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Volumn 140, Issue 3, 2013, Pages 223-238

Androgen receptors in hormone-dependent and castration-resistant prostate cancer

Author keywords

Abiraterone; Androgen receptor; Castration resistant prostate cancer; Enzalutamide (MDV3100); Prostate; Steroidogenesis

Indexed keywords

ABIRATERONE ACETATE; ANDROGEN RECEPTOR; BICALUTAMIDE; CYPROTERONE ACETATE; CYTOKINE; DEXAMETHASONE; ENZALUTAMIDE; FLUTAMIDE; GALETERONE; GOSERELIN; GROWTH FACTOR; LEUPRORELIN; NILUTAMIDE; ORTERONEL; PHOSPHOTRANSFERASE; PREDNISONE;

EID: 84885468685     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2013.07.003     Document Type: Review
Times cited : (286)

References (223)
  • 1
    • 79952363364 scopus 로고    scopus 로고
    • Comparison of 12-core versus 8-core prostate biopsy: Multivariate analysis of large series of US veterans
    • T.T. Abd, M. Goodman, J. Hall, C.W. Ritenour, J.A. Petros, and F.F. Marshall Comparison of 12-core versus 8-core prostate biopsy: Multivariate analysis of large series of US veterans Urol J 77 2011 541 547
    • (2011) Urol J , vol.77 , pp. 541-547
    • Abd, T.T.1    Goodman, M.2    Hall, J.3    Ritenour, C.W.4    Petros, J.A.5    Marshall, F.F.6
  • 2
    • 84859425018 scopus 로고    scopus 로고
    • Novel molecular targets for the therapy of castration-resistant prostate cancer
    • N. Agarwal, G. Sonpavde, and C.N. Sternberg Novel molecular targets for the therapy of castration-resistant prostate cancer Eur Urol 61 2012 950 960
    • (2012) Eur Urol , vol.61 , pp. 950-960
    • Agarwal, N.1    Sonpavde, G.2    Sternberg, C.N.3
  • 3
    • 55049115084 scopus 로고    scopus 로고
    • Target gene specific regulation of androgen receptor activity by p42/p44 MAPK
    • I.U. Agoulnik, W.E.I. Bingman, M. Nakka, W. Li, Q. Wang, and M. Brown Target gene specific regulation of androgen receptor activity by p42/p44 MAPK Mol Endocrinol 22 2008 2420 2432
    • (2008) Mol Endocrinol , vol.22 , pp. 2420-2432
    • Agoulnik, I.U.1    Bingman, W.E.I.2    Nakka, M.3    Li, W.4    Wang, Q.5    Brown, M.6
  • 4
    • 24744442616 scopus 로고    scopus 로고
    • Role of SRC-1 in the promotion of prostate cancer cell growth and tumor progression
    • I.U. Agoulnik, A. Vaid, W.E.I. Bingman, H. Erdeme, A. Frolov, and C.L. Smith Role of SRC-1 in the promotion of prostate cancer cell growth and tumor progression Cancer Res 65 2005 7959 7967
    • (2005) Cancer Res , vol.65 , pp. 7959-7967
    • Agoulnik, I.U.1    Vaid, A.2    Bingman, W.E.I.3    Erdeme, H.4    Frolov, A.5    Smith, C.L.6
  • 5
    • 33751304953 scopus 로고    scopus 로고
    • Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancer
    • I.U. Agoulnik, A. Vaid, M. Nakka, M. Alvarado, W.E.I. Bingman, and H. Erdem Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancer Cancer Res 66 2006 10594 10602
    • (2006) Cancer Res , vol.66 , pp. 10594-10602
    • Agoulnik, I.U.1    Vaid, A.2    Nakka, M.3    Alvarado, M.4    Bingman, W.E.I.5    Erdem, H.6
  • 6
    • 33748949049 scopus 로고    scopus 로고
    • Androgen receptor action in hormone-dependent and recurrent prostate cancer
    • I.U. Agoulnik, and N.L. Weigel Androgen receptor action in hormone-dependent and recurrent prostate cancer J Cell Biochem 99 2006 362 372
    • (2006) J Cell Biochem , vol.99 , pp. 362-372
    • Agoulnik, I.U.1    Weigel, N.L.2
  • 7
    • 46749097609 scopus 로고    scopus 로고
    • Androgen receptor coactivators and prostate cancer
    • I.U. Agoulnik, and N.L. Weigel Androgen receptor coactivators and prostate cancer Adv Exp Med Biol 617 2008 245 255
    • (2008) Adv Exp Med Biol , vol.617 , pp. 245-255
    • Agoulnik, I.U.1    Weigel, N.L.2
  • 8
    • 67349225032 scopus 로고    scopus 로고
    • Coactivator selective regulation of androgen receptor activity
    • I.U. Agoulnik, and N.L. Weigel Coactivator selective regulation of androgen receptor activity Steroids 74 2009 669 674
    • (2009) Steroids , vol.74 , pp. 669-674
    • Agoulnik, I.U.1    Weigel, N.L.2
