Cost of depression among adults in England in 2000. Br J Psychiatry Suppl 2003; 183: 514-9
    • (2003) Br J Psychiatry Suppl , vol.183 , pp. 514-519
    • Thomas, C.M.1    Morris, S.2
  • 5
    • 0028156958 scopus 로고
    • Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States: Results from the National Comorbidity Survey
    • Kessler RC, McGonagle KA, Zhao S, et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States: results from the National Comorbidity Survey. Arch Gen Psychiatry 1994; 51 (1): 8-19
    • (1994) Arch Gen Psychiatry , vol.51 , Issue.1 , pp. 8-19
    • Kessler, R.C.1    McGonagle, K.A.2    Zhao, S.3
  • 6
    • 0030968477 scopus 로고    scopus 로고
    • Depression in the community: The first pan-European study DEPRES (Depression Research in European Society)
    • Lepine JP, Gastpar M, Mendlewicz J, et al. Depression in the community: the first pan-European study DEPRES (Depression Research in European Society). Int Clin Psychopharmacol 1997; 12 (1): 19-29
    • (1997) Int Clin Psychopharmacol , vol.12 , Issue.1 , pp. 19-29
    • Lepine, J.P.1    Gastpar, M.2    Mendlewicz, J.3
  • 7
    • 0027247843 scopus 로고
    • Treatment of acute depression
    • Richelson E. Treatment of acute depression. Psychiatr Clin North Am 1993; 16 (3): 461-78
    • (1993) Psychiatr Clin North Am , vol.16 , Issue.3 , pp. 461-478
    • Richelson, E.1
  • 8
    • 0027992310 scopus 로고
    • The economic impact of depression in a workplace
    • Conti DJ, Burton WN. The economic impact of depression in a workplace. J Occup Med 1994; 36 (9): 983-8
    • (1994) J Occup Med , vol.36 , Issue.9 , pp. 983-988
    • Conti, D.J.1    Burton, W.N.2
  • 9
    • 0035025833 scopus 로고    scopus 로고
    • Pharmacology of antidepressants
    • Richelson E. Pharmacology of antidepressants. Mayo Clin Proc 2001; 76: 511-27
    • (2001) Mayo Clin Proc , vol.76 , pp. 511-527
    • Richelson, E.1
  • 12
    • 0034891508 scopus 로고    scopus 로고
    • Hypericum perforatum: A review of clinical studies
    • Kasper S. Hypericum perforatum: a review of clinical studies. Pharmacopsychiatry 2001; 34 Suppl. 1: S51-5
    • (2001) Pharmacopsychiatry , vol.34 , Issue.1 SUPPL.
    • Kasper, S.1
  • 13
    • 33646159016 scopus 로고    scopus 로고
    • The Efficacy of SJW extracts with more than 1% or less than 0.5% hyperforin content compared to placebo in the treatment of major depression
    • Berner M, Riemann D, Berger M. The Efficacy of SJW extracts with more than 1% or less than 0.5% hyperforin content compared to placebo in the treatment of major depression [abstract]. Eur Arch Psychiatry Clin Neurosci 2002; 252 Suppl. 1: 56
    • (2002) Eur Arch Psychiatry Clin Neurosci , vol.252 , Issue.1 SUPPL. , pp. 56
    • Berner, M.1    Riemann, D.2    Berger, M.3
  • 14
    • 0031747773 scopus 로고    scopus 로고
    • St. John's Wort in mild to moderate depression: The relevance of hyperforin for the clinical efficacy
    • Laakmann G, Schule C, Baghai T, et al. St. John's Wort in mild to moderate depression: the relevance of hyperforin for the clinical efficacy. Pharmacopsychiatry 1998; 31 Suppl. 1: 54-9
    • (1998) Pharmacopsychiatry , vol.31 , Issue.1 SUPPL. , pp. 54-59
    • Laakmann, G.1    Schule, C.2    Baghai, T.3
  • 15
    • 0035906295 scopus 로고    scopus 로고
    • Effectiveness of St John's Wort in major depression: A randomized controlled trial
    • Shelton RC, Keller MB, Gelenberg A, et al. Effectiveness of St John's Wort in major depression: a randomized controlled trial. JAMA 2001; 285 (15): 1978-86
    • (2001) JAMA , vol.285 , Issue.15 , pp. 1978-1986
    • Shelton, R.C.1    Keller, M.B.2    Gelenberg, A.3
  • 16
    • 13244296997 scopus 로고    scopus 로고
    • St John's Wort for depression: Meta-analysis of randomised controlled trials
    • Linde K, Berner M, Egger M, et al. St John's Wort for depression: meta-analysis of randomised controlled trials. Br J Psychiatry 2005; 186: 99-107
    • (2005) Br J Psychiatry , vol.186 , pp. 99-107
    • Linde, K.1    Berner, M.2    Egger, M.3
  • 19
    • 33646123262 scopus 로고    scopus 로고
    • St. John's Wort
    • St. John's Wort. European Pharmacopoeia 2003; 4 Suppl. 4.5: 2157-8
    • (2003) European Pharmacopoeia , vol.4 , Issue.SUPPL. 4.5 , pp. 2157-2158
  • 21
    • 0021149531 scopus 로고
    • Inhibition of monoamine oxidase by hypericin
    • Suzuki O, Katsumata Y, Oya M, et al. Inhibition of monoamine oxidase by hypericin. Planta Medica 1984; 50 (3): 272-4
    • (1984) Planta Medica , vol.50 , Issue.3 , pp. 272-274
    • Suzuki, O.1    Katsumata, Y.2    Oya, M.3
  • 22
    • 0036315755 scopus 로고    scopus 로고
    • Rutin is essential for the antidepressant activity of Hypericum perforatum extracts in the forced swimming test
    • Nöldner M, Schotz K. Rutin is essential for the antidepressant activity of Hypericum perforatum extracts in the forced swimming test. Planta Medica 2002; 68 (7): 577-80
    • (2002) Planta Medica , vol.68 , Issue.7 , pp. 577-580
    • Nöldner, M.1    Schotz, K.2
  • 23
    • 0025794335 scopus 로고
    • Vasoactive properties of procyanidins from Hypericum perforatum L. in isolated porcine coronary arteries
    • Melzer R, Fricke U, Holzl J. Vasoactive properties of procyanidins from Hypericum perforatum L. in isolated porcine coronary arteries. Arzneimittel Forschung 1991; 41 (5): 481-3
    • (1991) Arzneimittel Forschung , vol.41 , Issue.5 , pp. 481-483
    • Melzer, R.1    Fricke, U.2    Holzl, J.3
  • 24
    • 0034998557 scopus 로고    scopus 로고
    • St John's Wort (Hypericum perforatum L.): A review of its chemistry, pharmacology and clinical properties
    • Barnes J, Anderson LA, Phillipson JD. St John's Wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties. J Pharm Pharmacol 2001; 53 (5): 583-600
    • (2001) J Pharm Pharmacol , vol.53 , Issue.5 , pp. 583-600
    • Barnes, J.1    Anderson, L.A.2    Phillipson, J.D.3
  • 25
    • 0034914934 scopus 로고    scopus 로고
    • A study of the antidepressant activity of Hypericum perforatum on animal models
    • Gambarana C, Tolu PL, Masi F, et al. A study of the antidepressant activity of Hypericum perforatum on animal models. Pharmacopsychiatry 2001; 34 Suppl. 1: S42-4
    • (2001) Pharmacopsychiatry , vol.34 , Issue.1 SUPPL.
