-
1
-
-
0001067847
-
Beta-amyloid precursor protein of Alzheimer disease occurs as 110-to 135-kilodalton membrane-associated proteins in neural and nonneural tissues
-
Selkoe DJ, Podlisny MB, Joachim CL, Vickers EA, Lee G, Fritz LC, Oltersdorf T. Beta-amyloid precursor protein of Alzheimer disease occurs as 110-to 135-kilodalton membrane-associated proteins in neural and nonneural tissues. Proc Natl Acad Sci U S A 1988; 85: 7341-7345.
-
(1988)
Proc Natl Acad Sci U S A
, vol.85
, pp. 7341-7345
-
-
Selkoe, D.J.1
Podlisny, M.B.2
Joachim, C.L.3
Vickers, E.A.4
Lee, G.5
Fritz, L.C.6
Oltersdorf, T.7
-
2
-
-
84861721553
-
Functions of the APP gene family in the nervous system: Insights from mouse models
-
Aydin D, Weyer SW, Muller UC. Functions of the APP gene family in the nervous system: insights from mouse models. Exp Brain Res 2012; 217: 423-34.
-
(2012)
Exp Brain Res
, vol.217
, pp. 423-434
-
-
Aydin, D.1
Weyer, S.W.2
Muller, U.C.3
-
3
-
-
0025171335
-
The amyloid precursor protein of Alzheimer's disease is released by human platelets
-
Bush AI, Martins RN, Rumble B, Moir R, Fuller S, Milward E, Currie J, Ames D, Weidemann A, Fischer P, et al. The amyloid precursor protein of Alzheimer's disease is released by human platelets. J Biol Chem 1990; 265: 15977-15983.
-
(1990)
J Biol Chem
, vol.265
, pp. 15977-15983
-
-
Bush, A.I.1
Martins, R.N.2
Rumble, B.3
Moir, R.4
Fuller, S.5
Milward, E.6
Currie, J.7
Ames, D.8
Weidemann, A.9
Fischer, P.10
-
4
-
-
5444235015
-
Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts
-
Bellingham SA, Ciccotosto GD, Needham BE, Fodero LR, White AR, Masters CL, Cappai R, Camakaris J. Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts. J Neurochem 2004; 91: 423-428.
-
(2004)
J Neurochem
, vol.91
, pp. 423-428
-
-
Bellingham, S.A.1
Ciccotosto, G.D.2
Needham, B.E.3
Fodero, L.R.4
White, A.R.5
Masters, C.L.6
Cappai, R.7
Camakaris, J.8
-
5
-
-
77956647381
-
Iron-export ferroxidase activity of beta-amyloid precursor protein is inhibited by zinc in Alzheimer's disease
-
Duce JA, Tsatsanis A, Cater MA, James SA, Robb E, Wikhe K, Leong SL, Perez K, Johanssen T, Greenough MA, Cho HH, Galatis D, Moir RD, Masters CL, McLean C, Tanzi RE, Cappai R, Barnham KJ, Ciccotosto GD, Rogers JT, Bush AI. Iron-export ferroxidase activity of beta-amyloid precursor protein is inhibited by zinc in Alzheimer's disease. Cell 2010; 142: 857-867.
-
(2010)
Cell
, vol.142
, pp. 857-867
-
-
Duce, J.A.1
Tsatsanis, A.2
Cater, M.A.3
James, S.A.4
Robb, E.5
Wikhe, K.6
Leong, S.L.7
Perez, K.8
Johanssen, T.9
Greenough, M.A.10
Cho, H.H.11
Galatis, D.12
Moir, R.D.13
Masters, C.L.14
McLean, C.15
Tanzi, R.E.16
Cappai, R.17
Barnham, K.J.18
Ciccotosto, G.D.19
Rogers, J.T.20
Bush, A.I.21
more..
-
6
-
-
0027478347
-
Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein
-
Mattson MP, Cheng B, Culwell AR, Esch FS, Lieberburg I, Rydel RE. Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein. Neuron 1993; 10: 243-254.
-
(1993)
Neuron
, vol.10
, pp. 243-254
-
-
Mattson, M.P.1
Cheng, B.2
Culwell, A.R.3
Esch, F.S.4
Lieberburg, I.5
Rydel, R.E.6
-
7
-
-
27144547977
-
Homo-and heterodimerization of APP family members promotes intercellular adhesion
-
Soba P, Eggert S, Wagner K, Zentgraf H, Siehl K, Kreger S, Lower A, Langer A, Merdes G, Paro R, Masters CL, Muller U, Kins S, Beyreuther K. Homo-and heterodimerization of APP family members promotes intercellular adhesion. EMBO J 2005; 24: 3624-3634.
