Identification and characterization of novel nrf2 inducers designed to target the intervening region of keap1

Chemical Biology and Drug Design

Volumn 75, Issue 5, 2010, Pages 475-480

  Wu, Jian H ^a,b   Miao, Weimin ^a,c   Hu, Liang G ^a   Batist, Gerald ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITY OF TENNESSEE GRADUATE SCHOOL OF MEDICINE   (United States)

Author keywords

Chemoprevention; Keap1; Nrf2 inducers; Virtual screening

Indexed keywords

ANTINEOPLASTIC AGENT; BENZO[A]PYRENE; BM 10; BM 18; BM 19; BM 31; BM 4; BM 40; BM 6; BM 9; CYSTEINE; GLUTAMATE CYSTEINE LIGASE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; N METHYL N (1 METHYL 4 PYRROLIDINO 2 BUTYNYL)ACETAMIDE; OSTEONECTIN; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ARTICLE; CELL PROTECTION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; ENZYME REGULATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY SEQUENCE; UBIQUITINATION;

AMINO ACID SUBSTITUTION; BENZO(A)PYRENE; BINDING SITES; CARCINOGENS; CELL LINE; COMPUTER SIMULATION; DATABASES, FACTUAL; GLUTAMATE-CYSTEINE LIGASE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 77949993628     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2010.00955.x     Document Type: Article

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