    • Gambarana, C.1    Tolu, P.L.2    Masi, F.3
  • 26
    • 3042547257 scopus 로고    scopus 로고
    • Comparison of the synaptosomal uptake inhibition of serotonin by St John's Wort products
    • Schulte-Lobbert S, Holoubek G, Muller WE, et al. Comparison of the synaptosomal uptake inhibition of serotonin by St John's Wort products. J Pharm Pharmacol 2004; 56 (6): 813-8
    • (2004) J Pharm Pharmacol , vol.56 , Issue.6 , pp. 813-818
    • Schulte-Lobbert, S.1    Holoubek, G.2    Muller, W.E.3
  • 27
    • 0030865990 scopus 로고    scopus 로고
    • Effects of hypericum extract (LI 160) in biochemical models of antidepressant activity
    • Muller WE, Rolli M, Schafer C, et al. Effects of hypericum extract (LI 160) in biochemical models of antidepressant activity. Pharmacopsychiatry 1997; 30 Suppl. 2: 102-7
    • (1997) Pharmacopsychiatry , vol.30 , Issue.2 SUPPL. , pp. 102-107
    • Muller, W.E.1    Rolli, M.2    Schafer, C.3
  • 28
    • 0032479206 scopus 로고    scopus 로고
    • Hyperforin as a possible antidepressant component of hypericum extracts
    • Chatterjee SS, Bhattacharya SK, Wonnemann M, et al. Hyperforin as a possible antidepressant component of hypericum extracts. Life Sci 1998; 63 (6): 499-510
    • (1998) Life Sci , vol.63 , Issue.6 , pp. 499-510
    • Chatterjee, S.S.1    Bhattacharya, S.K.2    Wonnemann, M.3
  • 29
    • 0035936726 scopus 로고    scopus 로고
    • Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity
    • Jensen AG, Hansen SH, Nielsen EO. Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity. Life Sci 2001; 68 (14): 1593-605
    • (2001) Life Sci , vol.68 , Issue.14 , pp. 1593-1605
    • Jensen, A.G.1    Hansen, S.H.2    Nielsen, E.O.3
  • 30
    • 0034922673 scopus 로고    scopus 로고
    • Hyperforin: Antidepressant activity by a novel mechanism of action
    • Muller WE, Singer A, Wonnemann M. Hyperforin: antidepressant activity by a novel mechanism of action. Pharmacopsychiatry 2001; 34 Suppl. 1: S98-102
    • (2001) Pharmacopsychiatry , vol.34 , Issue.1 SUPPL.
    • Muller, W.E.1    Singer, A.2    Wonnemann, M.3
  • 32
    • 0034131070 scopus 로고    scopus 로고
    • Inhibition of synaptosomal uptake of 3H-L-glutamate and 3H-GABA by hyperforin, a major constituent of St. John's Wort: The role of amiloride sensitive sodium conductive pathways
    • Wonnemann M, Singer A, Muller WE. Inhibition of synaptosomal uptake of 3H-L-glutamate and 3H-GABA by hyperforin, a major constituent of St. John's Wort: the role of amiloride sensitive sodium conductive pathways. Neuropsychopharmacology 2000; 23 (2): 188-97
    • (2000) Neuropsychopharmacology , vol.23 , Issue.2 , pp. 188-197
    • Wonnemann, M.1    Singer, A.2    Muller, W.E.3
  • 33
    • 0032862589 scopus 로고    scopus 로고
    • Hypericum perforatum L. extract does not inhibit 5-HT transporter in rat brain cortex
    • Gobbi M, Valle FD, Ciapparelli C, et al. Hypericum perforatum L. extract does not inhibit 5-HT transporter in rat brain cortex. Naunyn Schmiedebergs Arch Pharmacol 1999; 360 (3): 262-9
    • (1999) Naunyn Schmiedebergs Arch Pharmacol , vol.360 , Issue.3 , pp. 262-269
    • Gobbi, M.1    Valle, F.D.2    Ciapparelli, C.3
  • 34
    • 0034926582 scopus 로고    scopus 로고
    • In vitro binding studies with two Hypericum perforatum extracts hyperforin, hypericin and biapigenin on 5-HT6, 5-HT7, GABA (A)/benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters
    • Gobbi M, Moia M, Pirona L, et al. In vitro binding studies with two Hypericum perforatum extracts hyperforin, hypericin and biapigenin on 5-HT6, 5-HT7, GABA (A)/benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters. Pharmacopsychiatry 2001; 34 Suppl. 1: S45-8
    • (2001) Pharmacopsychiatry , vol.34 , Issue.1 SUPPL.
    • Gobbi, M.1    Moia, M.2    Pirona, L.3
  • 35
    • 0037959775 scopus 로고    scopus 로고
    • Hyperforin inhibits vesicular uptake of monoamines by dissipating pH gradient across synaptic vesicle membrane
    • Roz N, Rehavi M. Hyperforin inhibits vesicular uptake of monoamines by dissipating pH gradient across synaptic vesicle membrane. Life Sci 2003; 73 (4): 461-70
    • (2003) Life Sci , vol.73 , Issue.4 , pp. 461-470
    • Roz, N.1    Rehavi, M.2
  • 36
    • 0037183747 scopus 로고    scopus 로고
    • Inhibition of vesicular uptake of monoamines by hyperforin
    • Roz N, Mazur Y, Hirshfeld A, et al. Inhibition of vesicular uptake of monoamines by hyperforin. Life Sci 2002; 71 (19): 2227-37
    • (2002) Life Sci , vol.71 , Issue.19 , pp. 2227-2237
    • Roz, N.1    Mazur, Y.2    Hirshfeld, A.3
  • 37
    • 4344589885 scopus 로고    scopus 로고
    • Hyperforin modifies neuronal membrane properties in vitro
    • Eckert GP, Keller JH, Jourdan C, et al. Hyperforin modifies neuronal membrane properties in vitro. Neurosci Lett 2004; 367 (2): 139-43
    • (2004) Neurosci Lett , vol.367 , Issue.2 , pp. 139-143
    • Eckert, G.P.1    Keller, J.H.2    Jourdan, C.3
  • 38
    • 4344573882 scopus 로고    scopus 로고
    • Activation of nonselective cation channels by hyperforin: A novel mechanism of antidepressant activity
    • Treiber K, Singer A, Müller WE. Activation of nonselective cation channels by hyperforin: a novel mechanism of antidepressant activity [abstract]. Soc Neurosci 2003; 29: 851
    • (2003) Soc Neurosci , vol.29 , pp. 851
    • Treiber, K.1    Singer, A.2    Müller, W.E.3
  • 39
    • 0032765281 scopus 로고    scopus 로고
    • Effects of Hypericum perforatum on levels of 5-hydroxytryptamine, noradrenaline and dopamine in the cortex, diencephalon and brainstem of the rat
    • Calapai G, Crupi A, Firenzuoli F, et al. Effects of Hypericum perforatum on levels of 5-hydroxytryptamine, noradrenaline and dopamine in the cortex, diencephalon and brainstem of the rat. J Pharm Pharmacol 1999; 51 (6): 723-8
    • (1999) J Pharm Pharmacol , vol.51 , Issue.6 , pp. 723-728
    • Calapai, G.1    Crupi, A.2    Firenzuoli, F.3
  • 40
    • 0033624787 scopus 로고    scopus 로고
    • Effect of the Hypericum perforatum extract on serotonin turnover in the mouse brain
    • Yu PH. Effect of the Hypericum perforatum extract on serotonin turnover in the mouse brain. Pharmacopsychiatry 2000; 33 (2): 60-5
    • (2000) Pharmacopsychiatry , vol.33 , Issue.2 , pp. 60-65
    • Yu, P.H.1
  • 41
    • 0034925845 scopus 로고    scopus 로고
    • The effects of extracts from St. John's Wort and Kava Kava on brain neurotransmitter levels in the mouse
    • Serdarevic N, Eckert GP, Muller WE. The effects of extracts from St. John's Wort and Kava Kava on brain neurotransmitter levels in the mouse. Pharmacopsychiatry 2001; 34 Suppl. 1: S134-6
    • (2001) Pharmacopsychiatry , vol.34 , Issue.1 SUPPL.
