Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: Synthesis, evaluation and SAR

European Journal of Medicinal Chemistry

Volumn 45, Issue 7, 2010, Pages 2957-2971

  Lee, Chong Yew ^a   Chew, Eng Hui ^a   Go, Mei Lin ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Aurones; Chemoprevention; NAD(P)H:quinone oxidoreductase 1; Phase II enzyme inducers

Indexed keywords

20',40',60' TRIHYDROXY 2 CHLOROACETOPHENONE; 4, 6 DIHYDROXYBENZOFURAN 3(2H) ONE; 4,6 DIMETHOXY 2 HYDROXYPHENYLACETIC ACID; 4,6 DIMETHOXYBENZOFURAN 2(3H) ONE; 5 HYDROXYBENZOFURAN 3(2H) ONE; 6 HYDROXYBENZOFURAN 3(2H) ONE; AROMATIC HYDROCARBON RECEPTOR; EXOCYCLIC DOUBLE BOND; FLAVONOID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMOPROPHYLAXIS; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ELECTROPHILICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME CONFORMATION; ENZYME INDUCTION; MOLECULAR INTERACTION; MOUSE; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SIGNAL TRANSDUCTION; STEREOCHEMISTRY; XENOBIOTIC METABOLISM;

ANIMALS; ANTIOXIDANTS; BENZOFURANS; CELL LINE, TUMOR; CYTOCHROME P-450 CYP1A1; ENZYME INDUCTION; MICE; MUTATION; NF-E2-RELATED FACTOR 2; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; QUINONE REDUCTASES; RECEPTORS, ARYL HYDROCARBON; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; XENOBIOTICS;

EID: 77954349448     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.03.023     Document Type: Article

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