-
(2005)
EMBO J
, vol.24
, pp. 3624-3634
-
-
Soba, P.1
Eggert, S.2
Wagner, K.3
Zentgraf, H.4
Siehl, K.5
Kreger, S.6
Lower, A.7
Langer, A.8
Merdes, G.9
Paro, R.10
Masters, C.L.11
Muller, U.12
Kins, S.13
Beyreuther, K.14
-
8
-
-
0026770381
-
F-spondin: A gene expressed at high levels in the floor plate encodes a secreted protein that promotes neural cell adhesion and neurite extension
-
Klar A, Baldassare M, Jessell TM. F-spondin: a gene expressed at high levels in the floor plate encodes a secreted protein that promotes neural cell adhesion and neurite extension. Cell 1992; 69: 95-110.
-
(1992)
Cell
, vol.69
, pp. 95-110
-
-
Klar, A.1
Baldassare, M.2
Jessell, T.M.3
-
9
-
-
33746216955
-
Amyloid precursor protein regulates differentiation of human neural stem cells
-
Kwak YD, Brannen CL, Qu T, Kim HM, Dong X, Soba P, Majumdar A, Kaplan A, Beyreuther K, Sugaya K. Amyloid precursor protein regulates differentiation of human neural stem cells. Stem Cells Dev 2006; 15: 381-389.
-
(2006)
Stem Cells Dev
, vol.15
, pp. 381-389
-
-
Kwak, Y.D.1
Brannen, C.L.2
Qu, T.3
Kim, H.M.4
Dong, X.5
Soba, P.6
Majumdar, A.7
Kaplan, A.8
Beyreuther, K.9
Sugaya, K.10
-
10
-
-
37549040612
-
A critical function for betaamyloid precursor protein in neuronal migration revealed by in utero RNA interference
-
Young-Pearse TL, Bai J, Chang R, Zheng JB, Lo-Turco JJ, Selkoe DJ. A critical function for betaamyloid precursor protein in neuronal migration revealed by in utero RNA interference. J Neurosci 2007; 27: 14459-14469.
-
(2007)
J Neurosci
, vol.27
, pp. 14459-14469
-
-
Young-Pearse, T.L.1
Bai, J.2
Chang, R.3
Zheng, J.B.4
Lo-Turco, J.J.5
Selkoe, D.J.6
-
11
-
-
0029257190
-
Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner
-
Qiu WQ, Ferreira A, Miller C, Koo EH, Selkoe DJ. Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner. J Neurosci 1995; 15: 2157-2167.
-
(1995)
J Neurosci
, vol.15
, pp. 2157-2167
-
-
Qiu, W.Q.1
Ferreira, A.2
Miller, C.3
Koo, E.H.4
Selkoe, D.J.5
-
12
-
-
28644449284
-
Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain
-
Leyssen M, Ayaz D, Hebert SS, Reeve S, De Strooper B, Hassan BA. Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain. EMBO J 2005; 24: 2944-2955.
-
(2005)
EMBO J
, vol.24
, pp. 2944-2955
-
-
Leyssen, M.1
Ayaz, D.2
Hebert, S.S.3
Reeve, S.4
De Strooper, B.5
Hassan, B.A.6
-
13
-
-
0035818998
-
Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP
-
Kamal A, Almenar-Queralt A, LeBlanc JF, Roberts EA, Goldstein LS. Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature 2001; 414: 643-648.
-
(2001)
Nature
, vol.414
, pp. 643-648
-
-
Kamal, A.1
Almenar-Queralt, A.2
LeBlanc, J.F.3
Roberts, E.A.4
Goldstein, L.S.5
-
14
-
-
0032514633
-
Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice
-
Meziane H, Dodart JC, Mathis C, Little S, Clemens J, Paul SM, Ungerer A. Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice. Proc Natl Acad Sci U S A 1998; 95: 12683-12688.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 12683-12688
-
-
Meziane, H.1
Dodart, J.C.2
Mathis, C.3
Little, S.4
Clemens, J.5
Paul, S.M.6
Ungerer, A.7
-
15
-
-
67649366042
-
Neuroprotective secreted amyloid precursor protein acts by disrupting amyloid precursor protein dimers
-
Gralle M, Botelho MG, Wouters FS. Neuroprotective secreted amyloid precursor protein acts by disrupting amyloid precursor protein dimers. J Biol Chem 2009; 284: 15016-15025.
