Disrupted IGF2 promoter control by silencing of promoter P1 in human hepatocellular carcinoma

Cancer Research

Volumn 57, Issue 10, 1997, Pages 2048-2054

  Li, Xuri ^a   Nong, Zhang ^b   Ekström, Christina ^a   Larsson, Erik ^c   Nordlinder, Hans ^c   Hofmann, Walter J ^d   Trautwein, Christian ^e   Odenthal, Margarete ^b   Dienes, Hans Peter ^b   Ekström, Tomas J ^a   Schirmacher, Peter ^b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

SOMATOMEDIN B;

ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; GENE EXPRESSION REGULATION; HETEROZYGOSITY LOSS; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY MECHANISM; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

ALLELES; CARCINOMA, HEPATOCELLULAR; EXONS; GENE DELETION; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HETEROZYGOTE; HUMANS; INSULIN-LIKE GROWTH FACTOR II; LIVER NEOPLASMS; MUSCLE PROTEINS; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; RNA, UNTRANSLATED;

EID: 15144361057     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Sussenbach, J. S. The gene structure of the insulin-like growth factor family. Prog. Growth Factor Res., 1: 33-48, 1989.
2. Ekström, T. J., Cui, H., Li, X., and Ohlsson, R. Promoter-specific IGF2 imprinting status and its plasticity during human liver development. Development (Camb.), 121: 309-316, 1995.
3. Li, X., Cui, H., Sandstedt, B., Nordlinder, H., Larsson, E., and Ekström, T. J. Expression level of IGF2 in the human liver: developmental relationships of the four promoters. J. Endocrinol., 149: 117-124, 1996.
4. van Dijk, M. A., Schaik, F. M. A. v., Boostma, H. J., Holthuizen, P., and Sussenbach, J. S. Initial characterization of the four promoters of the human insulin-like growth factor II gene. Mol. Cell. Endocrinol., 81: 81-94, 1991.
5. Nielsen, F. C., Østergaard, L., Nielsen, J., and Christiansen, J. Growth-dependent translation of IGF-II mRNA by a rapamycin-sensitive pathway. Nature (Lond.), 377: 358-362, 1995.
6. Vu, T. H., and Hoffman, A. R. Promoter-specific imprinting of the human insulin-like growth factor-II gene. Nature (Lond.), 371: 714-717, 1994.
7. Ogawa, O., Eccles, M. R., Szeto, J., McNoe, L. A., Yun, K., Maw, M. A., Smith, P. L., and Reeve, A. E. Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumor. Nature (Lond.), 362: 749-751, 1993.
8. Li, X., Adam, G., Cui, H., Sandstedt, B., Ohlsson, R., and Ekström, T. J. Expression, promoter usage and parental imprinting status of IGF2 and H19 status in human hepatoblastoma. Oncogene. 11: 221-229, 1995.
9. El-Badry, O. M., Romanus, J. A., Helman, L. J., Cooper, M. J., Rechler, M. M., and Israel, M. A. Autonomous growth in a human neuroblastoma cell line is mediated by insulin-like growth factor II. J. Clin. Invest., 84: 829-839, 1989.
10. Zhan, S., Shapiro, D. N., and Helman, L. J. Activation of an imprinted allele of the insulin-like growth factor II gene implicated in rhabdomyosarcoma. J. Clin. Invest., 94: 445-448, 1994.
11. Tricoli, J. V., Rall, L. B., Karakousis, C. P., Herrera, L., Petrelli, N. J., Bell, G. I., and Shows, T. B. Enhanced levels of insulin-like growth factor messenger RNA in human colon carcinomas and liposarcomas. Cancer Res., 46: 6169-6173, 1986.
12. Yee, D., Cullen, K. J., Paik, S., Perdue, J. F., Hampton, B., Schwartz, A., Lippman, M. E., and Rosen, N. Insulin-like growth factor II mRNA expression in human breast cancer. Cancer Res., 48: 6691-6696, 1988.
