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Volumn 64, Issue 3, 2013, Pages 626-637

Stop feeding cancer: Pro-inflammatory role of visceral adiposity in liver cancer

Author keywords

Endoplasmic reticulum (ER) stress; Inflammation; Liver cancer (HCC); Visceral adiposity

Indexed keywords

ADIPOCYTOKINE; C REACTIVE PROTEIN; FATTY ACID; HISTONE DEACETYLASE INHIBITOR; HYPOXIA INDUCIBLE FACTOR 1; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERLEUKIN 10; INTERLEUKIN 6; LEPTIN; MICRORNA; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PANOBINOSTAT; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; RETINOL BINDING PROTEIN 4; SNX 5422; SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN C; SORAFENIB; STAT3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SUPPRESSOR OF CYTOKINE SIGNALING 3; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN;

EID: 84886949542     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2013.09.009     Document Type: Review
Times cited : (35)

References (191)
  • 1
    • 7044229778 scopus 로고    scopus 로고
    • Primary liver cancer: worldwide incidence and trends
    • Bosch F.X., Ribes J., Diaz M., Cleries R. Primary liver cancer: worldwide incidence and trends. Gastroenterology 2004, 127(5 Suppl. 1):S5-S16.
    • (2004) Gastroenterology , vol.127 , Issue.5 SUPPL. 1
    • Bosch, F.X.1    Ribes, J.2    Diaz, M.3    Cleries, R.4
  • 2
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: from genes to environment
    • Farazi P.A., DePinho R.A. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 2006, 6:674-687.
    • (2006) Nat Rev Cancer , vol.6 , pp. 674-687
    • Farazi, P.A.1    DePinho, R.A.2
  • 3
    • 84861648384 scopus 로고    scopus 로고
    • Global burden of cancers attributable to infections in 2008: a review and synthetic analysis
    • de Martel C., Ferlay J., Franceschi S., Vignat J., Bray F., Forman D., et al. Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet Oncol 2012, 13(5):607-615.
    • (2012) Lancet Oncol , vol.13 , Issue.5 , pp. 607-615
    • de Martel, C.1    Ferlay, J.2    Franceschi, S.3    Vignat, J.4    Bray, F.5    Forman, D.6
  • 5
    • 77951456114 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection
    • Starley B.Q., Calcagno C.J., Harrison S.A. Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection. Hepatology 2010, 51(5):1820-1832.
    • (2010) Hepatology , vol.51 , Issue.5 , pp. 1820-1832
    • Starley, B.Q.1    Calcagno, C.J.2    Harrison, S.A.3
  • 6
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults
    • Calle E.E., Rodriguez C., Walker-Thurmond K., Thun M.J. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults. N Engl J Med 2003, 348:1625-1638.
    • (2003) N Engl J Med , vol.348 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3    Thun, M.J.4
  • 7
    • 0346689992 scopus 로고    scopus 로고
    • Overweight and obesity, hepatic steatosis, and progression of chronic hepatitis C: a retrospective study on a large cohort of patients in the United States
    • Hu K.Q., Kyulo N.L., Esrailian E., Thompson K., Chase R., Hillebrand D.J., et al. Overweight and obesity, hepatic steatosis, and progression of chronic hepatitis C: a retrospective study on a large cohort of patients in the United States. J Hepatol 2004, 40(1):147-154.
    • (2004) J Hepatol , vol.40 , Issue.1 , pp. 147-154
    • Hu, K.Q.1    Kyulo, N.L.2    Esrailian, E.3    Thompson, K.4    Chase, R.5    Hillebrand, D.J.6
  • 8
    • 84862524716 scopus 로고    scopus 로고
    • Fatty liver and metabolic syndrome in nonabdominally obese Taiwanese adults
    • Chang T.Y., Chen J.D. Fatty liver and metabolic syndrome in nonabdominally obese Taiwanese adults. Asia Pac J Public Health 2012, 24(3):472-479.
    • (2012) Asia Pac J Public Health , vol.24 , Issue.3 , pp. 472-479
    • Chang, T.Y.1    Chen, J.D.2
  • 9
    • 83855161551 scopus 로고    scopus 로고
    • Visceral adiposity index is associated with significant fibrosis in patients with non-alcoholic fatty liver disease
    • Petta S., Amato M.C., Di Marco V., Camma C., Pizzolanti G., Barcellona M.R., et al. Visceral adiposity index is associated with significant fibrosis in patients with non-alcoholic fatty liver disease. Aliment Pharmacol Ther 2012, 35(2):238-247.
    • (2012) Aliment Pharmacol Ther , vol.35 , Issue.2 , pp. 238-247
    • Petta, S.1    Amato, M.C.2    Di Marco, V.3    Camma, C.4    Pizzolanti, G.5    Barcellona, M.R.6
  • 10
    • 66649135527 scopus 로고    scopus 로고
    • Visceral fat accumulation is an independent risk factor for hepatocellular carcinoma recurrence after curative treatment in patients with suspected NASH
    • Ohki T., Tateishi R., Shiina S., Goto E., Sato T., Nakagawa H., et al. Visceral fat accumulation is an independent risk factor for hepatocellular carcinoma recurrence after curative treatment in patients with suspected NASH. Gut 2009, 58(6):839-844.
    • (2009) Gut , vol.58 , Issue.6 , pp. 839-844
    • Ohki, T.1    Tateishi, R.2    Shiina, S.3    Goto, E.4    Sato, T.5    Nakagawa, H.6
  • 11
    • 84870251301 scopus 로고    scopus 로고
    • Abdonimal obesity, weight gain during adulthood and risk factor of liver and biliary tract cancer in a European cohort
    • Schlesinger S., Aleksandrova K., Pischon T., Fedirko V., Jenab M., Trepo E., et al. Abdonimal obesity, weight gain during adulthood and risk factor of liver and biliary tract cancer in a European cohort. Int J Cancer 2013, 132(3):645-657.
    • (2013) Int J Cancer , vol.132 , Issue.3 , pp. 645-657
    • Schlesinger, S.1    Aleksandrova, K.2    Pischon, T.3    Fedirko, V.4    Jenab, M.5    Trepo, E.6
  • 12
    • 67650151005 scopus 로고    scopus 로고
    • Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
    • Colotta F., Allavena P., Sica A., Garlanda C., Mantovani A. Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 2009, 30(7):1073-1081.
    • (2009) Carcinogenesis , vol.30 , Issue.7 , pp. 1073-1081
    • Colotta, F.1    Allavena, P.2    Sica, A.3    Garlanda, C.4    Mantovani, A.5
  • 13
    • 84965173184 scopus 로고
    • Appearance of hepatomas in obese C3H male mice
    • Waxler S.H., Tabar P. Appearance of hepatomas in obese C3H male mice. Stanford Med Bull 1953, 11(4):272-273.
    • (1953) Stanford Med Bull , vol.11 , Issue.4 , pp. 272-273
    • Waxler, S.H.1    Tabar, P.2
  • 14
    • 84865512531 scopus 로고    scopus 로고
    • Excess body weight and the risk of primary liver cancer: an updated meta-analysis of prospective studies
    • Chen Y., Wang X., Wang J., Yan Z., Luo J. Excess body weight and the risk of primary liver cancer: an updated meta-analysis of prospective studies. Eur J Cancer 2012, 48(14):2137-2145.
    • (2012) Eur J Cancer , vol.48 , Issue.14 , pp. 2137-2145
    • Chen, Y.1    Wang, X.2    Wang, J.3    Yan, Z.4    Luo, J.5
  • 16
    • 34247556686 scopus 로고    scopus 로고
    • Adipose tissue as an endocrine organ
    • Ahima R.S. Adipose tissue as an endocrine organ. Obesity (Silver Spring) 2006, (Suppl. 5):242S-249S.
    • (2006) Obesity (Silver Spring) , Issue.5 SUPPL.
    • Ahima, R.S.1
  • 17
    • 2942741295 scopus 로고    scopus 로고
    • The case of visceral fat: argument for the defence
    • Klein S. The case of visceral fat: argument for the defence. J Clin Invest 2004, 113(11):1530-1532.
    • (2004) J Clin Invest , vol.113 , Issue.11 , pp. 1530-1532
    • Klein, S.1
  • 18
    • 65749115425 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and metabolic syndrome
    • Paschos P., Paletas K. Nonalcoholic fatty liver disease and metabolic syndrome. Hippokratia 2009, 13(1):9-19.
    • (2009) Hippokratia , vol.13 , Issue.1 , pp. 9-19
    • Paschos, P.1    Paletas, K.2
  • 19
    • 84872859485 scopus 로고    scopus 로고
    • Visceral adiposity in gastrointestinal and hepatic carcinogenesis
    • Vongsuvanh R., George J., Qiao L., van der Poorten D. Visceral adiposity in gastrointestinal and hepatic carcinogenesis. Cancer Lett 2013, 330(1):1-10.
    • (2013) Cancer Lett , vol.330 , Issue.1 , pp. 1-10
    • Vongsuvanh, R.1    George, J.2    Qiao, L.3    van der Poorten, D.4
  • 21
    • 84856426428 scopus 로고    scopus 로고
    • Role of the insulin-like growth factor 1 axis and visceral adiposity in oesophageal adenocarcinoma
    • Donohoe C.L., Doyle S.L., McGarrigle S., Cathcart M.C., Daly E., O'Grady A., et al. Role of the insulin-like growth factor 1 axis and visceral adiposity in oesophageal adenocarcinoma. Br J Surg 2012, 99(3):387-396.
    • (2012) Br J Surg , vol.99 , Issue.3 , pp. 387-396
    • Donohoe, C.L.1    Doyle, S.L.2    McGarrigle, S.3    Cathcart, M.C.4    Daly, E.5    O'Grady, A.6
  • 22
    • 80053319523 scopus 로고    scopus 로고
    • Pro-inflammatory and tumour proliferative properties of excess visceral adipose tissue
    • Lysaght J., van der Stok E.P., Allott E.H., Casey R., Donohoe C.L., Howard J.M., et al. Pro-inflammatory and tumour proliferative properties of excess visceral adipose tissue. Cancer Lett 2011, 312(1):62-72.
    • (2011) Cancer Lett , vol.312 , Issue.1 , pp. 62-72
    • Lysaght, J.1    van der Stok, E.P.2    Allott, E.H.3    Casey, R.4    Donohoe, C.L.5    Howard, J.M.6
  • 23
    • 68349150756 scopus 로고    scopus 로고
    • CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
    • Nishimura S., Manabe I., Nagasaki M., Eto K., Yamashita H., Ohsugi M., et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med 2009, 15(8):914-920.
    • (2009) Nat Med , vol.15 , Issue.8 , pp. 914-920
    • Nishimura, S.1    Manabe, I.2    Nagasaki, M.3    Eto, K.4    Yamashita, H.5    Ohsugi, M.6
  • 24
    • 75149169811 scopus 로고    scopus 로고
    • Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in diet-induced obese mice
    • Ohmura K., Ishimori N., Ohmura Y., Tokuhara S., Nozawa A., Horii S., et al. Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in diet-induced obese mice. Arterioscler Thromb Vasc Biol 2010, 30:193-199.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 193-199
    • Ohmura, K.1    Ishimori, N.2    Ohmura, Y.3    Tokuhara, S.4    Nozawa, A.5    Horii, S.6
  • 25
    • 33748314535 scopus 로고    scopus 로고
    • Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity
    • Cancello R., Tordjman J., Poitou C., Guilhem G., Bouillot J.L., Hugol D., et al. Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity. Diabetes 2006, 55:1554-1561.
