메뉴 건너뛰기




Volumn 17, Issue 24, 2011, Pages 7511-7517

Role of BRAF in thyroid oncogenesis

Author keywords

[No Author keywords available]

Indexed keywords

ARQ 736; AXITINIB; B RAF KINASE; B RAF KINASE INHIBITOR; DABRAFENIB; GLUTAMIC ACID; IODINE; MITOGEN ACTIVATED PROTEIN KINASE; MOTESANIB; PAZOPANIB; PLACEBO; PLATELET DERIVED GROWTH FACTOR; PROTEIN RET; REGORAFENIB; SELUMETINIB; SORAFENIB; SUNITINIB; TIPIFARNIB; UNCLASSIFIED DRUG; VALINE; VASCULOTROPIN; VEMURAFENIB;

EID: 84055222114     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-11-1155     Document Type: Review
Times cited : (109)

References (59)
  • 1
    • 30944447568 scopus 로고    scopus 로고
    • The extracellular signal-regulated kinase: Multiple substrates regulate diverse cellular functions
    • DOI 10.1159/000094762, PII N130170763401
    • Yoon S, Seger R. The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. Growth Factors 2006;24:21-44. (Pubitemid 43108774)
    • (2006) Growth Factors , vol.24 , Issue.1 , pp. 21-44
    • Yoon, S.1    Seger, R.2
  • 4
  • 6
    • 29144462587 scopus 로고    scopus 로고
    • Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization
    • DOI 10.1016/j.molcel.2005.10.022, PII S109727650501717X
    • Garnett MJ, Rana S, Paterson H, Barford D, Marais R. Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization. Mol Cell 2005;20:963-9. (Pubitemid 41814884)
    • (2005) Molecular Cell , vol.20 , Issue.6 , pp. 963-969
    • Garnett, M.J.1    Rana, S.2    Paterson, H.3    Barford, D.4    Marais, R.5
  • 13
    • 74849109743 scopus 로고    scopus 로고
    • Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
    • Heidorn SJ, Milagre C, Whittaker S, Nourry A, Niculescu-Duvas I, Dhomen N, et al. Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF. Cell 2010;140:209-21.
    • (2010) Cell , vol.140 , pp. 209-221
    • Heidorn, S.J.1    Milagre, C.2    Whittaker, S.3    Nourry, A.4    Niculescu-Duvas, I.5    Dhomen, N.6
  • 15
    • 0036654443 scopus 로고    scopus 로고
    • A genome-based strategy uncovers frequent BRAF mutations in melanoma
    • DOI 10.1016/S1535-6108(02)00089-2
    • Pollock PM, Meltzer PS. A genome-based strategy uncovers frequent BRAF mutations in melanoma. Cancer Cell 2002;2:5-7. (Pubitemid 41043982)
    • (2002) Cancer Cell , vol.2 , Issue.1 , pp. 5-7
    • Pollock, P.M.1    Meltzer, P.S.2
  • 19
    • 0032535770 scopus 로고    scopus 로고
    • A National Cancer Data Base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985-1995
    • DOI 10.1002/(SICI)1097-0142(19981215)83:12<2638::AID-CNCR31>3.0. CO;2-1
    • Hundahl SA, Fleming ID, Fremgen AM, Menck HR. A National Cancer Data Base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985-1995. Cancer 1998;83:2638-48. (Pubitemid 29019586)
    • (1998) Cancer , vol.83 , Issue.12 , pp. 2638-2648
    • Hundahl, S.A.1    Fleming, I.D.2    Fremgen, A.M.3    Menck, H.R.4
  • 20
    • 21244457181 scopus 로고    scopus 로고
    • BRAF mutation in thyroid cancer
    • DOI 10.1677/erc.1.0978
    • Xing M. BRAF mutation in thyroid cancer. Endocr Relat Cancer 2005;12:245-62. (Pubitemid 40896444)
    • (2005) Endocrine-Related Cancer , vol.12 , Issue.2 , pp. 245-262
    • Xing, M.1
  • 21
    • 33645307434 scopus 로고    scopus 로고
    • Pathogenetic mechanisms in thyroid follicular-cell neoplasia
    • Kondo T, Ezzat S, Asa SL. Pathogenetic mechanisms in thyroid follicular-cell neoplasia. Nat Rev Cancer 2006;6:292-306.
