Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice

Chemico-Biological Interactions

Volumn 183, Issue 2, 2010, Pages 276-283

  Miyamoto, Shingo ^a   Yasui, Yumiko ^b,c   Ohigashi, Hajime ^a   Tanaka, Takuji ^b,c   Murakami, Akira ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KANAZAWA MEDICAL UNIVERSITY   (Japan)

^c Tohkai Cytopathology Institute: Cancer Research and Prevention   (Japan)

Author keywords

ACF; BCAC; Colon carcinogenesis; db db mice; Flavonoid

Indexed keywords

AZOXYMETHANE; BETA CATENIN; CHRYSIN; FLAVONOID; GROWTH FACTOR; INSULIN; LEPTIN; MESSENGER RNA; NOBILETIN; QUERCETIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; COLON CANCER; COLON CARCINOGENESIS; CONTROLLED STUDY; DIABETES MELLITUS; DIET THERAPY; GENE EXPRESSION; HORMONE BLOOD LEVEL; HORMONE RELEASE; INSULIN BLOOD LEVEL; INTESTINE CRYPT; MALE; MOUSE; NONHUMAN; OBESITY; PHENOTYPE; PRECANCER;

ANIMALS; ANTIOXIDANTS; AZOXYMETHANE; CARCINOGENS; COLONIC NEOPLASMS; DIETARY SUPPLEMENTS; FLAVONES; FLAVONOIDS; INSULIN; LEPTIN; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; PRECANCEROUS CONDITIONS; QUERCETIN;

MUS;

EID: 72149105299     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2009.11.002     Document Type: Article

References (47)