    • (2006) Diabetes , vol.55 , pp. 1554-1561
    • Cancello, R.1    Tordjman, J.2    Poitou, C.3    Guilhem, G.4    Bouillot, J.L.5    Hugol, D.6
  • 26
    • 78049281029 scopus 로고    scopus 로고
    • Adipose tissue endothelial cells from obese human subjects: differences among depots in angiogenic, metabolic and inflammatory gene expression and cellular senescence
    • Villaret A., Galitzky J., Decaunes P., Esteve D., Marques M.A., Sengenes C., et al. Adipose tissue endothelial cells from obese human subjects: differences among depots in angiogenic, metabolic and inflammatory gene expression and cellular senescence. Diabetes 2010, 59:2755-2763.
    • (2010) Diabetes , vol.59 , pp. 2755-2763
    • Villaret, A.1    Galitzky, J.2    Decaunes, P.3    Esteve, D.4    Marques, M.A.5    Sengenes, C.6
  • 27
    • 33750254204 scopus 로고    scopus 로고
    • Effect of DHEA-sulfate on adiponectin gene expression in adipose tissue from different fat depots in morbidly obese humans
    • Hernandez-Morante J.J., Milagro F., Gabaldon J.A., Martinez J.A., Zamora S., Garaulet M. Effect of DHEA-sulfate on adiponectin gene expression in adipose tissue from different fat depots in morbidly obese humans. Eur J Endocrinol 2006, 155:593-600.
    • (2006) Eur J Endocrinol , vol.155 , pp. 593-600
    • Hernandez-Morante, J.J.1    Milagro, F.2    Gabaldon, J.A.3    Martinez, J.A.4    Zamora, S.5    Garaulet, M.6
  • 28
    • 38349169664 scopus 로고    scopus 로고
    • Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
    • Filipowicz W., Bhattacharyya S.N., Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?. Nat Rev Genet 2008, 9(2):102-114.
    • (2008) Nat Rev Genet , vol.9 , Issue.2 , pp. 102-114
    • Filipowicz, W.1    Bhattacharyya, S.N.2    Sonenberg, N.3
  • 29
    • 70349976210 scopus 로고    scopus 로고
    • MicroRNAs: novel regulators in the hallmarks of human cancer
    • Ruan K., Fang X., Ouyang G. MicroRNAs: novel regulators in the hallmarks of human cancer. Cancer Lett 2009, 285(2):116-126.
    • (2009) Cancer Lett , vol.285 , Issue.2 , pp. 116-126
    • Ruan, K.1    Fang, X.2    Ouyang, G.3
  • 30
    • 84873296666 scopus 로고    scopus 로고
    • MicroRNAs: new tools for diagnosis, prognosis, and therapy in hepatocellular carcinoma?
    • Giordano S., Columbano A. MicroRNAs: new tools for diagnosis, prognosis, and therapy in hepatocellular carcinoma?. Hepatology 2013, 57(2):840-847.
    • (2013) Hepatology , vol.57 , Issue.2 , pp. 840-847
    • Giordano, S.1    Columbano, A.2
  • 31
    • 77954342986 scopus 로고    scopus 로고
    • Differential expression of miRNAs in the visceral adipose tissue of patients with non-alcoholic fatty liver disease
    • Estep M., Armistead D., Hossain N., Elarainy H., Goodman Z., Baranova A., et al. Differential expression of miRNAs in the visceral adipose tissue of patients with non-alcoholic fatty liver disease. Aliment Pharmacol Ther 2010, 32(3):487-497.
    • (2010) Aliment Pharmacol Ther , vol.32 , Issue.3 , pp. 487-497
    • Estep, M.1    Armistead, D.2    Hossain, N.3    Elarainy, H.4    Goodman, Z.5    Baranova, A.6
  • 32
    • 84883476367 scopus 로고    scopus 로고
    • Clinical significance and prognostic value of microRNA expression signatures in hepatocellular carcinoma
    • Wei RR, Huang GL, Zhang MY, Li BK, Zhang HZ, Shi M, et al. Clinical significance and prognostic value of microRNA expression signatures in hepatocellular carcinoma. Clin Cancer Res 2013;19(17):4780-91.
    • (2013) Clin Cancer Res , vol.19 , Issue.17 , pp. 4780-4791
    • Wei, R.R.1    Huang, G.L.2    Zhang, M.Y.3    Li, B.K.4    Zhang, H.Z.5    Shi, M.6
  • 33
    • 84882939134 scopus 로고    scopus 로고
    • MicroRNA and liver cancer associated iron overload: therapeutic targets unravelled
    • Greene CM, Varley R, Lawless MW. MicroRNA and liver cancer associated iron overload: therapeutic targets unravelled. World J Gastroenterol 2013;19(32):5212-26.
    • (2013) World J Gastroenterol , vol.19 , Issue.32 , pp. 5212-5226
    • Greene, C.M.1    Varley, R.2    Lawless, M.W.3
  • 34
    • 84864761391 scopus 로고    scopus 로고
    • Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver
    • Hsu S.H., Wang B., Kota J., Yu J., Costinean S., Kutay H., et al. Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver. J Clin Invest 2012, 122(8):2871-2883.
    • (2012) J Clin Invest , vol.122 , Issue.8 , pp. 2871-2883
    • Hsu, S.H.1    Wang, B.2    Kota, J.3    Yu, J.4    Costinean, S.5    Kutay, H.6
  • 35
    • 80051688308 scopus 로고    scopus 로고
    • MicroRNA-122 sensitizes HCC cancer cells to adriamycin and vincristine through modulating expression of MDR and inducing cell cycle arrest
    • Xu Y., Xia F., Ma L., Shan J., Shen J., Yang Z., et al. MicroRNA-122 sensitizes HCC cancer cells to adriamycin and vincristine through modulating expression of MDR and inducing cell cycle arrest. Cancer Lett 2011, 10(2):160-169.
    • (2011) Cancer Lett , vol.10 , Issue.2 , pp. 160-169
    • Xu, Y.1    Xia, F.2    Ma, L.3    Shan, J.4    Shen, J.5    Yang, Z.6
  • 36
    • 84873838963 scopus 로고    scopus 로고
    • Modulation of miR-122 expression affects the interferon response in human hepatoma cells
    • Li A., Qian J., He J., Zhang Q., Zhai A., Song W., et al. Modulation of miR-122 expression affects the interferon response in human hepatoma cells. Mol Med Rep 2013, 7(2):585-590.
    • (2013) Mol Med Rep , vol.7 , Issue.2 , pp. 585-590
    • Li, A.1    Qian, J.2    He, J.3    Zhang, Q.4    Zhai, A.5    Song, W.6
  • 37
    • 84857065456 scopus 로고    scopus 로고
    • Establishment of a novel permissive cell line for the propagation of hepatitis C virus by expression of microRNA miR122
    • Kambara H., Fukuhara T., Shiokawa M., Ono C., Ohara Y., Kamitani W., et al. Establishment of a novel permissive cell line for the propagation of hepatitis C virus by expression of microRNA miR122. J Virol 2012, 86(3):1382-1393.
    • (2012) J Virol , vol.86 , Issue.3 , pp. 1382-1393
    • Kambara, H.1    Fukuhara, T.2    Shiokawa, M.3    Ono, C.4    Ohara, Y.5    Kamitani, W.6
  • 38
    • 34247863931 scopus 로고    scopus 로고
    • Abnormal lipid and glucose metabolism in obesity: implications for non-alcoholic fatty liver disease
    • Parekh S., Anania F.A. Abnormal lipid and glucose metabolism in obesity: implications for non-alcoholic fatty liver disease. Gastroenterology 2007, 132:2191-2207.
    • (2007) Gastroenterology , vol.132 , pp. 2191-2207
    • Parekh, S.1    Anania, F.A.2
  • 39
    • 52949142682 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: a manifestation of the metabolic syndrome
    • Kim C.H., Younossi Z.M. Nonalcoholic fatty liver disease: a manifestation of the metabolic syndrome. Cleveland Clin J Med 2008, 75(10):721-728.
    • (2008) Cleveland Clin J Med , vol.75 , Issue.10 , pp. 721-728
    • Kim, C.H.1    Younossi, Z.M.2
  • 40
    • 84855774531 scopus 로고    scopus 로고
    • Clinical features of non-alcoholic fatty liver disease-associated hepatocellular carcinoma
    • Duan X.Y., Qiao L., Fan J.G. Clinical features of non-alcoholic fatty liver disease-associated hepatocellular carcinoma. Hepatobilliary Pancreat Dis Int 2012, 11(1):18-27.
    • (2012) Hepatobilliary Pancreat Dis Int , vol.11 , Issue.1 , pp. 18-27
    • Duan, X.Y.1    Qiao, L.2    Fan, J.G.3
  • 42
    • 84862181086 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in non-alcoholic fatty liver cirrhosis and alcoholic cirrhosis: risk factor analysis in liver transplant recipients
    • Jain D., Nayak N.C., Saigal S. Hepatocellular carcinoma in non-alcoholic fatty liver cirrhosis and alcoholic cirrhosis: risk factor analysis in liver transplant recipients. Eur J Gastroenterol Hepatol 2012, 24(7):840-848.
    • (2012) Eur J Gastroenterol Hepatol , vol.24 , Issue.7 , pp. 840-848
    • Jain, D.1    Nayak, N.C.2    Saigal, S.3
  • 43
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with non-alcoholic fatty liver disease
    • Donnelly K.L., Smith C.I., Schwarzenberg S.J., Jessurun J., Boldt M.D., Parks E.J. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with non-alcoholic fatty liver disease. J Clin Invest 2005, 115:1343-1351.
    • (2005) J Clin Invest , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3    Jessurun, J.4    Boldt, M.D.5    Parks, E.J.6
  • 44
    • 77956321989 scopus 로고    scopus 로고
    • The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity
    • O'Connell J., Lynch L., Fatwood T.J., Kwasnik A., Nolan N., Geoghegan J., et al. The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity. PloS ONE 2010, 5(4):e9997. 10.1371/journal.pone.0009997.
    • (2010) PloS ONE , vol.5 , Issue.4
    • O'Connell, J.1    Lynch, L.2    Fatwood, T.J.3    Kwasnik, A.4    Nolan, N.5    Geoghegan, J.6
  • 45
    • 33845490856 scopus 로고    scopus 로고
    • The role of insulin resistance in non-alcoholic fatty liver disease
    • Utzschneider K.M., Kahn S.E. The role of insulin resistance in non-alcoholic fatty liver disease. J Clin Endocrinol Metab 2006, 91(12):4753-4761.
    • (2006) J Clin Endocrinol Metab , vol.91 , Issue.12 , pp. 4753-4761
    • Utzschneider, K.M.1    Kahn, S.E.2
  • 46
    • 73149083947 scopus 로고    scopus 로고
    • Hypoxia aggravates non-alcoholic steatohepatitis in mice lacking hepatocellular PTEN
    • Piquet A.C., Stroka D., Zimmermann A., Dufour J.F. Hypoxia aggravates non-alcoholic steatohepatitis in mice lacking hepatocellular PTEN. Clin Sci (Lond) 2009, 118(6):401-410.