    • Serdarevic, N.1    Eckert, G.P.2    Muller, W.E.3
  • 42
    • 0034639638 scopus 로고    scopus 로고
    • Acute heart transplant rejection due to Saint John's Wort
    • Ruschitzka F, Meier PJ, Turina M, et al. Acute heart transplant rejection due to Saint John's Wort. Lancet 2000; 355 (9203): 548-9
    • (2000) Lancet , vol.355 , Issue.9203 , pp. 548-549
    • Ruschitzka, F.1    Meier, P.J.2    Turina, M.3
  • 43
    • 0037151365 scopus 로고    scopus 로고
    • Effects of St. John's Wort on irinotecan metabolism
    • Mathijssen RH, Verweij J, de Bruijn P, et al. Effects of St. John's Wort on irinotecan metabolism. J Natl Cancer Inst 2002; 94 (16): 1247-9
    • (2002) J Natl Cancer Inst , vol.94 , Issue.16 , pp. 1247-1249
    • Mathijssen, R.H.1    Verweij, J.2    De Bruijn, P.3
  • 44
    • 0034620261 scopus 로고    scopus 로고
    • Herb-drug interactions
    • Fugh-Berman A. Herb-drug interactions. Lancet 2000; 355 (9198): 134-8
    • (2000) Lancet , vol.355 , Issue.9198 , pp. 134-138
    • Fugh-Berman, A.1
  • 45
    • 0036188407 scopus 로고    scopus 로고
    • St John's Wort supplements endanger the success of organ transplantation
    • Ernst E. St John's Wort supplements endanger the success of organ transplantation. Arch Surg 2002; 137 (3): 316-9
    • (2002) Arch Surg , vol.137 , Issue.3 , pp. 316-319
    • Ernst, E.1
  • 46
    • 0033547648 scopus 로고    scopus 로고
    • Second thoughts about safety of St John's Wort
    • Ernst E. Second thoughts about safety of St John's Wort. Lancet 1999; 354 (9195): 2014-6
    • (1999) Lancet , vol.354 , Issue.9195 , pp. 2014-2016
    • Ernst, E.1
  • 47
    • 0031741887 scopus 로고    scopus 로고
    • Adverse effects profile of the herbal antidepressant St. John's Wort (Hypericum perforatum L.)
    • Ernst E, Rand JI, Barnes J, et al. Adverse effects profile of the herbal antidepressant St. John's Wort (Hypericum perforatum L.). Eur J Clin Pharmacol 1998; 54 (8): 589-94
    • (1998) Eur J Clin Pharmacol , vol.54 , Issue.8 , pp. 589-594
    • Ernst, E.1    Rand, J.I.2    Barnes, J.3
  • 48
    • 4744359869 scopus 로고    scopus 로고
    • Hyperforin content determines the magnitude of the St John's Wort-cyclosporine drug interaction
    • Mai I, Bauer S, Perloff ES, et al. Hyperforin content determines the magnitude of the St John's Wort-cyclosporine drug interaction. Clin Pharmacol Ther 2004; 76 (4): 330-40
    • (2004) Clin Pharmacol Ther , vol.76 , Issue.4 , pp. 330-340
    • Mai, I.1    Bauer, S.2    Perloff, E.S.3
  • 49
    • 0033826492 scopus 로고    scopus 로고
    • St John's Wort, a herbal antidepressant, activates the steroid X receptor
    • Wentworth JM, Agostini M, Love J, et al. St John's Wort, a herbal antidepressant, activates the steroid X receptor. J Endocrinol 2000; 166 (3): R11-6
    • (2000) J Endocrinol , vol.166 , Issue.3
    • Wentworth, J.M.1    Agostini, M.2    Love, J.3
  • 50
    • 0037501542 scopus 로고    scopus 로고
    • 2.1 A crystal structure of human PXR in complex with the St. John's Wort compound hyperforin
    • Watkins RE, Maglich JM, Moore LB, et al. 2.1 A crystal structure of human PXR in complex with the St. John's Wort compound hyperforin. Biochemistry 2003; 42 (6): 1430-8
    • (2003) Biochemistry , vol.42 , Issue.6 , pp. 1430-1438
    • Watkins, R.E.1    Maglich, J.M.2    Moore, L.B.3
  • 51
    • 0034691064 scopus 로고    scopus 로고
    • St. John's Wort induces hepatic drug metabolism through activation of the pregnane X receptor
    • U S A
    • Moore LB, Goodwin B, Jones SA, et al. St. John's Wort induces hepatic drug metabolism through activation of the pregnane X receptor. Proc Natl Acad Sci U S A 2000; 97 (13): 7500-2
    • (2000) Proc Natl Acad Sci , vol.97 , Issue.13 , pp. 7500-7502
    • Moore, L.B.1    Goodwin, B.2    Jones, S.A.3
  • 52
    • 0032914931 scopus 로고    scopus 로고
    • Potential metabolic interaction between St. John's Wort and theophylline
    • Nebel A, Schneider BJ, Baker RK, et al. Potential metabolic interaction between St. John's Wort and theophylline. Ann Pharmacother 1999; 33 (4): 502
    • (1999) Ann Pharmacother , vol.33 , Issue.4 , pp. 502
    • Nebel, A.1    Schneider, B.J.2    Baker, R.K.3
  • 53
    • 0031015345 scopus 로고    scopus 로고
    • Human P450 metabolism of warfarin
    • Kaminsky LS, Zhang ZY. Human P450 metabolism of warfarin. Pharmacol Ther 1997; 73 (1): 67-74
    • (1997) Pharmacol Ther , vol.73 , Issue.1 , pp. 67-74
    • Kaminsky, L.S.1    Zhang, Z.Y.2
  • 54
    • 0141611906 scopus 로고    scopus 로고
    • Effect of St John's Wort on drug metabolism by induction of cytochrome P450 3A4 enzyme
    • Markowitz JS, Donovan JL, DeVane CL, et al. Effect of St John's Wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA 2003; 290 (11): 1500-4
    • (2003) JAMA , vol.290 , Issue.11 , pp. 1500-1504
    • Markowitz, J.S.1    Donovan, J.L.2    Devane, C.L.3
  • 55
    • 2442536902 scopus 로고    scopus 로고
    • Drug interactions with St. John's Wort (Hypericum perforatum): A review of the clinical evidence