-
(2009)
J Biol Chem
, vol.284
, pp. 15016-15025
-
-
Gralle, M.1
Botelho, M.G.2
Wouters, F.S.3
-
16
-
-
33746233383
-
Synapse formation and function is modulated by the amyloid precursor protein
-
Priller C, Bauer T, Mitteregger G, Krebs B, Kretzschmar HA, Herms J. Synapse formation and function is modulated by the amyloid precursor protein. J Neurosci 2006; 26: 7212-7221.
-
(2006)
J Neurosci
, vol.26
, pp. 7212-7221
-
-
Priller, C.1
Bauer, T.2
Mitteregger, G.3
Krebs, B.4
Kretzschmar, H.A.5
Herms, J.6
-
17
-
-
0027970897
-
Synaptotrophic effects of human amyloid beta protein precursors in the cortex of transgenic mice
-
Mucke L, Masliah E, Johnson WB, Ruppe MD, Alford M, Rockenstein EM, Forss-Petter S, Pietropaolo M, Mallory M, Abraham CR. Synaptotrophic effects of human amyloid beta protein precursors in the cortex of transgenic mice. Brain Res 1994; 666: 151-167.
-
(1994)
Brain Res
, vol.666
, pp. 151-167
-
-
Mucke, L.1
Masliah, E.2
Johnson, W.B.3
Ruppe, M.D.4
Alford, M.5
Rockenstein, E.M.6
Forss-Petter, S.7
Pietropaolo, M.8
Mallory, M.9
Abraham, C.R.10
-
18
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 1999; 286: 735-741.
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
Denis, P.6
Teplow, D.B.7
Ross, S.8
Amarante, P.9
Loeloff, R.10
Luo, Y.11
Fisher, S.12
Fuller, J.13
Edenson, S.14
Lile, J.15
Jarosinski, M.A.16
Biere, A.L.17
Curran, E.18
Burgess, T.19
Louis, J.C.20
Collins, F.21
Treanor, J.22
Rogers, G.23
Citron, M.24
more..
-
19
-
-
0034652309
-
Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein
-
Lin X, Koelsch G, Wu S, Downs D, Dashti A, Tang J. Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc Natl Acad Sci U S A 2000; 97: 1456-1460.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 1456-1460
-
-
Lin, X.1
Koelsch, G.2
Wu, S.3
Downs, D.4
Dashti, A.5
Tang, J.6
-
20
-
-
0037431082
-
Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex
-
De Strooper B. Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex. Neuron 2003; 38: 9-12.
-
(2003)
Neuron
, vol.38
, pp. 9-12
-
-
De Strooper, B.1
-
21
-
-
0023105114
-
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
-
Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, Grzeschik KH, Multhaup G, Beyreuther K, Muller-Hill B. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 1987; 325: 733-736.
-
(1987)
Nature
, vol.325
, pp. 733-736
-
-
Kang, J.1
Lemaire, H.G.2
Unterbeck, A.3
Salbaum, J.M.4
Masters, C.L.5
Grzeschik, K.H.6
Multhaup, G.7
Beyreuther, K.8
Muller-Hill, B.9
-
22
-
-
0035823495
-
Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease
-
Scheuermann S, Hambsch B, Hesse L, Stumm J, Schmidt C, Beher D, Bayer TA, Beyreuther K, Multhaup G. Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease. J Biol Chem 2001; 276: 33923-33929.
-
(2001)
J Biol Chem
, vol.276
, pp. 33923-33929
-
-
Scheuermann, S.1
Hambsch, B.2
Hesse, L.3
Stumm, J.4
Schmidt, C.5
Beher, D.6
Bayer, T.A.7
Beyreuther, K.8
Multhaup, G.9
-
23
-
-
33644962142
-
Visualization of APP dimerization and APPNotch2 heterodimerization in living cells using bimolecular fluorescence complementation
-
Chen CD, Oh SY, Hinman JD, Abraham CR. Visualization of APP dimerization and APPNotch2 heterodimerization in living cells using bimolecular fluorescence complementation. J Neurochem 2006; 97: 30-43.
-
(2006)
J Neurochem
, vol.97
, pp. 30-43
-
-
Chen, C.D.1
Oh, S.Y.2
Hinman, J.D.3
Abraham, C.R.4
-
24
-
-
77749271010
-
Cell-type dependent modulation of Notch signaling by the amyloid precursor protein
-
Oh SY, Chen CD, Abraham CR. Cell-type dependent modulation of Notch signaling by the amyloid precursor protein. J Neurochem 2010; 113: 262-274.
