-
1
-
-
41049090456
-
The melanocortin 1 receptor and the UV response of human melanocytes-a shift in paradigm
-
Abdel-Malek Z.A., et al. The melanocortin 1 receptor and the UV response of human melanocytes-a shift in paradigm. Photochem. Photobiol. 2008, 84:501-508.
-
(2008)
Photochem. Photobiol.
, vol.84
, pp. 501-508
-
-
Abdel-Malek, Z.A.1
-
2
-
-
21544454681
-
Role of nuclear factor-kappa B in melanoma
-
Amiri K.I., Richmond A. Role of nuclear factor-kappa B in melanoma. Cancer Metastasis Rev. 2005, 24:301-313.
-
(2005)
Cancer Metastasis Rev.
, vol.24
, pp. 301-313
-
-
Amiri, K.I.1
Richmond, A.2
-
3
-
-
0035253672
-
Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression
-
Assoian R.K., Schwartz M.A. Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression. Curr. Opin. Genet. Dev. 2001, 11:48-53.
-
(2001)
Curr. Opin. Genet. Dev.
, vol.11
, pp. 48-53
-
-
Assoian, R.K.1
Schwartz, M.A.2
-
4
-
-
0029874138
-
The NF-kappa B and I kappa B proteins: new discoveries and insights
-
Baldwin A.S. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu. Rev. Immunol. 1996, 14:649-683.
-
(1996)
Annu. Rev. Immunol.
, vol.14
, pp. 649-683
-
-
Baldwin, A.S.1
-
5
-
-
0028809479
-
The mouse B-raf gene encodes multiple protein isoforms with tissue-specific expression
-
Barnier J.V., et al. The mouse B-raf gene encodes multiple protein isoforms with tissue-specific expression. J. Biol. Chem. 1995, 270:23381-23389.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 23381-23389
-
-
Barnier, J.V.1
-
6
-
-
0030764345
-
C-Rel arrests the proliferation of HeLa cells and affects critical regulators of the G1/S-phase transition
-
Bash J., et al. c-Rel arrests the proliferation of HeLa cells and affects critical regulators of the G1/S-phase transition. Mol. Cell. Biol. 1997, 17:6526-6536.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 6526-6536
-
-
Bash, J.1
-
7
-
-
0027412665
-
Prognostic significance of K-ras mutations in colorectal carcinoma
-
Benhattar J., et al. Prognostic significance of K-ras mutations in colorectal carcinoma. Gastroenterology 1993, 104:1044-1048.
-
(1993)
Gastroenterology
, vol.104
, pp. 1044-1048
-
-
Benhattar, J.1
-
8
-
-
19644397029
-
Adhesion control of cyclin D1 and p27Kip1 levels is deregulated in melanoma cells through BRAF-MEK-ERK signaling
-
Bhatt K.V., et al. Adhesion control of cyclin D1 and p27Kip1 levels is deregulated in melanoma cells through BRAF-MEK-ERK signaling. Oncogene 2005, 24:3459-3471.
-
(2005)
Oncogene
, vol.24
, pp. 3459-3471
-
-
Bhatt, K.V.1
-
9
-
-
0032508674
-
Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF-kappa B
-
Bond M., et al. Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF-kappa B. FEBS Lett. 1998, 435:29-34.
-
(1998)
FEBS Lett.
, vol.435
, pp. 29-34
-
-
Bond, M.1
-
10
-
-
0021915337
-
Structure and biological activity of human homologs of the raf/mil oncogene
-
Bonner T.I., et al. Structure and biological activity of human homologs of the raf/mil oncogene. Mol. Cell. Biol. 1985, 5:1400-1407.
-
(1985)
Mol. Cell. Biol.
, vol.5
, pp. 1400-1407
-
-
Bonner, T.I.1
-
11
-
-
1542315627
-
NF-kappaB binds to a polymorphic repressor element in the MMP-3 promoter
-
Borghaei R.C., et al. NF-kappaB binds to a polymorphic repressor element in the MMP-3 promoter. Biochem. Biophys. Res. Commun. 2004, 316:182-188.
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.316
, pp. 182-188
-
-
Borghaei, R.C.1
-
12
-
-
0034734896
-
ABC Of colorectal cancer: epidemiology
-
Boyle P., Langman J.S. ABC Of colorectal cancer: epidemiology. Br. Med. J. 2000, 321:805-808.
-
(2000)
Br. Med. J.
, vol.321
, pp. 805-808
-
-
Boyle, P.1
Langman, J.S.2
-
13
-
-
0034127724
-
Cyclic AMP a key messenger in the regulation of skin pigmentation
-
Busca R., Ballotti R. Cyclic AMP a key messenger in the regulation of skin pigmentation. Pigment Cell Res. 2000, 13:60-69.
-
(2000)
Pigment Cell Res.
, vol.13
, pp. 60-69
-
-
Busca, R.1
Ballotti, R.2
-
14
-
-
79955751512
-
BRAFV600E: implications for carcinogenesis and molecular therapy
-
Cantwell-Dorris E.R., et al. BRAFV600E: implications for carcinogenesis and molecular therapy. Mol. Cancer Ther. 2011, 10:385-394.
-
(2011)
Mol. Cancer Ther.
, vol.10
, pp. 385-394
-
-
Cantwell-Dorris, E.R.1
-
15
-
-
84055222114
-
Role of BRAF in thyroid oncogenesis
-
Caronia L.M., et al. Role of BRAF in thyroid oncogenesis. Clin. Cancer Res. 2011, 17:7511-7517.
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 7511-7517
-
-
Caronia, L.M.1
-
16
-
-
0029164688
-
A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function
-
Catling A.D., et al. A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function. Mol. Cell. Biol. 1995, 15:5214-5225.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 5214-5225
-
-
Catling, A.D.1
-
17
-
-
0035504081
-
Transcriptional regulation of bcl-2 by nuclear factor kappa B and its significance in prostate cancer
-
Catz S.D., Johnson J.L. Transcriptional regulation of bcl-2 by nuclear factor kappa B and its significance in prostate cancer. Oncogene 2001, 20:7342-7351.
