Methoxylation of resveratrol: Effects on induction of NAD(P)H Quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 3, 2011, Pages 1032-1035

  Zhang, Wei ^a   Go, Mei Lin ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Growth inhibitory effects; Methoxy analogs; NQO1 induction; Resveratrol; Structure activity relationship

Indexed keywords

DOXORUBICIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); RESVERATROL; STILBENE DERIVATIVE;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CHEMICAL MODIFICATION; CHEMICAL REACTION; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; ENZYME INDUCTION; HEPATOMA CELL; HUMAN; HUMAN CELL; ISOMER; METHOXYLATION; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; ENZYME INHIBITORS; HUMANS; MICE; NAD(P)H DEHYDROGENASE (QUINONE); STILBENES; STRUCTURE-ACTIVITY RELATIONSHIP;

MURINAE;

EID: 78751646363     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.12.029     Document Type: Article

References (22)

1. J.-G. Fang, and B. Zhou J. Agric. Food Chem. 56 2008 11458
2. S.A. Adesanya, R. Nia, M.-T. Martin, N. Boukamcha, A. Montagnac, and M. Paies J. Nat. Prod. 62 1999 1694
3. E.H. Siemann, and L.L. Creasy Am. J. Enol. Vitic. 43 1992 49
4. J.A. Baur, and D.A. Sinclair Nat. Rev. Drug Disc. 5 2006 493
5. S. Sale, R.D. Verschoyle, D. Boocock, D.J.L. Jones, N. Wilsher, K.C. Ruparelia, G.A. Potter, P.B. Farmer, W.P. Steward, and A.J. Gescher Br. J. Cancer 90 2004 736
6. M. Cuendet, C.P. Oteham, R.C. Moon, and J.M. Pezzuto J. Nat. Prod. 69 2006 460
7. W. Zhang, and M.L. Go Eur. J. Med. Chem. 42 2007 841
8. C. Koehle, and K.W. Bock Biochem. Pharmacol. 73 2007 1853
9. W. Miao, L. Hu, P.J. Scrivens, and G. Batist J. Biol. Chem. 280 2005 20340
10. A. Marchand, R. Barouki, and M. Garlatti Mol. Pharmacol. 65 2004 1029
11. Q. Ma, K. Kinneer, Y. Bi, J.Y. Chan, and Y.W. Kan Biochem. J. 377 2004 205
12. S.W. Kennedy, and S.P. Jones Anal. Biochem. 222 1994 217
13. W. Zhang, and M.-L. Go Bioorg. Med. Chem. 17 2009 2077
14. C. Koehle, and K.W. Bock Biochem. Pharmacol. 72 2006 795
15. 50 was determined from the sigmoidal curve obtained by plotting % surviving cells versus concentration using OriginPro 7.5 SR1 (Version V7.5776 B776), OriginLab Corporation, MA.
16. 2, 37 °C. Cell viability was determined as described in Ref. 15.
17. V. Cardile, R. Chillemi, L. Lombardo, S. Sciuto, C. Spatafora, C.Z. Tringali, and C. Naturforsch J. Biosci. 62 2007 189
18. A. Gosslau, M. Chen, C.-T. Ho, and K.Y. Chen Br. J. Cancer 92 2005 513
19. S. Fulda Drug Discovery Today 15 2010 757
20. F. Cacciapuoti Metab. Syndr. Relat. Disord. 7 2009 397
21. A.S. Darvesh, R.T. Carroll, A. Bishayee, W.J. Geldenhuys, and C.J. Van der Schyf Expert Rev. Neurother. 10 2010 729
22. V.R. Ramprasath, and P.J.H. Jones Eur. J. Clin. Nutr. 64 2010 660