    • (2006) Nat Rev Cancer , vol.6 , pp. 292-306
    • Kondo, T.1    Ezzat, S.2    Asa, S.L.3
  • 22
    • 20144372793 scopus 로고    scopus 로고
    • V600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation
    • DOI 10.1158/0008-5472.CAN-05-0047
    • Knauf JA, Ma X, Smith EP, Zhang L, Mitsutake N, Liao XH, et al. Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation. Cancer Res 2005;65:4238-45. (Pubitemid 40775662)
    • (2005) Cancer Research , vol.65 , Issue.10 , pp. 4238-4245
    • Knauf, J.A.1    Ma, X.2    Smith, E.P.3    Zhang, L.4    Mitsutake, N.5    Liao, X.-H.6    Refetoff, S.7    Nikiforov, Y.E.8    Fagin, J.A.9
  • 24
    • 8144230516 scopus 로고    scopus 로고
    • BRAF mutations in anaplastic thyroid carcinoma: Implications for tumor origin, diagnosis and treatment
    • DOI 10.1038/modpathol.3800198
    • Begum S, Rosenbaum E, Henrique R, Cohen Y, Sidransky D, Westra WH. BRAF mutations in anaplastic thyroid carcinoma: implications for tumor origin, diagnosis and treatment. Mod Pathol 2004;17:1359-63. (Pubitemid 39472990)
    • (2004) Modern Pathology , vol.17 , Issue.11 , pp. 1359-1363
    • Begum, S.1    Rosenbaum, E.2    Henrique, R.3    Cohen, Y.4    Sidransky, D.5    Westra, W.H.6
  • 26
    • 33847072340 scopus 로고    scopus 로고
    • RET/PTC rearrangements and BRAF mutations in thyroid tumorigenesis
    • Ciampi R, Nikiforov YE. RET/PTC rearrangements and BRAF mutations in thyroid tumorigenesis. Endocrinology 2007;148:936-41.
    • (2007) Endocrinology , vol.148 , pp. 936-941
    • Ciampi, R.1    Nikiforov, Y.E.2
  • 28
    • 77955452828 scopus 로고    scopus 로고
    • Surgical implications of BRafV600E mutation in fine-needle aspiration of thyroid nodules
    • Mekel M, Nucera C, Hodin RA, Parangi S. Surgical implications of BRafV600E mutation in fine-needle aspiration of thyroid nodules. Am J Surg 2010;200:136-43.
    • (2010) Am J Surg , vol.200 , pp. 136-143
    • Mekel, M.1    Nucera, C.2    Hodin, R.A.3    Parangi, S.4
  • 29
    • 0021136279 scopus 로고
    • Fine-needle aspiration biopsy of the thyroid. The problem of suspicious cytologic findings
    • Gharib H, Goellner JR, Zinsmeister AR, Grant CS, Van Heerden JA. Fine-needle aspiration biopsy of the thyroid. The problem of suspicious cytologic findings. Ann Intern Med 1984;101:25-8. (Pubitemid 14088062)
    • (1984) Annals of Internal Medicine , vol.101 , Issue.1 , pp. 25-28
    • Gharib, H.1    Goellner, J.R.2    Zinsmeister, A.R.3
  • 30
    • 79952638022 scopus 로고    scopus 로고
    • Molecular testing for somatic mutations improves the accuracy of thyroid fine-needle aspiration biopsy
    • Moses W, Weng J, Sansano I, Peng M, Khanafshar E, Ljung BM, et al. Molecular testing for somatic mutations improves the accuracy of thyroid fine-needle aspiration biopsy. World J Surg 2010;34:2589-94.
