BRAF Mutations in Thyroid Tumors Are Restricted to Papillary Carcinomas and Anaplastic or Poorly Differentiated Carcinomas Arising from Papillary Carcinomas

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 11, 2003, Pages 5399-5404

  Nikiforova, Marina N ^a   Kimura, Edna T ^b   Gandhi, Manoj ^a   Biddinger, Paul W ^a   Knauf, Jeffrey A ^b   Basolo, Fulvio ^c   Zhu, Zhaowen ^a   Giannini, Riccardo ^c   Salvatore, Giuliana ^d   Fusco, Alfredo ^d   Santoro, Massimo ^d   Fagin, James A ^b   Nikiforov, Yuri E ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

^c Dipartimento di Biologia   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ANAPLASTIC CARCINOMA; ARTICLE; BENIGN TUMOR; BRAF GENE; CANCER STAGING; CELL DIFFERENTIATION; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENE SEQUENCE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; ONCOGENE; PAPILLARY CARCINOMA; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL; THYROID MEDULLARY CARCINOMA; THYROID PARAFOLLICULAR CELL; THYROID TUMOR;

ADULT; AGED; CARCINOMA, PAPILLARY; CELL DIFFERENTIATION; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; ONCOGENE PROTEINS; PHENOTYPE; POINT MUTATION; PREVALENCE; PROTO-ONCOGENE PROTEINS B-RAF; THYROID NEOPLASMS; THYROID NODULE;

EID: 10744222003     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-030838     Document Type: Article

References (33)