13. Suzuki, H., Ueda, R., Takahashi, T., and Takahashi, T. Altered imprinting in lung cancer. Nat. Genet., 6: 332-333, 1994.
14. Cariani, E., Lasserre, C., Seurin, D., Hamelin, B., Kemeny, F., Franco, D., Czech, M. P., Ullrich, A., and Brechot, C. Differential expression of insulin-like growth factor II mRNA in human primary liver cancers, benign liver tumors, and liver cirrhosis. Cancer Res., 48: 6844-6849, 1988.
15. Fu, X-X., Su, C. Y., Lee, Y., Hintz, R., Biempica, L., Snyder, R., and Rogler, C. Insulin-like growth factor II expression and oval cell proliferation associated with hepatocarcinogenesis in woodchuck hepatitis virus carriers. J. Virol., 62: 3422-3430, 1988.
16. Ueno, T., Takahashi, K., Matsuguchi, T., Ikejiri, K., Endo, H., and Yamamoto, M. Reactivation of rat insulin-like growth factor II gene during hepatocarcinogenesis. Carcinogenesis (Lond.), 9: 1779-1783, 1988.
17. Schirmacher, P., Held, W. A., Yang, D., Chisari, F. V., Rustum, Y., and Rogler, C. E. Reactivation of insulin-like growth factor II during hepatocarcinogenesis in transgenic mice suggests a role in malignant growth. Cancer Res., 52: 2549-2556, 1992.
18. Rogler, C. E., Yang, D., Rossetti, L., Donohoe, J., Alt, E., Chang, C. J., Rosenfeld, R., Neely, K., and Hintz, R. Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice. J. Biol. Chem., 269: 13779-13784, 1994.
19. Christofori, G., Naik, P., and Hanahan, D. Deregulation of both imprinted and expressed alleles of the insulin-like growth factor 2 gene during β-cell tumorigenesis. Nat. Genet., 10: 196-201, 1995.
20. Steenman, M. J. C., Rainier, S., Dobry, C. J., Grundy, P., Horon, I. L., and Einberg, A. P. Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumor. Nat. Genet., 7: 433-439, 1994.
21. Casola, S., Ungaro P., Pedone, P. V., Lazzaro, D., Fattori, E., Ciliberto, G., Zarrilli, R., Bruni, C. B., and Riccio, A. Loss of heterozygosity of imprinted genes in SV 40t/T antigen-induced hepatocellular carcinomas. Oncogene, 11: 711-721, 1995.
22. Hao, Y., Crenshaw, T., Moulton, T., Newcomb, E., and Tycko, B. Tumor-suppressor activity of H19 RNA. Nature (Lond.), 365: 764-767, 1993.
23. Adam, G. R., Cui, H., Miller, S. J., Flam, F., and Ohlsson, R. Allele-specific in situ hybridization (ASISH) analysis: a novel technique which resolves differential allelic usage of H19 within the same cell lineage during human placental development. Development (Camb.), 122: 839-847, 1996.
24. Jinno, Y., Ikeda, Y., Yun, K., Maw, M., Masuzaki, H., Fukuda, H., Inuzuka, K., Fujishita, A., Ohtani, Y., Okimoto, T., Ishimaru, T., and Niikawa, N. Establishment of functional imprinting of H19 gene in human developing placentae. Nat. Genet., 10: 318-324, 1995.
25. Leighton, P. A., Ingram, R. S., Eggenschwiler, J., Efstratiadis, A., and Tilghman, S. M. Disruption of imprinting caused by deletion of the H19 gene region in mice. Nature (Lond.), 375: 34-39, 1995.
26. Liu, J., Kahri, A. I., Heikkilä, P., Ilvesmäki, V., and Voutilainen, R. H19 and insulin-like growth factor-II gene expression in adrenal tumors and cultured adrenal cells. J. Clin. Endocrinol. Metab., 80: 492-496, 1995.
27. Hibi, K., Nakamura, H., Hirai, A., Fujikake, Y., Kasai, Y., Akiyama, S., Ito, K., and Takagi, H. Loss Of H19 imprinting in esophageal cancer. Cancer Res., 56: 480-482, 1996.