    • (2010) World J Surg , vol.34 , pp. 2589-2594
    • Moses, W.1    Weng, J.2    Sansano, I.3    Peng, M.4    Khanafshar, E.5    Ljung, B.M.6
  • 31
    • 3242697688 scopus 로고    scopus 로고
    • High sensitivity scanning of colorectal tumors and matched plasma DNA for mutations in APC, TP53, K-RAS, and BRAF genes with a novel DHPLC fluorescence detection platform
    • DOI 10.1196/annals.1318.039
    • Lilleberg SL, Durocher J, Sanders C, Walters K, Culver K. High sensitivity scanning of colorectal tumors and matched plasma DNA for mutations in APC, TP53, K-RAS, and BRAF genes with a novel DHPLC fluorescence detection platform. AnnNY Acad Sci 2004;1022: 250-6. (Pubitemid 38951611)
    • (2004) Annals of the New York Academy of Sciences , vol.1022 , pp. 250-256
    • Lilleberg, S.L.1    Durocher, J.2    Sanders, C.3    Walters, K.4    Culver, K.5
  • 33
    • 77953486392 scopus 로고    scopus 로고
    • Clinical impact of the detection of BRAF mutations in thyroid pathology: Potential usefulness as diagnostic, prognostic and theragnostic applications
    • Lassalle S, Hofman V, Ilie M, Butori C, Bozec A, Santini J, et al. Clinical impact of the detection of BRAF mutations in thyroid pathology: potential usefulness as diagnostic, prognostic and theragnostic applications. Curr Med Chem 2010;17:1839-50.
    • (2010) Curr Med Chem , vol.17 , pp. 1839-1850
    • Lassalle, S.1    Hofman, V.2    Ilie, M.3    Butori, C.4    Bozec, A.5    Santini, J.6
  • 34
    • 77952883863 scopus 로고    scopus 로고
    • Molecular prognostic markers in papillary and follicular thyroid cancer: Current status and future directions
    • Handkiewicz-Junak D, Czarniecka A, Jarzab B. Molecular prognostic markers in papillary and follicular thyroid cancer: Current status and future directions. Mol Cell Endocrinol 2010;322:8-28.
    • (2010) Mol Cell Endocrinol , vol.322 , pp. 8-28
    • Handkiewicz-Junak, D.1    Czarniecka, A.2    Jarzab, B.3
  • 35
    • 37349131738 scopus 로고    scopus 로고
    • BRAF mutation in papillary thyroid cancer: Pathogenic role, molecular bases, and clinical implications
    • DOI 10.1210/er.2007-0007
    • Xing M. BRAF mutation in papillary thyroid cancer: pathogenic role, molecular bases, and clinical implications. Endocr Rev 2007;28: 742-62. (Pubitemid 350294294)
    • (2007) Endocrine Reviews , vol.28 , Issue.7 , pp. 742-762
    • Xing, M.1
  • 36
    • 34250893789 scopus 로고    scopus 로고
    • Clinicopathologic significance of BRAFV600E mutation in papillary carcinomas of the thyroid: A meta-analysis
    • Lee JH, Lee ES, Kim YS. Clinicopathologic significance of BRAFV600E mutation in papillary carcinomas of the thyroid: a meta-analysis. Cancer 2007;110:38-46.
    • (2007) Cancer , vol.110 , pp. 38-46
    • Lee, J.H.1    Lee, E.S.2    Kim, Y.S.3
  • 37
    • 34548192281 scopus 로고    scopus 로고
    • The prevalence and prognostic value of BRAF mutation in thyroid cancer
    • discussion 470-1
    • Kebebew E, Weng J, Bauer J, Ranvier G, Clark OH, Duh QY, et al. The prevalence and prognostic value of BRAF mutation in thyroid cancer. Ann Surg 2007;246:466-70, discussion 470-1.
