Hypoxia aggravates non-alcoholic steatohepatitis in mice lacking hepatocellular PTEN

Clinical Science

Volumn 118, Issue 6, 2010, Pages 401-410

  Piguet, Anne Christine ^a   Stroka, Deborah ^a   Zimmermann, Arthur ^a   Dufour, Jean François ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

oxidation; Fatty liver; Lipogenesis; Non alcoholic steatohepatitis (NASH); Peroxisome proliferator activated receptor (PPAR); Phosphatase and tensin homologue deleted on chromosome 10 (PTEN); Sterol regulatory element binding protein 1c (SREBP 1c)

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ACETYL COENZYME A CARBOXYLASE 1; ACETYL COENZYME A CARBOXYLASE 2; ASPARTATE AMINOTRANSFERASE; CYTOCHROME P450 2E1; GLUCOSE; HEPCIDIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRANSCRIPTION FACTOR FKHR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; CONTROLLED STUDY; DISEASE ACTIVITY; DOWN REGULATION; ENZYME DEFICIENCY; EXPERIMENTAL MOUSE; FATTY ACID OXIDATION; FEMALE; GENE EXPRESSION REGULATION; GLUCOSE BLOOD LEVEL; HEMATOCRIT; HISTOPATHOLOGY; HYPOXIA; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; LIPID METABOLISM; LIPOGENESIS; LIVER WEIGHT; MITOCHONDRION; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION;

ANIMALS; ANOXIA; DISEASE PROGRESSION; FATTY LIVER; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; IMMUNOHISTOCHEMISTRY; INSULIN RESISTANCE; MICE; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; PTEN PHOSPHOHYDROLASE;

EID: 73149083947     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20090313     Document Type: Article

References (44)