-
(2001)
Oncogene
, vol.20
, pp. 7342-7351
-
-
Catz, S.D.1
Johnson, J.L.2
-
18
-
-
33645229806
-
Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein
-
Chadee D.N., et al. Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:4463-4468.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 4463-4468
-
-
Chadee, D.N.1
-
19
-
-
33847072340
-
RET/PTC rearrangements and BRAF mutations in thyroid tumorigenesis
-
Ciampi R., Nikiforov Y.E. RET/PTC rearrangements and BRAF mutations in thyroid tumorigenesis. Endocrinology 2007, 148:936-941.
-
(2007)
Endocrinology
, vol.148
, pp. 936-941
-
-
Ciampi, R.1
Nikiforov, Y.E.2
-
20
-
-
0038664387
-
BRAF mutation in papillary thyroid carcinoma
-
Cohen Y., et al. BRAF mutation in papillary thyroid carcinoma. J. Natl. Cancer Inst. 2003, 95:625-627.
-
(2003)
J. Natl. Cancer Inst.
, vol.95
, pp. 625-627
-
-
Cohen, Y.1
-
21
-
-
0141483383
-
Adhesion-dependent activation of the ERK1/2 cascade is by-passed in melanoma cells
-
Conner S.R., et al. Adhesion-dependent activation of the ERK1/2 cascade is by-passed in melanoma cells. J. Biol. Chem. 2003, 278:34548-34554.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 34548-34554
-
-
Conner, S.R.1
-
22
-
-
1642553461
-
The dark side of Ras: regulation of apoptosis
-
Cox A.D., Der C.J. The dark side of Ras: regulation of apoptosis. Oncogene 2003, 22:8999-9006.
-
(2003)
Oncogene
, vol.22
, pp. 8999-9006
-
-
Cox, A.D.1
Der, C.J.2
-
23
-
-
27844567142
-
Distinct sets of genetic alterations in melanoma
-
Curtin J.A., et al. Distinct sets of genetic alterations in melanoma. N. Engl. J. Med. 2005, 353:2135-2147.
-
(2005)
N. Engl. J. Med.
, vol.353
, pp. 2135-2147
-
-
Curtin, J.A.1
-
24
-
-
4043055279
-
BRAF alterations are associated with complex mutational profiles in malignant melanoma
-
Daniotti M., et al. BRAF alterations are associated with complex mutational profiles in malignant melanoma. Oncogene 2004, 23:5968-5977.
-
(2004)
Oncogene
, vol.23
, pp. 5968-5977
-
-
Daniotti, M.1
-
25
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H., et al. Mutations of the BRAF gene in human cancer. Nature 2002, 417:949-954.
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
-
26
-
-
0033135049
-
Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression
-
Deng G., et al. Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression. Cancer Res. 1999, 59:2029-2033.
-
(1999)
Cancer Res.
, vol.59
, pp. 2029-2033
-
-
Deng, G.1
-
27
-
-
0035808413
-
2-Acetylaminofluorene up-regulates rat mdr1b expression through generating reactive oxygen species that activate NF-kappa B pathway
-
Deng L., et al. 2-Acetylaminofluorene up-regulates rat mdr1b expression through generating reactive oxygen species that activate NF-kappa B pathway. J. Biol. Chem. 2001, 276:413-420.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 413-420
-
-
Deng, L.1
-
28
-
-
0032522738
-
IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
-
Deveraux Q.L., et al. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J. 1998, 17:2215-2223.
-
(1998)
EMBO J.
, vol.17
, pp. 2215-2223
-
-
Deveraux, Q.L.1
-
29
-
-
33846201272
-
New insight into BRAF mutations in cancer
-
Dhomen N., Marais R. New insight into BRAF mutations in cancer. Curr. Opin. Genet. Dev. 2007, 17:31-39.
-
(2007)
Curr. Opin. Genet. Dev.
, vol.17
, pp. 31-39
-
-
Dhomen, N.1
Marais, R.2
-
30
-
-
65649090993
-
BRAF signaling and targeted therapies in melanoma
-
ix
-
Dhomen N., Marais R. BRAF signaling and targeted therapies in melanoma. Hematol. Oncol. Clin. North Am. 2009, 23:529-545. ix.
-
(2009)
Hematol. Oncol. Clin. North Am.
, vol.23
, pp. 529-545
-
-
Dhomen, N.1
Marais, R.2
-
31
-
-
0026081804
-
Peroxidase as an alternative to tyrosinase in the oxidative polymerization of 5,6-dihydroxyindoles to melanin(s)
-
d'Ischia M., et al. Peroxidase as an alternative to tyrosinase in the oxidative polymerization of 5,6-dihydroxyindoles to melanin(s). Biochim. Biophys. Acta 1991, 1073:423-430.
-
(1991)
Biochim. Biophys. Acta
, vol.1073
, pp. 423-430
-
-
d'Ischia, M.1
-
32
-
-
13244264729
-
Progressive methylation during the serrated neoplasia pathway of the colorectum
-
Dong S.M., et al. Progressive methylation during the serrated neoplasia pathway of the colorectum. Mod. Pathol. 2005, 18:170-178.
-
(2005)
Mod. Pathol.
, vol.18
, pp. 170-178
-
-
Dong, S.M.1
-
33
-
-
33750284658
-
In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling
-
Dumaz N., et al. In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling. Cancer Res. 2006, 66:9483-9491.
-
(2006)
Cancer Res.
, vol.66
, pp. 9483-9491
-
-
Dumaz, N.1
-
34
-
-
34447134910
-
BRAF mutations in papillary thyroid carcinomas inhibit genes involved in iodine metabolism
-
Durante C., et al. BRAF mutations in papillary thyroid carcinomas inhibit genes involved in iodine metabolism. J. Clin. Endocrinol. Metab. 2007, 92:2840-2843.