    • Izzo AA. Drug interactions with St. John's Wort (Hypericum perforatum): a review of the clinical evidence. Int J Clin Pharmacol Ther 2004; 42 (3): 139-48
    • (2004) Int J Clin Pharmacol Ther , vol.42 , Issue.3 , pp. 139-148
    • Izzo, A.A.1
  • 56
    • 11144355476 scopus 로고    scopus 로고
    • Induction and inhibition of cytochromes P450 by the St. John's Wort constituent hyperforin in human hepatocyte cultures
    • Komoroski BJ, Zhang S, Cai H, et al. Induction and inhibition of cytochromes P450 by the St. John's Wort constituent hyperforin in human hepatocyte cultures. Drug Metab Dispos 2004; 32 (5): 512-8
    • (2004) Drug Metab Dispos , vol.32 , Issue.5 , pp. 512-518
    • Komoroski, B.J.1    Zhang, S.2    Cai, H.3
  • 57
    • 0037241016 scopus 로고    scopus 로고
    • Unwanted pregnancy on self-medication with St John's Wort despite hormonal contraception
    • Schwarz UI, Buschel B, Kirch W. Unwanted pregnancy on self-medication with St John's Wort despite hormonal contraception. Br J Clin Pharmacol 2003; 55 (1): 112-3
    • (2003) Br J Clin Pharmacol , vol.55 , Issue.1 , pp. 112-113
    • Schwarz, U.I.1    Buschel, B.2    Kirch, W.3
  • 58
    • 0036428646 scopus 로고    scopus 로고
    • St John's Wort (Hypericum perforatum): Drug interactions and clinical outcomes
    • Henderson L, Yue QY, Bergquist C, et al. St John's Wort (Hypericum perforatum): drug interactions and clinical outcomes. Br J Clin Pharmacol 2002; 54 (4): 349-56
    • (2002) Br J Clin Pharmacol , vol.54 , Issue.4 , pp. 349-356
    • Henderson, L.1    Yue, Q.Y.2    Bergquist, C.3
  • 59
    • 0344081240 scopus 로고    scopus 로고
    • Interaction of St John's Wort with low-dose oral contraceptive therapy: A randomized controlled trial
    • Pfrunder A, Schiesser M, Gerber S, et al. Interaction of St John's Wort with low-dose oral contraceptive therapy: a randomized controlled trial. Br J Clin Pharmacol 2003; 56 (6): 683-90
    • (2003) Br J Clin Pharmacol , vol.56 , Issue.6 , pp. 683-690
    • Pfrunder, A.1    Schiesser, M.2    Gerber, S.3
  • 60
    • 0346874440 scopus 로고    scopus 로고
    • The interaction between St John's Wort and an oral contraceptive
    • Hall SD, Wang Z, Huang SM, et al. The interaction between St John's Wort and an oral contraceptive. Clin Pharmacol Ther 2003; 74 (6): 525-35
    • (2003) Clin Pharmacol Ther , vol.74 , Issue.6 , pp. 525-535
    • Hall, S.D.1    Wang, Z.2    Huang, S.M.3
  • 61
    • 0000006828 scopus 로고    scopus 로고
    • Pharmacokinetic interaction of digoxin with an herbal extract from St John's Wort (Hypericum perforatum)
    • Johne A, Brockmoller J, Bauer S, et al. Pharmacokinetic interaction of digoxin with an herbal extract from St John's Wort (Hypericum perforatum). Clin Pharmacol Ther 1999; 66 (4): 338-45
    • (1999) Clin Pharmacol Ther , vol.66 , Issue.4 , pp. 338-345
    • Johne, A.1    Brockmoller, J.2    Bauer, S.3
  • 62
    • 1042304296 scopus 로고    scopus 로고
    • Quantitative characterization of direct P-glycoprotein inhibition by St John's Wort constituents hypericin and hyperforin
    • Wang EJ, Barecki-Roach M, Johnson WW. Quantitative characterization of direct P-glycoprotein inhibition by St John's Wort constituents hypericin and hyperforin. J Pharm Pharmacol 2004; 56 (1): 123-8
    • (2004) J Pharm Pharmacol , vol.56 , Issue.1 , pp. 123-128
    • Wang, E.J.1    Barecki-Roach, M.2    Johnson, W.W.3
  • 63
    • 0036286921 scopus 로고    scopus 로고
    • Effect of St John's Wort on the pharmacokinetics of fexofenadine
    • Wang Z, Hamman MA, Huang SM, et al. Effect of St John's Wort on the pharmacokinetics of fexofenadine. Clin Pharmacol Ther 2002; 71 (6): 414-20
    • (2002) Clin Pharmacol Ther , vol.71 , Issue.6 , pp. 414-420
    • Wang, Z.1    Hamman, M.A.2    Huang, S.M.3
  • 64
    • 0345505691 scopus 로고    scopus 로고
    • The role of multidrug transporters in drug availability, metabolism and toxicity
    • Bodo A, Bakos E, Szeri F, et al. The role of multidrug transporters in drug availability, metabolism and toxicity. Toxicol Lett 2003; 140-141: 133-43
    • (2003) Toxicol Lett , vol.140-141 , pp. 133-143
    • Bodo, A.1    Bakos, E.2    Szeri, F.3
  • 65
    • 0034520267 scopus 로고    scopus 로고
    • St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4
    • Durr D, Stieger B, Kullak-Ublick GA, et al. St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4. Clin Pharmacol Ther 2000; 68 (6): 598-604
    • (2000) Clin Pharmacol Ther , vol.68 , Issue.6 , pp. 598-604
    • Durr, D.1    Stieger, B.2    Kullak-Ublick, G.A.3
  • 66
    • 4544235407 scopus 로고    scopus 로고
    • Drug interactions with St John's Wort: Mechanisms and clinical implications
    • Mannel M. Drug interactions with St John's Wort: mechanisms and clinical implications. Drug Saf 2004; 27 (11): 773-97
    • (2004) Drug Saf , vol.27 , Issue.11 , pp. 773-797
    • Mannel, M.1
  • 67
    • 0030874985 scopus 로고    scopus 로고
    • Biologically active and other chemical constituents of the herb of Hypericum perforatum L.