-
(2010)
J Neurochem
, vol.113
, pp. 262-274
-
-
Oh, S.Y.1
Chen, C.D.2
Abraham, C.R.3
-
25
-
-
27744521430
-
Amyloid precursor protein interacts with notch receptors
-
Oh SY, Ellenstein A, Chen CD, Hinman JD, Berg EA, Costello CE, Yamin R, Neve RL, Abraham CR. Amyloid precursor protein interacts with notch receptors. J Neurosci Res 2005; 82: 32-42.
-
(2005)
J Neurosci Res
, vol.82
, pp. 32-42
-
-
Oh, S.Y.1
Ellenstein, A.2
Chen, C.D.3
Hinman, J.D.4
Berg, E.A.5
Costello, C.E.6
Yamin, R.7
Neve, R.L.8
Abraham, C.R.9
-
26
-
-
65249143369
-
Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2
-
Kaden D, Voigt P, Munter LM, Bobowski KD, Schaefer M, Multhaup G. Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2. J Cell Sci 2009; 122: 368-377.
-
(2009)
J Cell Sci
, vol.122
, pp. 368-377
-
-
Kaden, D.1
Voigt, P.2
Munter, L.M.3
Bobowski, K.D.4
Schaefer, M.5
Multhaup, G.6
-
27
-
-
2642582435
-
Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation
-
Cao X, Sudhof TC. Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation. J Biol Chem 2004; 279: 24601-24611.
-
(2004)
J Biol Chem
, vol.279
, pp. 24601-24611
-
-
Cao, X.1
Sudhof, T.C.2
-
28
-
-
77950385325
-
Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein
-
Dahms SO, Hoefgen S, Roeser D, Schlott B, Guhrs KH, Than ME. Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein. Proc Natl Acad Sci U S A 2010; 107: 5381-5386.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 5381-5386
-
-
Dahms, S.O.1
Hoefgen, S.2
Roeser, D.3
Schlott, B.4
Guhrs, K.H.5
Than, M.E.6
-
29
-
-
5444275067
-
The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor
-
von Rotz RC, Kohli BM, Bosset J, Meier M, Suzuki T, Nitsch RM, Konietzko U. The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor. J Cell Sci 2004; 117: 4435-4448.
-
(2004)
J Cell Sci
, vol.117
, pp. 4435-4448
-
-
von Rotz, R.C.1
Kohli, B.M.2
Bosset, J.3
Meier, M.4
Suzuki, T.5
Nitsch, R.M.6
Konietzko, U.7
-
30
-
-
43749112022
-
Homophilic interactions of the amyloid precursor protein (APP) ectodomain are regulated by the loop region and affect beta-secretase cleavage of APP
-
Kaden D, Munter LM, Joshi M, Treiber C, Weise C, Bethge T, Voigt P, Schaefer M, Beyermann M, Reif B, Multhaup G. Homophilic interactions of the amyloid precursor protein (APP) ectodomain are regulated by the loop region and affect beta-secretase cleavage of APP. J Biol Chem 2008; 283: 7271-7279.
-
(2008)
J Biol Chem
, vol.283
, pp. 7271-7279
-
-
Kaden, D.1
Munter, L.M.2
Joshi, M.3
Treiber, C.4
Weise, C.5
Bethge, T.6
Voigt, P.7
Schaefer, M.8
Beyermann, M.9
Reif, B.10
Multhaup, G.11
-
31
-
-
0030030005
-
Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I
-
Beher D, Hesse L, Masters CL, Multhaup G. Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I. J Biol Chem 1996; 271: 1613-1620.
-
(1996)
J Biol Chem
, vol.271
, pp. 1613-1620
-
-
Beher, D.1
Hesse, L.2
Masters, C.L.3
Multhaup, G.4
-
32
-
-
4143105782
-
The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain
-
Wang Y, Ha Y. The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain. Mol Cell 2004; 15: 343-353.
-
(2004)
Mol Cell
, vol.15
, pp. 343-353
-
-
Wang, Y.1
Ha, Y.2
-
33
-
-
80053571400
-
N-cadherin enhances APP dimerization at the extracellular domain and modulates Abeta production
-
Asada-Utsugi M, Uemura K, Noda Y, Kuzuya A, Maesako M, Ando K, Kubota M, Watanabe K, Takahashi M, Kihara T, Shimohama S, Takahashi R, Berezovska O, Kinoshita A. N-cadherin enhances APP dimerization at the extracellular domain and modulates Abeta production. J Neurochem 2011; 119: 354-363.