  • 9
    • 73249149751 scopus 로고    scopus 로고
    • HDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancer
    • J. Ai, Y. Wang, J.A. Dar, J. Liu, L. Liu, and J.B. Nelson HDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancer Mol Endocrinol 23 2009 1963 1972
    • (2009) Mol Endocrinol , vol.23 , pp. 1963-1972
    • Ai, J.1    Wang, Y.2    Dar, J.A.3    Liu, J.4    Liu, L.5    Nelson, J.B.6
  • 10
    • 68149098902 scopus 로고    scopus 로고
    • Study group for the combined androgen blockade therapy of prostate cancer. Combined androgen blockade with bicalutamide for advanced prostate cancer: Long-term follow-up of a phase 3, double-blind, randomized study for survival
    • H. Akaza, S. Hinotsu, M. Usami, Y. Arai, H. Kanetake, and S. Naito Study group for the combined androgen blockade therapy of prostate cancer. Combined androgen blockade with bicalutamide for advanced prostate cancer: long-term follow-up of a phase 3, double-blind, randomized study for survival Cancer 115 2009 3437 3445
    • (2009) Cancer , vol.115 , pp. 3437-3445
    • Akaza, H.1    Hinotsu, S.2    Usami, M.3    Arai, Y.4    Kanetake, H.5    Naito, S.6
  • 11
    • 77953280591 scopus 로고    scopus 로고
    • Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor
    • R.J. Andersen, N.R. Mawji, J. Wang, G. Wang, S. Haim, and J.K. Myung Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor Cancer Cell 17 2010 535 546
    • (2010) Cancer Cell , vol.17 , pp. 535-546
    • Andersen, R.J.1    Mawji, N.R.2    Wang, J.3    Wang, G.4    Haim, S.5    Myung, J.K.6
  • 12
    • 0037352215 scopus 로고    scopus 로고
    • The role of antiandrogen monotherapy in the treatment of prostate cancer
    • J. Anderson The role of antiandrogen monotherapy in the treatment of prostate cancer BJU Int 91 2003 455 461
    • (2003) BJU Int , vol.91 , pp. 455-461
    • Anderson, J.1
  • 13
    • 53749090666 scopus 로고    scopus 로고
    • Phase i clinical trial of a selective inhibitor of CYP17, abiralerone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven
    • G. Attard, A.H. Reid, T.A. Yap, F. Raynaud, M. Dowsett, and S. Settatree Phase I clinical trial of a selective inhibitor of CYP17, abiralerone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven J Clin Oncol 26 2008 4563 4571
    • (2008) J Clin Oncol , vol.26 , pp. 4563-4571
    • Attard, G.1    Reid, A.H.2    Yap, T.A.3    Raynaud, F.4    Dowsett, M.5    Settatree, S.6
  • 15
    • 34250897355 scopus 로고    scopus 로고
    • Expression of the forkhead transcription factor FOXP1 is associated both with hypoxia inducible factors (HIFs) and the androgen receptor in prostate cancer but is not directly regulated by androgens or hypoxia
    • A.H. Banham, J. Boddy, R. Launchbury, C. Han, H. Turley, and P.R. Malone Expression of the forkhead transcription factor FOXP1 is associated both with hypoxia inducible factors (HIFs) and the androgen receptor in prostate cancer but is not directly regulated by androgens or hypoxia Prostate 67 2007 1091 1098
    • (2007) Prostate , vol.67 , pp. 1091-1098
    • Banham, A.H.1    Boddy, J.2    Launchbury, R.3    Han, C.4    Turley, H.5    Malone, P.R.6
  • 17
    • 84869223265 scopus 로고    scopus 로고
    • The reactive stroma microenvironment and prostate cancer progression
    • D.A. Barron, and D.R. Rowley The reactive stroma microenvironment and prostate cancer progression Endocr Relat Cancer 19 2012 R187 R204
    • (2012) Endocr Relat Cancer , vol.19
    • Barron, D.A.1    Rowley, D.R.2
  • 18
    • 31444440675 scopus 로고    scopus 로고
    • Identification of the major oxidative 3alpha-hydroxysteroid dehydrogenase in human prostate that converts 5alpha-androstane-3alpha, 17beta-diol to 5alpha-dihydrotestosterone: A potential therapeutic target for androgen-dependent disease
    • D.R. Bauman, S. Steckelbroeck, M.V. Williams, D.M. Peehl, and T.M. Penning Identification of the major oxidative 3alpha-hydroxysteroid dehydrogenase in human prostate that converts 5alpha-androstane-3alpha, 17beta-diol to 5alpha-dihydrotestosterone: A potential therapeutic target for androgen-dependent disease Mol Endocrinol 20 2006 444 458