1. Gastaut, H., Tassinari, C. A. and Duron, B. (1965) Polygraphic study of diurnal and nocturnal (hypnic and respiratory) episodal manifestations of Pickwick syndrome. Rev. Neurol. (Paris) 112, 568-579
2. Tasali, E. and Ip, M. S. (2008) Obstructive sleep apnea and metabolic syndrome: alterations in glucose metabolism and inflammation. Proc. Am. Thorac. Soc. 5, 207-217
3. Tanne, F., Gagnadoux, F., Chazouilleres, O., Fleury, B., Wendum, D., Lasnier, E., Lebeau, B., Poupon, R. and Serfaty, L. (2005) Chronic liver injury during obstructive sleep apnea. Hepatology 41, 1290-1296
4. Tomlinson, J.W.,Walker, E. A., Bujalska, I. J., Draper, N., Lavery, G. G., Cooper, M. S., Hewison, M. and Stewart, P. M. (2004) 11β-Hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response. Endocr. Rev. 25, 831-866
5. Savransky, V., Bevans, S., Nanayakkara, A., Li, J., Smith, P. L., Torbenson, M. S. and Polotsky, V. Y. (2007) Chronic intermittent hypoxia causes hepatitis in a mouse model of diet-induced fatty liver. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G871-G877
6. Horie, Y., Suzuki, A., Kataoka, E., Sasaki, T., Hamada, K., Sasaki, J., Mizuno, K., Hasegawa, G., Kishimoto, H., Iizuka, M. et al. (2004) Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J. Clin. Invest. 113, 1774-1783
7. Mulder, H., Sorhede-Winzell, M., Contreras, J. A., Fex, M., Strom, K., Ploug, T., Galbo, H., Arner, P., Lundberg, C., Sundler, F. et al. (2003) Hormone-sensitive lipase null mice exhibit signs of impaired insulin sensitivity whereas insulin secretion is intact. J. Biol. Chem. 278, 36380-36388
8. Kleiner, D. E., Brunt, E. M., Van Natta, M., Behling, C., Contos, M. J., Cummings, O. W., Ferrell, L. D., Liu, Y. C., Torbenson, M. S., Unalp-Arida, A. et al. (2005) Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41, 1313-1321
9. Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275
10. Huff, J. E., Kaufman, G. E. and Ingram, M. (1975) Hematologic changes in mice during and after exposure to severe hypobaric hypoxia. Aviat. Space Environ. Med. 46, 1147-1151
11. Horton, J. D., Goldstein, J. L. and Brown, M. S. (2002) SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 109, 1125-1131
12. Abu-Elheiga, L., Matzuk, M. M., Abo-Hashema, K. A. and Wakil, S. J. (2001) Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science 291, 2613-2616
13. Tessari, P., Coracina, A., Cosma, A. and Tiengo, A. (2009) Hepatic lipid metabolism and non-alcoholic fatty liver disease. Nutr. Metab. Cardiovasc. Dis. 19, 291-302
14. Kim, J. B., Wright, H. M., Wright, M. and Spiegelman, B. M. (1998) ADD1/ SREBP1 activates PPARγ through the production of endogenous ligand. Proc. Natl. Acad. Sci. U.S.A. 95, 4333-4337
15. Fajas, L., Schoonjans, K., Gelman, L., Kim, J. B., Najib, J., Martin, G., Fruchart, J. C., Briggs, M., Spiegelman, B. M. and Auwerx, J. (1999) Regulation of peroxisome proliferator-activated receptor expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism. Mol. Cell. Biol. 19, 5495-5503
16. Nakae, J., Kitamura, T., Kitamura, Y., Biggs, III, W. H., Arden, K. C. and Accili, D. (2003) The forkhead transcription factor Foxo1 regulates adipocyte differentiation. Dev. Cell 4, 119-129
17. Rankin, E. B., Rha, J., Selak, M. A., Unger, T. L., Keith, B., Liu, Q. and Haase, V. H. (2009) Hypoxia-inducible factor 2 regulates hepatic lipid metabolism. Mol. Cell. Biol. 29, 4527-4538
18. Tremblay, F. and Marette, A. (2001) Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J. Biol. Chem. 276, 38052-38060
19. Harrington, L. S., Findlay, G. M., Gray, A., Tolkacheva, T., Wigfield, S., Rebholz, H., Barnett, J., Leslie, N. R., Cheng, S., Shepherd, P. R. et al. (2004) The TSC1-TSC2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J. Cell Biol. 166, 213-223
20. Haase, V. H., Glickman, J. N., Socolovsky, M. and Jaenisch, R. (2001) Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc. Natl. Acad. Sci. U.S.A. 98, 1583-1588
21. Savransky, V., Nanayakkara, A., Vivero, A., Li, J., Bevans, S., Smith, P. L., Torbenson, M. S. and Polotsky, V. Y. (2007) Chronic intermittent hypoxia predisposes to liver injury. Hepatology 45, 1007-1013
22. Li, J., Grigoryev, D. N., Ye, S. Q., Thorne, L., Schwartz, A. R., Smith, P. L., O'Donnell, C. P. and Polotsky, V. Y. (2005) Chronic intermittent hypoxia upregulates genes of lipid biosynthesis in obese mice. J. Appl. Physiol. 99, 1643-1648