1. Abu-Abid S., Szold A., and Klausner J. Obesity and cancer. J. Med. 33 1-4 (2002) 73-86
2. McMillan D., Sattar N., and McArdle C. ABC of obesity. Obesity and cancer. BMJ 333 7578 (2006) 1109-1111
3. Yakar S., Nunez N., Pennisi P., Brodt P., Sun H., Fallavollita L., Zhao H., Scavo L., Novosyadlyy R., Kurshan N., Stannard B., East-Palmer J., Smith N., Perkins S., Fuchs-Young R., Barrett J., Hursting S., and LeRoith D. Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones. Endocrinology 147 12 (2006) 5826-5834
4. Hursting S., Lavigne J., Berrigan D., Perkins S., and Barrett J. Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humans. Annu. Rev. Med. 54 (2003) 131-152
5. Pischon T., Nöthlings U., and Boeing H. Obesity and cancer. Proc. Nutr. Soc. 67 2 (2008) 128-145
6. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., and Friedman J. Positional cloning of the mouse obese gene and its human homologue. Nature 372 6505 (1994) 425-432
7. Kolaczynski J., Ohannesian J., Considine R., Marco C., and Caro J. Response of leptin to short-term and prolonged overfeeding in humans. J. Clin. Endocrinol. Metab. 81 11 (1996) 4162-4165
8. Sinha M., Ohannesian J., Heiman M., Kriauciunas A., Stephens T., Magosin S., Marco C., and Caro J. Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects. J. Clin. Invest. 97 5 (1996) 1344-1347
9. Potter J. Colorectal cancer: molecules and populations. J. Natl. Cancer Inst. 91 11 (1999) 916-932
10. Chen H., Charlat O., Tartaglia L., Woolf E., Weng X., Ellis S., Lakey N., Culpepper J., Moore K., Breitbart R., Duyk G., Tepper R., and Morgenstern J. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84 3 (1996) 491-495
11. Nishina P., Lowe S., Wang J., and Paigen B. Characterization of plasma lipids in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow. Metabolism 43 5 (1994) 549-553
12. Garofalo C., and Surmacz E. Leptin and cancer. J. Cell Physiol. 207 1 (2006) 12-22
13. Hardwick J., Van Den Brink G., Offerhaus G., Van Deventer S., and Peppelenbosch M. Leptin is a growth factor for colonic epithelial cells. Gastroenterology 121 1 (2001) 79-90
14. Liu Z., Uesaka T., Watanabe H., and Kato N. High fat diet enhances colonic cell proliferation and carcinogenesis in rats by elevating serum leptin. Int. J. Oncol. 19 5 (2001) 1009-1014
15. Havsteen B. Flavonoids, a class of natural products of high pharmacological potency. Biochem. Pharmacol. 32 7 (1983) 1141-1148
16. Mora A., Payá M., Ríos J., and Alcaraz M. Structure-activity relationships of polymethoxyflavones and other flavonoids as inhibitors of non-enzymic lipid peroxidation. Biochem. Pharmacol. 40 4 (1990) 793-797
17. Miyamoto S., Kohno H., Suzuki R., Sugie S., Murakami A., Ohigashi H., and Tanaka T. Preventive effects of chrysin on the development of azoxymethane-induced colonic aberrant crypt foci in rats. Oncol. Rep. 15 5 (2006) 1169-1173
18. Tanaka T., Kawabata K., Honjo S., Kohno H., Murakami M., Shimada R., Matsunaga K., Yamada Y., and Shimizu M. Inhibition of azoxymethane-induced aberrant crypt foci in rats by natural compounds, caffeine, quercetin and morin. Oncol. Rep. 6 6 (1999) 1333-1340
19. Suzuki R., Kohno H., Murakami A., Koshimizu K., Ohigashi H., Yano M., Tokuda H., Nishino H., and Tanaka T. Citrus nobiletin inhibits azoxymethane-induced large bowel carcinogenesis in rats. Biofactors 22 1-4 (2004) 111-114
20. Hasegawa N., Yamda N., and Mori M. Powdered green tea has antilipogenic effect on Zucker rats fed a high-fat diet. Phytother. Res. 17 5 (2003) 477-480
21. Ito Y., Ichikawa T., Morohoshi Y., Nakamura T., Saegusa Y., and Ishihara K. Effect of tea catechins on body fat accumulation in rats fed a normal diet. Biomed. Res. 29 1 (2008) 27-32
22. Hsu C., and Yen G. Induction of cell apoptosis in 3T3-L1 pre-adipocytes by flavonoids is associated with their antioxidant activity. Mol. Nutr. Food Res. 50 11 (2006) 1072-1079
23. Bird R., and Good C. The significance of aberrant crypt foci in understanding the pathogenesis of colon cancer. Toxicol. Lett. 112-113 (2000) 395-402
24. Yamada Y., and Mori H. Pre-cancerous lesions for colorectal cancers in rodents: a new concept. Carcinogenesis 24 6 (2003) 1015-1019
25. Niho N., Takahashi M., Kitamura T., Shoji Y., Itoh M., Noda T., Sugimura T., and Wakabayashi K. Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands. Cancer Res. 63 18 (2003) 6090-6095