-
(2011)
J Neurochem
, vol.119
, pp. 354-363
-
-
Asada-Utsugi, M.1
Uemura, K.2
Noda, Y.3
Kuzuya, A.4
Maesako, M.5
Ando, K.6
Kubota, M.7
Watanabe, K.8
Takahashi, M.9
Kihara, T.10
Shimohama, S.11
Takahashi, R.12
Berezovska, O.13
Kinoshita, A.14
-
34
-
-
33947597857
-
GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42
-
Munter LM, Voigt P, Harmeier A, Kaden D, Gottschalk KE, Weise C, Pipkorn R, Schaefer M, Langosch D, Multhaup G. GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42. EMBO J 2007; 26: 1702-1712.
-
(2007)
EMBO J
, vol.26
, pp. 1702-1712
-
-
Munter, L.M.1
Voigt, P.2
Harmeier, A.3
Kaden, D.4
Gottschalk, K.E.5
Weise, C.6
Pipkorn, R.7
Schaefer, M.8
Langosch, D.9
Multhaup, G.10
-
35
-
-
40549088246
-
Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants
-
Gorman PM, Kim S, Guo M, Melnyk RA, McLaurin J, Fraser PE, Bowie JU, Chakrabartty A. Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants. BMC Neurosci 2008; 9: 17.
-
(2008)
BMC Neurosci
, vol.9
, pp. 17
-
-
Gorman, P.M.1
Kim, S.2
Guo, M.3
Melnyk, R.A.4
McLaurin, J.5
Fraser, P.E.6
Bowie, J.U.7
Chakrabartty, A.8
-
36
-
-
3843102625
-
Sequence context modulates the stability of a GxxxG-mediated transmembrane helix-helix dimer
-
Doura AK, Kobus FJ, Dubrovsky L, Hibbard E, Fleming KG. Sequence context modulates the stability of a GxxxG-mediated transmembrane helix-helix dimer. J Mol Biol 2004; 341: 991-998.
-
(2004)
J Mol Biol
, vol.341
, pp. 991-998
-
-
Doura, A.K.1
Kobus, F.J.2
Dubrovsky, L.3
Hibbard, E.4
Fleming, K.G.5
-
37
-
-
0031956790
-
The dimerization motif of the glycophorin A transmembrane segment in membranes: Importance of glycine residues
-
Brosig B, Langosch D. The dimerization motif of the glycophorin A transmembrane segment in membranes: importance of glycine residues. Protein Sci 1998; 7: 1052-1056.
-
(1998)
Protein Sci
, vol.7
, pp. 1052-1056
-
-
Brosig, B.1
Langosch, D.2
-
38
-
-
70350350069
-
Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production
-
Eggert S, Midthune B, Cottrell B, Koo EH. Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production. J Biol Chem 2009; 284: 28943-28952.
-
(2009)
J Biol Chem
, vol.284
, pp. 28943-28952
-
-
Eggert, S.1
Midthune, B.2
Cottrell, B.3
Koo, E.H.4
-
39
-
-
43149088724
-
Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs
-
Kienlen-Campard P, Tasiaux B, Van Hees J, Li M, Huysseune S, Sato T, Fei JZ, Aimoto S, Courtoy PJ, Smith SO, Constantinescu SN, Octave JN. Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs. J Biol Chem 2008; 283: 7733-7744.
-
(2008)
J Biol Chem
, vol.283
, pp. 7733-7744
-
-
Kienlen-Campard, P.1
Tasiaux, B.2
Van Hees, J.3
Li, M.4
Huysseune, S.5
Sato, T.6
Fei, J.Z.7
Aimoto, S.8
Courtoy, P.J.9
Smith, S.O.10
Constantinescu, S.N.11
Octave, J.N.12
-
40
-
-
45149105232
-
Substrate-targeting gamma-secretase modulators
-
Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, Healy B, Chapman R, Welzel AT, Price RW, Moore B, Rangachari V, Cusack B, Eriksen J, Jansen-West K, Verbeeck C, Yager D, Eckman C, Ye W, Sagi S, Cottrell BA, Torpey J, Rosenberry TL, Fauq A, Wolfe MS, Schmidt B, Walsh DM, Koo EH, Golde TE. Substrate-targeting gamma-secretase modulators. Nature 2008; 453: 925-929.
-
(2008)
Nature
, vol.453
, pp. 925-929
-
-
Kukar, T.L.1
Ladd, T.B.2
Bann, M.A.3
Fraering, P.C.4
Narlawar, R.5
Maharvi, G.M.6
Healy, B.7
Chapman, R.8
Welzel, A.T.9
Price, R.W.10
Moore, B.11
Rangachari, V.12
Cusack, B.13
Eriksen, J.14
Jansen-West, K.15
Verbeeck, C.16
Yager, D.17
Eckman, C.18
Ye, W.19
Sagi, S.20
Cottrell, B.A.21
Torpey, J.22
Rosenberry, T.L.23
Fauq, A.24
Wolfe, M.S.25
Schmidt, B.26
Walsh, D.M.27
Koo, E.H.28
Golde, T.E.29
more..