1. Fusco A, Grieco M, Santoro M, Berlingieri MT, Pilotti S, Pierotti MA, Della Porta G, Vecchio G 1987 A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases. Nature 328:170-172
2. Santoro M, Carlomagno F, Hay ID, Herrmann MA, Grieco M, Melillo R, Pierotti MA, Bongarzone I, Della Porta G, Berger N, Peix JL, Paulin C, Fabien N, Vecchio G, Jenkins RB, Fusco A 1992 RET oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype. J Clin Invest 89:1517-1522
3. Greco A, Pierotti MA, Bongarzone I, Pagliardini S, Lanzi C, Della Porta G 1992 TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas. Oncogene 7:237-242
4. Kroll TG, Sarraf P, Pecciarini L, Chen CJ, Mueller E, Spiegelman BM, Fletcher JA 2000 PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma. Science 289:1357-1360
5. Nikiforova MN, Biddinger PW, Caudill CM, Kroll TG, Nikiforov YE 2002 PAX8-PPARgamma rearrangement in thyroid tumors: RT-PCR and immunohistochemical analyses. Am J Surg Pathol 26:1016-1023
6. Lemoine NR, Mayall ES, Wyllie FS, Williams ED, Goyns M, Stringer B, Wynford-Thomas D 1989 High frequency of ras oncogene activation in all stages of human thyroid tumorigenesis. Oncogene 4:159-164
7. Namba H, Rubin SA, Fagin JA 1990 Point mutations of ras oncogenes are an early event in thyroid tumorigenesis. Mol Endocrinol 4:1474-1479
8. Zhu Z, Gandhi M, Nikiforova MN, Fischer AH, Nikiforov YE 2003 Molecular profile and clinical-pathologic features of the follicular variant of papillary thyroid carcinoma: an unusually high prevalence of RAS mutations. Am J Clin Pathol 120:71-77
9. Kimura ET, Nikiforova MN, Zhu Z, Knauf JA, Nikiforov YE, Fagin JA 2003 High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res 63:1454-1457
10. Cohen Y, Xing M, Mambo E, Guo Z, Wu G, Trink B, Beller U, Westra WH, Ladenson PW, Sidransky D 2003 BRAF mutation in papillary thyroid carcinoma. J Natl Cancer Inst 95:625-627
11. Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davis N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V, Menzies A, Mould C, Parker A, Stevens C, Watt S, Hooper S, Wilson R, Jayatilake H, Gusterson BA, Cooper C, Shipley J, Hargrave D, Pritchard-Jones K, Maitland N, Chenevix-Trench G, Riggins GJ, Bigner DD, Palmieri G, Cossu A, Flanagan A, Nicholson A, Ho JW, Leung SY, Yuen ST, Weber BL, Seigler HF, Darrow TL, Paterson H, Marais R, Marshall CJ, Wooster R, Stratton MR, Futreal PA 2002 Mutations of the BRAF gene in human cancer. Nature 417:949-954
12. Rajagopalan H, Bardelli A, Lengauer C, Kinzler KW, Vogelstein B, Velculescu VE 2002 Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature 418:934
13. Rosai J, Carcangiu ML, DeLellis RA 1992 Tumors of the thyroid gland. Atlas of tumor pathology. Washington, DC: Armed Forces Institute of Pathology
14. LiVolsi VA 1990 Surgical pathology of the thyroid. Philadelphia: WB Saunders
15. Fiore L, Pollina LE, Fontanini G, Casalone R, Berlingieri MT, Giannini R, Pacini F, Miccoli P, Toniolo A, Fusco A, Basolo F 1997 Cytokine production by a new undifferentiated human thyroid carcinoma cell line, FB-1. J Clin Endocrinol Metab 82:4094-4100
16. Gioanni J, Zanghellini E, Mazeau C, Zhang D, Courdi A, Farges M, Lambert JC, Duplay H, Schneider M 1991 Characterization of a human cell line from an anaplastic carcinoma of the thyroid gland. Bull Cancer 78:1053-1062
17. Ain KB, Tofiq S, Taylor KD 1996 Antineoplastic activity of taxol against human anaplastic thyroid carcinoma cell lines in vitro and in vivo. J Clin Endocrinol Metab 81:3650-3653
18. Pang XP, Hershman JM, Chung M, Pekary AE 1989 Characterization of tumor necrosis factor-alpha receptors in human and rat thyroid cells and regulation of the receptors by thyrotropin. Endocrinology 125:1783-1788
19. Palyi I, Peter I, Daubner D, Vincze B, Lorincz I 1993 Establishment, characterization and drug sensitivity of a new anaplastic thyroid carcinoma cell line (BHT-101). Virchows Arch B Cell Pathol Incl Mol Pathol 63:263-269
20. Ito T, Seyama T, Mizuno T, Tsuyama N, Hayashi T, Hayashi Y, Dohi K, Nakamura N, Akiyama M 1992 Unique association of p53 mutations with undifferentiated but not with differentiated carcinomas of the thyroid gland. Cancer Res 52:1369-1371
21. Nikiforov YE, Nikiforova MN, Gnepp DR, Fagin JA 1996 Prevalence of mutations of ras and p53 in benign and malignant thyroid tumors from children exposed to radiation after the Chernobyl nuclear accident. Oncogene 13:687-693
22. Nikiforova MN, Caudill CM, Biddinger P, Nikiforov YE 2002 Prevalence of RET/PTC rearrangements in Hashimoto's thyroiditis and papillary thyroid carcinomas. Int J Surg Pathol 10:15-22
23. Argani P, Zakowski MF, Klimstra DS, Rosai J, Ladanyi M 1998 Detection of the SYT-SSX chimeric RNA of synovial sarcoma in paraffin-embedded tissue and its application in problematic cases. Mod Pathol 11:65-71
24. 2002 AJCC Cancer staging manual. 6th ed. New York: Springer-Verlag
25. Aldinger KA, Samaan NA, Ibanez M, Hill Jr CS 1978 Anaplastic carcinoma of the thyroid: a review of 84 cases of spindle and giant cell carcinoma of the thyroid. Cancer 41:2267-2275
26. Nishiyama RH, Dunn EL, Thompson NW 1972 Anaplastic spindle-cell and giant-cell tumors of the thyroid gland. Cancer 30:113-127
27. Spires JR, Schwartz MR, Miller RH 1988 Anaplastic thyroid carcinoma. Association with differentiated thyroid cancer. Arch Otolaryngol Head Neck Surg 114:40-44
28. Venkatesh YS, Ordonez NG, Schultz PN, Hickey RC, Goepfert H, Samaan NA 1990 Anaplastic carcinoma of the thyroid. A clinicopathologic study of 121 cases. Cancer 66:321-330
29. Asakawa H, Kobayashi T 2002 Multistep carcinogenesis in anaplastic thyroid carcinoma: a case report. Pathology 34:94-97
30. Wiseman SM, Loree TR, Hicks Jr WL, Rigual NR, Winston JS, Tan D, Anderson GR, Stoler DL 2003 Anaplastic thyroid cancer evolved from papillary carcinoma: demonstration of anaplastic transformation by means of the inter-simple sequence repeat polymerase chain reaction. Arch Otolaryngol Head Neck Surg 129:96-100
31. Johnson TL, Lloyd RV, Thompson NW, Beierwaltes WH, Sisson JC 1988 Prognostic implications of the tall cell variant of papillary thyroid carcinoma. Am J Surg Pathol 12:22-27
32. Flint A, Davenport RD, Lloyd RV 1991 The tall cell variant of papillary carcinoma of the thyroid gland. Comparison with the common form of papillary carcinoma by DNA and morphometric analysis. Arch Pathol Lab Med 115:169-171
33. Prendiville S, Burman KD, Ringel MD, Shmookler BM, Deeb ZE, Wolfe K, Azumi N, Wartofsky L, Sessions RB 2000 Tall cell variant: an aggressive form of papillary thyroid carcinoma. Otolaryngol Head Neck Surg 122:352-357