    • (2007) Ann Surg , vol.246 , pp. 466-470
    • Kebebew, E.1    Weng, J.2    Bauer, J.3    Ranvier, G.4    Clark, O.H.5    Duh, Q.Y.6
  • 38
    • 53749086690 scopus 로고    scopus 로고
    • BRAF (V600E) mutation and outcome of patients with papillary thyroid carcinoma: A 15-year median follow-up study
    • Elisei R, Ugolini C, Viola D, Lupi C, Biagini A, Giannini R, et al. BRAF (V600E) mutation and outcome of patients with papillary thyroid carcinoma: a 15-year median follow-up study. J Clin Endocrinol Metab 2008;93:3943-9.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 3943-3949
    • Elisei, R.1    Ugolini, C.2    Viola, D.3    Lupi, C.4    Biagini, A.5    Giannini, R.6
  • 39
    • 62549101651 scopus 로고    scopus 로고
    • BRAF mutation in papillary thyroid carcinoma in a Japanese population: Its lack of correlation with high-risk clinicopathological features and disease-free survival of patients
    • Ito Y, Yoshida H, Maruo R, Morita S, Takano T, Hirokawa M, et al. BRAF mutation in papillary thyroid carcinoma in a Japanese population: its lack of correlation with high-risk clinicopathological features and disease-free survival of patients. Endocr J 2009;56: 89-97.
    • (2009) Endocr J , vol.56 , pp. 89-97
    • Ito, Y.1    Yoshida, H.2    Maruo, R.3    Morita, S.4    Takano, T.5    Hirokawa, M.6
  • 41
    • 26644473629 scopus 로고    scopus 로고
    • No correlation between BRAFV600E mutation and clinicopathological features of papillary thyroid carcinomas in Taiwan
    • Liu RT, Chen YJ, Chou FF, Li CL, Wu WL, Tsai PC, et al. No correlation between BRAFV600E mutation and clinicopathological features of papillary thyroid carcinomas in Taiwan. Clin Endocrinol (Oxf) 2005;63:461-6.
    • (2005) Clin Endocrinol (Oxf) , vol.63 , pp. 461-466
    • Liu, R.T.1    Chen, Y.J.2    Chou, F.F.3    Li, C.L.4    Wu, W.L.5    Tsai, P.C.6
  • 44
    • 78650976224 scopus 로고    scopus 로고
    • The BRAF mutation is predictive of aggressive clinicopathological characteristics in papillary thyroid microcarcinoma
    • Lin KL, Wang OC, Zhang XH, Dai XX, Hu XQ, Qu JM. The BRAF mutation is predictive of aggressive clinicopathological characteristics in papillary thyroid microcarcinoma. Ann Surg Oncol 2010;17:3294-300.
    • (2010) Ann Surg Oncol , vol.17 , pp. 3294-3300
    • Lin, K.L.1    Wang, O.C.2    Zhang, X.H.3    Dai, X.X.4    Hu, X.Q.5    Qu, J.M.6
  • 45
    • 59449090715 scopus 로고    scopus 로고
    • Analysis of differential BRAF (V600E) mutational status in high aggressive papillary thyroid micro-carcinoma
    • Lee X, Gao M, Ji Y, Yu Y, Feng Y, Li Y, et al. Analysis of differential BRAF (V600E) mutational status in high aggressive papillary thyroid micro-carcinoma. Ann Surg Oncol 2009;16:240-5.
    • (2009) Ann Surg Oncol , vol.16 , pp. 240-245
    • Lee, X.1    Gao, M.2    Ji, Y.3    Yu, Y.4    Feng, Y.5    Li, Y.6
  • 46
    • 66349098309 scopus 로고    scopus 로고
    • Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1
    • Ricarte-Filho JC, Ryder M, Chitale DA, Rivera M, Heguy A, Ladanyi M, et al. Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1. Cancer Res 2009;69: 4885-93.
    • (2009) Cancer Res , vol.69 , pp. 4885-4893
    • Ricarte-Filho, J.C.1    Ryder, M.2    Chitale, D.A.3    Rivera, M.4    Heguy, A.5    Ladanyi, M.6
  • 47
    • 34147161209 scopus 로고    scopus 로고
    • Inhibition of tumor endothelial ERK activation, angiogenesis, and tumor growth by sorafenib (BAY43-9006)
    • DOI 10.2353/ajpath.2006.050711
    • Murphy DA, Makonnen S, Lassoued W, Feldman MD, Carter C, Lee WM. Inhibition of tumor endothelial ERK activation, angiogenesis, and tumor growth by sorafenib (BAY43-9006). Am J Pathol 2006;169: 1875-85. (Pubitemid 351182016)
    • (2006) American Journal of Pathology , vol.169 , Issue.5 , pp. 1875-1885
    • Murphy, D.A.1    Makonnen, S.2    Lassoued, W.3    Feldman, M.D.4    Carter, C.5    Lee, W.M.F.6
  • 50
    • 33645698808 scopus 로고    scopus 로고
    • Inhibitors of Raf kinase activity block growth of thyroid cancer cells with RET/PTC or BRAF mutations in vitro and in vivo
    • Ouyang B, Knauf JA, Smith EP, Zhang L, Ramsey T, Yusuff N, et al. Inhibitors of Raf kinase activity block growth of thyroid cancer cells with RET/PTC or BRAF mutations in vitro and in vivo. Clin Cancer Res 2006;12:1785-93.