    • Nahrstedt A, Butterweck V. Biologically active and other chemical constituents of the herb of Hypericum perforatum L. Pharmacopsychiatry 1997; 30 Suppl. 2: 129-34
    • (1997) Pharmacopsychiatry , vol.30 , Issue.2 SUPPL. , pp. 129-134
    • Nahrstedt, A.1    Butterweck, V.2
  • 68
    • 0142124319 scopus 로고    scopus 로고
    • Development of a high-performance-liquid-chromatographic method for the determination of biapigenin in biorelevant media
    • Schulte-Lobbert S, Westerhoff K, Wilke A, et al. Development of a high-performance-liquid-chromatographic method for the determination of biapigenin in biorelevant media. J Pharm Biomed Anal 2003; 33 (1): 53-60
    • (2003) J Pharm Biomed Anal , vol.33 , Issue.1 , pp. 53-60
    • Schulte-Lobbert, S.1    Westerhoff, K.2    Wilke, A.3
  • 69
    • 0343247685 scopus 로고    scopus 로고
    • Antioxidant flavonols and coronary heart disease risk
    • Hertog MG, Feskens EJ, Kromhout D. Antioxidant flavonols and coronary heart disease risk. Lancet 1997; 349 (9053): 699
    • (1997) Lancet , vol.349 , Issue.9053 , pp. 699
    • Hertog, M.G.1    Feskens, E.J.2    Kromhout, D.3
  • 70
    • 0033562605 scopus 로고    scopus 로고
    • Dietary flavonoid intake and risk of cardiovascular disease in postmenopausal women
    • published erratum appears in Am J Epidemiol 1999 Aug 15; 150 (4): 432
    • Yochum L, Kushi LH, Meyer K, et al. Dietary flavonoid intake and risk of cardiovascular disease in postmenopausal women [published erratum appears in Am J Epidemiol 1999 Aug 15; 150 (4): 432]. Am J Epidemiol 1999; 149 (10): 943-9
    • (1999) Am J Epidemiol , vol.149 , Issue.10 , pp. 943-949
    • Yochum, L.1    Kushi, L.H.2    Meyer, K.3
  • 71
    • 0034058307 scopus 로고    scopus 로고
    • Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II): A randomized, double-blind, placebo-controlled trial
    • Kiesewetter H, Koscielny J, Kalus U, et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II): a randomized, double-blind, placebo-controlled trial. Arzneimittel Forschung 2000; 50 (2): 109-17
    • (2000) Arzneimittel Forschung , vol.50 , Issue.2 , pp. 109-117
    • Kiesewetter, H.1    Koscielny, J.2    Kalus, U.3
  • 72
    • 0029785036 scopus 로고    scopus 로고
    • Leg oedema protection from a buckwheat herb tea in patients with chronic venous insufficiency: A single-centre, randomised, double-blind, placebo-controlled clinical trial
    • Ihme N, Kiesewetter H, Jung F, et al. Leg oedema protection from a buckwheat herb tea in patients with chronic venous insufficiency: a single-centre, randomised, double-blind, placebo-controlled clinical trial. Eur J Clin Pharmacol 1996; 50 (6): 443-7
    • (1996) Eur J Clin Pharmacol , vol.50 , Issue.6 , pp. 443-447
    • Ihme, N.1    Kiesewetter, H.2    Jung, F.3
  • 73
    • 0024469955 scopus 로고
    • Identification of selective MAO-Typ a inhibition of Hypericum perforatum L
    • Demisch L, Hölzl J, Gollnik B, et al. Identification of selective MAO-Typ A inhibition of Hypericum perforatum L [abstract]. Pharmacopsychiatry 1989; 22: 194
    • (1989) Pharmacopsychiatry , vol.22 , pp. 194
    • Demisch, L.1    Hölzl, J.2    Gollnik, B.3
  • 74
    • 0027994755 scopus 로고
    • Inhibition of MAO and COMT by hypericum extracts and hypericin
    • Thiede HM, Walper A. Inhibition of MAO and COMT by hypericum extracts and hypericin. J Geriatr Psychiatry Neurol 1994; 7 Suppl. 1: S54-6
    • (1994) J Geriatr Psychiatry Neurol , vol.7 , Issue.1 SUPPL.
    • Thiede, H.M.1    Walper, A.2
  • 75
    • 0003091260 scopus 로고    scopus 로고
    • Pharmacology of St. John's Wort: Botanical and chemical aspects
    • Cracchiolo C. Pharmacology of St. John's Wort: botanical and chemical aspects. Sci Rev Alt Med 1998; 2: 29-35
    • (1998) Sci Rev Alt Med , vol.2 , pp. 29-35
    • Cracchiolo, C.1
  • 76
    • 0030881089 scopus 로고    scopus 로고
    • In vitro receptor binding and enzyme inhibition by Hypericum perforatum extract
    • Cott JM. In vitro receptor binding and enzyme inhibition by Hypericum perforatum extract. Pharmacopsychiatry 1997; 30 Suppl. 2: 108-12
    • (1997) Pharmacopsychiatry , vol.30 , Issue.2 SUPPL. , pp. 108-112
    • Cott, J.M.1
  • 77
    • 0036019551 scopus 로고    scopus 로고
    • In vitro receptor screening of pure constituents of St. John's Wort reveals novel interactions with a number of GPCRs
    • Berl
    • Butterweck V, Nahrstedt A, Evans J, et al. In vitro receptor screening of pure constituents of St. John's Wort reveals novel interactions with a number of GPCRs. Psychopharmacology (Berl) 2002; 162 (2): 193-202
    • (2002) Psychopharmacology , vol.162 , Issue.2 , pp. 193-202
    • Butterweck, V.1    Nahrstedt, A.2    Evans, J.3
  • 78
    • 0033963119 scopus 로고    scopus 로고
    • Flavonoids from Hypericum perforatum show antidepressant activity in the forced swimming test
    • Butterweck V, Jurgenliemk G, Nahrstedt A, et al. Flavonoids from Hypericum perforatum show antidepressant activity in the forced swimming test. Planta Med 2000; 66 (1): 3-6
    • (2000) Planta Med , vol.66 , Issue.1 , pp. 3-6
    • Butterweck, V.1    Jurgenliemk, G.2    Nahrstedt, A.3
  • 79
    • 0018763594 scopus 로고
    • Animal model of depression
    • Porsolt RD. Animal model of depression. Biomedicine 1979; 30 (3): 139-40
    • (1979) Biomedicine , vol.30 , Issue.3 , pp. 139-140
    • Porsolt, R.D.1
  • 81
    • 0034922417 scopus 로고    scopus 로고
    • Pharmacological and endocrine effects of Hypericum perforatum and hypericin after repeated treatment
    • Butterweck V, Korte B, Winterhoff H. Pharmacological and endocrine effects of Hypericum perforatum and hypericin after repeated treatment. Pharmacopsychiatry 2001; 34 Suppl. 1: S2-7
    • (2001) Pharmacopsychiatry , vol.34 , Issue.1 SUPPL.