    • (2009) Clin Sci (Lond) , vol.118 , Issue.6 , pp. 401-410
    • Piquet, A.C.1    Stroka, D.2    Zimmermann, A.3    Dufour, J.F.4
  • 47
    • 21044456174 scopus 로고    scopus 로고
    • Insulin resistance is a cause of steatosis and fibrosis progression in chronic hepatitis C
    • Fartoux L., Poujol-Robert A., Guechot J., Wendum D., Poupon R., Serfaty L. Insulin resistance is a cause of steatosis and fibrosis progression in chronic hepatitis C. Gut 2005, 54(7):1003-1008.
    • (2005) Gut , vol.54 , Issue.7 , pp. 1003-1008
    • Fartoux, L.1    Poujol-Robert, A.2    Guechot, J.3    Wendum, D.4    Poupon, R.5    Serfaty, L.6
  • 48
    • 0026694055 scopus 로고
    • Insulin regulation of insulin-like growth factor binding protein-1 in obese and nonobese humans
    • Conover C.A., Lee P.D., Kanaley J.A., Clarkson J.T., Jensen M.D. Insulin regulation of insulin-like growth factor binding protein-1 in obese and nonobese humans. J Clin Endocrinol Metab 1992, 74(6):1355-1360.
    • (1992) J Clin Endocrinol Metab , vol.74 , Issue.6 , pp. 1355-1360
    • Conover, C.A.1    Lee, P.D.2    Kanaley, J.A.3    Clarkson, J.T.4    Jensen, M.D.5
  • 49
    • 0037014743 scopus 로고    scopus 로고
    • Insulin, insulin-like growth factor-1 (IGF-1), IGF binding proteins, their biological interactions and colorectal cancer
    • Sandhu M.S., Dunger D.B., Giovannucci E.L. Insulin, insulin-like growth factor-1 (IGF-1), IGF binding proteins, their biological interactions and colorectal cancer. J Natl Cancer Inst 2002, 94(13):972-980.
    • (2002) J Natl Cancer Inst , vol.94 , Issue.13 , pp. 972-980
    • Sandhu, M.S.1    Dunger, D.B.2    Giovannucci, E.L.3
  • 50
    • 79960084386 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 and the liver
    • Bonefeld K., Moller S. Insulin-like growth factor-1 and the liver. Liver Int 2011, 31(7):911-919.
    • (2011) Liver Int , vol.31 , Issue.7 , pp. 911-919
    • Bonefeld, K.1    Moller, S.2
  • 51
    • 84863940804 scopus 로고    scopus 로고
    • Serum insulin-like growth factor-1 levels predict outcomes of patients with advanced hepatocellular carcinoma receiving antiangiogenic therapy
    • Shao Y.Y., Huang C., Lin S.D., Hsu C.H., Cheng A.L. Serum insulin-like growth factor-1 levels predict outcomes of patients with advanced hepatocellular carcinoma receiving antiangiogenic therapy. Clin Cancer Res 2012, 18(14):3992-3997.
    • (2012) Clin Cancer Res , vol.18 , Issue.14 , pp. 3992-3997
    • Shao, Y.Y.1    Huang, C.2    Lin, S.D.3    Hsu, C.H.4    Cheng, A.L.5
  • 52
    • 15144361057 scopus 로고    scopus 로고
    • Disrupted IGF2 promoter control by silencing of promoter P1 in human hepatocellular carcinoma
    • Li X., Nong Z., Ekstrom C., Larsson E., Nordlinder H., Hofmann W.J., et al. Disrupted IGF2 promoter control by silencing of promoter P1 in human hepatocellular carcinoma. Cancer Res 1997, 57:2048-2054.
    • (1997) Cancer Res , vol.57 , pp. 2048-2054
    • Li, X.1    Nong, Z.2    Ekstrom, C.3    Larsson, E.4    Nordlinder, H.5    Hofmann, W.J.6
  • 53
    • 0034972116 scopus 로고    scopus 로고
    • The IGF axis and hepatocarcinogenesis
    • Scharf J.G., Dombrowski F., Ramadori G. The IGF axis and hepatocarcinogenesis. Mol Pathol 2001, 54(3):138-144.
    • (2001) Mol Pathol , vol.54 , Issue.3 , pp. 138-144
    • Scharf, J.G.1    Dombrowski, F.2    Ramadori, G.3
  • 54
    • 14444267347 scopus 로고    scopus 로고
    • Case report: insulin-like growth factor II expression in hepatocellular carcinoma with alcoholic liver fibrosis accompanied by hypoglycaemia
    • Yamaguchi M., Kamimura S., Takada J., Iwata K., Lida T., Kobayashi K., et al. Case report: insulin-like growth factor II expression in hepatocellular carcinoma with alcoholic liver fibrosis accompanied by hypoglycaemia. J Gastroenterol Hepatol 1998, 13(1):47-51.
    • (1998) J Gastroenterol Hepatol , vol.13 , Issue.1 , pp. 47-51
    • Yamaguchi, M.1    Kamimura, S.2    Takada, J.3    Iwata, K.4    Lida, T.5    Kobayashi, K.6
  • 55
    • 0029422279 scopus 로고
    • Big insulin-like growth factor II-producing hepatocellular carcinoma associated with hypoglycaemia
    • Ishida S., Noda M., Kuzuya N., Kubo F., Yamada S., Yamanaka T., et al. Big insulin-like growth factor II-producing hepatocellular carcinoma associated with hypoglycaemia. Int Med 1995, 34(12):1201-1206.
    • (1995) Int Med , vol.34 , Issue.12 , pp. 1201-1206
    • Ishida, S.1    Noda, M.2    Kuzuya, N.3    Kubo, F.4    Yamada, S.5    Yamanaka, T.6
  • 56
    • 77950323927 scopus 로고    scopus 로고
    • Pathogenesis of non-alcoholic fatty liver disease
    • Dowman J.K., Tomlinson J.W., Newsome P.N. Pathogenesis of non-alcoholic fatty liver disease. Q J Med 2010, 103:71-83.
    • (2010) Q J Med , vol.103 , pp. 71-83
    • Dowman, J.K.1    Tomlinson, J.W.2    Newsome, P.N.3
  • 57
    • 3042824524 scopus 로고    scopus 로고
    • Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway
    • Feldstein A.E., Werneburg N.W., Canbay A., Guicciardi M.E., Bronk S.F., Rydzewski R., et al. Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatology 2004, 40:185-194.
    • (2004) Hepatology , vol.40 , pp. 185-194
    • Feldstein, A.E.1    Werneburg, N.W.2    Canbay, A.3    Guicciardi, M.E.4    Bronk, S.F.5    Rydzewski, R.6
  • 58
    • 0038509036 scopus 로고    scopus 로고
    • Lipotoxicity: when tissues overeat
    • Schaffer J.E. Lipotoxicity: when tissues overeat. Curr Opin Lipidol 2003, 14:281-287.
    • (2003) Curr Opin Lipidol , vol.14 , pp. 281-287
    • Schaffer, J.E.1
  • 59
    • 77949329629 scopus 로고    scopus 로고
    • Cellular hypoxia and adipose tissue dysfunction in obesity
    • Wood I.S., Heredia F.P., Want B., Trayhurn P. Cellular hypoxia and adipose tissue dysfunction in obesity. Proc Nutr Soc 2009, 68:370-377.
    • (2009) Proc Nutr Soc , vol.68 , pp. 370-377
    • Wood, I.S.1    Heredia, F.P.2    Want, B.3    Trayhurn, P.4
  • 60
    • 74549167737 scopus 로고    scopus 로고
    • Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
    • Park E.J., Lee J.H., Yu G.Y., He G., Ali S.R., Holzer R.G., et al. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 2010, 140(2):197-208.
    • (2010) Cell , vol.140 , Issue.2 , pp. 197-208
    • Park, E.J.1    Lee, J.H.2    Yu, G.Y.3    He, G.4    Ali, S.R.5    Holzer, R.G.6
  • 61
    • 84867707157 scopus 로고    scopus 로고
    • Inflammation and stress-related signalling pathways in hepatocarcinogenesis
    • Nakagawa H., Maeda S. Inflammation and stress-related signalling pathways in hepatocarcinogenesis. World J Gastroenterol 2012, 18(31):4071-4081.
    • (2012) World J Gastroenterol , vol.18 , Issue.31 , pp. 4071-4081
    • Nakagawa, H.1    Maeda, S.2
  • 62
    • 33750602672 scopus 로고    scopus 로고
    • Mesenteric adipose tissue-derived monocyte chemoattractant protein-1 plays a crucial role in adipose tissue macrophage migration and activation in obese mice
    • Yu R., Kim C.S., Kwon B.S., Kawada T. Mesenteric adipose tissue-derived monocyte chemoattractant protein-1 plays a crucial role in adipose tissue macrophage migration and activation in obese mice. Obesity (Silver Spring) 2006, 14(8):1353-1362.
    • (2006) Obesity (Silver Spring) , vol.14 , Issue.8 , pp. 1353-1362
    • Yu, R.1    Kim, C.S.2    Kwon, B.S.3    Kawada, T.4
  • 63
    • 84861070806 scopus 로고    scopus 로고
    • The role of visceral fat
    • Batra A., Siegmund B. The role of visceral fat. Dig Dis 2012, 30(1):70-74.
    • (2012) Dig Dis , vol.30 , Issue.1 , pp. 70-74
    • Batra, A.1    Siegmund, B.2
  • 64
    • 84860250440 scopus 로고    scopus 로고
    • Visceral fat accumulation is an indicator of adipose tissue macrophage infiltration in women
    • Michaud A., Drolet R., Noel S., Paris G., Tchernof A. Visceral fat accumulation is an indicator of adipose tissue macrophage infiltration in women. Metabolism 2012, 61(5):689-698.
    • (2012) Metabolism , vol.61 , Issue.5 , pp. 689-698
    • Michaud, A.1    Drolet, R.2    Noel, S.3    Paris, G.4    Tchernof, A.5
  • 65
    • 84879888338 scopus 로고    scopus 로고
    • Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
    • Yoshimoto S., Loo T.M., Atarashi K., Kanda H., Sato S., Oyadomari S., et al. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature 2013, 499:97-101.
    • (2013) Nature , vol.499 , pp. 97-101
    • Yoshimoto, S.1    Loo, T.M.2    Atarashi, K.3    Kanda, H.4    Sato, S.5    Oyadomari, S.6
  • 67
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • Friedman J.M., Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 1998, 395:763-770.
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 68
    • 33644764960 scopus 로고    scopus 로고
    • Adipose overexpression of phosphoenolpyruvate carboxykinase leads to high susceptibility to diet-induced insulin resistance and obesity
    • Franckhauser S., Munoz S., Elias I., Ferre T., Bosch F. Adipose overexpression of phosphoenolpyruvate carboxykinase leads to high susceptibility to diet-induced insulin resistance and obesity. Diabetes 2006, 55(2):273-280.
    • (2006) Diabetes , vol.55 , Issue.2 , pp. 273-280
    • Franckhauser, S.1    Munoz, S.2    Elias, I.3    Ferre, T.4    Bosch, F.5
  • 70
    • 33645066625 scopus 로고    scopus 로고
    • Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli
    • Garofalo C., Koda M., Cascio S., Sulkowska M., Kanczuga-Koda L., Golaszewska J., et al. Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli. Clin Cancer Res 2006, 12(5):1447-1453.