23. Polotsky, V. Y., Li, J., Punjabi, N. M., Rubin, A. E., Smith, P. L., Schwartz, A. R. and O'Donnell, C. P. (2003) Intermittent hypoxia increases insulin resistance in genetically obese mice. J. Physiol. 552, 253-264
24. Iiyori, N., Alonso, L. C., Li, J., Sanders, M. H., Garcia-Ocana, A., O'Doherty, R. M., Polotsky, V. Y. and O'Donnell, C. P. (2007) Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity. Am. J. Respir. Crit. Care Med. 175, 851-857
25. Meslier, N., Gagnadoux, F., Giraud, P., Person, C., Ouksel, H., Urban, T. and Racineux, J. L. (2003) Impaired glucose-insulin metabolism in males with obstructive sleep apnoea syndrome. Eur. Respir. J. 22, 156-160
26. Makino, S., Handa, H., Suzukawa, K., Fujiwara, M., Nakamura, M., Muraoka, S., Takasago, I., Tanaka, Y., Hashimoto, K. and Sugimoto, T. (2006) Obstructive sleep apnoea syndrome, plasma adiponectin levels, and insulin resistance. Clin. Endocrinol. 64, 12-19
27. Woodcroft, K. J. and Novak, R. F. (1997) Insulin effects on CYP2E1, 2B, 3A, and 4A expression in primary cultured rat hepatocytes. Chem-Biol. Interact. 107, 75-91
28. DeWaziers, I., Garlatti, M., Bouguet, J., Beaune, P. H. and Barouki, R. (1995) Insulin down-regulates cytochrome P450 2B and 2E expression at the post-transcriptional level in the rat hepatoma cell line. Mol. Pharmacol. 47, 474-479
29. Ekstrom, G. and Ingelman-Sundberg, M. (1989) Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P-450 (P-450IIE1). Biochem. Pharmacol. 38, 1313-1319
30. Weltman, M. D., Farrell, G. C., Hall, P., Ingelman-Sundberg, M. and Liddle, C. (1998) Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis. Hepatology 27, 128-133
31. Schattenberg, J. M., Wang, Y., Singh, R., Rigoli, R. M. and Czaja, M. J. (2005) Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling. J. Biol. Chem. 280, 9887-9894
32. Shimano, H., Horton, J. D., Shimomura, I., Hammer, R. E., Brown, M. S. and Goldstein, J. L. (1997) Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. J. Clin. Invest. 99, 846-854
33. Shimomura, I., Bashmakov, Y. and Horton, J. D. (1999) Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. J. Biol. Chem. 274, 30028-30032
34. Gonzalez, F. J. (1997) Recent update on the PPARa-null mouse. Biochimie 79, 139-144
35. Braissant, O., Foufelle, F., Scotto, C., Dauca, M. andWahli, W. (1996) Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-α, -β, and -γ in the adult rat. Endocrinology 137, 354-366
36. Devchand, P. R., Keller, H., Peters, J. M., Vazquez, M., Gonzalez, F. J. and Wahli, W. (1996) The PPARα-leukotriene B4 pathway to inflammation control. Nature 384, 39-43
37. Vanden Berghe, W., Vermeulen, L., Delerive, P., De Bosscher, K., Staels, B. and Haegeman, G. (2003) A paradigm for gene regulation: inflammation, NF-κB and PPAR. Adv. Exp. Med. Biol. 544, 181-196
38. Bedoucha, M., Atzpodien, E. and Boelsterli, U. A. (2001) Diabetic KKAy mice exhibit increased hepatic PPARγ 1 gene expression and develop hepatic steatosis upon chronic treatment with antidiabetic thiazolidinediones. J. Hepatol. 35, 17-23
39. Memon, R. A., Tecott, L. H., Nonogaki, K., Beigneux, A., Moser, A. H., Grunfeld, C. and Feingold, K. R. (2000) Up-regulation of peroxisome proliferator-activated receptors (PPAR-α) and PPAR-γ messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-γ -responsive adipose tissue-specific genes in the liver of obese diabetic mice. Endocrinology 141, 4021-4031
40. Yu, S., Matsusue, K., Kashireddy, P., Cao, W. Q., Yeldandi, V., Yeldandi, A. V., Rao, M. S., Gonzalez, F. J. and Reddy, J. K. (2003) Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor γ1 (PPARγ 1) overexpression. J. Biol. Chem. 278, 498-505
41. Nicolas, G., Chauvet, C., Viatte, L., Danan, J. L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A. and Vaulont, S. (2002) The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J. Clin. Invest. 110, 1037-1044
42. Fleming, R. E. and Sly, W. S. (2001) Hepcidin: a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease. Proc. Natl. Acad. Sci. U.S.A. 98, 8160-8162
43. Lavie, L. (2003) Obstructive sleep apnoea syndrome-an oxidative stress disorder. Sleep Med. Rev. 7, 35-51
44. Vinciguerra, M., Veyrat-Durebex, C., Moukil, M. A., Rubbia-Brandt, L., Rohner-Jeanrenaud, F. and Foti, M. (2008) PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-κBp65/ mTOR-dependent mechanism. Gastroenterology 134, 268-280