A novel kavalactone derivative protects against H2O2-induced PC12 cell death via Nrf2/ARE activation

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 9, 2010, Pages 3133-3139

  Tanaka, Arisa ^a,b   Hamada, Nanako ^a   Fujita, Yasunori ^a   Itoh, Tomohiro ^a   Nozawa, Yoshinori ^a   Iinuma, Munekazu ^b   Ito, Masafumi ^a  

^a GIFU INTERNATIONAL INSTITUTE OF BIOTECHNOLOGY   (Japan)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Antioxidant response element; Kavalactone; Neuroprotection; Nrf2; Oxidative stress

Indexed keywords

2',6' DICHLORO 5 METHOXYMETHYL DEMETHOXYYANGONIN; ANTIOXIDANT; DEMETHOXYYANGONIN; HEME OXYGENASE 1; HYDROGEN PEROXIDE; KAWAIN; METHYSTICIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; YANGONIN;

ALZHEIMER DISEASE; ANIMAL CELL; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL DEATH; CELL NUCLEUS; CELL STRAIN; CELL VIABILITY; CHEMICAL MODIFICATION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; GENE ACTIVATION; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOGENESIS; PIPER METHYSTICUM; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CELL DEATH; HYDROGEN PEROXIDE; KAVA; LACTONES; MOLECULAR STRUCTURE; NF-E2-RELATED FACTOR 2; PC12 CELLS; RATS; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION;

PIPER METHYSTICUM; PIPERACEAE; RATTUS;

EID: 77951206691     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.03.034     Document Type: Article

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