-
(2007)
J. Clin. Endocrinol. Metab.
, vol.92
, pp. 2840-2843
-
-
Durante, C.1
-
35
-
-
0032793067
-
B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway
-
Erhardt P., et al. B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway. Mol. Cell. Biol. 1999, 19:5308-5315.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 5308-5315
-
-
Erhardt, P.1
-
36
-
-
0027364980
-
Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase
-
Fabian J.R., et al. Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase. Mol. Cell. Biol. 1993, 13:7170-7179.
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 7170-7179
-
-
Fabian, J.R.1
-
37
-
-
1342299898
-
Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas
-
Fransen K., et al. Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas. Carcinogenesis 2004, 25:527-533.
-
(2004)
Carcinogenesis
, vol.25
, pp. 527-533
-
-
Fransen, K.1
-
38
-
-
5444227865
-
Guilty as charged: B-RAF is a human oncogene
-
Garnett M.J., Marais R. Guilty as charged: B-RAF is a human oncogene. Cancer Cell 2004, 6:313-319.
-
(2004)
Cancer Cell
, vol.6
, pp. 313-319
-
-
Garnett, M.J.1
Marais, R.2
-
39
-
-
29144462587
-
Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization
-
Garnett M.J., et al. Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization. Mol. Cell 2005, 20:963-969.
-
(2005)
Mol. Cell
, vol.20
, pp. 963-969
-
-
Garnett, M.J.1
-
40
-
-
34247647905
-
Comprehensive evaluation of allele frequency differences of MC1R variants across populations
-
Gerstenblith M.R., et al. Comprehensive evaluation of allele frequency differences of MC1R variants across populations. Hum. Mutat. 2007, 28:495-505.
-
(2007)
Hum. Mutat.
, vol.28
, pp. 495-505
-
-
Gerstenblith, M.R.1
-
41
-
-
17744388986
-
The role of B-RAF in melanoma
-
Gray-Schopfer V.C., et al. The role of B-RAF in melanoma. Cancer Metastasis Rev. 2005, 24:165-183.
-
(2005)
Cancer Metastasis Rev.
, vol.24
, pp. 165-183
-
-
Gray-Schopfer, V.C.1
-
42
-
-
1542328234
-
The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer
-
Greten F.R., Karin M. The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer. Cancer Lett. 2004, 206:193-199.
-
(2004)
Cancer Lett.
, vol.206
, pp. 193-199
-
-
Greten, F.R.1
Karin, M.2
-
43
-
-
66749153133
-
BRAFV600E mutation and X-linked inhibitor of apoptosis expression in papillary thyroid carcinoma
-
Gu L.Q., et al. BRAFV600E mutation and X-linked inhibitor of apoptosis expression in papillary thyroid carcinoma. Thyroid 2009, 19:347-354.
-
(2009)
Thyroid
, vol.19
, pp. 347-354
-
-
Gu, L.Q.1
-
44
-
-
0034282892
-
Negative regulation of the serine/threonine kinase B-Raf by Akt
-
Guan K.L., et al. Negative regulation of the serine/threonine kinase B-Raf by Akt. J. Biol. Chem. 2000, 275:27354-27359.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 27354-27359
-
-
Guan, K.L.1
-
45
-
-
0032588186
-
NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1
-
Guttridge D.C., et al. NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol. Cell. Biol. 1999, 19:5785-5799.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 5785-5799
-
-
Guttridge, D.C.1
-
46
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell 2000, 100:57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
47
-
-
0141816881
-
Suppression of BRAF(V599E) in human melanoma abrogates transformation
-
Hingorani S.R., et al. Suppression of BRAF(V599E) in human melanoma abrogates transformation. Cancer Res. 2003, 63:5198-5202.
-
(2003)
Cancer Res.
, vol.63
, pp. 5198-5202
-
-
Hingorani, S.R.1
-
48
-
-
0032588170
-
NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition
-
Hinz M., et al. NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition. Mol. Cell. Biol. 1999, 19:2690-2698.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 2690-2698
-
-
Hinz, M.1
-
49
-
-
2942607408
-
Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis
-
Houben R., et al. Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis. J. Carcinog. 2004, 3:6.
-
(2004)
J. Carcinog.
, vol.3
, pp. 6
-
-
Houben, R.1
-
50
-
-
0036467578
-
Anchorage-dependent ERK signaling-mechanisms and consequences
-
Howe A.K., et al. Anchorage-dependent ERK signaling-mechanisms and consequences. Curr. Opin. Genet. Dev. 2002, 12:30-35.
-
(2002)
Curr. Opin. Genet. Dev.
, vol.12
, pp. 30-35
-
-
Howe, A.K.1
-
51
-
-
0022527259
-
Actively transcribed genes in the raf oncogene group, located on the X chromosome in mouse and human
-
Huebner K., et al. Actively transcribed genes in the raf oncogene group, located on the X chromosome in mouse and human. Proc. Natl. Acad. Sci. U. S. A. 1986, 83:3934-3938.
-
(1986)
Proc. Natl. Acad. Sci. U. S. A.
, vol.83
, pp. 3934-3938
-
-
Huebner, K.1
-
52
-
-
0032535770
-
A National Cancer Data Base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985-1995 [see commetns]
-
Hundahl S.A., et al. A National Cancer Data Base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985-1995 [see commetns]. Cancer 1998, 83:2638-2648.
-
(1998)
Cancer
, vol.83
, pp. 2638-2648
-
-
Hundahl, S.A.1
-
53
-
-
0026672245
-
Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1)
-
Iademarco M.F., et al. Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1). J. Biol. Chem. 1992, 267:16323-16329.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 16323-16329
-
-
Iademarco, M.F.1
-
54
-
-
0024026952
-
B-raf, a new member of the raf family, is activated by DNA rearrangement
-
Ikawa S., et al. B-raf, a new member of the raf family, is activated by DNA rearrangement. Mol. Cell. Biol. 1988, 8:2651-2654.
-
(1988)
Mol. Cell. Biol.
, vol.8
, pp. 2651-2654
-
-
Ikawa, S.1
-
55
-
-
20344365798
-
BRAF mutation associated with dysregulation of apoptosis in human colorectal neoplasms
-
Ikehara N., et al. BRAF mutation associated with dysregulation of apoptosis in human colorectal neoplasms. Int. J. Cancer 2005, 115:943-950.