    • Butterweck, V.1    Korte, B.2    Winterhoff, H.3
  • 82
    • 7644232422 scopus 로고    scopus 로고
    • Flavonoids of St. John's Wort reduce HPA axis function in the rat
    • Butterweck V, Hegger M, Winterhoff H. Flavonoids of St. John's Wort reduce HPA axis function in the rat. Planta Med 2004; 70 (10): 1008-11
    • (2004) Planta Med , vol.70 , Issue.10 , pp. 1008-1011
    • Butterweck, V.1    Hegger, M.2    Winterhoff, H.3
  • 83
    • 0029984024 scopus 로고    scopus 로고
    • Adrenal gland volume in major depression: Relationship to basal and stimulated pituitary-adrenal cortical axis function
    • Rubin RT, Phillips JJ, McCracken JT, et al. Adrenal gland volume in major depression: relationship to basal and stimulated pituitary-adrenal cortical axis function. Biol Psychiatry 1996; 40 (2): 89-97
    • (1996) Biol Psychiatry , vol.40 , Issue.2 , pp. 89-97
    • Rubin, R.T.1    Phillips, J.J.2    McCracken, J.T.3
  • 84
    • 0028920574 scopus 로고
    • Adrenal gland volume in major depression. Increase during the depressive episode and decrease with successful treatment
    • Rubin RT, Phillips JJ, Sadow TF, et al. Adrenal gland volume in major depression. Increase during the depressive episode and decrease with successful treatment. Arch Gen Psychiatry 1995; 52 (3): 213-8
    • (1995) Arch Gen Psychiatry , vol.52 , Issue.3 , pp. 213-218
    • Rubin, R.T.1    Phillips, J.J.2    Sadow, T.F.3
  • 85
    • 0021908898 scopus 로고
    • Neuroendocrinologic and endocrinologic research in depressive patients
    • Holsboer F, Benkert O. Neuroendocrinologic and endocrinologic research in depressive patients [in German]. Nervenarzt 1985; 56 (1): 1-11
    • (1985) Nervenarzt , vol.56 , Issue.1 , pp. 1-11
    • Holsboer, F.1    Benkert, O.2
  • 86
    • 0019972363 scopus 로고
    • Repeated dexamethasone suppression test during depressive illness: Normalisation of test result compared with clinical improvement
    • Holsboer F, Liebl R, Hofschuster E. Repeated dexamethasone suppression test during depressive illness: normalisation of test result compared with clinical improvement. J Affect Disord 1982; 4 (2): 93-101
    • (1982) J Affect Disord , vol.4 , Issue.2 , pp. 93-101
    • Holsboer, F.1    Liebl, R.2    Hofschuster, E.3
  • 87
    • 0343035701 scopus 로고    scopus 로고
    • Inhibition of benzodiazepine binding in vitro by amentoflavone, a constituent of various species of Hypericum
    • Baureithel KH, Buter KB, Engesser A, et al. Inhibition of benzodiazepine binding in vitro by amentoflavone, a constituent of various species of Hypericum. Pharm Acta Helv 1997; 72 (3): 153-7
    • (1997) Pharm Acta Helv , vol.72 , Issue.3 , pp. 153-157
    • Baureithel, K.H.1    Buter, K.B.2    Engesser, A.3
  • 88
    • 0344670186 scopus 로고    scopus 로고
    • Plasma levels of hypericin in presence of procyanidin B2 and hyperoside: A pharmacokinetic study in rats
    • Butterweck V, Lieflander-Wulf U, Winterhoff H, et al. Plasma levels of hypericin in presence of procyanidin B2 and hyperoside: a pharmacokinetic study in rats. Planta Med 2003; 69 (3): 189-92
    • (2003) Planta Med , vol.69 , Issue.3 , pp. 189-192
    • Butterweck, V.1    Lieflander-Wulf, U.2    Winterhoff, H.3
  • 89
    • 0037087102 scopus 로고    scopus 로고
    • Long-term effects of St. John's Wort and hypericin on monoamine levels in rat hypothalamus and hippocampus
    • Butterweck V, Bockers T, Korte B, et al. Long-term effects of St. John's Wort and hypericin on monoamine levels in rat hypothalamus and hippocampus. Brain Res 2002; 930 (1-2): 21-9
    • (2002) Brain Res , vol.930 , Issue.1-2 , pp. 21-29
    • Butterweck, V.1    Bockers, T.2    Korte, B.3
  • 90
    • 0034886177 scopus 로고    scopus 로고
    • St John's Wort, hypericin, and imipramine: A comparative analysis of mRNA levels in brain areas involved in HPA axis control following short-term and long-term administration in normal and stressed rats
    • Butterweck V, Winterhoff H, Herkenham M. St John's Wort, hypericin, and imipramine: a comparative analysis of mRNA levels in brain areas involved in HPA axis control following short-term and long-term administration in normal and stressed rats. Mol Psychiatry 2001; 6 (5): 547-64
    • (2001) Mol Psychiatry , vol.6 , Issue.5 , pp. 547-564
    • Butterweck, V.1    Winterhoff, H.2    Herkenham, M.3
  • 91
    • 0031830782 scopus 로고    scopus 로고
    • Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test
    • Butterweck V, Petereit F, Winterhoff H, et al. Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test. Planta Med 1998; 64 (4): 291-4
    • (1998) Planta Med , vol.64 , Issue.4 , pp. 291-294
    • Butterweck, V.1    Petereit, F.2    Winterhoff, H.3
  • 92
    • 0030761151 scopus 로고    scopus 로고
    • Hypericin and pseudohypericin: Pharmacokinetics and effects on photosensitivity in humans
    • Brockmöller J, Reum T, Bauer S, et al. Hypericin and pseudohypericin: pharmacokinetics and effects on photosensitivity in humans. Pharmacopsychiatry 1997; 30 Suppl. 2: 94-101
    • (1997) Pharmacopsychiatry , vol.30 , Issue.2 SUPPL. , pp. 94-101
    • Brockmöller, J.1    Reum, T.2    Bauer, S.3
  • 93
  • 94
    • 0027389005 scopus 로고
    • Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: Inhibition of fusion and syncytia formation
    • U S A
    • Lenard J, Rabson A, Vanderoef R. Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: inhibition of fusion and syncytia formation. Proc Natl Acad Sci U S A 1993; 90 (1): 158-62
    • (1993) Proc Natl Acad Sci , vol.90 , Issue.1 , pp. 158-162
    • Lenard, J.1    Rabson, A.2    Vanderoef, R.3
  • 95
    • 0025743413 scopus 로고
    • In vitro virucidal activity of selected anthraquinones and anthraquinone derivatives
    • Andersen DO, Weber ND, Wood SG, et al. In vitro virucidal activity of selected anthraquinones and anthraquinone derivatives. Antiviral Res 1991; 16 (2): 185-96
    • (1991) Antiviral Res , vol.16 , Issue.2 , pp. 185-196
    • Andersen, D.O.1    Weber, N.D.2    Wood, S.G.3
  • 97
    • 0002074818 scopus 로고
    • Johanniskraut: Eine Alternative zu synthetischen Antidepressiva?
    • Hölzl J, Sattler S, Schütt H. Johanniskraut: eine Alternative zu synthetischen Antidepressiva? Pharmazeutische Zeitung 1994; 139: 3959-77
    • (1994) Pharmazeutische Zeitung , vol.139 , pp. 3959-3977
    • Hölzl, J.1    Sattler, S.2    Schütt, H.3
  • 98
    • 0031778665 scopus 로고    scopus 로고
    • Hyperforin, possibly the major non-nitrogenous secondary metabolite of Hypericum perforatum L.
    • Erdelmeier CA. Hyperforin, possibly the major non-nitrogenous secondary metabolite of Hypericum perforatum L. Pharmacopsychiatry 1998; 31 Suppl. 1: 2-6
    • (1998) Pharmacopsychiatry , vol.31 , Issue.1 SUPPL. , pp. 2-6
    • Erdelmeier, C.A.1
  • 100
    • 0031779971 scopus 로고    scopus 로고
    • Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers
    • Biber A, Fischer H, Romer A, et al. Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers. Pharmacopsychiatry 1998; 31 Suppl. 1: 36-43
    • (1998) Pharmacopsychiatry , vol.31 , Issue.1 SUPPL. , pp. 36-43
    • Biber, A.1    Fischer, H.2    Romer, A.3
  • 101
    • 0032788651 scopus 로고    scopus 로고
    • Neuroendocrine evidence for dopaminergic actions of hypericum extract (LI 160) in healthy volunteers
    • Franklin M, Chi J, McGavin C, et al. Neuroendocrine evidence for dopaminergic actions of hypericum extract (LI 160) in healthy volunteers. Biol Psychiatry 1999; 46 (4): 581-4
    • (1999) Biol Psychiatry , vol.46 , Issue.4 , pp. 581-584
    • Franklin, M.1    Chi, J.2    McGavin, C.3
  • 102
    • 0034532081 scopus 로고    scopus 로고
    • Oral bioavailability of active principles from herbal products in humans: A study on Hypericum perforatum extracts using the soft gelatin capsule technology
    • Agrosi M, Mischiatti S, Harrasser PC, et al. Oral bioavailability of active principles from herbal products in humans: a study on Hypericum perforatum extracts using the soft gelatin capsule technology. Phytomedicine 2000; 7 (6): 455-62
    • (2000) Phytomedicine , vol.7 , Issue.6 , pp. 455-462
    • Agrosi, M.1    Mischiatti, S.2    Harrasser, P.C.3
  • 103
    • 0037111457 scopus 로고    scopus 로고
    • Determination of hyperforin in human plasma using solid-phase extraction and high-performance liquid chromatography with ultraviolet detection
    • Cui Y, Gurley B, Ang CY, et al. Determination of hyperforin in human plasma using solid-phase extraction and high-performance liquid chromatography with ultraviolet detection. J Chromatogr B Analyt Technol Biomed Life Sci 2002; 780 (1): 129-35
    • (2002) J Chromatogr B Analyt Technol Biomed Life Sci , vol.780 , Issue.1 , pp. 129-135
    • Cui, Y.1    Gurley, B.2    Ang, C.Y.3
  • 104
    • 12944296601 scopus 로고    scopus 로고
    • Investigation of the bioavailability of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin following single and multiple oral dosing of a hypericum extract containing tablet
    • Schulz HU, Schurer M, Bassler D, et al. Investigation of the bioavailability of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin following single and multiple oral dosing of a hypericum extract containing tablet. Arzneimittel Forschung 2005; 55 (1): 15-22
    • (2005) Arzneimittel Forschung , vol.55 , Issue.1 , pp. 15-22
    • Schulz, H.U.1    Schurer, M.2    Bassler, D.3
  • 105
    • 0034915637 scopus 로고    scopus 로고
    • Batch-to-batch reproducibility of St. John's Wort preparations
    • Wurglics M, Westerhoff K, Kaunzinger A, et al. Batch-to-batch reproducibility of St. John's Wort preparations. Pharmacopsychiatry 2001; 34 Suppl. 1: S152-6
    • (2001) Pharmacopsychiatry , vol.34 , Issue.1 SUPPL.
