Arsenic and chromium in drinking water promote tumorigenesis in a mouse colitis-associated colorectal cancer model and the potential mechanism is ROS-mediated Wnt/β-catenin signaling pathway

Toxicology and Applied Pharmacology

Volumn 262, Issue 1, 2012, Pages 11-21

  Wang, Xin ^a   Mandal, Ardhendu K ^a   Saito, Hiroshi ^b   Pulliam, Joseph F ^c   Lee, Eun Y ^c   Ke, Zun Ji ^a   Lu, Jian ^a   Ding, Songze ^a   Li, Li ^d   Shelton, Brent J ^b   Tucker, Thomas ^b   Evers, B Mark ^b   Zhang, Zhuo ^a   Shi, Xianglin ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

2D DIGE; As(III); Colorectal cancer; Cr(VI); ROS; Tumorigenesis; Wnt catenin pathway

Indexed keywords

ARSENIC; BETA CATENIN; CATALASE; CHROMIUM; GLYCOGEN SYNTHASE KINASE 3; PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; COLITIS; COLORECTAL CANCER; DISEASE SEVERITY; IMMUNE RESPONSE; IN VITRO STUDY; MASS SPECTROMETRY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; TUMOR VOLUME; TWO DIMENSIONAL DIFFERENCE GEL ELECTROPHORESIS; WATER CONTAMINATION;

ANIMALS; ANTIOXIDANTS; ARSENIC; AZOXYMETHANE; CARCINOGENS, ENVIRONMENTAL; CELL LINE; CHROMIUM; COLITIS; COLORECTAL NEOPLASMS; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; DRINKING WATER; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; HUMANS; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; REACTIVE OXYGEN SPECIES; WATER POLLUTANTS, CHEMICAL; WNT SIGNALING PATHWAY;

ANIMALIA;

EID: 84861733575     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.04.014     Document Type: Article

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