YL-I-108, a synthetic chalcone derivative, inhibits lipopolysaccharide- stimulated nitric oxide production in RAW 264.7 murine macrophages: Involvement of heme oxygenase-1 induction and blockade of activator protein-1

Archives of Pharmacal Research

Volumn 32, Issue 1, 2009, Pages 79-89

  Park, Pil Hoon ^a   Kim, Hak Sung ^a   Hur, Jin ^a   Jin, Xing Yu ^a   Jin, Ying Lan ^a   Sohn, Dong Hwan ^a  

^a Wonkwang University   (South Korea)

Author keywords

AP 1; Chalcone; Heme oxygenase 1; Inflammation; Nitric oxide; Nrf2

Indexed keywords

1 (2 METHOXY 4,6 BIS(METHOXYMETHOXY)PHENYL) 3 (3 NITROPHENYL)PROP 2 EN 1 ONE; CHALCONE DERIVATIVE; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRITE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; YL I 108;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; GENE EXPRESSION; MACROPHAGE; MOUSE; NONHUMAN; REPORTER GENE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CHALCONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME INDUCTION; HEME OXYGENASE-1; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MACROPHAGES; MEMBRANE PROTEINS; METALLOPORPHYRINS; MICE; NF-E2-RELATED FACTOR 2; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PROTOPORPHYRINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 59449101744     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-009-1121-5     Document Type: Article

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