Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 1-(4-methanesulfonylphenyl)-5-aryl-1H-pyrazol-3-carboxylic acids: Synthesis, nitric oxide release studies and anti-inflammatory activities

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 13, 2008, Pages 6528-6534

  Abdellatif, Khaled R A ^a   Chowdhury, Morshed Alam ^a   Dong, Ying ^a   Knaus, Edward E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

1,5 Diarylpyrazoles; Anti inflammatory activity; Diazen 1 ium 1,2 diolate nitric oxide donor; NONO coxib ester prodrugs

Indexed keywords

1 (4 METHANESULFONYLPHENYL) 5 (4 METHYLPHENYL) 1H PYRAZOL 3 CARBOXYLIC ACID; 1 (4 METHANESULFONYLPHENYL) 5 ARYL 1H PYRAZOL 3 CARBOXYLIC ACID DERIVATIVE; 1 (4 METHANESULFONYLPHENYL) 5 PHENYL 1H PYRAZOL 3 CARBOXYLIC ACID; 5 (4 FLUOROPHENYL) 1 (4 METHANESULFONYLPHENYL) 1H PYRAZOL 3 CARBOXYLIC ACID; ACETYLSALICYLIC ACID; ANTIINFLAMMATORY AGENT; CARBOXYLIC ACID DERIVATIVE; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; ESTER; NITRIC OXIDE; O 2 ACETOXYMETHYL 1 (N ETHYL N METHYLAMINO)DIADZEN 1 IUM 1,2 DIOLATE 1 (4 METHANESULFONYLPHENYL) 5 (4 METHYLPHENYL) 1H PYRAZOL 3 CARBOXYLIC ACID; O 2 ACETOXYMETHYL 1 (N ETHYL N METHYLAMINO)DIADZEN 1 IUM 1,2 DIOLATE 1 (4 METHANESULFONYLPHENYL) 5 PHENYL 1H PYRAZOL 3 CARBOXYLIC ACID; O 2 ACETOXYMETHYL 1 (N ETHYL N METHYLAMINO)DIADZEN 1 IUM 1,2 DIOLATE 5 (4 FLUOROPHENYL) 1 (4 METHANESULFONYLPHENYL) 1H PYRAZOL 3 CARBOXYLIC ACID; PRODRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; PAW EDEMA; RAT; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CYCLOOXYGENASE 2 INHIBITORS; ESTERS; HYDRAZINES; INFLAMMATION; MOLECULAR STRUCTURE; NITRIC OXIDE; NITRIC OXIDE DONORS; PRODRUGS; PYRAZOLES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 44849132107     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.05.028     Document Type: Article

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