-
41
-
-
77957096840
-
Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization
-
Richter L, Munter LM, Ness J, Hildebrand PW, Dasari M, Unterreitmeier S, Bulic B, Beyermann M, Gust R, Reif B, Weggen S, Langosch D, Multhaup G. Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization. Proc Natl Acad Sci U S A 2010; 107: 14597-14602.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 14597-14602
-
-
Richter, L.1
Munter, L.M.2
Ness, J.3
Hildebrand, P.W.4
Dasari, M.5
Unterreitmeier, S.6
Bulic, B.7
Beyermann, M.8
Gust, R.9
Reif, B.10
Weggen, S.11
Langosch, D.12
Multhaup, G.13
-
42
-
-
77954359268
-
Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif
-
Munter LM, Botev A, Richter L, Hildebrand PW, Althoff V, Weise C, Kaden D, Multhaup G. Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif. J Biol Chem 2010; 285: 21636-21643.
-
(2010)
J Biol Chem
, vol.285
, pp. 21636-21643
-
-
Munter, L.M.1
Botev, A.2
Richter, L.3
Hildebrand, P.W.4
Althoff, V.5
Weise, C.6
Kaden, D.7
Multhaup, G.8
-
43
-
-
7944233158
-
Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases
-
Selkoe DJ. Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases. Nat Cell Biol 2004; 6: 1054-1061.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 1054-1061
-
-
Selkoe, D.J.1
-
44
-
-
0026879650
-
Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene
-
Hendriks L, van Duijn CM, Cras P, Cruts M, Van Hul W, van Harskamp F, Warren A, McInnis MG, Antonarakis SE, Martin JJ, et al. Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene. Nat Genet 1992; 1: 218-221.
-
(1992)
Nat Genet
, vol.1
, pp. 218-221
-
-
Hendriks, L.1
van Duijn, C.M.2
Cras, P.3
Cruts, M.4
Van Hul, W.5
van Harskamp, F.6
Warren, A.7
McInnis, M.G.8
Antonarakis, S.E.9
Martin, J.J.10
-
45
-
-
0026907151
-
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid
-
Mullan M, Crawford F, Axelman K, Houlden H, Lilius L, Winblad B, Lannfelt L. A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid. Nat Genet 1992; 1: 345-347.
-
(1992)
Nat Genet
, vol.1
, pp. 345-347
-
-
Mullan, M.1
Crawford, F.2
Axelman, K.3
Houlden, H.4
Lilius, L.5
Winblad, B.6
Lannfelt, L.7
-
46
-
-
0034327364
-
Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease
-
Kumar-Singh S, De Jonghe C, Cruts M, Kleinert R, Wang R, Mercken M, De Strooper B, Vanderstichele H, Lofgren A, Vanderhoeven I, Backhovens H, Vanmechelen E, Kroisel PM, Van Broeckhoven C. Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease. Hum Mol Genet 2000; 9: 2589-2598.
-
(2000)
Hum Mol Genet
, vol.9
, pp. 2589-2598
-
-
Kumar-Singh, S.1
De Jonghe, C.2
Cruts, M.3
Kleinert, R.4
Wang, R.5
Mercken, M.6
De Strooper, B.7
Vanderstichele, H.8
Lofgren, A.9
Vanderhoeven, I.10
Backhovens, H.11
Vanmechelen, E.12
Kroisel, P.M.13
Van Broeckhoven, C.14
-
47
-
-
0037188380
-
An Iranian family with Alzheimer's disease caused by a novel APP mutation (Thr714Ala)
-
Pasalar P, Najmabadi H, Noorian AR, Moghimi B, Jannati A, Soltanzadeh A, Krefft T, Crook R, Hardy J. An Iranian family with Alzheimer's disease caused by a novel APP mutation (Thr714Ala). Neurology 2002; 58: 1574-1575.
-
(2002)
Neurology
, vol.58
, pp. 1574-1575
-
-
Pasalar, P.1
Najmabadi, H.2
Noorian, A.R.3
Moghimi, B.4
Jannati, A.5
Soltanzadeh, A.6
Krefft, T.7
Crook, R.8
Hardy, J.9
-
48
-
-
0344153476
-
Novel APP mutation V715A associated with presenile Alzheimer's disease in a German family
-
Cruts M, Dermaut B, Rademakers R, Van den Broeck M, Stogbauer F, Van Broeckhoven C. Novel APP mutation V715A associated with presenile Alzheimer's disease in a German family. J Neurol 2003; 250: 1374-1375.