    • (2006) Clin Cancer Res , vol.12 , Issue.5 , pp. 1447-1453
    • Garofalo, C.1    Koda, M.2    Cascio, S.3    Sulkowska, M.4    Kanczuga-Koda, L.5    Golaszewska, J.6
  • 71
    • 0034927064 scopus 로고    scopus 로고
    • Leptin augments inflammatory and profibrogenic responses in the murine liver induced by hepatotoxic chemicals
    • Ikejima K., Honda H., Yoshikawa M., Hirose M., Kitamura T., Takei Y., et al. Leptin augments inflammatory and profibrogenic responses in the murine liver induced by hepatotoxic chemicals. Hepatology 2001, 34:288-297.
    • (2001) Hepatology , vol.34 , pp. 288-297
    • Ikejima, K.1    Honda, H.2    Yoshikawa, M.3    Hirose, M.4    Kitamura, T.5    Takei, Y.6
  • 73
    • 0035654626 scopus 로고    scopus 로고
    • Overfeeding rapidly induces leptin and insulin resistance
    • Wang J., Obici S., Morgan K., Barzilai N., Feng Z., Rossetti L. Overfeeding rapidly induces leptin and insulin resistance. Diabetes 2001, 50(12):2786-2791.
    • (2001) Diabetes , vol.50 , Issue.12 , pp. 2786-2791
    • Wang, J.1    Obici, S.2    Morgan, K.3    Barzilai, N.4    Feng, Z.5    Rossetti, L.6
  • 74
    • 0030013679 scopus 로고    scopus 로고
    • Relationship between insulin sensitivity and plasma leptin concentration in lean and obese men
    • Segal K.R., Landt M., Klein S. Relationship between insulin sensitivity and plasma leptin concentration in lean and obese men. Diabetes 1996, 45(7):988-991.
    • (1996) Diabetes , vol.45 , Issue.7 , pp. 988-991
    • Segal, K.R.1    Landt, M.2    Klein, S.3
  • 75
    • 10544220841 scopus 로고    scopus 로고
    • Serum leptin concentration, obesity and insulin resistance in Western Samoans: cross sectional study
    • Zimmet P., Hodge A., Nicolson M., Staten M., de Courten M., Moore J., et al. Serum leptin concentration, obesity and insulin resistance in Western Samoans: cross sectional study. BMJ 1996, 313(7063):965-969.
    • (1996) BMJ , vol.313 , Issue.7063 , pp. 965-969
    • Zimmet, P.1    Hodge, A.2    Nicolson, M.3    Staten, M.4    de Courten, M.5    Moore, J.6
  • 76
    • 48049105312 scopus 로고    scopus 로고
    • Serum leptin and soluble leptin receptor in non-alcoholic fatty liver disease
    • Huang X.D., Fan Y., Zhang H., Wang P., Yuan J.P., Li M.J., et al. Serum leptin and soluble leptin receptor in non-alcoholic fatty liver disease. World J Gastroenterol 2009, 14(18):2888-2893.
    • (2009) World J Gastroenterol , vol.14 , Issue.18 , pp. 2888-2893
    • Huang, X.D.1    Fan, Y.2    Zhang, H.3    Wang, P.4    Yuan, J.P.5    Li, M.J.6
  • 77
    • 2342537773 scopus 로고    scopus 로고
    • From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes
    • Curat C.A., Miranville A., Sengenes C., Diehl M., Tonus C., Busse R., et al. From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes. Diabetes 2004, 53:1285-1292.
    • (2004) Diabetes , vol.53 , pp. 1285-1292
    • Curat, C.A.1    Miranville, A.2    Sengenes, C.3    Diehl, M.4    Tonus, C.5    Busse, R.6
  • 78
    • 36049051889 scopus 로고    scopus 로고
    • Leptin requires canonical migratory signalling pathways for induction of monocyte and macrophage chemotaxis
    • Gruen M.L., Hao M.M., Piston D.W., Hasty A.H. Leptin requires canonical migratory signalling pathways for induction of monocyte and macrophage chemotaxis. Am J Physiol Cell Physiol 2007, 293:C1481-C1488.
    • (2007) Am J Physiol Cell Physiol , vol.293
    • Gruen, M.L.1    Hao, M.M.2    Piston, D.W.3    Hasty, A.H.4
  • 80
    • 34547819751 scopus 로고    scopus 로고
    • Leptin induces proliferation and anti-apoptosis in human hepatocarcinoma cells by up-regulating cyclin D1 and down-regulating Bax via a Janus kinase 2-linked pathway
    • Chen C., Chang Y.C., Liu C.L., Liu T.P., Chang K.J., Guo I.C. Leptin induces proliferation and anti-apoptosis in human hepatocarcinoma cells by up-regulating cyclin D1 and down-regulating Bax via a Janus kinase 2-linked pathway. Endocr Relat Cancer 2007, 14:513-529.
    • (2007) Endocr Relat Cancer , vol.14 , pp. 513-529
    • Chen, C.1    Chang, Y.C.2    Liu, C.L.3    Liu, T.P.4    Chang, K.J.5    Guo, I.C.6
  • 81
    • 81455138111 scopus 로고    scopus 로고
    • Increased levels of serum leptin are a risk factor for the recurrence of stage I/II hepatocellular carcinoma after curative treatment
    • Watanabe N., Takai K., Lmai K., Shimizu M., Naiki T., Nagaki M., et al. Increased levels of serum leptin are a risk factor for the recurrence of stage I/II hepatocellular carcinoma after curative treatment. J Clin Biochem Nutr 2011, 49(3):153-158.
    • (2011) J Clin Biochem Nutr , vol.49 , Issue.3 , pp. 153-158
    • Watanabe, N.1    Takai, K.2    Lmai, K.3    Shimizu, M.4    Naiki, T.5    Nagaki, M.6
  • 82
    • 0028787490 scopus 로고
    • Lodish HFl. A novel serum protein similar to C1q, produced exclusively in adipocytes
    • Scherer P.E., Williams S., Fogliano M., Baldini G. Lodish HFl. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 1995, 270:26746-26749.
    • (1995) J Biol Chem , vol.270 , pp. 26746-26749
    • Scherer, P.E.1    Williams, S.2    Fogliano, M.3    Baldini, G.4
  • 84
    • 3242883351 scopus 로고    scopus 로고
    • Obesity, adipocytokines, and insulin resistance in breast cancer
    • Rose D.P., Komninou D., Stephenson G.D. Obesity, adipocytokines, and insulin resistance in breast cancer. Obes Rev 2004, 5:153-165.
    • (2004) Obes Rev , vol.5 , pp. 153-165
    • Rose, D.P.1    Komninou, D.2    Stephenson, G.D.3
  • 85
    • 33749171254 scopus 로고    scopus 로고
    • Adiponectin as a biomarker of clinical manifestation of metabolic syndrome
    • Tajtakova M., Petrasova D., Petrovicova J., Pytliak M., Semanova Z. Adiponectin as a biomarker of clinical manifestation of metabolic syndrome. Endocr Regul 2006, 10(1):15-19.
    • (2006) Endocr Regul , vol.10 , Issue.1 , pp. 15-19
    • Tajtakova, M.1    Petrasova, D.2    Petrovicova, J.3    Pytliak, M.4    Semanova, Z.5
  • 86
    • 77953417982 scopus 로고    scopus 로고
    • The relationship between serum adiponectin, tumor necrosis factor-alpha, leptin levels and insulin sensitivity in childhood and adolescent obesity: adiponectin is a marker of metabolic syndrome
    • Alikasifoglu A., Gonc N., Ozon Z.A., Sen Y., Kandemir N. The relationship between serum adiponectin, tumor necrosis factor-alpha, leptin levels and insulin sensitivity in childhood and adolescent obesity: adiponectin is a marker of metabolic syndrome. J Clin Res Pediatr Endocrinol 2009, 1(5):233-239.
    • (2009) J Clin Res Pediatr Endocrinol , vol.1 , Issue.5 , pp. 233-239
    • Alikasifoglu, A.1    Gonc, N.2    Ozon, Z.A.3    Sen, Y.4    Kandemir, N.5
  • 87
    • 79951976645 scopus 로고    scopus 로고
    • Associations of insulin resistance and adiponectin with mortality in women with breast cancer
    • Duggan C., Irwin M.L., Xiao L., Henderson K.D., Smith A.W., Baumgartner R.N., et al. Associations of insulin resistance and adiponectin with mortality in women with breast cancer. J Clin Oncol 2011, 29(1):32-39.
    • (2011) J Clin Oncol , vol.29 , Issue.1 , pp. 32-39
    • Duggan, C.1    Irwin, M.L.2    Xiao, L.3    Henderson, K.D.4    Smith, A.W.5    Baumgartner, R.N.6
  • 89
    • 84155162521 scopus 로고    scopus 로고
    • Both adiponectin and iterleukin-10 inhibit LPS-induced activation of the NF-κB pathway in 3T3-L1 adipocytes
    • Lira F.S., Rosa J.C., Pimentel G.D., Seelaender M., Damaso A.R., Oyama L.M., et al. Both adiponectin and iterleukin-10 inhibit LPS-induced activation of the NF-κB pathway in 3T3-L1 adipocytes. Cytokine 2012, 57(1):98-106.
    • (2012) Cytokine , vol.57 , Issue.1 , pp. 98-106
    • Lira, F.S.1    Rosa, J.C.2    Pimentel, G.D.3    Seelaender, M.4    Damaso, A.R.5    Oyama, L.M.6
  • 90
    • 78049525062 scopus 로고    scopus 로고
    • Adiponectin antagonizes the oncogenic actions of leptin in hepatocellular carcinogenesis
    • Sharma D., Wang J., Fu P.P., Sharma S., Nagalingam A., Mells J., et al. Adiponectin antagonizes the oncogenic actions of leptin in hepatocellular carcinogenesis. Hepatology 2010, 52(5):1713-1722.
    • (2010) Hepatology , vol.52 , Issue.5 , pp. 1713-1722
    • Sharma, D.1    Wang, J.2    Fu, P.P.3    Sharma, S.4    Nagalingam, A.5    Mells, J.6
  • 91
    • 78049478003 scopus 로고    scopus 로고
    • Adiponectin modulates C-jun N-terminal kinase and mammalian target of rapamycin and inhibits hepatocellular carcinoma
    • Saxena N.K., Fu P.P., Nagalingam A., Wang J., Handy J., Cohen J., et al. Adiponectin modulates C-jun N-terminal kinase and mammalian target of rapamycin and inhibits hepatocellular carcinoma. Gastroenterology 2010, 139(5):1762-1773.
    • (2010) Gastroenterology , vol.139 , Issue.5 , pp. 1762-1773
    • Saxena, N.K.1    Fu, P.P.2    Nagalingam, A.3    Wang, J.4    Handy, J.5    Cohen, J.6
  • 92
    • 84863720799 scopus 로고    scopus 로고
    • The promoting effect of adiponectin in hepatocellular carcinoma
    • Chen M.J., Yeh Y.T., Lee K.T., Tsai C.J., Lee H.H., Wang S.N. The promoting effect of adiponectin in hepatocellular carcinoma. J Surg Oncol 2012, 106(2):181-187.
