Transmembrane structures of amyloid precursor protein dimer predicted by replica-exchange molecular dynamics simulations

Journal of the American Chemical Society

Volumn 131, Issue 10, 2009, Pages 3438-3439

  Miyashita, Naoyuki ^a,b,c   Straub, John E ^a,b,c,d   Thirumalai, D ^a,b,c,e   Sugita, Yuji ^a,b,c  

^a RIKEN   (Japan)

^b Boston University   (United States)

^c Bldg 142   (United States)

^d BOSTON UNIVERSITY   (United States)

^e UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ALZHEIMER'S DISEASE; AMYLOID PRECURSOR PROTEINS; CLEAVAGE SITES; CONFORMATIONAL DIFFERENCES; EXPERIMENTAL STUDIES; HOMODIMERIZATION; HYDROPHOBIC INTERACTIONS; IMPLICIT MEMBRANE MODELS; REPLICA-EXCHANGE MOLECULAR DYNAMICS SIMULATIONS; SECRETASES; TRANSMEMBRANE STRUCTURE; WILD TYPES;

AMINES; DIMERIZATION; GLYCOPROTEINS; HYDROGEN; HYDROGEN BONDS; HYDROPHOBICITY; MOLECULAR DYNAMICS;

PUMPING PLANTS;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; GLYCINE; LEUCINE; MEMBRANE PROTEIN; MUTANT PROTEIN;

ARTICLE; DIMERIZATION; ENZYME ACTIVE SITE; MEMBRANE MODEL; MOLECULAR DYNAMICS; PREDICTION; PROTEIN CONFORMATION; PROTEIN SECRETION; PROTEIN STRUCTURE; SIMULATION; WILD TYPE; CHEMICAL STRUCTURE; CHEMISTRY; HYDROGEN BOND; NUCLEAR MAGNETIC RESONANCE; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

AMYLOID BETA-PROTEIN PRECURSOR; DIMERIZATION; HYDROGEN BONDING; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

EID: 70249091154     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja809227c     Document Type: Article

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