-
(2003)
J Neurol
, vol.250
, pp. 1374-1375
-
-
Cruts, M.1
Dermaut, B.2
Rademakers, R.3
Van den Broeck, M.4
Stogbauer, F.5
Van Broeckhoven, C.6
-
49
-
-
9844261165
-
A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43)
-
Eckman CB, Mehta ND, Crook R, Perez-tur J, Prihar G, Pfeiffer E, Graff-Radford N, Hinder P, Yager D, Zenk B, Refolo LM, Prada CM, Younkin SG, Hutton M, Hardy J. A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43). Hum Mol Genet 1997; 6: 2087-2089.
-
(1997)
Hum Mol Genet
, vol.6
, pp. 2087-2089
-
-
Eckman, C.B.1
Mehta, N.D.2
Crook, R.3
Perez-tur, J.4
Prihar, G.5
Pfeiffer, E.6
Graff-Radford, N.7
Hinder, P.8
Yager, D.9
Zenk, B.10
Refolo, L.M.11
Prada, C.M.12
Younkin, S.G.13
Hutton, M.14
Hardy, J.15
-
50
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
Goate A, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, Fidani L, Giuffra L, Haynes A, Irving N, James L, et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991; 349: 704-706.
-
(1991)
Nature
, vol.349
, pp. 704-706
-
-
Goate, A.1
Chartier-Harlin, M.C.2
Mullan, M.3
Brown, J.4
Crawford, F.5
Fidani, L.6
Giuffra, L.7
Haynes, A.8
Irving, N.9
James, L.10
-
51
-
-
0025950987
-
A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease
-
Murrell J, Farlow M, Ghetti B, Benson MD. A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science 1991; 254: 97-99.
-
(1991)
Science
, vol.254
, pp. 97-99
-
-
Murrell, J.1
Farlow, M.2
Ghetti, B.3
Benson, M.D.4
-
52
-
-
0033616590
-
Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715--> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease
-
Ancolio K, Dumanchin C, Barelli H, Warter JM, Brice A, Campion D, Frebourg T, Checler F. Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715--> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease. Proc Natl Acad Sci U S A 1999; 96: 4119-4124.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 4119-4124
-
-
Ancolio, K.1
Dumanchin, C.2
Barelli, H.3
Warter, J.M.4
Brice, A.5
Campion, D.6
Frebourg, T.7
Checler, F.8
-
53
-
-
33644861986
-
Identification of new fluorescent protein fragments for bimolecular fluorescence complementation analysis under physiological conditions
-
Shyu YJ, Liu H, Deng X, Hu CD. Identification of new fluorescent protein fragments for bimolecular fluorescence complementation analysis under physiological conditions. Biotechniques 2006; 40: 61-66.
-
(2006)
Biotechniques
, vol.40
, pp. 61-66
-
-
Shyu, Y.J.1
Liu, H.2
Deng, X.3
Hu, C.D.4
-
54
-
-
0036138908
-
A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications
-
Nagai T, Ibata K, Park ES, Kubota M, Mikoshiba K, Miyawaki A. A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications. Nat Biotechnol 2002; 20: 87-90.
-
(2002)
Nat Biotechnol
, vol.20
, pp. 87-90
-
-
Nagai, T.1
Ibata, K.2
Park, E.S.3
Kubota, M.4
Mikoshiba, K.5
Miyawaki, A.6
-
55
-
-
34347222583
-
Design and implementation of bimolecular fluorescence complementation (BiFC) assays for the visualization of protein interactions in living cells
-
Kerppola TK. Design and implementation of bimolecular fluorescence complementation (BiFC) assays for the visualization of protein interactions in living cells. Nat Protoc 2006; 1: 1278-1286.
-
(2006)
Nat Protoc
, vol.1
, pp. 1278-1286
-
-
Kerppola, T.K.1
-
56
-
-
36349024875
-
Active gamma-secretase complexes contain only one of each component
-
Sato T, Diehl TS, Narayanan S, Funamoto S, Ihara Y, De Strooper B, Steiner H, Haass C, Wolfe MS. Active gamma-secretase complexes contain only one of each component. J Biol Chem 2007; 282: 33985-33993.