-
(2005)
Int. J. Cancer
, vol.115
, pp. 943-950
-
-
Ikehara, N.1
-
56
-
-
10744232660
-
Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors
-
Ikenoue T., et al. Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors. Cancer Res. 2003, 63:8132-8137.
-
(2003)
Cancer Res.
, vol.63
, pp. 8132-8137
-
-
Ikenoue, T.1
-
57
-
-
2442660578
-
Different effects of point mutations within the B-Raf glycine-rich loop in colorectal tumors on mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase and nuclear factor kappaB pathway and cellular transformation
-
Ikenoue T., et al. Different effects of point mutations within the B-Raf glycine-rich loop in colorectal tumors on mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase and nuclear factor kappaB pathway and cellular transformation. Cancer Res. 2004, 64:3428-3435.
-
(2004)
Cancer Res.
, vol.64
, pp. 3428-3435
-
-
Ikenoue, T.1
-
58
-
-
0032560489
-
The Eleventh Datta Lecture. The structural basis for substrate recognition and control by protein kinases
-
Johnson L.N., et al. The Eleventh Datta Lecture. The structural basis for substrate recognition and control by protein kinases. FEBS Lett. 1998, 430:1-11.
-
(1998)
FEBS Lett.
, vol.430
, pp. 1-11
-
-
Johnson, L.N.1
-
59
-
-
4344584872
-
B-RAF is a therapeutic target in melanoma
-
Karasarides M., et al. B-RAF is a therapeutic target in melanoma. Oncogene 2004, 23:6292-6298.
-
(2004)
Oncogene
, vol.23
, pp. 6292-6298
-
-
Karasarides, M.1
-
60
-
-
1442356717
-
NF-kappa B in the vascular progression of melanoma
-
Kashani-Sabet M., et al. NF-kappa B in the vascular progression of melanoma. J. Clin. Oncol. 2004, 22:617-623.
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 617-623
-
-
Kashani-Sabet, M.1
-
61
-
-
0030772159
-
Helicobacter pylori infection activates NF-kappa B in gastric epithelial cells
-
Keates S., et al. Helicobacter pylori infection activates NF-kappa B in gastric epithelial cells. Gastroenterology 1997, 113:1099-1109.
-
(1997)
Gastroenterology
, vol.113
, pp. 1099-1109
-
-
Keates, S.1
-
62
-
-
0032522816
-
High-intensity Raf signals convert mitotic cell cycling into cellular growth
-
Kerkhoff E., Rapp U.R. High-intensity Raf signals convert mitotic cell cycling into cellular growth. Cancer Res. 1998, 58:1636-1640.
-
(1998)
Cancer Res.
, vol.58
, pp. 1636-1640
-
-
Kerkhoff, E.1
Rapp, U.R.2
-
63
-
-
70350534499
-
Oncogenic KRAS and BRAF differentially regulate hypoxia-inducible factor-1alpha and -2alpha in colon cancer
-
Kikuchi H., et al. Oncogenic KRAS and BRAF differentially regulate hypoxia-inducible factor-1alpha and -2alpha in colon cancer. Cancer Res. 2009, 69:8499-8506.
-
(2009)
Cancer Res.
, vol.69
, pp. 8499-8506
-
-
Kikuchi, H.1
-
64
-
-
0030592517
-
Lessons from hereditary colorectal cancer
-
Kinzler K.W., Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996, 87:159-170.
-
(1996)
Cell
, vol.87
, pp. 159-170
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
65
-
-
0037150228
-
Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling
-
Kuo M.T., et al. Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling. Oncogene 2002, 21:1945-1954.
-
(2002)
Oncogene
, vol.21
, pp. 1945-1954
-
-
Kuo, M.T.1
-
66
-
-
0034024114
-
Cyclin D1 expression in oral squamous cell carcinomas: clinicopathological relevance and correlation with p53 expression
-
Lam K.Y., et al. Cyclin D1 expression in oral squamous cell carcinomas: clinicopathological relevance and correlation with p53 expression. J. Oral Pathol. Med. 2000, 29:167-172.
-
(2000)
J. Oral Pathol. Med.
, vol.29
, pp. 167-172
-
-
Lam, K.Y.1
-
67
-
-
33646684498
-
Papillary carcinoma of thyroid: a 30-year clinicopathological review of the histological variants
-
Lam A.K., et al. Papillary carcinoma of thyroid: a 30-year clinicopathological review of the histological variants. Endocr Pathol 2005, 16:323-330.
-
(2005)
Endocr Pathol
, vol.16
, pp. 323-330
-
-
Lam, A.K.1
-
68
-
-
47549110163
-
Quantitative analysis of survivin in colorectal adenocarcinoma: increased expression and correlation with telomerase activity
-
Lam A.K., et al. Quantitative analysis of survivin in colorectal adenocarcinoma: increased expression and correlation with telomerase activity. Hum. Pathol. 2008, 39:1229-1233.
-
(2008)
Hum. Pathol.
, vol.39
, pp. 1229-1233
-
-
Lam, A.K.1
-
69
-
-
33746589029
-
MC1R germline variants confer risk for BRAF-mutant melanoma
-
Landi M.T., et al. MC1R germline variants confer risk for BRAF-mutant melanoma. Science 2006, 313:521-522.
-
(2006)
Science
, vol.313
, pp. 521-522
-
-
Landi, M.T.1
-
70
-
-
33947290100
-
Suppression of BRAF/MEK/MAP kinase pathway restores expression of iodide-metabolizing genes in thyroid cells expressing the V600E BRAF mutant
-
Liu D., et al. Suppression of BRAF/MEK/MAP kinase pathway restores expression of iodide-metabolizing genes in thyroid cells expressing the V600E BRAF mutant. Clin. Cancer Res. 2007, 13:1341-1349.
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 1341-1349
-
-
Liu, D.1
-
71
-
-
47949096781
-
Cancer-related inflammation
-
Mantovani A., et al. Cancer-related inflammation. Nature 2008, 454:436-444.