26. Hayashi K., Suzuki R., Miyamoto S., Shin-Ichiroh Y., Kohno H., Sugie S., Takashima S., and Tanaka T. Citrus auraptene suppresses azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db mice. Nutr. Cancer 58 1 (2007) 75-84
27. Maeda H., Hosokawa M., Sashima T., Takahashi N., Kawada T., and Miyashita K. Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells. Int. J. Mol. Med. 18 1 (2006) 147-152
28. Tanaka T., Kawabata K., Kakumoto M., Makita H., Hara A., Mori H., Satoh K., Murakami A., Kuki W., Takahashi Y., Yonei H., Koshimizu K., and Ohigashi H. Citrus auraptene inhibits chemically induced colonic aberrant crypt foci in male F344 rats. Carcinogenesis 18 11 (1997) 2155-2161
29. Hirose Y., Kuno T., Yamada Y., Sakata K., Katayama M., Yoshida K., Qiao Z., Hata K., Yoshimi N., and Mori H. Azoxymethane-induced beta-catenin-accumulated crypts in colonic mucosa of rodents as an intermediate biomarker for colon carcinogenesis. Carcinogenesis 24 1 (2003) 107-111
30. McLellan E., Medline A., and Bird R. Sequential analyses of the growth and morphological characteristics of aberrant crypt foci: putative preneoplastic lesions. Cancer Res. 51 19 (1991) 5270-5274
31. Pretlow T., O'Riordan M., Somich G., Amini S., and Pretlow T. Aberrant crypts correlate with tumor incidence in F344 rats treated with azoxymethane and phytate. Carcinogenesis 13 9 (1992) 1509-1512
32. Bird R. Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett. 93 1 (1995) 55-71
33. Kim J., and Chen J. Regulation of peroxisome proliferator-activated receptor-gamma activity by mammalian target of rapamycin and amino acids in adipogenesis. Diabetes 53 11 (2004) 2748-2756
34. Szkudelski T. Intracellular mediators in regulation of leptin secretion from adipocytes. Physiol. Res. (2006)
35. Miyamoto S., Yasui Y., Tanaka T., Ohigashi H., and Murakami A. Suppressive effects of nobiletin on hyperleptinemia and colitis-related colon carcinogenesis in male ICR mice. Carcinogenesis 29 5 (2008) 1057-1063
36. Zhang B., Graziano M., Doebber T., Leibowitz M., White-Carrington S., Szalkowski D., Hey P., Wu M., Cullinan C., Bailey P., Lollmann B., Frederich R., Flier J., Strader C., and Smith R. Down-regulation of the expression of the obese gene by an antidiabetic thiazolidinedione in Zucker diabetic fatty rats and db/db mice. J. Biol. Chem. 271 16 (1996) 9455-9459
37. Ogunwobi O., and Beales I. The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt. Int. J. Colorectal Dis. 22 4 (2007) 401-409
38. Kaaks R., and Lukanova A. Energy balance and cancer: the role of insulin and insulin-like growth factor-I. Proc. Nutr. Soc. 60 1 (2001) 91-106
39. Moore M., Sobue T., Kuriki K., Tajima K., Tokudome S., and Kono S. Comparison of Japanese, American-Whites and African-Americans--pointers to risk factors to underlying distribution of tumours in the colorectum. Asian Pac. J. Cancer Prev. 6 3 (2005) 412-419
40. Fenton J., Hord N., Lavigne J., Perkins S., and Hursting S. Leptin, insulin-like growth factor-1, and insulin-like growth factor-2 are mitogens in ApcMin/+ but not Apc+/+ colonic epithelial cell lines. Cancer Epidemiol. Biomarkers Prev. 14 7 (2005) 1646-1652
41. Murakami A., Ashida H., and Terao J. Multitargeted cancer prevention by quercetin. Cancer Lett. 269 2 (2008) 315-325
42. Morley K., Ferguson P., and Koropatnick J. Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells. Cancer Lett. 251 1 (2007) 168-178
43. Wang W., VanAlstyne P., Irons K., Chen S., Stewart J., and Birt D. Individual and interactive effects of apigenin analogs on G2/M cell-cycle arrest in human colon carcinoma cell lines. Nutr. Cancer 48 1 (2004) 106-114
44. Lane M., Tang Q., and Jiang M. Role of the CCAAT enhancer binding proteins (C/EBPs) in adipocyte differentiation. Biochem. Biophys. Res. Commun. 266 3 (1999) 677-683
45. Chawla A., Schwarz E., Dimaculangan D., and Lazar M. Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation. Endocrinology 135 2 (1994) 798-800
46. Hollenberg A., Susulic V., Madura J., Zhang B., Moller D., Tontonoz P., Sarraf P., Spiegelman B., and Lowell B. Functional antagonism between CCAAT/Enhancer binding protein-alpha and peroxisome proliferator-activated receptor-gamma on the leptin promoter. J. Biol. Chem. 272 8 (1997) 5283-5290
47. Fang X., Gao J., and Zhu D. Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity. Life Sci. 82 11-12 (2008) 615-622