-
(2007)
J Biol Chem
, vol.282
, pp. 33985-33993
-
-
Sato, T.1
Diehl, T.S.2
Narayanan, S.3
Funamoto, S.4
Ihara, Y.5
De Strooper, B.6
Steiner, H.7
Haass, C.8
Wolfe, M.S.9
-
57
-
-
84860221024
-
Contribution of Kunitz protease inhibitor and transmembrane domains to amyloid precursor protein homodimerization
-
Ben Khalifa N, Tyteca D, Courtoy PJ, Renauld JC, Constantinescu SN, Octave JN, Kienlen-Campard P. Contribution of Kunitz protease inhibitor and transmembrane domains to amyloid precursor protein homodimerization. Neurodegener Dis 2012; 10: 92-95.
-
(2012)
Neurodegener Dis
, vol.10
, pp. 92-95
-
-
Ben Khalifa, N.1
Tyteca, D.2
Courtoy, P.J.3
Renauld, J.C.4
Constantinescu, S.N.5
Octave, J.N.6
Kienlen-Campard, P.7
-
58
-
-
11144242097
-
Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme
-
Westmeyer GG, Willem M, Lichtenthaler SF, Lurman G, Multhaup G, Assfalg-Machleidt I, Reiss K, Saftig P, Haass C. Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme. J Biol Chem 2004; 279: 53205-53212.
-
(2004)
J Biol Chem
, vol.279
, pp. 53205-53212
-
-
Westmeyer, G.G.1
Willem, M.2
Lichtenthaler, S.F.3
Lurman, G.4
Multhaup, G.5
Assfalg-McHleidt, I.6
Reiss, K.7
Saftig, P.8
Haass, C.9
-
59
-
-
4544271980
-
Human BACE forms dimers and colocalizes with APP
-
Schmechel A, Strauss M, Schlicksupp A, Pipkorn R, Haass C, Bayer TA, Multhaup G. Human BACE forms dimers and colocalizes with APP. J Biol Chem 2004; 279: 39710-39717.
-
(2004)
J Biol Chem
, vol.279
, pp. 39710-39717
-
-
Schmechel, A.1
Strauss, M.2
Schlicksupp, A.3
Pipkorn, R.4
Haass, C.5
Bayer, T.A.6
Multhaup, G.7
-
60
-
-
0242331600
-
A presenilin dimer at the core of the gamma-secretase enzyme: Insights from parallel analysis of Notch 1 and APP proteolysis
-
Schroeter EH, Ilagan MX, Brunkan AL, Hecimovic S, Li YM, Xu M, Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Goate A, Wolfe MS, Shearman M, Kopan R. A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proc Natl Acad Sci U S A 2003; 100: 13075-13080.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 13075-13080
-
-
Schroeter, E.H.1
Ilagan, M.X.2
Brunkan, A.L.3
Hecimovic, S.4
Li, Y.M.5
Xu, M.6
Lewis, H.D.7
Saxena, M.T.8
De Strooper, B.9
Coonrod, A.10
Tomita, T.11
Iwatsubo, T.12
Moore, C.L.13
Goate, A.14
Wolfe, M.S.15
Shearman, M.16
Kopan, R.17
-
61
-
-
4344632844
-
Functional implications of the presenilin dimerization: Reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins
-
Cervantes S, Saura CA, Pomares E, Gonzalez-Duarte R, Marfany G. Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins. J Biol Chem 2004; 279: 36519-36529.
-
(2004)
J Biol Chem
, vol.279
, pp. 36519-36529
-
-
Cervantes, S.1
Saura, C.A.2
Pomares, E.3
Gonzalez-Duarte, R.4
Marfany, G.5
-
62
-
-
70249091154
-
Transmembrane structures of amyloid precursor protein dimer predicted by replica-exchange molecular dynamics simulations
-
Miyashita N, Straub JE, Thirumalai D, Sugita Y. Transmembrane structures of amyloid precursor protein dimer predicted by replica-exchange molecular dynamics simulations. J Am Chem Soc 2009; 131: 3438-3439.
-
(2009)
J Am Chem Soc
, vol.131
, pp. 3438-3439
-
-
Miyashita, N.1
Straub, J.E.2
Thirumalai, D.3
Sugita, Y.4
-
63
-
-
60849131737
-
A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis
-
Sato T, Tang TC, Reubins G, Fei JZ, Fujimoto T, Kienlen-Campard P, Constantinescu SN, Octave JN, Aimoto S, Smith SO. A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis. Proc Natl Acad Sci U S A 2009; 106: 1421-1426.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 1421-1426
-
-
Sato, T.1
Tang, T.C.2
Reubins, G.3
Fei, J.Z.4
Fujimoto, T.5
Kienlen-Campard, P.6
Constantinescu, S.N.7
Octave, J.N.8
Aimoto, S.9
Smith, S.O.10
|