-
(2008)
Nature
, vol.454
, pp. 436-444
-
-
Mantovani, A.1
-
72
-
-
0029006126
-
Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation
-
Marais R., et al. Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation. EMBO J. 1995, 14:3136-3145.
-
(1995)
EMBO J.
, vol.14
, pp. 3136-3145
-
-
Marais, R.1
-
73
-
-
0031041171
-
Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases
-
Marais R., et al. Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases. J. Biol. Chem. 1997, 272:4378-4383.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 4378-4383
-
-
Marais, R.1
-
74
-
-
0028872649
-
Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation
-
Marshall C.J. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 1995, 80:179-185.
-
(1995)
Cell
, vol.80
, pp. 179-185
-
-
Marshall, C.J.1
-
75
-
-
0033561041
-
Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation
-
Mason C.S., et al. Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation. EMBO J. 1999, 18:2137-2148.
-
(1999)
EMBO J.
, vol.18
, pp. 2137-2148
-
-
Mason, C.S.1
-
76
-
-
23244447037
-
BRAFE600-associated senescence-like cell cycle arrest of human naevi
-
Michaloglou C., et al. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 2005, 436:720-724.
-
(2005)
Nature
, vol.436
, pp. 720-724
-
-
Michaloglou, C.1
-
77
-
-
0034743199
-
NF-kappaB signals induce the expression of c-FLIP
-
Micheau O., et al. NF-kappaB signals induce the expression of c-FLIP. Mol. Cell. Biol. 2001, 21:5299-5305.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 5299-5305
-
-
Micheau, O.1
-
78
-
-
34249785078
-
Role of BRAF-V600E in the serrated pathway of colorectal tumourigenesis
-
Minoo P., et al. Role of BRAF-V600E in the serrated pathway of colorectal tumourigenesis. J. Pathol. 2007, 212:124-133.
-
(2007)
J. Pathol.
, vol.212
, pp. 124-133
-
-
Minoo, P.1
-
79
-
-
0021711728
-
Serine- and threonine-specific protein kinase activities of purified gag-mil and gag-raf proteins
-
Moelling K., et al. Serine- and threonine-specific protein kinase activities of purified gag-mil and gag-raf proteins. Nature 1984, 312:558-561.
-
(1984)
Nature
, vol.312
, pp. 558-561
-
-
Moelling, K.1
-
81
-
-
0027168907
-
Identification of the major phosphorylation sites of the Raf-1 kinase
-
Morrison D.K., et al. Identification of the major phosphorylation sites of the Raf-1 kinase. J. Biol. Chem. 1993, 268:17309-17316.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 17309-17316
-
-
Morrison, D.K.1
-
82
-
-
0141453014
-
Clinical implication of hot spot BRAF mutation, V599E, in papillary thyroid cancers
-
Namba H., et al. Clinical implication of hot spot BRAF mutation, V599E, in papillary thyroid cancers. J. Clin. Endocrinol. Metab. 2003, 88:4393-4397.
-
(2003)
J. Clin. Endocrinol. Metab.
, vol.88
, pp. 4393-4397
-
-
Namba, H.1
-
83
-
-
0029923970
-
Hydrogen peroxide generation associated with the oxidations of the eumelanin precursors 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid
-
Nappi A.J., Vass E. Hydrogen peroxide generation associated with the oxidations of the eumelanin precursors 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid. Melanoma Res. 1996, 6:341-349.
-
(1996)
Melanoma Res.
, vol.6
, pp. 341-349
-
-
Nappi, A.J.1
Vass, E.2
-
84
-
-
1442274588
-
Quantitative measures of the effect of the melanocortin 1 receptor on human pigmentary status
-
Naysmith L., et al. Quantitative measures of the effect of the melanocortin 1 receptor on human pigmentary status. J. Invest. Dermatol. 2004, 122:423-428.
-
(2004)
J. Invest. Dermatol.
, vol.122
, pp. 423-428
-
-
Naysmith, L.1
-
85
-
-
0032169043
-
Expression of P-glycoprotein, a multidrug-resistance gene product, is induced by radiotherapy in patients with oral squamous cell carcinoma
-
Ng I.O., et al. Expression of P-glycoprotein, a multidrug-resistance gene product, is induced by radiotherapy in patients with oral squamous cell carcinoma. Cancer 1998, 83:851-857.
-
(1998)
Cancer
, vol.83
, pp. 851-857
-
-
Ng, I.O.1
-
86
-
-
10744222003
-
BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas
-
Nikiforova M.N., et al. BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas. J. Clin. Endocrinol. Metab. 2003, 88:5399-5404.
-
(2003)
J. Clin. Endocrinol. Metab.
, vol.88
, pp. 5399-5404
-
-
Nikiforova, M.N.1
-
88
-
-
84879619977
-
Clinicopathological relevance of BRAF mutations in human cancer
-
Pakneshan S., et al. Clinicopathological relevance of BRAF mutations in human cancer. Pathology 2013, 45:346-356.
-
(2013)
Pathology
, vol.45
, pp. 346-356
-
-
Pakneshan, S.1
-
89
-
-
33751549248
-
BRAFV600E promotes invasiveness of thyroid cancer cells through nuclear factor kappaB activation
-
Palona I., et al. BRAFV600E promotes invasiveness of thyroid cancer cells through nuclear factor kappaB activation. Endocrinology 2006, 147:5699-5707.
-
(2006)
Endocrinology
, vol.147
, pp. 5699-5707
-
-
Palona, I.1
-
90
-
-
0037372340
-
Frequent CpG island methylation in serrated adenomas of the colorectum
-
Park S.J., et al. Frequent CpG island methylation in serrated adenomas of the colorectum. Am. J. Pathol. 2003, 162:815-822.
-
(2003)
Am. J. Pathol.
, vol.162
, pp. 815-822
-
-
Park, S.J.1
-
91
-
-
13444258032
-
BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma
-
Patton E.E., et al. BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr. Biol. 2005, 15:249-254.