    • Wurglics, M.1    Westerhoff, K.2    Kaunzinger, A.3
  • 106
    • 0034928466 scopus 로고    scopus 로고
    • Evaluation of synaptosomal uptake inhibition of most relevant constituents of St. John's Wort
    • Wonnemann M, Singer A, Siebert B, et al. Evaluation of synaptosomal uptake inhibition of most relevant constituents of St. John's Wort. Pharmacopsychiatry 2001; 34 Suppl. 1: S148-51
    • (2001) Pharmacopsychiatry , vol.34 , Issue.1 SUPPL.
    • Wonnemann, M.1    Singer, A.2    Siebert, B.3
  • 107
    • 0036452412 scopus 로고    scopus 로고
    • Role of hyperforin in the antidepressant-like activity of Hypericum perforatum extracts
    • Cervo L, Rozio M, Ekalle-Soppo CB, et al. Role of hyperforin in the antidepressant-like activity of Hypericum perforatum extracts. Psychopharmacology 2002; 164 (4): 423-8
    • (2002) Psychopharmacology , vol.164 , Issue.4 , pp. 423-428
    • Cervo, L.1    Rozio, M.2    Ekalle-Soppo, C.B.3
  • 108
    • 0242569316 scopus 로고    scopus 로고
    • Determination of hyperforin in mouse brain by high-performance liquid chromatography/tandem mass spectrometry
    • Keller JH, Karas M, Muller WE, et al. Determination of hyperforin in mouse brain by high-performance liquid chromatography/tandem mass spectrometry. Anal Chem 2003; 75 (22): 6084-8
    • (2003) Anal Chem , vol.75 , Issue.22 , pp. 6084-6088
    • Keller, J.H.1    Karas, M.2    Muller, W.E.3
  • 109
    • 0025769619 scopus 로고
    • A method for the quantitation of hypericin, an antiviral agent, in biological fluids by high-performance liquid chromatography
    • Liebes L, Mazur Y, Freeman D, et al. A method for the quantitation of hypericin, an antiviral agent, in biological fluids by high-performance liquid chromatography. Anal Biochem 1991; 195 (1): 77-85
    • (1991) Anal Biochem , vol.195 , Issue.1 , pp. 77-85
    • Liebes, L.1    Mazur, Y.2    Freeman, D.3
  • 110
    • 0035814267 scopus 로고    scopus 로고
    • Determination of hyperforin, hypericin, and pseudohypericin in human plasma using high-performance liquid chromatography analysis with fluorescence and ultraviolet detection
    • Bauer S, Stormer E, Graubaum HJ, et al. Determination of hyperforin, hypericin, and pseudohypericin in human plasma using high-performance liquid chromatography analysis with fluorescence and ultraviolet detection. J Chromatogr B Biomed Sci Appl 2001; 765 (1): 29-35
    • (2001) J Chromatogr B Biomed Sci Appl , vol.765 , Issue.1 , pp. 29-35
    • Bauer, S.1    Stormer, E.2    Graubaum, H.J.3
  • 111
    • 0037174141 scopus 로고    scopus 로고
    • Simultaneous determination of hypericin and hyperforin in human plasma and serum using liquid-liquid extraction, high-performance liquid chromatography and liquid chromatography-tandem mass spectrometry
    • Pirker R, Huck CW, Bonn GK. Simultaneous determination of hypericin and hyperforin in human plasma and serum using liquid-liquid extraction, high-performance liquid chromatography and liquid chromatography-tandem mass spectrometry. J Chromatogr B Anal Technol Biomed Life Sci 2002; 777 (1-2): 147-53
    • (2002) J Chromatogr B Anal Technol Biomed Life Sci , vol.777 , Issue.1-2 , pp. 147-153
    • Pirker, R.1    Huck, C.W.2    Bonn, G.K.3
  • 112
    • 0029794744 scopus 로고    scopus 로고
    • Single-dose and steady-state pharmacokinetics of hypericin and pseudohypericin
    • Kerb R, Brockmoller J, Staffeldt B, et al. Single-dose and steady-state pharmacokinetics of hypericin and pseudohypericin. Antimicrob Agents Chemother 1996; 40 (9): 2087-93
    • (1996) Antimicrob Agents Chemother , vol.40 , Issue.9 , pp. 2087-2093
    • Kerb, R.1    Brockmoller, J.2    Staffeldt, B.3
  • 113
    • 0027946782 scopus 로고
    • Pharmacokinetics of hypericin and pseudohypericin after oral intake of the hypericum perforatum extract LI 160 in healthy volunteers
    • Staffeldt B, Kerb R, Brockmoller J, et al. Pharmacokinetics of hypericin and pseudohypericin after oral intake of the hypericum perforatum extract LI 160 in healthy volunteers. J Geriatr Psychiatry Neurol 1994; 7 Suppl. 1: S47-53
    • (1994) J Geriatr Psychiatry Neurol , vol.7 , Issue.1 SUPPL.