    • (2012) J Surg Oncol , vol.106 , Issue.2 , pp. 181-187
    • Chen, M.J.1    Yeh, Y.T.2    Lee, K.T.3    Tsai, C.J.4    Lee, H.H.5    Wang, S.N.6
  • 93
    • 84860453490 scopus 로고    scopus 로고
    • The significance of serum levels of adiponectin, leptin, and hyaluronic acid in hepatocellular carcinoma of cirrhotic and noncirrhotic patients
    • Sadik N.A., Ahmed A., Ahmed S. The significance of serum levels of adiponectin, leptin, and hyaluronic acid in hepatocellular carcinoma of cirrhotic and noncirrhotic patients. Hum Exp Toxicol 2012, 31(4):311-321.
    • (2012) Hum Exp Toxicol , vol.31 , Issue.4 , pp. 311-321
    • Sadik, N.A.1    Ahmed, A.2    Ahmed, S.3
  • 94
    • 81055145083 scopus 로고    scopus 로고
    • Total and high molecular weight adiponectin and hepatocellular carcinoma with HCV infection
    • Sumie S., Kawaquchi T., Kuromatsu R., Takata A., Nakano M., Satani M., et al. Total and high molecular weight adiponectin and hepatocellular carcinoma with HCV infection. PloS ONE 2011, 6(11):e26840.
    • (2011) PloS ONE , vol.6 , Issue.11
    • Sumie, S.1    Kawaquchi, T.2    Kuromatsu, R.3    Takata, A.4    Nakano, M.5    Satani, M.6
  • 95
    • 20444480549 scopus 로고    scopus 로고
    • Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6
    • Park H.S., Park J.Y., Yu R. Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6. Diab Res Clin Pract 2005, 69(1):29-35.
    • (2005) Diab Res Clin Pract , vol.69 , Issue.1 , pp. 29-35
    • Park, H.S.1    Park, J.Y.2    Yu, R.3
  • 96
    • 7744226116 scopus 로고    scopus 로고
    • Serum levels of interleukin-6 and C-reactive protein correlate with body mass index across the broad range of obesity
    • Khaodhiar L., Ling P.R., Blackburn G.L., Bistrian B.R. Serum levels of interleukin-6 and C-reactive protein correlate with body mass index across the broad range of obesity. JPEN J Parenter Enteral Nutr 2004, 28(6):410-415.
    • (2004) JPEN J Parenter Enteral Nutr , vol.28 , Issue.6 , pp. 410-415
    • Khaodhiar, L.1    Ling, P.R.2    Blackburn, G.L.3    Bistrian, B.R.4
  • 97
    • 79952279156 scopus 로고    scopus 로고
    • Proinflammatory cytokines IL-6 and TNF-α and the development of inflammation in obese subjects
    • Popko K., Gorska E., Stelmaszczyk-Emmel A., Plywaczewski R., Stoklosa A., Gorecka D., et al. Proinflammatory cytokines IL-6 and TNF-α and the development of inflammation in obese subjects. Eur J Med Res 2010, 15(Suppl. 2):120-122.
    • (2010) Eur J Med Res , vol.15 , Issue.2 SUPPL. , pp. 120-122
    • Popko, K.1    Gorska, E.2    Stelmaszczyk-Emmel, A.3    Plywaczewski, R.4    Stoklosa, A.5    Gorecka, D.6
  • 98
    • 78049522194 scopus 로고    scopus 로고
    • Evolution of inflammation in non-alcoholic fatty liver disease: the multiple parallel hits hypothesis
    • Tilg H., Moschen A.R. Evolution of inflammation in non-alcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology 2010, 52(5):1836-1846.
    • (2010) Hepatology , vol.52 , Issue.5 , pp. 1836-1846
    • Tilg, H.1    Moschen, A.R.2
  • 100
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha - direct role in obesity-linked insulin resistance
    • Hotamisligil G.S., Shargill N.S., Spiegelman B.M. Adipose expression of tumor necrosis factor-alpha - direct role in obesity-linked insulin resistance. Science 1993, 259:87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 101
    • 0033874108 scopus 로고    scopus 로고
    • Proinflammatory cytokines
    • Dinarello C.A. Proinflammatory cytokines. Chest 2000, 118(2):503-508.
    • (2000) Chest , vol.118 , Issue.2 , pp. 503-508
    • Dinarello, C.A.1
  • 102
    • 0042887449 scopus 로고    scopus 로고
    • Influence of pro-inflammatory (IL-1 alpha, IL-6, TNA-alpha, IFN-gamma) and anti-inflammatory (IL-4) cytokines on chondrocyte function
    • Schuerwegh A.J., Dombrecht E.J., Stevens W.J., Van Offel J.F., Bridts C.H., De Clerck L.S. Influence of pro-inflammatory (IL-1 alpha, IL-6, TNA-alpha, IFN-gamma) and anti-inflammatory (IL-4) cytokines on chondrocyte function. Osteoarthr Cartilage 2003, 11(9):681-687.
    • (2003) Osteoarthr Cartilage , vol.11 , Issue.9 , pp. 681-687
    • Schuerwegh, A.J.1    Dombrecht, E.J.2    Stevens, W.J.3    Van Offel, J.F.4    Bridts, C.H.5    De Clerck, L.S.6
  • 103
    • 0036105564 scopus 로고    scopus 로고
    • The role of TNF-α in the pathogenesis of inflammation and joint destruction in rheumatoid arthritis (RA): a study using a human RA/SCID mouse chimera
    • Matsuno H., Yudoh K., Katayama R., Nakazawa F., Uzuki M., Sawai T., et al. The role of TNF-α in the pathogenesis of inflammation and joint destruction in rheumatoid arthritis (RA): a study using a human RA/SCID mouse chimera. Br Soc Rheumatol 2002, 41:329-337.
    • (2002) Br Soc Rheumatol , vol.41 , pp. 329-337
    • Matsuno, H.1    Yudoh, K.2    Katayama, R.3    Nakazawa, F.4    Uzuki, M.5    Sawai, T.6
  • 104
    • 34047235187 scopus 로고    scopus 로고
    • TNF/VEGF cross-talk in chronic inflammation-related cancer initiation and progression: an early target in anticancer therapeutic strategy
    • Guadagni F., Ferroni P., Palmirotta R., Portarena I., Formica V., Roselli M. TNF/VEGF cross-talk in chronic inflammation-related cancer initiation and progression: an early target in anticancer therapeutic strategy. In Vivo 2007, 21(2):147-161.
    • (2007) In Vivo , vol.21 , Issue.2 , pp. 147-161
    • Guadagni, F.1    Ferroni, P.2    Palmirotta, R.3    Portarena, I.4    Formica, V.5    Roselli, M.6
  • 105
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-α function
    • Uysal K.T., Wiesbrock S.M., Marino M.W., Hotamisligil G.S. Protection from obesity-induced insulin resistance in mice lacking TNF-α function. Nature 1997, 389:610-614.
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 106
    • 0346880504 scopus 로고    scopus 로고
    • Inflammatory pathways and insulin action
    • Hotamisligil G.S. Inflammatory pathways and insulin action. Int J Obesity 2003, 27(Suppl. 3):S53-S55.
    • (2003) Int J Obesity , vol.27 , Issue.3 SUPPL.
    • Hotamisligil, G.S.1
  • 107
    • 4243150843 scopus 로고    scopus 로고
    • The role of TNF-alpha in insulin resistance
    • Borst S.E. The role of TNF-alpha in insulin resistance. Endocrine 2004, 23(2-3):177-182.
    • (2004) Endocrine , vol.23 , Issue.2-3 , pp. 177-182
    • Borst, S.E.1
  • 109
    • 80053038572 scopus 로고    scopus 로고
    • Cyclin-dependent kinase-5 is a key molecule in tumor necrosis factor-α induced insulin resistance
    • Nohara A., Okada S., Ohshima K., Pessin J.E., Mori M. Cyclin-dependent kinase-5 is a key molecule in tumor necrosis factor-α induced insulin resistance. J Biol Chem 2011, 286(38):33457-33465.
    • (2011) J Biol Chem , vol.286 , Issue.38 , pp. 33457-33465
    • Nohara, A.1    Okada, S.2    Ohshima, K.3    Pessin, J.E.4    Mori, M.5
  • 110
    • 0347990602 scopus 로고    scopus 로고
    • Stimulation of lipolysis by tumour necrosis factor-α in 3T3-L1 adipocytes is glucose dependent: implications for long-term regulation of lipolysis
    • Green A., Rumberger J.M., Stuart C.A., Ruhoff M.S. Stimulation of lipolysis by tumour necrosis factor-α in 3T3-L1 adipocytes is glucose dependent: implications for long-term regulation of lipolysis. Diabetes 2004, 53(1):74-81.
    • (2004) Diabetes , vol.53 , Issue.1 , pp. 74-81
    • Green, A.1    Rumberger, J.M.2    Stuart, C.A.3    Ruhoff, M.S.4
  • 111
    • 79952533014 scopus 로고    scopus 로고
    • Tumor necrosis factor α stimulates endothelin-1 synthesis in rat hepatic stellate cells in hepatic wound healing through a novel IKK/JNK pathway
    • Zhan S., Rockey D.C. Tumor necrosis factor α stimulates endothelin-1 synthesis in rat hepatic stellate cells in hepatic wound healing through a novel IKK/JNK pathway. Exp Cell Res 2011, 317(7):1040-1048.
    • (2011) Exp Cell Res , vol.317 , Issue.7 , pp. 1040-1048
    • Zhan, S.1    Rockey, D.C.2
  • 112
    • 84856263295 scopus 로고    scopus 로고
    • Visceral obesity, metabolic syndrome, insulin resistance and cancer
    • Doyle S.L., Donohoe C.L., Lysaght J., Reynolds J.V. Visceral obesity, metabolic syndrome, insulin resistance and cancer. Proc Nutr Soc 2012, 71:181-189.
    • (2012) Proc Nutr Soc , vol.71 , pp. 181-189
    • Doyle, S.L.1    Donohoe, C.L.2    Lysaght, J.3    Reynolds, J.V.4
  • 113
    • 34047155003 scopus 로고    scopus 로고
    • Visceral fat adipokine secretion is associated with systemic inflammation in obese humans
    • Fontana L., Eagon J.C., Trujillo M.E., Scherer P.E., Klein S. Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 2007, 56(4):1010-1013.
    • (2007) Diabetes , vol.56 , Issue.4 , pp. 1010-1013
    • Fontana, L.1    Eagon, J.C.2    Trujillo, M.E.3    Scherer, P.E.4    Klein, S.5
  • 114
    • 44949233003 scopus 로고    scopus 로고
    • Increased hepatic and circulating interleukin-6 levels in human non-alcoholic steatohepatitis
    • Wieckowska A., Papouchado B.G., Li Z., Lopez R., Zein N.N., Feldstein A.E. Increased hepatic and circulating interleukin-6 levels in human non-alcoholic steatohepatitis. Am J Gastroenterol 2008, 103(6):1372-1379.