-
(2005)
Curr. Biol.
, vol.15
, pp. 249-254
-
-
Patton, E.E.1
-
92
-
-
4644324186
-
NF-kappaB functions as a tumour promoter in inflammation-associated cancer
-
Pikarsky E., et al. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 2004, 431:461-466.
-
(2004)
Nature
, vol.431
, pp. 461-466
-
-
Pikarsky, E.1
-
93
-
-
21044448948
-
Silencing of the tumor suppressor gene SLC5A8 is associated with BRAF mutations in classical papillary thyroid carcinomas
-
Porra V., et al. Silencing of the tumor suppressor gene SLC5A8 is associated with BRAF mutations in classical papillary thyroid carcinomas. J. Clin. Endocrinol. Metab. 2005, 90:3028-3035.
-
(2005)
J. Clin. Endocrinol. Metab.
, vol.90
, pp. 3028-3035
-
-
Porra, V.1
-
94
-
-
20744447485
-
Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells
-
Pruitt K., et al. Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells. J. Biol. Chem. 2005, 280:23363-23370.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 23363-23370
-
-
Pruitt, K.1
-
95
-
-
0037194728
-
Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status
-
Rajagopalan H., et al. Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature 2002, 418:934.
-
(2002)
Nature
, vol.418
, pp. 934
-
-
Rajagopalan, H.1
-
96
-
-
0343492260
-
Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus
-
Rapp U.R., et al. Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus. Proc. Natl. Acad. Sci. U. S. A. 1983, 80:4218-4222.
-
(1983)
Proc. Natl. Acad. Sci. U. S. A.
, vol.80
, pp. 4218-4222
-
-
Rapp, U.R.1
-
97
-
-
1442359847
-
Bcl-2 proteins: master switches at the intersection of death signaling and the survival control by Raf kinases
-
Rapp U.R., et al. Bcl-2 proteins: master switches at the intersection of death signaling and the survival control by Raf kinases. Biochim. Biophys. Acta 2004, 1644:149-158.
-
(2004)
Biochim. Biophys. Acta
, vol.1644
, pp. 149-158
-
-
Rapp, U.R.1
-
98
-
-
0035067368
-
Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-kappaB
-
Ravi R., et al. Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-kappaB. Nat. Cell Biol. 2001, 3:409-416.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 409-416
-
-
Ravi, R.1
-
99
-
-
33645964942
-
The oncogene BRAF V600E is associated with a high risk of recurrence and less differentiated papillary thyroid carcinoma due to the impairment of Na+/I- targeting to the membrane
-
Riesco-Eizaguirre G., et al. The oncogene BRAF V600E is associated with a high risk of recurrence and less differentiated papillary thyroid carcinoma due to the impairment of Na+/I- targeting to the membrane. Endocr. Relat. Cancer 2006, 13:257-269.
-
(2006)
Endocr. Relat. Cancer
, vol.13
, pp. 257-269
-
-
Riesco-Eizaguirre, G.1
-
100
-
-
0030898417
-
Mitogen-activated protein kinase pathways
-
Robinson M.J., Cobb M.H. Mitogen-activated protein kinase pathways. Curr. Opin. Cell Biol. 1997, 9:180-186.
-
(1997)
Curr. Opin. Cell Biol.
, vol.9
, pp. 180-186
-
-
Robinson, M.J.1
Cobb, M.H.2
-
101
-
-
0034283023
-
Vascular endothelial growth factor, interleukin 8, platelet-derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma xenografts
-
Rofstad E.K., Halsor E.F. Vascular endothelial growth factor, interleukin 8, platelet-derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma xenografts. Cancer Res. 2000, 60:4932-4938.
-
(2000)
Cancer Res.
, vol.60
, pp. 4932-4938
-
-
Rofstad, E.K.1
Halsor, E.F.2
-
102
-
-
77956124562
-
RAF protein-serine/threonine kinases: structure and regulation
-
Roskoski J.R. RAF protein-serine/threonine kinases: structure and regulation. Biochem. Biophys. Res. Commun. 2010, 399:313-317.
-
(2010)
Biochem. Biophys. Res. Commun.
, vol.399
, pp. 313-317
-
-
Roskoski, J.R.1
-
103
-
-
14644429805
-
MC1R and the response of melanocytes to ultraviolet radiation
-
Rouzaud F., et al. MC1R and the response of melanocytes to ultraviolet radiation. Mutat. Res. Fundam. Mol. Mech. Mutagen. 2005, 571:133-152.
-
(2005)
Mutat. Res. Fundam. Mol. Mech. Mutagen.
, vol.571
, pp. 133-152
-
-
Rouzaud, F.1
-
104
-
-
33644786244
-
Regulation and role of Raf-1/B-Raf heterodimerization
-
Rushworth L.K., et al. Regulation and role of Raf-1/B-Raf heterodimerization. Mol. Cell. Biol. 2006, 26:2262-2272.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 2262-2272
-
-
Rushworth, L.K.1
-
105
-
-
84884413106
-
Co-regulatory potential of vascular endothelial growth factor-A and vascular endothelial growth factor-C in thyroid carcinoma
-
Salajegheh A., et al. Co-regulatory potential of vascular endothelial growth factor-A and vascular endothelial growth factor-C in thyroid carcinoma. Hum Pathol. 2013, 44:2204-2212.
-
(2013)
Hum Pathol.
, vol.44
, pp. 2204-2212
-
-
Salajegheh, A.1
-
106
-
-
78650257143
-
Single nucleotide polymorphisms and mRNA expression of VEGF-A in papillary thyroid carcinoma: potential markers for aggressive phenotypes
-
Salajegheh A., et al. Single nucleotide polymorphisms and mRNA expression of VEGF-A in papillary thyroid carcinoma: potential markers for aggressive phenotypes. Eur. J. Surg. Oncol. 2011, 37:93-99.
-
(2011)
Eur. J. Surg. Oncol.
