Slow actions of neuroactive steroids at GABAA receptors

Journal of Neuroscience

Volumn 24, Issue 30, 2004, Pages 6667-6675

  Shu, Hong Jin ^a   Eisenman, Lawrence N ^a   Jinadasa, Deepani ^a   Covey, Douglas F ^a   Zorumski, Charles F ^a   Mennerick, Steven ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Allopregnanolone; Anesthesia; GABA; Hippocampus; Inhibition; Neurosteroid

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ANESTHETIC AGENT; GAMMA CYCLODEXTRIN; NEUROSTEROID; SEDATIVE AGENT;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL MEMBRANE; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; LIGAND BINDING; MEMBRANE CURRENT; NERVE CELL EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION;

ANIMALS; BINDING SITES; CELL MEMBRANE; CELLS, CULTURED; CHLORIDES; GABA AGONISTS; GABA ANTAGONISTS; GAMMA-CYCLODEXTRINS; HIPPOCAMPUS; ION CHANNEL GATING; ION TRANSPORT; KINETICS; LIGANDS; NEURONS; OOCYTES; PATCH-CLAMP TECHNIQUES; PREGNANOLONE; PROTEIN BINDING; PYRIDAZINES; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; RNA, MESSENGER; TRANSFECTION; XENOPUS;

EID: 3342903485     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1399-04.2004     Document Type: Article

References (26)

1. Adam JM, Bennett DJ, Bom A, Clark JK, Feilden H, Hutchinson EJ, Palin R, Prosser A, Rees DC, Rosair GM, Stevenson D, Tarver GJ, Zhang MQ (2002) Cyclodextrin-derived host molecules as reversal agents for the neuromuscular blocker rocuronium bromide: synthesis and structure-activity relationships. J Med Chem 45:1806-1816.
2. Bekkers JM, Stevens CF (1991) Excitatory and inhibitory autaptic currents in isolated hippocampal neurons maintained in cell culture. Proc Natl Acad Sci USA 88:7834-7838.
3. A receptor channels. J Neurosci 21:9083-9091.
4. Bom A, Bradley M, Cameron K, Clark JK, Van Egmond J, Feilden H, MacLean EJ, Muir AW, Palin R, Rees DC, Zhang MQ (2002) A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic host. Angew Chem Int Ed Engl 41:266-270.
5. Brickley SG, CullCandy SG, Farrant M (1996) Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABA(A) receptors. J Physiol (Lond) 497:753-759.
6. Callachan H, Cottrell GA, Hather NY, Lambert JJ, Nooney JM, Peters JA (1987) Modulation of the GABAA receptor by progesterone metabolites. Proc R Soc Lond B Biol Sci 231:359-369.
7. Caraiscos VB, Elliott EM, You-Ten KE, Cheng VY, Belelli D, Newell JG, Jackson MF, Lambert JJ, Rosahl TW, Wafford KA, MacDonald JF, Orser BA (2004) Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors. Proc Natl Acad Sci USA 101:3662-3667.
8. Christian AE, Haynes MP, Phillips MC, Rothblat GH (1997) Use of cyclodextrins for manipulating cellular cholesterol content. J Lipid Res 38:2264-2272.
9. Cottrell GA, Lambert JJ, Peters JA (1987) Modulation of GABAA receptor activity by alphaxalone. Br J Pharmacol 90:491-500.
10. Haynes MP, Phillips MC, Rothblat GH (2000) Efflux of cholesterol from different cellular pools. Biochemistry 39:4508-4517.
11. Jones MV, Westbrook GL (1995) Desensitized states prolong GABAA channel responses to brief agonist pulses. Neuron 15:181-191.
12. A receptor. J Neurosci 18:8590-8604.
13. Lerma J, Herranz AS, Herreras O, Abraira V, Martin del Rio R (1986) In vivo determination of extracellular concentration of amino acids in the rat hippocampus. A method based on brain dialysis and computerized analysis. Brain Res 384:145-155.
14. Liu QY, Chang YH, Schaffner AE, Smith SV, Barker JL (2002) Allopregnanolone activates GABA(A) receptor/Cl(-) channels in a multiphasic manner in embryonic rat hippocampal neurons. J Neurophysiol 88:1147-1158.
15. Mennerick S, Que J, Benz A, Zorumski CF (1995) Passive and synaptic properties of neurons grown in microcultures and in mass cultures. J Neurophysiol 73:320-332.
16. Mennerick S, He Y, Jiang X, Manion B, Wang M, Shute AA, Benz A, Evers AS, Covey DF, Zorumski C (2004) Selective antagonism of 5α-reduced neurosteroid potentiation of GABA-A receptors. Mol Pharmacol 65:1191-1197.
17. Nusser Z, Mody I (2002) Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells. J Neurophysiol 87:2624-2628.
18. Ohtani Y, Irie T, Uekama K, Fukunaga K, Pitha J (1989) Differential effects of alpha-, beta- and gamma-cyclodextrins on human erythrocytes. Eur J Biochem 186:17-22.
19. A receptors. Neuron 4:759-765.
20. Rao A, Cha EM, Craig AM (2000) Mismatched appositions of presynaptic and postsynaptic components in isolated hippocampal neurons. J Neurosci 20:8344-8353.
21. Szejtli J (1998) Introduction and general overview of cyclodextrin chemistry. Chem Rev 98:1743-1754.
22. A receptor. J Neurosci 17:625-634.
23. Wang MD, Wahlstrom G, Backstrom T (1997) The regional brain distribution of the neurosteroids pregnenolone and pregnenolone sulfate following intravenous infusion. J Steroid Biochem Mol Biol 62:299-306.
24. Westover EJ, Covey DF, Brockman HL, Brown RE, Pike LJ (2003) Cholesterol depletion results in site-specific increases in epidermal growth factor receptor phosphorylation due to membrane level effects. Studies with cholesterol enantiomers. J Biol Chem 278:51125-51133.
25. A receptors containing the delta subunit. J Neurosci 22:1541-1549.
26. Yancey PG, Rodrigueza WV, Kilsdonk EP, Stoudt GW, Johnson WJ, Phillips MC, Rothblat GH (1996) Cellular cholesterol efflux mediated by cyclodextrins. Demonstration of kinetic pools and mechanism of efflux. J Biol Chem 271:16026-16034.