    • (2008) Am J Gastroenterol , vol.103 , Issue.6 , pp. 1372-1379
    • Wieckowska, A.1    Papouchado, B.G.2    Li, Z.3    Lopez, R.4    Zein, N.N.5    Feldstein, A.E.6
  • 115
    • 84860390493 scopus 로고    scopus 로고
    • C-reactive protein levels in relation to various features of non-alcoholic fatty liver disease among obese patients
    • Zimmermann E., Anty R., Tordjman J., Verrijken A., Gual P., Tran A., et al. C-reactive protein levels in relation to various features of non-alcoholic fatty liver disease among obese patients. J Hepatol 2011, 55(3):660-665.
    • (2011) J Hepatol , vol.55 , Issue.3 , pp. 660-665
    • Zimmermann, E.1    Anty, R.2    Tordjman, J.3    Verrijken, A.4    Gual, P.5    Tran, A.6
  • 116
    • 34548602984 scopus 로고    scopus 로고
    • Serum C-reactive protein levels predict survival in hepatocellular carcinoma
    • Nagaoka S., Yoshida T., Akiyoshi J., Akiba J., Torimura T., Adachi H., et al. Serum C-reactive protein levels predict survival in hepatocellular carcinoma. Liver Int 2007, 27(8):1091-1097.
    • (2007) Liver Int , vol.27 , Issue.8 , pp. 1091-1097
    • Nagaoka, S.1    Yoshida, T.2    Akiyoshi, J.3    Akiba, J.4    Torimura, T.5    Adachi, H.6
  • 117
    • 0033999288 scopus 로고    scopus 로고
    • C-reactive protein concentration in children: relationship to adiposity and other cardiovascular risk factors
    • Cook D.G., Mendall M.A., Whincup P.H., Carey I.M., Ballam L., Morris J.E., et al. C-reactive protein concentration in children: relationship to adiposity and other cardiovascular risk factors. Atherosclerosis 2000, 149:139-150.
    • (2000) Atherosclerosis , vol.149 , pp. 139-150
    • Cook, D.G.1    Mendall, M.A.2    Whincup, P.H.3    Carey, I.M.4    Ballam, L.5    Morris, J.E.6
  • 118
    • 84872107512 scopus 로고    scopus 로고
    • Association between circulating cytokine levels, diabetes and insulin resistance in a population-based sample (CoLaus study)
    • Marques-Vidal P., Bastardot F., von Kanel R., Paccaud F., Preisiq M., Waeber G., et al. Association between circulating cytokine levels, diabetes and insulin resistance in a population-based sample (CoLaus study). Clin Endocrinol (Oxf) 2013, 78(2):232-241.
    • (2013) Clin Endocrinol (Oxf) , vol.78 , Issue.2 , pp. 232-241
    • Marques-Vidal, P.1    Bastardot, F.2    von Kanel, R.3    Paccaud, F.4    Preisiq, M.5    Waeber, G.6
  • 119
    • 22944434929 scopus 로고    scopus 로고
    • Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
    • Yang Q., Graham T.E., Mody N., Preitner F., Peroni O.D., Zabolotny J.M., et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature (Lond) 2005, 436:356-362.
    • (2005) Nature (Lond) , vol.436 , pp. 356-362
    • Yang, Q.1    Graham, T.E.2    Mody, N.3    Preitner, F.4    Peroni, O.D.5    Zabolotny, J.M.6
  • 120
    • 34347208708 scopus 로고    scopus 로고
    • Serum retinol-binding protein: a link between obesity, insulin resistance, and type 2 diabetes
    • Wolf G. Serum retinol-binding protein: a link between obesity, insulin resistance, and type 2 diabetes. Nutr Rev 2007, 65:251-256.
    • (2007) Nutr Rev , vol.65 , pp. 251-256
    • Wolf, G.1
  • 121
    • 35948988483 scopus 로고    scopus 로고
    • Serum retinol-binding protein 4 concentration and its ratio to serum retinol are associated with obesity and metabolic syndrome components in children
    • Aeberli I., Biebinger R., Lehmann R., L'allemand D., Spinas G.A., Zimmermann M.B. Serum retinol-binding protein 4 concentration and its ratio to serum retinol are associated with obesity and metabolic syndrome components in children. J Clin Endocrinol Metab 2007, 92:4359-4365.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 4359-4365
    • Aeberli, I.1    Biebinger, R.2    Lehmann, R.3    L'allemand, D.4    Spinas, G.A.5    Zimmermann, M.B.6
  • 122
    • 0036776098 scopus 로고    scopus 로고
    • Structural organization of the endoplasmic reticulum
    • Voeltz G.K., Rolls M.M., Rapoport T.A. Structural organization of the endoplasmic reticulum. EMBO Rep 2002, 3(10):944-950.
    • (2002) EMBO Rep , vol.3 , Issue.10 , pp. 944-950
    • Voeltz, G.K.1    Rolls, M.M.2    Rapoport, T.A.3
  • 123
    • 0031081340 scopus 로고    scopus 로고
    • The ER-overload response: activation of NF-kappa B
    • Pahl H.L., Baeuerle P.A. The ER-overload response: activation of NF-kappa B. Trends Biochem Sci 1997, 22(2):63-67.
    • (1997) Trends Biochem Sci , vol.22 , Issue.2 , pp. 63-67
    • Pahl, H.L.1    Baeuerle, P.A.2
  • 124
    • 62749104401 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress: another link between obesity and insulin resistance/inflammation?
    • Boden G. Endoplasmic reticulum stress: another link between obesity and insulin resistance/inflammation?. Diabetes 2009, 58(3):518-519.
    • (2009) Diabetes , vol.58 , Issue.3 , pp. 518-519
    • Boden, G.1
  • 125
    • 34548419344 scopus 로고    scopus 로고
    • Adipocyte stress: the endoplasmic reticulum and metabolic disease
    • Gregor M.F., Hotamisligil G.S. Adipocyte stress: the endoplasmic reticulum and metabolic disease. J Lipid Res 2007, 48:1905-1914.
    • (2007) J Lipid Res , vol.48 , pp. 1905-1914
    • Gregor, M.F.1    Hotamisligil, G.S.2
  • 126
    • 84869184022 scopus 로고    scopus 로고
    • Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue
    • Kawasaki N., Asada R., Saito A., Kanemoto S., Imaizumi K. Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue. Sci Rep 2012, 2:799.
    • (2012) Sci Rep , vol.2 , pp. 799
    • Kawasaki, N.1    Asada, R.2    Saito, A.3    Kanemoto, S.4    Imaizumi, K.5
  • 127
    • 84872445186 scopus 로고    scopus 로고
    • Signaling dynamics of palmitate-induced ER stress responses mediated by ATF4 in HepG2 cells
    • Cho H., Wu M., Zhang L., Thompson R., Nath A., Chan C. Signaling dynamics of palmitate-induced ER stress responses mediated by ATF4 in HepG2 cells. BMC Syst Biol 2013, 7:9.
    • (2013) BMC Syst Biol , vol.7 , pp. 9
    • Cho, H.1    Wu, M.2    Zhang, L.3    Thompson, R.4    Nath, A.5    Chan, C.6
  • 128
    • 84863012179 scopus 로고    scopus 로고
    • Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation
    • Lee J.S., Mendez R., Heng H.H., Yang Z.Q., Zhang K. Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation. Am J Transl Res 2012, 4(1):102-113.
    • (2012) Am J Transl Res , vol.4 , Issue.1 , pp. 102-113
    • Lee, J.S.1    Mendez, R.2    Heng, H.H.3    Yang, Z.Q.4    Zhang, K.5
  • 129
    • 84862270029 scopus 로고    scopus 로고
    • Ectopic fat and insulin resistance: pathophysiology and effect of diet and lifestyle interventions
    • Snel M., Jonker J.T., Schoones J., Lamb H., de Roos A., Pijl H., et al. Ectopic fat and insulin resistance: pathophysiology and effect of diet and lifestyle interventions. Int J Endicrinol 2012, 2012:983814. 10.1155/2012/983814.
    • (2012) Int J Endicrinol , vol.2012 , pp. 983814
    • Snel, M.1    Jonker, J.T.2    Schoones, J.3    Lamb, H.4    de Roos, A.5    Pijl, H.6
  • 130
    • 5644231992 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    • Ozcan U., Cao Q., Yilmaz E., Lee A.H., Iwakoshi N.N., Ozdelen E., et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004, 306(5695):457-461.
    • (2004) Science , vol.306 , Issue.5695 , pp. 457-461
    • Ozcan, U.1    Cao, Q.2    Yilmaz, E.3    Lee, A.H.4    Iwakoshi, N.N.5    Ozdelen, E.6
  • 131
    • 57349110829 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects
    • Sharma N.K., Das S.K., Mondal A.K., Hackney O.G., Chu W.S., Kern P.A., et al. Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects. J Clin Endocrinol Metab 2008, 93(11):4532-4541.
    • (2008) J Clin Endocrinol Metab , vol.93 , Issue.11 , pp. 4532-4541
    • Sharma, N.K.1    Das, S.K.2    Mondal, A.K.3    Hackney, O.G.4    Chu, W.S.5    Kern, P.A.6
  • 132
    • 62749178966 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss
    • Gregor M.F., Yang L., Fabbrini E., Mohammed B.S., Eagon J.C., Hotamisligil G.S., et al. Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss. Diabetes 2009, 58(3):693-700.
    • (2009) Diabetes , vol.58 , Issue.3 , pp. 693-700
    • Gregor, M.F.1    Yang, L.2    Fabbrini, E.3    Mohammed, B.S.4    Eagon, J.C.5    Hotamisligil, G.S.6
  • 133
    • 34248583886 scopus 로고    scopus 로고
    • MAP kinase signalling pathways in cancer
    • Dhillon A.S., Hagan S., Rath O., Kolch W. MAP kinase signalling pathways in cancer. Oncogene 2007, 26(22):3279-3290.
    • (2007) Oncogene , vol.26 , Issue.22 , pp. 3279-3290
    • Dhillon, A.S.1    Hagan, S.2    Rath, O.3    Kolch, W.4
  • 134
    • 80052887167 scopus 로고    scopus 로고
    • A critical role for the NFκB pathway in multiple myeloma
    • Demchenko Y.N., Kuehl W.M. A critical role for the NFκB pathway in multiple myeloma. Oncotarget 2011, 1(1):59-68.
    • (2011) Oncotarget , vol.1 , Issue.1 , pp. 59-68
    • Demchenko, Y.N.1    Kuehl, W.M.2
  • 135
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: a leading role for STAT3
    • Yu H., Pardoll D., Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 2009, 9:798-809.
    • (2009) Nat Rev Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 136
    • 37849035627 scopus 로고    scopus 로고
    • TLR signalling by tumour and immune cells: a double-edged sword
    • Huang B., Zhao J., Unkeless J.C., Feng Z.H., Xiong H. TLR signalling by tumour and immune cells: a double-edged sword. Oncogene 2008, 27:218-224.
    • (2008) Oncogene , vol.27 , pp. 218-224
    • Huang, B.1    Zhao, J.2    Unkeless, J.C.3    Feng, Z.H.4    Xiong, H.5
  • 137
    • 84861197159 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace
    • Baffy G., Brunt E.M., Caldwell S.H. Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace. J Hepatol 2012, 56(6):1384-1391.
    • (2012) J Hepatol , vol.56 , Issue.6 , pp. 1384-1391
    • Baffy, G.1    Brunt, E.M.2    Caldwell, S.H.3
  • 138
    • 78650859531 scopus 로고    scopus 로고
    • NF-B and STAT3 - key players in liver inflammation and cancer
    • He G., Karin M. NF-B and STAT3 - key players in liver inflammation and cancer. Cell Res 2011, 21:159-168.