, vol.37
, pp. 93-99
-
-
Salajegheh, A.1
-
107
-
-
0030871667
-
High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1
-
Sewing A., et al. High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1. Mol. Cell. Biol. 1997, 17:5588-5597.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 5588-5597
-
-
Sewing, A.1
-
108
-
-
79952985927
-
Correlation between BRAF mutation and the clinicopathological parameters in papillary thyroid carcinoma with particular reference to follicular variant
-
Smith R.A., et al. Correlation between BRAF mutation and the clinicopathological parameters in papillary thyroid carcinoma with particular reference to follicular variant. Hum. Pathol. 2011, 42:500-506.
-
(2011)
Hum. Pathol.
, vol.42
, pp. 500-506
-
-
Smith, R.A.1
-
109
-
-
0025266334
-
Expression of raf family proto-oncogenes in normal mouse tissues
-
Storm S.M., et al. Expression of raf family proto-oncogenes in normal mouse tissues. Oncogene 1990, 5:345-351.
-
(1990)
Oncogene
, vol.5
, pp. 345-351
-
-
Storm, S.M.1
-
110
-
-
0037902558
-
The role of melanocortin-1 receptor polymorphism in skin cancer risk phenotypes
-
Sturm R.A., et al. The role of melanocortin-1 receptor polymorphism in skin cancer risk phenotypes. Pigment Cell Res. 2003, 16:266-272.
-
(2003)
Pigment Cell Res.
, vol.16
, pp. 266-272
-
-
Sturm, R.A.1
-
111
-
-
77951020685
-
BRAF mutation in papillary thyroid carcinoma: pathogenic role and clinical implications
-
Tang K.T., Lee C.H. BRAF mutation in papillary thyroid carcinoma: pathogenic role and clinical implications. J. Chin. Med. Assoc. 2010, 73:113-128.
-
(2010)
J. Chin. Med. Assoc.
, vol.73
, pp. 113-128
-
-
Tang, K.T.1
Lee, C.H.2
-
112
-
-
0036163763
-
Apoptosis index and apoptosis-related antigen expression in serrated adenoma of the colorectum: the saw-toothed structure may be related to inhibition of apoptosis
-
Tateyama H., et al. Apoptosis index and apoptosis-related antigen expression in serrated adenoma of the colorectum: the saw-toothed structure may be related to inhibition of apoptosis. Am. J. Surg. Pathol. 2002, 26:249-256.
-
(2002)
Am. J. Surg. Pathol.
, vol.26
, pp. 249-256
-
-
Tateyama, H.1
-
113
-
-
0035921734
-
Increased and correlated nuclear factor-kappa B and Ku autoantigen activities are associated with development of multidrug resistance
-
Um J.H., et al. Increased and correlated nuclear factor-kappa B and Ku autoantigen activities are associated with development of multidrug resistance. Oncogene 2001, 20:6048-6056.
-
(2001)
Oncogene
, vol.20
, pp. 6048-6056
-
-
Um, J.H.1
-
114
-
-
0029058460
-
Frequent p53 accumulation in the chronically sun-exposed epidermis and clonal expansion of p53 mutant cells in the epidermis adjacent to basal cell carcinoma
-
Urano Y., et al. Frequent p53 accumulation in the chronically sun-exposed epidermis and clonal expansion of p53 mutant cells in the epidermis adjacent to basal cell carcinoma. J. Invest. Dermatol. 1995, 104:928-932.
-
(1995)
J. Invest. Dermatol.
, vol.104
, pp. 928-932
-
-
Urano, Y.1
-
115
-
-
0029839525
-
The Asp84Glu variant of the melanocortin 1 receptor (MC1R) is associated with melanoma
-
Valverde P., et al. The Asp84Glu variant of the melanocortin 1 receptor (MC1R) is associated with melanoma. Hum. Mol. Genet. 1996, 5:1663-1666.
-
(1996)
Hum. Mol. Genet.
, vol.5
, pp. 1663-1666
-
-
Valverde, P.1
-
116
-
-
0027992051
-
12-O-tetradecanoylphorbol-13-acetate- and tumor necrosis factor alpha-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone. Functional analysis of the human intercellular adhesion molecular-1 promoter
-
van de Stolpe A., et al. 12-O-tetradecanoylphorbol-13-acetate- and tumor necrosis factor alpha-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone. Functional analysis of the human intercellular adhesion molecular-1 promoter. J. Biol. Chem. 1994, 269:6185-6192.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 6185-6192
-
-
van de Stolpe, A.1
-
117
-
-
53149097362
-
BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis?
-
Velho S., et al. BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis?. BMC Cancer 2008, 8:255.
-
(2008)
BMC Cancer
, vol.8
, pp. 255
-
-
Velho, S.1
-
118
-
-
12144289677
-
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
-
Wan P.T., et al. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 2004, 116:855-867.
-
(2004)
Cell
, vol.116
, pp. 855-867
-
-
Wan, P.T.1
-
119
-
-
0032508414
-
NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
-
Wang C.Y., et al. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 1998, 281:1680-1683.
-
(1998)
Science
, vol.281
, pp. 1680-1683
-
-
Wang, C.Y.1
-
120
-
-
0032905030
-
Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB
-
Wang C.Y., et al. Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB. Nat. Med. 1999, 5:412-417.
-
(1999)
Nat. Med.
, vol.5
, pp. 412-417
-
-
Wang, C.Y.1
-
121
-
-
0035328521
-
Active Ras induces heterodimerization of cRaf and BRaf
-
Weber C.K., et al. Active Ras induces heterodimerization of cRaf and BRaf. Cancer Res. 2001, 61:3595-3598.
-
(2001)
Cancer Res.
, vol.61
, pp. 3595-3598
-
-
Weber, C.K.1
-
122
-
-
33745541234
-
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
-
Weisenberger D.J., et al. CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat. Genet. 2006, 38:787-793.
-
(2006)
Nat. Genet.
, vol.38
, pp. 787-793
-
-
Weisenberger, D.J.1
-
124
-
-
0025877890
-
An NF kappa B-like factor is essential but not sufficient for cytokine induction of endothelial leukocyte adhesion molecule 1 (ELAM-1) gene transcription
-
Whelan J., et al. An NF kappa B-like factor is essential but not sufficient for cytokine induction of endothelial leukocyte adhesion molecule 1 (ELAM-1) gene transcription. Nucleic Acids Res. 1991, 19:2645-2653.
