Anchorage-dependent ERK signaling - Mechanisms and consequences

Current Opinion in Genetics and Development

Volumn 12, Issue 1, 2002, Pages 30-35

  Howe, Alan K ^a   Aplin, Andrew E ^b   Juliano, R L ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b ALBANY MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; FOCAL ADHESION KINASE; GROWTH FACTOR; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P21; RAC PROTEIN; RAS PROTEIN;

ANOIKIS; CANCER CELL; CELL ADHESION; CELL DIVISION; CELL MIGRATION; CELL SURVIVAL; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0036467578     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(01)00260-X     Document Type: Review

References (51)

1. Integrin signaling
2. Interactions between mitogenic stimuli, or, a thousand and one connections
3. Signal transduction and signal modulation by cell adhesion receptors: The role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins
4. 1 phase cell-cycle progression
5. Focal adhesion kinase mediates the integrin signaling requirement for growth factor activation of MAP kinase
6. Focal adhesion kinase facilitates platelet-derived growth factor-BB-stimulated ERK2 activation required for chemotaxis migration of vascular smooth muscle cells
7. Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase
8. Distinct roles of the adaptor protein Shc and focal adhesion kinase in integrin signaling to ERK
9. Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK
10. Pak to the future
11. The SH2 and SH3 adapter Nck: A two-gene family and a linker between tyrosine kinases and multiple signaling networks
12. Cell adhesion regulates the interaction between Nck and p21-activated kinase
13. Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins
14. The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338
15. Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells
16. Integrin and cytoskeletal regulation of growth factor signaling to the MAP kinase pathway
17. Paxillin interactions
18. An oncogenic epidermal growth factor receptor signals via a p21-activated kinase-caldesmon-myosin phosphotyrosine complex
19. Activated PAK4 regulates cell adhesion and anchorage-independent growth
20. Regulation of nuclear localization during signaling
21. Integrin-mediated adhesion regulates ERK nuclear translocation and phosphorylation of Elk-1
22. Two independent signaling pathways mediate the antiapoptotic action of macrophage-stimulating protein on epithelial cells
23. Molecular mechanisms controlling actin filament dynamics in nonmuscle cells
24. Dual stimulation of Ras/mitogen-activated protein kinase and RhoA by cell adhesion to fibronectin supports growth factor-stimulated cell cycle progression
25. Signal transduction from the extracellular matrix
26. Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry
27. Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta
28. Induction of beta3-integrin gene expression by sustained activation of the Ras-regulated Raf-MEK-extracellular signal-regulated kinase signaling pathway
29. Beta(3)A-integrin downregulates the urokinase-type plasminogen activator receptor (u-PAR) through a PEA3/ets transcriptional silencing element in the u-PAR promoter
30. Differential usage of signal transduction pathways defines two types of serum response factor target gene
31. Extracellular matrix composition determines the transcriptional response to epidermal growth factor receptor activation
32. Proliferation, cell cycle and apoptosis in cancer
33. Fibroblast quiescence in floating or released collagen matrices. Contribution of the ERK signaling pathway and actin cytoskeletal organization
34. Alpha5beta1 integrin controls cyclin D1 expression by sustaining mitogen-activated protein kinase activity in growth factor-treated cells
35. An anchorage-dependent signal distinct from p42/44 MAP kinase activation is required for cell cycle progression
36. Specific residues within the alpha 2 integrin subunit cytoplasmic domain regulate migration and cell cycle progression via distinct MAPK pathways
37. Integrin-specific activation of Rac controls progression through the G(1) phase of the cell cycle
38. Mechanisms and consequences of activation of protein kinase B/Akt
39. Matrix-independent survival of human keratinocytes through an EGF receptor/MAPK-kinase-dependent pathway
40. The p42/p44 MAP kinase pathway prevents apoptosis induced by anchorage and serum removal
41. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
42. Matrix attachment regulates Fas-induced apoptosis in endothelial cells: A role for c-flip and implications for anoikis
43. Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase
44. Modulation of cell-substrate adhesion by arachidonic acid: Lipoxygenase regulates cell spreading and erk1/2-inducible cyclooxygenase regulates cell migration in nih-3t3 fibroblasts
45. Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells
46. Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix
47. FAK integrates growth-factor and integrin signals to promote cell migration
48. Active ERK/MAP kinase is targeted to newly forming cell-matrix adhesions by integrin engagement and v-Src
49. Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal growth factor receptor signaling
50. Cell adhesion molecules, signal transduction and cell growth
51. Signal-regulated activation of serum response factor is mediated by changes in actin dynamics