    • (2011) Cell Res , vol.21 , pp. 159-168
    • He, G.1    Karin, M.2
  • 139
    • 6944237757 scopus 로고    scopus 로고
    • Adipokines: inflammation and the pleiotropic role of white adipose tissue
    • Trayhurn P., Wood I.S. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 2004, 92:347-355.
    • (2004) Br J Nutr , vol.92 , pp. 347-355
    • Trayhurn, P.1    Wood, I.S.2
  • 140
    • 0031974197 scopus 로고    scopus 로고
    • Insulin-like growth factor II induced by hypoxia may contribute to angiogenesis of human hepatocellular carcinoma
    • Kim K.W., Bae S.K., Lee O.H., Bae M.H., Lee M.J., Park B.C. Insulin-like growth factor II induced by hypoxia may contribute to angiogenesis of human hepatocellular carcinoma. Cancer Res 1998, 58(2):348-351.
    • (1998) Cancer Res , vol.58 , Issue.2 , pp. 348-351
    • Kim, K.W.1    Bae, S.K.2    Lee, O.H.3    Bae, M.H.4    Lee, M.J.5    Park, B.C.6
  • 141
    • 0035164117 scopus 로고    scopus 로고
    • Dual mechanism of vascular endothelial growth factor upregulation by hypoxia in human hepatocellular carcinoma
    • Von Marschall Z., Cramer T., Hocker M., Finkenzeller G., Wiedenmann B., Rosewicz S. Dual mechanism of vascular endothelial growth factor upregulation by hypoxia in human hepatocellular carcinoma. Gut 2001, 48(1):87-96.
    • (2001) Gut , vol.48 , Issue.1 , pp. 87-96
    • Von Marschall, Z.1    Cramer, T.2    Hocker, M.3    Finkenzeller, G.4    Wiedenmann, B.5    Rosewicz, S.6
  • 142
    • 80355130117 scopus 로고    scopus 로고
    • Expression characteristics of hypoxia-inducible factor-1a and its clinical values in diagnosis and prognosis of hepatocellular carcinoma
    • Li S., Yao D., Wang L., Wu W., Qiu L., Yao M., et al. Expression characteristics of hypoxia-inducible factor-1a and its clinical values in diagnosis and prognosis of hepatocellular carcinoma. Hepat Mon 2011, 11(10):821-828.
    • (2011) Hepat Mon , vol.11 , Issue.10 , pp. 821-828
    • Li, S.1    Yao, D.2    Wang, L.3    Wu, W.4    Qiu, L.5    Yao, M.6
  • 143
    • 0027210562 scopus 로고
    • General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia
    • Wang G.L., Semenza G.L. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci USA 1993, 90:4304-4308.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 4304-4308
    • Wang, G.L.1    Semenza, G.L.2
  • 144
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza G.L. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003, 3:721-732.
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 145
    • 80053408653 scopus 로고    scopus 로고
    • Disruption of hypoxia-inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in high-fat diet-fed mice
    • Jiang C., Qu A., Matsubara T., Chanturiya T., Jou W., Gavrilova O., et al. Disruption of hypoxia-inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in high-fat diet-fed mice. Diabetes 2011, 60(10):2484-2495.
    • (2011) Diabetes , vol.60 , Issue.10 , pp. 2484-2495
    • Jiang, C.1    Qu, A.2    Matsubara, T.3    Chanturiya, T.4    Jou, W.5    Gavrilova, O.6
  • 146
    • 78349265397 scopus 로고    scopus 로고
    • Reactive oxygen species mediate human hepatocyte injury during hypoxia/reoxygenation
    • Bhogal R.H., Curbishley S.M., Weston C.J., Adams D.H., Afford S.C. Reactive oxygen species mediate human hepatocyte injury during hypoxia/reoxygenation. Liver Transpl 2010, 16(11):1303-1313.
    • (2010) Liver Transpl , vol.16 , Issue.11 , pp. 1303-1313
    • Bhogal, R.H.1    Curbishley, S.M.2    Weston, C.J.3    Adams, D.H.4    Afford, S.C.5
  • 148
    • 77953859606 scopus 로고    scopus 로고
    • NF-κB as a critical link between inflammation and cancer
    • Karin M. NF-κB as a critical link between inflammation and cancer. Cold Spring Harb Perspect Biol 2009, 1(5):a000141. 10.1101/cshperspect.a000141.
    • (2009) Cold Spring Harb Perspect Biol , vol.1 , Issue.5
    • Karin, M.1
  • 149
    • 79751492851 scopus 로고    scopus 로고
    • NF-κB in the liver-linking injury, fibrosis and hepatocellular carcinoma
    • Luedde T., Schwabe R.F. NF-κB in the liver-linking injury, fibrosis and hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol 2011, 8(2):108-118.
    • (2011) Nat Rev Gastroenterol Hepatol , vol.8 , Issue.2 , pp. 108-118
    • Luedde, T.1    Schwabe, R.F.2
  • 150
    • 84858718448 scopus 로고    scopus 로고
    • NF-κB and the link between inflammation and cancer
    • DiDonato J.A., Mercurio F., Karin M. NF-κB and the link between inflammation and cancer. Immunol Rev 2012, 246(1):379-400.
    • (2012) Immunol Rev , vol.246 , Issue.1 , pp. 379-400
    • DiDonato, J.A.1    Mercurio, F.2    Karin, M.3
  • 153
    • 0033163393 scopus 로고    scopus 로고
    • Is NF-kappaB the sensor of oxidative stress?
    • Li N., Karin M. Is NF-kappaB the sensor of oxidative stress?. FASEB J 1999, 13(10):1137-1143.
    • (1999) FASEB J , vol.13 , Issue.10 , pp. 1137-1143
    • Li, N.1    Karin, M.2
  • 154
    • 0033517189 scopus 로고    scopus 로고
    • NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase
    • Ozes O.N., Mayo L.D., Gustin J.A., Pfeffer S.R., Pfeffer L.M., Donner D.B. NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 1999, 401(6748):82-85.
    • (1999) Nature , vol.401 , Issue.6748 , pp. 82-85
    • Ozes, O.N.1    Mayo, L.D.2    Gustin, J.A.3    Pfeffer, S.R.4    Pfeffer, L.M.5    Donner, D.B.6
  • 156
    • 33644862368 scopus 로고    scopus 로고
    • JNK signalling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species
    • Shen H.M., Liu Z.G. JNK signalling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species. Free Radic Biol Med 2006, 40(6):928-939.
    • (2006) Free Radic Biol Med , vol.40 , Issue.6 , pp. 928-939
    • Shen, H.M.1    Liu, Z.G.2
  • 158
    • 63249092765 scopus 로고    scopus 로고
    • Persistently activated STAT3 maintains constitutive NFκB activity in tumours
    • Lee H., Herrmann A., Deng J.H., Kujawski M., Niu G., Li Z.W., et al. Persistently activated STAT3 maintains constitutive NFκB activity in tumours. Cancer Cell 2009, 15(4):283-293.
    • (2009) Cancer Cell , vol.15 , Issue.4 , pp. 283-293
    • Lee, H.1    Herrmann, A.2    Deng, J.H.3    Kujawski, M.4    Niu, G.5    Li, Z.W.6
  • 159
    • 1942466512 scopus 로고    scopus 로고
    • Liver tumours escape negative control of proliferation via PI3/Akt-mediated block of C/EBP alpha growth inhibitory activity
    • Wang G.L., Lakova P., Wilde M., Awad S., Timchenko N.A. Liver tumours escape negative control of proliferation via PI3/Akt-mediated block of C/EBP alpha growth inhibitory activity. Genes Dev 2004, 18(8):912-925.
    • (2004) Genes Dev , vol.18 , Issue.8 , pp. 912-925
    • Wang, G.L.1    Lakova, P.2    Wilde, M.3    Awad, S.4    Timchenko, N.A.5
  • 160
    • 6344263492 scopus 로고    scopus 로고
    • Interleukin-6 augments hepatocyte growth factor-induced liver regeneration; involvement of STAT3 activation
    • Kaido T., Oe H., Imamura M. Interleukin-6 augments hepatocyte growth factor-induced liver regeneration; involvement of STAT3 activation. Hepatogastroenterology 2004, 51(60):1667-1670.
    • (2004) Hepatogastroenterology , vol.51 , Issue.60 , pp. 1667-1670
    • Kaido, T.1    Oe, H.2    Imamura, M.3
  • 162
    • 77956409919 scopus 로고    scopus 로고
    • IL-6, a risk factor for hepatocellular carcinoma: FLLL32 inhibits IL-6-induced STAT3 phosphorylation in human hepatocellular cancer cells
    • Liu Y., Fuchs J., Li C.L., Lin J.Y. IL-6, a risk factor for hepatocellular carcinoma: FLLL32 inhibits IL-6-induced STAT3 phosphorylation in human hepatocellular cancer cells. Landes Biosci (Cell Cycle) 2010, 9(17):3423-3427.
    • (2010) Landes Biosci (Cell Cycle) , vol.9 , Issue.17 , pp. 3423-3427
    • Liu, Y.1    Fuchs, J.2    Li, C.L.3    Lin, J.Y.4
  • 163
    • 74549217325 scopus 로고    scopus 로고
    • Hepatocyte IKK/NF-κB inhibits tumour promotion and progression by preventing oxidative stress-driven STAT3 activation
    • He G., Yu G.Y., Temkin V., Ogata H., Kuntzen C., Sakurai T., et al. Hepatocyte IKK/NF-κB inhibits tumour promotion and progression by preventing oxidative stress-driven STAT3 activation. Cancer Cell 2010, 17:286-297.
    • (2010) Cancer Cell , vol.17 , pp. 286-297
    • He, G.1    Yu, G.Y.2    Temkin, V.3    Ogata, H.4    Kuntzen, C.5    Sakurai, T.6
  • 164
    • 0031561127 scopus 로고    scopus 로고
    • Increased MAPK expression and activity in primary human hepatocellular carcinoma
    • Schmidt C.M., McKillop I.H., Cahill P.A., Sitzmann J.V. Increased MAPK expression and activity in primary human hepatocellular carcinoma. Biochem Biophys Res Commun 1997, 236(1):54-58.
    • (1997) Biochem Biophys Res Commun , vol.236 , Issue.1 , pp. 54-58
    • Schmidt, C.M.1    McKillop, I.H.2    Cahill, P.A.3    Sitzmann, J.V.4
  • 165
    • 79251614052 scopus 로고    scopus 로고
    • NF-κB, JNK, and TLR signalling pathways in hepatocarcinogenesis
    • Maeda S. NF-κB, JNK, and TLR signalling pathways in hepatocarcinogenesis. Gastroenterol Res Pract 2010, 2010:367694. 10.1155/2010/367694.
    • (2010) Gastroenterol Res Pract , vol.2010 , pp. 367694
    • Maeda, S.1
  • 166
    • 0037153158 scopus 로고    scopus 로고
    • A central role for JNK in obesity and insulin resistance
    • Hirosumi J., Tuncman G., Chang L., Gorgun C.Z., Uysal K.T., Maeda K., et al. A central role for JNK in obesity and insulin resistance. Nature 2002, 420(6913):333-336.
