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Volumn 59, Issue 9, 1999, Pages 2029-2033

Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; COLORECTAL CANCER; DNA SEQUENCE; GENE EXPRESSION SYSTEM; GENE MUTATION; GENE SILENCING; HUMAN; HUMAN CELL; METHYLATION; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; PROMOTER REGION;

EID: 0033135049     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (356)

References (20)
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  • 4
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    • Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
    • Ionov, Y., Peinado, M. A., Malkhosyan, S., Shibata, D., and Perucho, M. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature (Lond.), 363: 558-561, 1993.
    • (1993) Nature (Lond.) , vol.363 , pp. 558-561
    • Ionov, Y.1    Peinado, M.A.2    Malkhosyan, S.3    Shibata, D.4    Perucho, M.5
  • 11
    • 0031017268 scopus 로고    scopus 로고
    • Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
    • Kane, M. F., Loda, M., Gaida, G. M., Lipman, J., Mishra, R., Goldman, H., Jessup, J. M., and Kolodner, R. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res., 57: 808-811, 1997.
    • (1997) Cancer Res. , vol.57 , pp. 808-811
    • Kane, M.F.1    Loda, M.2    Gaida, G.M.3    Lipman, J.4    Mishra, R.5    Goldman, H.6    Jessup, J.M.7    Kolodner, R.8
  • 15
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    • BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines
    • Hoang, J-M., Cottu, P. H., Thuille, B., Salmon, R. J., Thomas, G., and Hamelin, R. BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines. Cancer Res., 57: 300-303, 1997.
    • (1997) Cancer Res. , vol.57 , pp. 300-303
    • Hoang, J.-M.1    Cottu, P.H.2    Thuille, B.3    Salmon, R.J.4    Thomas, G.5    Hamelin, R.6
  • 17
    • 0029853804 scopus 로고    scopus 로고
    • Allele loss occurs frequently at hMLH1, hut rarely at hMSH2, in sporadic colorectal cancers with microsatellite instability
    • Tomlinson, I. P. M., Ilyas, M., and Bodmer, W. F. Allele loss occurs frequently at hMLH1, hut rarely at hMSH2, in sporadic colorectal cancers with microsatellite instability. Br. J. Cancer, 74: 1514-1517, 1996.
    • (1996) Br. J. Cancer , vol.74 , pp. 1514-1517
    • Tomlinson, I.P.M.1    Ilyas, M.2    Bodmer, W.F.3
  • 18
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    • Promoter-specific modulation of insulin-like growth factor II genomic imprinting by inhibitors of DNA methylation
    • Hu, J-F., Vu, T. H., and Hoffman, A. R. Promoter-specific modulation of insulin-like growth factor II genomic imprinting by inhibitors of DNA methylation. J. Biol. Chem., 271: 18253-18262, 1996.
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    • Hu, J.-F.1    Vu, T.H.2    Hoffman, A.R.3
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    • Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation
    • Graff, J. R., Herman, J. G., Myohanen, S., Baylin, S. B., and Vertino, P. M. Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation. J. Biot. Chem., 272: 22322-22329, 1997.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.