    • (2006) Clin Cancer Res , vol.12 , pp. 1785-1793
    • Ouyang, B.1    Knauf, J.A.2    Smith, E.P.3    Zhang, L.4    Ramsey, T.5    Yusuff, N.6
  • 54
    • 72949106263 scopus 로고    scopus 로고
    • Beneficial effects of sorafenib on tumor progression, but not on radioiodine uptake, in patients with differentiated thyroid carcinoma
    • Hoftijzer H, Heemstra KA, Morreau H, Stokkel MP, Corssmit EP, Gelderblom H, et al. Beneficial effects of sorafenib on tumor progression, but not on radioiodine uptake, in patients with differentiated thyroid carcinoma. Eur J Endocrinol 2009;161:923-31.
    • (2009) Eur J Endocrinol , vol.161 , pp. 923-931
    • Hoftijzer, H.1    Heemstra, K.A.2    Morreau, H.3    Stokkel, M.P.4    Corssmit, E.P.5    Gelderblom, H.6
  • 55
    • 72549092909 scopus 로고    scopus 로고
    • Phase I trial of a combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in advanced malignancies
    • Hong DS, Sebti SM,Newman RA, Blaskovich MA, Ye L, Gagel RF, et al. Phase I trial of a combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in advanced malignancies. Clin Cancer Res 2009;15:7061-8.
    • (2009) Clin Cancer Res , vol.15 , pp. 7061-7068
    • Hong, D.S.1    Sebti, S.M.2    Newman, R.A.3    Blaskovich, M.A.4    Ye, L.5    Gagel, R.F.6
  • 56
    • 70349513281 scopus 로고    scopus 로고
    • AZD6244 (ARRY-142886) enhances the therapeutic efficacy of sorafenib in mouse models of gastric cancer
    • Yang S, Ngo VC, Lew GB, Chong LW, Lee SS, Ong WJ, et al. AZD6244 (ARRY-142886) enhances the therapeutic efficacy of sorafenib in mouse models of gastric cancer. Mol Cancer Ther 2009;8:2537-45.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2537-2545
    • Yang, S.1    Ngo, V.C.2    Lew, G.B.3    Chong, L.W.4    Lee, S.S.5    Ong, W.J.6
  • 57
    • 79953021811 scopus 로고    scopus 로고
    • Targeting BRAFV600E with PLX4720 displays potent antimigratory and anti-invasive activity in preclinical models of human thyroid cancer
    • Nucera C, Nehs MA, Nagarkatti SS, Sadow PM, Mekel M, Fischer AH, et al. Targeting BRAFV600E with PLX4720 displays potent antimigratory and anti-invasive activity in preclinical models of human thyroid cancer. Oncologist 2011;16:296-309.
    • (2011) Oncologist , vol.16 , pp. 296-309
    • Nucera, C.1    Nehs, M.A.2    Nagarkatti, S.S.3    Sadow, P.M.4    Mekel, M.5    Fischer, A.H.6
  • 58
    • 78650303507 scopus 로고    scopus 로고
    • Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
    • Nazarian R, Shi H, Wang Q, Kong X, Koya RC, Lee H, et al. Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature 2010;468:973-7.
    • (2010) Nature , vol.468 , pp. 973-977
    • Nazarian, R.1    Shi, H.2    Wang, Q.3    Kong, X.4    Koya, R.C.5    Lee, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.