-
(1991)
Nucleic Acids Res.
, vol.19
, pp. 2645-2653
-
-
Whelan, J.1
-
125
-
-
0030464444
-
How Ras-related proteins talk to their effectors
-
Wittinghofer A., Nassar N. How Ras-related proteins talk to their effectors. Trends Biochem. Sci. 1996, 21:488-491.
-
(1996)
Trends Biochem. Sci.
, vol.21
, pp. 488-491
-
-
Wittinghofer, A.1
Nassar, N.2
-
126
-
-
0030835430
-
Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1
-
Woods D., et al. Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. Mol. Cell. Biol. 1997, 17:5598-5611.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 5598-5611
-
-
Woods, D.1
-
127
-
-
21244457181
-
BRAF mutation in thyroid cancer
-
Xing M. BRAF mutation in thyroid cancer. Endocr. Relat. Cancer 2005, 12:245-262.
-
(2005)
Endocr. Relat. Cancer
, vol.12
, pp. 245-262
-
-
Xing, M.1
-
128
-
-
37349131738
-
BRAF mutation in papillary thyroid cancer: pathogenic role, molecular bases, and clinical implications
-
Xing M. BRAF mutation in papillary thyroid cancer: pathogenic role, molecular bases, and clinical implications. Endocr. Rev. 2007, 28:742-762.
-
(2007)
Endocr. Rev.
, vol.28
, pp. 742-762
-
-
Xing, M.1
-
129
-
-
28744442816
-
BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer
-
Xing M., et al. BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer. J. Clin. Endocrinol. Metab. 2005, 90:6373-6379.
-
(2005)
J. Clin. Endocrinol. Metab.
, vol.90
, pp. 6373-6379
-
-
Xing, M.1
-
130
-
-
84875952085
-
Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer
-
Xing M., et al. Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer. JAMA 2013, 309:1493-1501.
-
(2013)
JAMA
, vol.309
, pp. 1493-1501
-
-
Xing, M.1
-
131
-
-
7044253667
-
BRAF and KRAS mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status
-
Yang S., et al. BRAF and KRAS mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status. Am. J. Surg. Pathol. 2004, 28:1452-1459.
-
(2004)
Am. J. Surg. Pathol.
, vol.28
, pp. 1452-1459
-
-
Yang, S.1
-
132
-
-
0028838235
-
Phosphorylation of Raf by ceramide-activated protein kinase
-
Yao B., et al. Phosphorylation of Raf by ceramide-activated protein kinase. Nature 1995, 378:307-310.
-
(1995)
Nature
, vol.378
, pp. 307-310
-
-
Yao, B.1
-
133
-
-
56449093108
-
The potential clinical relevance of serum vascular endothelial growth factor (VEGF) and VEGF-C in recurrent papillary thyroid carcinoma
-
(discussion 940-931)
-
Yu X.M., et al. The potential clinical relevance of serum vascular endothelial growth factor (VEGF) and VEGF-C in recurrent papillary thyroid carcinoma. Surgery 2008, 144:934-940. (discussion 940-931).
-
(2008)
Surgery
, vol.144
, pp. 934-940
-
-
Yu, X.M.1
-
134
-
-
42249087955
-
Serum vascular endothelial growth factor C correlates with lymph node metastases and high-risk tumor profiles in papillary thyroid carcinoma
-
Yu X.M., et al. Serum vascular endothelial growth factor C correlates with lymph node metastases and high-risk tumor profiles in papillary thyroid carcinoma. Ann. Surg. 2008, 247:483-489.
-
(2008)
Ann. Surg.
, vol.247
, pp. 483-489
-
-
Yu, X.M.1
-
135
-
-
0036737193
-
Clinicopathologic significance of bcl-2 expression in the surgical treatment of oral tongue carcinoma
-
Yuen A.P., et al. Clinicopathologic significance of bcl-2 expression in the surgical treatment of oral tongue carcinoma. Eur. J. Surg. Oncol. 2002, 28:667-672.
-
(2002)
Eur. J. Surg. Oncol.
, vol.28
, pp. 667-672
-
-
Yuen, A.P.1
-
136
-
-
0037112438
-
Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia
-
Yuen S.T., et al. Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia. Cancer Res. 2002, 62:6451-6455.
-
(2002)
Cancer Res.
, vol.62
, pp. 6451-6455
-
-
Yuen, S.T.1
-
137
-
-
33745327045
-
Back to the roots: the remarkable RAF oncogene story
-
Zebisch A., Troppmair J. Back to the roots: the remarkable RAF oncogene story. Cell. Mol. Life Sci. 2006, 63:1314-1330.
-
(2006)
Cell. Mol. Life Sci.
, vol.63
, pp. 1314-1330
-
-
Zebisch, A.1
Troppmair, J.2
-
138
-
-
0034675919
-
Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601
-
Zhang B.H., Guan K.L. Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601. EMBO J. 2000, 19:5429-5439.
-
(2000)
EMBO J.
, vol.19
, pp. 5429-5439
-
-
Zhang, B.H.1
Guan, K.L.2
-
139
-
-
0030609891
-
NF-kappaB-mediated induction of mdr1b expression by insulin in rat hepatoma cells
-
Zhou G., Kuo M.T. NF-kappaB-mediated induction of mdr1b expression by insulin in rat hepatoma cells. J. Biol. Chem. 1997, 272:15174-15183.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 15174-15183
-
-
Zhou, G.1
Kuo, M.T.2
-
140
-
-
0033607633
-
Phosphorylation and regulation of Raf by Akt (protein kinase B)
-
Zimmermann S., Moelling K. Phosphorylation and regulation of Raf by Akt (protein kinase B). Science 1999, 286:1741-1744.
-
(1999)
Science
, vol.286
, pp. 1741-1744
-
-
Zimmermann, S.1
Moelling, K.2
|