    • (2002) Nature , vol.420 , Issue.6913 , pp. 333-336
    • Hirosumi, J.1    Tuncman, G.2    Chang, L.3    Gorgun, C.Z.4    Uysal, K.T.5    Maeda, K.6
  • 167
    • 34249314755 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase pathway is involved in protein kinase Ca-regulated invasion in human hepatocellular carcinoma cells
    • Hsieh Y.H., Wu T.T., Huang C.Y., Hsieh Y.S., Hwang J.M., Liu J.Y. P38 mitogen-activated protein kinase pathway is involved in protein kinase Ca-regulated invasion in human hepatocellular carcinoma cells. Cancer Res 2007, 67:4320.
    • (2007) Cancer Res , vol.67 , pp. 4320
    • Hsieh, Y.H.1    Wu, T.T.2    Huang, C.Y.3    Hsieh, Y.S.4    Hwang, J.M.5    Liu, J.Y.6
  • 168
    • 57449109370 scopus 로고    scopus 로고
    • Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation
    • Hui L., Zatloukal K., Scheuch H., Stepniak E., Wagner E.F. Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation. J Clin Invest 2008, 118(12):3943-3953.
    • (2008) J Clin Invest , vol.118 , Issue.12 , pp. 3943-3953
    • Hui, L.1    Zatloukal, K.2    Scheuch, H.3    Stepniak, E.4    Wagner, E.F.5
  • 171
    • 77950899271 scopus 로고    scopus 로고
    • Saturated fatty acids and inflammation: who pays the toll?
    • Chait A., Kim F. Saturated fatty acids and inflammation: who pays the toll?. Arterioscher, Throm Vasc Biol 2010, 30:692-693.
    • (2010) Arterioscher, Throm Vasc Biol , vol.30 , pp. 692-693
    • Chait, A.1    Kim, F.2
  • 172
    • 36849005372 scopus 로고    scopus 로고
    • A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via toll-like receptors 2 and 4 and JNK-dependent pathways
    • Nguyen M.T.A., Favelyukis S., Nguyen A., Reichart D., Scott P.A., Jenn A., et al. A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via toll-like receptors 2 and 4 and JNK-dependent pathways. JBC 2007, 282(48):35279-35292.
    • (2007) JBC , vol.282 , Issue.48 , pp. 35279-35292
    • Nguyen, M.T.A.1    Favelyukis, S.2    Nguyen, A.3    Reichart, D.4    Scott, P.A.5    Jenn, A.6
  • 173
    • 33846323706 scopus 로고    scopus 로고
    • Role of the toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages
    • Suganami T., Tanimoto-Koyama K., Nishida J., Itoh M., Yuan X., Mizuarai S., et al. Role of the toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler Thromb Vasc Biol 2007, 27(1):84-91.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , Issue.1 , pp. 84-91
    • Suganami, T.1    Tanimoto-Koyama, K.2    Nishida, J.3    Itoh, M.4    Yuan, X.5    Mizuarai, S.6
  • 174
    • 19644362276 scopus 로고    scopus 로고
    • Tissue-specific mRNA expression profiles of human toll-like receptors and related genes
    • Nishimura M., Naito S. Tissue-specific mRNA expression profiles of human toll-like receptors and related genes. Biol Pharm Bull 2005, 28:886-892.
    • (2005) Biol Pharm Bull , vol.28 , pp. 886-892
    • Nishimura, M.1    Naito, S.2
  • 175
    • 84862334759 scopus 로고    scopus 로고
    • Toll-like receptor signalling in liver disease: ER stress the missing link?
    • Lawless M.W., Greene C.M. Toll-like receptor signalling in liver disease: ER stress the missing link?. Cytokine 2012, 59(2):195-202.
    • (2012) Cytokine , vol.59 , Issue.2 , pp. 195-202
    • Lawless, M.W.1    Greene, C.M.2
  • 176
    • 79952230506 scopus 로고    scopus 로고
    • Role of toll-like receptors and their downstream molecules in the development of non-alcoholic fatty liver disease
    • Miura K., Seki E., Ohnishi H., Brenner D.A. Role of toll-like receptors and their downstream molecules in the development of non-alcoholic fatty liver disease. Gastroenterol Res Pract 2010, 2010:362847. 10.1155/2010/362847.
    • (2010) Gastroenterol Res Pract , vol.2010 , pp. 362847
    • Miura, K.1    Seki, E.2    Ohnishi, H.3    Brenner, D.A.4
  • 177
    • 78650494568 scopus 로고    scopus 로고
    • The application of Toll like receptors for cancer therapy
    • So E.Y., Ouchi T. The application of Toll like receptors for cancer therapy. Int J Biol Sci 2010, 6(7):675-681.
    • (2010) Int J Biol Sci , vol.6 , Issue.7 , pp. 675-681
    • So, E.Y.1    Ouchi, T.2
  • 178
    • 33846212284 scopus 로고    scopus 로고
    • Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumour angiogenesis, and induces tumour cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
    • Liu L., Cao Y., Chen C., Zhang X., McNabola A., Wilkie D., et al. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumour angiogenesis, and induces tumour cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res 2006, 66(24):11851-11858.
    • (2006) Cancer Res , vol.66 , Issue.24 , pp. 11851-11858
    • Liu, L.1    Cao, Y.2    Chen, C.3    Zhang, X.4    McNabola, A.5    Wilkie, D.6
  • 179
    • 79251485284 scopus 로고    scopus 로고
    • Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model
    • Feng Y.X., Wang T., Deng Y.Z., Yang P., Li J.J., Guan D.X., et al. Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model. Hepatology 2011, 53(2):483-492.
    • (2011) Hepatology , vol.53 , Issue.2 , pp. 483-492
    • Feng, Y.X.1    Wang, T.2    Deng, Y.Z.3    Yang, P.4    Li, J.J.5    Guan, D.X.6
  • 180
    • 84861183742 scopus 로고    scopus 로고
    • Combination therapy for hepatocellular carcinoma: additive preclinical efficacy of the HDAC inhibitor panobinostat with sorafenib
    • Lachenmayer A., Toffanin S., Cabellos L., Alsinet C., Hoshida Y., Villanueva A., et al. Combination therapy for hepatocellular carcinoma: additive preclinical efficacy of the HDAC inhibitor panobinostat with sorafenib. J Hepatol 2012, 56(6):1343-1350.
    • (2012) J Hepatol , vol.56 , Issue.6 , pp. 1343-1350
    • Lachenmayer, A.1    Toffanin, S.2    Cabellos, L.3    Alsinet, C.4    Hoshida, Y.5    Villanueva, A.6
  • 181
    • 84865479772 scopus 로고    scopus 로고
    • Histone deacetylases activate hepatocyte growth factor signalling by repressing microRNA-449 in hepatocellular carcinoma cells
    • E1-15
    • Buurman R., Gurlevik E., Schaffer V., Eilers M., Sandbothe M., Kreipe H., et al. Histone deacetylases activate hepatocyte growth factor signalling by repressing microRNA-449 in hepatocellular carcinoma cells. Gastroenterology 2012, 143(3):811-820. E1-15.
    • (2012) Gastroenterology , vol.143 , Issue.3 , pp. 811-820
    • Buurman, R.1    Gurlevik, E.2    Schaffer, V.3    Eilers, M.4    Sandbothe, M.5    Kreipe, H.6
  • 182
    • 79952003715 scopus 로고    scopus 로고
    • FFA-induced adipocyte inflammation and insulin resistance: involvement of ER stress and IKKβ pathways
    • Jiao P., Ma J., Feng B., Zhang H., Diehl J.A., Chin Y.E., et al. FFA-induced adipocyte inflammation and insulin resistance: involvement of ER stress and IKKβ pathways. Obesity 2011, 19:483-491.
    • (2011) Obesity , vol.19 , pp. 483-491
    • Jiao, P.1    Ma, J.2    Feng, B.3    Zhang, H.4    Diehl, J.A.5    Chin, Y.E.6
  • 183
    • 78149477200 scopus 로고    scopus 로고
    • Changes in hepatic gene expression upon oral administration of Taurine-conjugated ursodeoxycholic acid in ob/ob mice
    • Yang J.S., Kim J.T., Jeon J., Park H.S., Kang G.H., Park K.S., et al. Changes in hepatic gene expression upon oral administration of Taurine-conjugated ursodeoxycholic acid in ob/ob mice. PloS ONE 2010, 5(11):e13858.
    • (2010) PloS ONE , vol.5 , Issue.11
    • Yang, J.S.1    Kim, J.T.2    Jeon, J.3    Park, H.S.4    Kang, G.H.5    Park, K.S.6
  • 184
    • 77449107440 scopus 로고    scopus 로고
    • Ursodeoxycholic acid switches oxaliplatin-induced necrosis to apoptosis by inhibiting reactive oxygen species production and activating p53-caspase 8 pathway in HepG2 hepatocellular carcinoma
    • Lim S.C., Choi J.E., Kang H.S., Han S.I. Ursodeoxycholic acid switches oxaliplatin-induced necrosis to apoptosis by inhibiting reactive oxygen species production and activating p53-caspase 8 pathway in HepG2 hepatocellular carcinoma. Int J Cancer 2010, 126(7):1582-1595.
    • (2010) Int J Cancer , vol.126 , Issue.7 , pp. 1582-1595
    • Lim, S.C.1    Choi, J.E.2    Kang, H.S.3    Han, S.I.4
  • 185
  • 187
    • 38349132541 scopus 로고    scopus 로고
    • A critical role for HSP90 in cancer cell invasion involves interaction with the extracellular domain of HER-2
    • Sidera K., Gaitanou M., Stellas D., Matsas R., Patsavoudi E. A critical role for HSP90 in cancer cell invasion involves interaction with the extracellular domain of HER-2. J Biol Chem 2008, 283:2031-2041.
    • (2008) J Biol Chem , vol.283 , pp. 2031-2041
    • Sidera, K.1    Gaitanou, M.2    Stellas, D.3    Matsas, R.4    Patsavoudi, E.5
  • 188
    • 77952834231 scopus 로고    scopus 로고
    • Novel HSP90 inhibitors, NVP-AUY922 and NVP-BEP800, radiosensitise tumour cells through cell-cycle impairment, increased DNA damage and repair protraction
    • Stingl L., Stuhmer T., Chatterjee M., Jensen M.R., Flentje M., Djuzenova C.S. Novel HSP90 inhibitors, NVP-AUY922 and NVP-BEP800, radiosensitise tumour cells through cell-cycle impairment, increased DNA damage and repair protraction. Br J Cancer 2010, 102:1578-1591.
    • (2010) Br J Cancer , vol.102 , pp. 1578-1591
    • Stingl, L.1    Stuhmer, T.2    Chatterjee, M.3    Jensen, M.R.4    Flentje, M.5    Djuzenova, C.S.6
  • 189
    • 36749028203 scopus 로고    scopus 로고
    • Molecular pathways and related target therapies in liver carcinoma
    • Tommasi S., Pinto R., Pilato B., Paradiso A. Molecular pathways and related target therapies in liver carcinoma. Curr Pharm Des 2007, 13:3279-3287.
    • (2007) Curr Pharm Des , vol.13 , pp. 3279-3287
    • Tommasi, S.1    Pinto, R.2    Pilato, B.3    Paradiso, A.4


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