28. Ariel, I., Sappir, M., Lustig, O., De-Groot, N., Schneider, T., Hochberg, A., and Pizov, G. The imprinted H19 gene as a tumor marker in bladder carcinoma. Urology, 45: 335-338, 1995.
29. Ohlsson, R., Hedborg, F., Holmgren, L., Walsh, C., and Ekström, T. J. Overlapping patterns of IGF2 and H19 expression during human development: biallelic IGF2 expression correlates with a lack of H19 expression. Development (Camb.), 120: 361-368, 1994.
30. Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162: 156-159, 1987.
31. Tadokoro, K., Fujii, H., Inoue, T., and Yamada, M. Polymerase chain reaction (PCR) for detection of ApaI polymorphism at the insulin like growth factor II gene (IGF2). Nucleic Acids Res., 19: 6967, 1991.
32. Takeda, S., Kondo, M., Kumada, T., Koshikawa, T., Ueda, R., Nishio, M., Osada, H., Suzuki, H., Nagatake, M., Washimi, O., Takagi, K., Takahashi, T., Nakao, A., and Takahashi, T. Allelic-expression imbalance of the insulin-like growth factor 2 gene in hepatocellular carcinomas and underlying disease. Oncogene, 12: 1589-1592, 1996.
33. van Dijk, M. A., Rodenburg, R. J. T., Holthuizen, P., and Sussenbach, J. S. The liver-specific promoter of the human insulin-like growth factor II gene is activated by CCAAT/enhancer binding protein (C/EBP). Nucleic Acids Res., 20: 3099-3104, 1992.
34. Desouza, A. T., Hankins, G. R., Washington, M. K., Orton, T. C., and Jirtle, R. L. M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity. Nat. Genet., 11: 447-449, 1995.
35. Minniti, C. P., Luan, D., O'Grady, C., Rosenfeld, R. G., Oh, Y., and Helman, L. J. Insulin-like growth factor II overexpression in myoblasts induces phenotypic changes typical of the malignant phenotype. Cell Growth & Differ., 6: 263-269, 1995.
36. Doucrasy, S., Barrois, M., Fogel, S., Ahomadegbe, J. C., Stehelin, D., Coll, J., and Riou, G. High incidence of loss of heterozygosity and abnormal imprinting of H19 and IGF2 genes in invasive cervical carcinomas: uncoupling of H19 and IGF2 expression and biallelic hypomethylation of H19. Oncogene, 12: 423-430, 1996.
37. Yun, K., Fukumoto, M., and Jinno, Y. Monoallelic expression of the insulin-like growth factor 2 gene in ovarian cancer. Am. J. Pathol., 148: 1081-1087, 1996.
38. Christofori, G., Naik, P., and Hanahan, D. A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis. Nature (Lond.), 369: 414-417, 1994.
39. Wada, M., Seeger, R. C., Mizoguchi, H., and Koeffler, H. P. Maintenance of normal imprinting of H19 and IGF2 genes in neuroblastoma. Cancer Res., 55: 3386-3388, 1995.
40. Hashimoto, K., Azuma, C., Kamiura, S., Koyama, M., Nobunaga, T., Tokugawa, Y., Kimura, T., Kubota, Y., Sawai, K., and Saji, F. Maintenance of imprinting of the insulin-like growth factor II gene (IGF2) and the small nuclear ribonucleoprotein polypeptide N gene (Snrpn) in the human uterus and leiomyoma. Gynecol. Obstet. Invest., 41: 50-54, 1996.
41. Kondo, M., Suzuki, H., Ueda, R., Osada, H., Takagi, K., Takahashi, T., and Takahashi, T. Frequent loss of imprinting of the H19 gene is often associated with its overexpression in human lung cancers. Oncogene, 10: 1193-1198, 1995.
42. Rachmilewitz, J., Elkin, M., Rosensaft, J., Gelman-Kohan, Z., Ariel, I., Lustig, O., Schneider, T., Goshen, R., Biran, H., Groo, N. D., and Hochberg, A. H19 expression and tumorigenieity of choriocarcinoma derived cell lines. Oncogene, 11: 863-870, 1995.