Selective serotonin reuptake inhibitors pathway

Pharmacogenetics and Genomics

Volumn 19, Issue 11, 2009, Pages 907-909

  Sangkuhl, Katrin ^a   Klein, Teri E ^a   Altman, Russ B ^a  

^a STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; BRAIN DERIVED NEUROTROPHIC FACTOR; CITALOPRAM; CYCLIC AMP; DIACYLGLYCEROL; FLUOXETINE; FLUVOXAMINE; INOSITOL 1,4,5 TRISPHOSPHATE; PAROXETINE; PHOSPHOLIPASE C BETA; RECEPTOR SUBUNIT; SEROTONIN; SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER; SERTRALINE; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; TRYPTOPHAN; TRYPTOPHAN HYDROXYLASE 2; VESICULAR MONOAMINE TRANSPORTER 2;

ARTICLE; EXOCYTOSIS; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; PRIORITY JOURNAL; PROTEIN VARIANT; SEROTONIN RELEASE; SEROTONIN UPTAKE; SIGNAL TRANSDUCTION; SYNAPSE VESICLE;

ANTIDEPRESSIVE AGENTS; HUMANS; METABOLIC NETWORKS AND PATHWAYS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, SEROTONIN; SECOND MESSENGER SYSTEMS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS;

EID: 74049087828     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e32833132cb     Document Type: Article

References (22)

1. Zhou M, Engel K, Wang J. Evidence for significant contribution of a newly identified monoamine transporter (PMAT) to serotonin uptake in the human brain. Biochem Pharmacol 2007; 73:147-154. (Pubitemid 44853932)
2. Struder HK, Weicker H. Physiology and pathophysiology of the serotonergic system and its implications on mental and physical performance. Part I. Int J Sports Med 2001; 22:467-481. (Pubitemid 32980382)
3. Walther DJ, Peter JU, Bashammakh S, Hortnagl H, Voits M, Fink H, et al. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 2003; 299:76. (Pubitemid 36042402)
4. Sakowski SA, Geddes TJ, Thomas DM, Levi E, Hatfield JS, Kuhn DM. Differential tissue distribution of tryptophan hydroxylase isoforms 1 and 2 as revealed with monospecific antibodies. Brain Res 2006; 1085:11-18. (Pubitemid 43728204)
5. Hoffman BJ, Hansson SR, Mezey E, Palkovits M. Localization and dynamic regulation of biogenic amine transporters in the mammalian central nervous system. Front Neuroendocrinol 1998; 19:187-231. (Pubitemid 28347696)
6. Boadle-Biber MC. Regulation of serotonin synthesis. Prog Biophys Mol Biol 1993; 60:1-15.
7. Briley M, Moret C. Neurobiological mechanisms involved in antidepressant therapies. Clin Neuropharmacol 1993; 16:387-400. (Pubitemid 23292094)
8. Bockaert J, Claeysen S, Becamel C, Dumuis A, Marin P. Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation. Cell Tissue Res 2006; 326: 553-572. (Pubitemid 44435826)
9. Raymond JR, Mukhin YV, Gelasco A, Turner J, Colllnsworth G, Gettys TW, et al. Multiplicity of mechanisms of serotonin receptor signal transduction. Pharmacol Ther 2001; 92:179-212. (Pubitemid 34251133)
10. Niesler B, Kapeller J, Hammer C, Rappold G. Serotonin type 3 receptor genes: HTR3A, B, C, D, E. Pharmacogenomics 2008; 9:501-504. (Pubitemid 351803911)
11. Hannon J, Hoyer D. Molecular biology of 5-HT receptors. Behav Brain Res 2008; 195:198-213.
12. Balu DT, Hoshaw BA, Malberg JE, Rosenzweig-Lipson S, Schechter LE, Lucki I. Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments. Brain Res. 2008; 1211:37-43.
13. Drago A, De Ronchi D, Serretti A. Pharmacogenetics of antidepressant response: an update. Hum Genomics. 2009; 3:257-274.
14. Quick MW. Regulating the conducting states of a mammalian serotonin transporter. Neuron 2003; 40:537-549.
15. Donati RJ, Rasenick MM. G protein signaling and the molecular basis of antidepressant action. Life Sci. 2003; 73:1-17. (Pubitemid 36519215)
16. Hiemke C, Hartter S. Pharmacokinetics of selective serotonin reuptake inhibitors. Pharmacol Ther 2000; 85:11-28.
17. Cipriani A, La Ferla T, Furukawa TA, Signoretti A, Nakagawa A, Churchill R, et al. Sertraline versus other antidepressive agents for depression. Cochrane Database Syst Rev 2009; CD006117.
18. Demyttenaere K, Jaspers L. Review: bupropion and SSRI-induced side effects. J Psychopharmacol 2008; 22:792-804.
19. Vidal R, Valdizan EM, Mostany R, Pazos A, Castro E. Long-term treatment with fluoxetine induces desensltization of 5-HT receptor-dependent signalling and functionality in rat brain. J Neurochem 2009; 110:1120-1127.
20. Hashimoto K. Emerging role of glutamate in the pathophysiology of major depressive disorder. Brain Res Rev 2009; [Epub ahead of print].
21. Serretti A, Artioli P. The pharmacogenomics of selective serotonin reuptake inhibitors. Pharmacogenomics J 2004; 4:233-244. (Pubitemid 39136766)
22. Thomas KL, Ellingrod VL. Pharmacogenetics of selective serotonin reuptake inhibitors and associated adverse drug reactions. Pharmacotherapy 2009; 29:822-831.