    • Staffeldt, B.1    Kerb, R.2    Brockmoller, J.3
  • 114
    • 0001437764 scopus 로고
    • Pharmakokinetik von Hypericin nach der oralen Einnahme des Johanniskraut-Extrakte LI160
    • Weiser D. Pharmakokinetik von Hypericin nach der oralen Einnahme des Johanniskraut-Extrakte LI160. Nervenheilkunde 1991; 10: 318-9
    • (1991) Nervenheilkunde , vol.10 , pp. 318-319
    • Weiser, D.1
  • 115
    • 0034912383 scopus 로고    scopus 로고
    • Plasma pharmacokinetics and cerebrospinal fluid penetration of hypericin in nonhuman primates
    • Fox E, Murphy RF, McCully CL, et al. Plasma pharmacokinetics and cerebrospinal fluid penetration of hypericin in nonhuman primates. Cancer Chemother Pharmacol 2001; 47 (1): 41-4
    • (2001) Cancer Chemother Pharmacol , vol.47 , Issue.1 , pp. 41-44
    • Fox, E.1    Murphy, R.F.2    McCully, C.L.3
  • 116
    • 0028793218 scopus 로고
    • Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers
    • Hollman PC, de Vries JH, van Leeuwen SD, et al. Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers. Am J Clin Nutr 1995; 62 (6): 1276-82
    • (1995) Am J Clin Nutr , vol.62 , Issue.6 , pp. 1276-1282
    • Hollman, P.C.1    De Vries, J.H.2    Van Leeuwen, S.D.3
  • 117
    • 0030775750 scopus 로고    scopus 로고
    • Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man
    • Hollman PC, van Trijp JM, Buysman MN, et al. Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man. FEBS Lett 1997; 418 (1-2): 152-6
    • (1997) FEBS Lett , vol.418 , Issue.1-2 , pp. 152-156
    • Hollman, P.C.1    Van Trijp, J.M.2    Buysman, M.N.3
  • 118
    • 0032759560 scopus 로고    scopus 로고
    • The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man
    • Hollman PC, Bijsman MN, van Gameren Y, et al. The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man. Free Radic Res 1999; 31 (6): 569-73
    • (1999) Free Radic Res , vol.31 , Issue.6 , pp. 569-573
    • Hollman, P.C.1    Bijsman, M.N.2    Van Gameren, Y.3
  • 119
    • 0042419922 scopus 로고    scopus 로고
    • The bioavailability of quercetin in pigs depends on the glycoside moiety and on dietary factors
    • Cermak R, Landgraf S, Wolffram S. The bioavailability of quercetin in pigs depends on the glycoside moiety and on dietary factors. J Nutr 2003; 133 (9): 2802-7
    • (2003) J Nutr , vol.133 , Issue.9 , pp. 2802-2807
    • Cermak, R.1    Landgraf, S.2    Wolffram, S.3
  • 120
    • 0036213863 scopus 로고    scopus 로고
    • Quercetin-3-glucoside is transported by the glucose carrier SGLT1 across the brush border membrane of rat small intestine
    • Wolffram S, Block M, Ader P. Quercetin-3-glucoside is transported by the glucose carrier SGLT1 across the brush border membrane of rat small intestine. J Nutr 2002; 132 (4): 630-5
    • (2002) J Nutr , vol.132 , Issue.4 , pp. 630-635
    • Wolffram, S.1    Block, M.2    Ader, P.3
  • 121
    • 17744396286 scopus 로고    scopus 로고
    • Pharmacokinetics and bioavailability of quercetin glycosides in humans
    • Graefe EU, Wittig J, Mueller S, et al. Pharmacokinetics and bioavailability of quercetin glycosides in humans. J Clin Pharmacol 2001; 41 (5): 492-9
    • (2001) J Clin Pharmacol , vol.41 , Issue.5 , pp. 492-499
    • Graefe, E.U.1    Wittig, J.2    Mueller, S.3
  • 122
    • 0035692180 scopus 로고    scopus 로고
    • Human metabolism of dietary flavonoids: Identification of plasma metabolites of quercetin
    • Day AJ, Mellon F, Barron D, et al. Human metabolism of dietary flavonoids: identification of plasma metabolites of quercetin. Free Radic Res 2001; 35 (6): 941-52
    • (2001) Free Radic Res , vol.35 , Issue.6 , pp. 941-952
    • Day, A.J.1    Mellon, F.2    Barron, D.3
  • 123
    • 0035812210 scopus 로고    scopus 로고
    • Determination of rutin in human plasma by high-performance liquid chromatography utilizing solid-phase extraction and ultraviolet detection
    • Ishii K, Furuta T, Kasuya Y. Determination of rutin in human plasma by high-performance liquid chromatography utilizing solid-phase extraction and ultraviolet detection. J Chromatogr B Biomed Sci Appl 2001; 759 (1): 161-8
    • (2001) J Chromatogr B Biomed Sci Appl , vol.759 , Issue.1 , pp. 161-168
    • Ishii, K.1    Furuta, T.2    Kasuya, Y.3
  • 124
    • 0030949275 scopus 로고    scopus 로고
    • Bioavailability of rutin and quercetin in rats
    • Manach C, Morand C, Demigne C, et al. Bioavailability of rutin and quercetin in rats. FEBS Lett 1997; 409 (1): 12-6
    • (1997) FEBS Lett , vol.409 , Issue.1 , pp. 12-16
    • Manach, C.1    Morand, C.2    Demigne, C.3
  • 125
    • 0037300834 scopus 로고    scopus 로고
    • Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: The role of human beta-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism
    • O'Leary KA, Day AJ, Needs PW, et al. Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: the role of human beta-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism. Biochem Pharmacol 2003; 65 (3): 479-91
    • (2003) Biochem Pharmacol , vol.65 , Issue.3 , pp. 479-491
    • O'Leary, K.A.1    Day, A.J.2    Needs, P.W.3
  • 126
    • 0032964858 scopus 로고    scopus 로고
    • Pharmacokinetics and bioavailability of the flavonol quercetin in humans
    • Graefe EU, Derendorf H, Veit M. Pharmacokinetics and bioavailability of the flavonol quercetin in humans. Int J Clin Pharmacol Ther 1999; 37 (5): 219-33
    • (1999) Int J Clin Pharmacol Ther , vol.37 , Issue.5 , pp. 219-233
    • Graefe, E.U.1    Derendorf, H.2    Veit, M.3
  • 127
    • 0033661837 scopus 로고    scopus 로고
    • Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers
    • Erlund I, Kosonen T, Alfthan G, et al. Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers. Eur J Clin Pharmacol 2000; 56 (8): 545-53
    • (2000) Eur J Clin Pharmacol , vol.56 , Issue.8 , pp. 545-553
    • Erlund, I.1    Kosonen, T.2    Alfthan, G.3
  • 128
    • 0032898331 scopus 로고    scopus 로고
    • Validated method for the quantitation of quercetin from human plasma using high-performance liquid chromatography with electrochemical detection
    • Erlund I, Alfthan G, Siren H, et al. Validated method for the quantitation of quercetin from human plasma using high-performance liquid chromatography with electrochemical detection. J Chromatogr B Biomed Sci Appl 1999; 727 (1-2): 179-89
    • (1999) J Chromatogr B Biomed Sci Appl , vol.727 , Issue.1-2 , pp. 179-189
    • Erlund, I.1    Alfthan, G.2    Siren, H.3
  • 129
    • 0347320505 scopus 로고    scopus 로고
    • In vitro studies indicate that miquelianin (quercetin 3-O-beta-D-glucuronopyranoside) is able to reach the CNS from the small intestine
    • Juergenliemk G, Boje K, Huewel S, et al. In vitro studies indicate that miquelianin (quercetin 3-O-beta-D-glucuronopyranoside) is able to reach the CNS from the small intestine. Planta Med 2003; 69 (11): 1013-7
    • (2003) Planta Med , vol.69 , Issue.11 , pp. 1013-1017
    • Juergenliemk, G.1    Boje, K.2    Huewel, S.3
  • 130
    • 0036747114 scopus 로고    scopus 로고
    • Transport of amentoflavone across the blood-brain barrier in vitro
    • Gutmann H, Bruggisser R, Schaffner W, et al. Transport of amentoflavone across the blood-brain barrier in vitro. Planta Med 2002; 68 (9): 804-7
    • (2002) Planta Med , vol.68 , Issue.9 , pp. 804-807
    • Gutmann, H.1    Bruggisser, R.2    Schaffner, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.