    • (2006) Mol Endocrinol , vol.20 , pp. 444-458
    • Bauman, D.R.1    Steckelbroeck, S.2    Williams, M.V.3    Peehl, D.M.4    Penning, T.M.5
  • 19
    • 0033867110 scopus 로고    scopus 로고
    • Effect of the androgen receptor CAG repeat polymorphism on transcriptional activity: Specificity in prostate and non-prostate cell lines
    • J. Beilin, E.M. Ball, J.M. Favaloro, and J.D. Zajac Effect of the androgen receptor CAG repeat polymorphism on transcriptional activity: Specificity in prostate and non-prostate cell lines J Mol Endocrinol 25 2000 85 89
    • (2000) J Mol Endocrinol , vol.25 , pp. 85-89
    • Beilin, J.1    Ball, E.M.2    Favaloro, J.M.3    Zajac, J.D.4
  • 20
    • 84876064523 scopus 로고    scopus 로고
    • Targeted next-generation sequencing of advanced prostate cancer identifies potential therapeutic targets and disease heterogeneity
    • H. Beltran, R. Yelensky, G.M. Frampton, K. Park, S.R. Downing, and T.Y. MacDonald Targeted next-generation sequencing of advanced prostate cancer identifies potential therapeutic targets and disease heterogeneity Eur Urol 63 2013 920 926
    • (2013) Eur Urol , vol.63 , pp. 920-926
    • Beltran, H.1    Yelensky, R.2    Frampton, G.M.3    Park, K.4    Downing, S.R.5    Macdonald, T.Y.6
  • 21
    • 38349167518 scopus 로고    scopus 로고
    • Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer: Updated survival in the TAX 327 study
    • D.R. Berthold, G.R. Pond, F. Soban, R. de Wit, M. Eisenberger, and I.F. Tannock Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer: Updated survival in the TAX 327 study J Clin Oncol 26 2008 242 245
    • (2008) J Clin Oncol , vol.26 , pp. 242-245
    • Berthold, D.R.1    Pond, G.R.2    Soban, F.3    De Wit, R.4    Eisenberger, M.5    Tannock, I.F.6
  • 22
    • 0033512783 scopus 로고    scopus 로고
    • The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1
    • C.L. Bevan, S. Hoare, F. Claessens, D.M. Heery, and M.G. Parker The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1 Mol Cell Biol 19 1999 8383 8392
    • (1999) Mol Cell Biol , vol.19 , pp. 8383-8392
    • Bevan, C.L.1    Hoare, S.2    Claessens, F.3    Heery, D.M.4    Parker, M.G.5
  • 23
    • 0031057105 scopus 로고    scopus 로고
    • Casodex (bicalutamide): Overview of a new antiandrogen developed for the treatment of prostate cancer
    • G.R. Blackledge, I.D. Cockshott, and B.J. Furr Casodex (bicalutamide): Overview of a new antiandrogen developed for the treatment of prostate cancer Eur Urol 31 1997 30 39
    • (1997) Eur Urol , vol.31 , pp. 30-39
    • Blackledge, G.R.1    Cockshott, I.D.2    Furr, B.J.3
  • 24
    • 27744489232 scopus 로고    scopus 로고
    • The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, and the prolyl hydroxylases in human prostate cancer
    • J.L. Boddy, S.B. Fox, C. Han, L. Campo, H. Turley, and S. Kanga The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, and the prolyl hydroxylases in human prostate cancer Clin Cancer Res 11 2005 7658 7663
    • (2005) Clin Cancer Res , vol.11 , pp. 7658-7663
    • Boddy, J.L.1    Fox, S.B.2    Han, C.3    Campo, L.4    Turley, H.5    Kanga, S.6
  • 25
    • 17844376217 scopus 로고    scopus 로고
    • Structural basis for antagonism and resistance of bicalutamide in prostate cancer
    • C.E. Bohl, W. Gao, D.D. Miller, C.E. Bell, and J.T. Dalton Structural basis for antagonism and resistance of bicalutamide in prostate cancer Proc Natl Acad Sci U S A 102 2005 6201 6206
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 6201-6206
    • Bohl, C.E.1    Gao, W.2    Miller, D.D.3    Bell, C.E.4    Dalton, J.T.5
  • 26
    • 0030856678 scopus 로고    scopus 로고
    • Improved survival in patients with locally advanced prostate cancer treated with radiotherapy and goserelin
    • M. Bolla, D. Gonzalez, P. Warde, J.B. Dubois, R.O. Mirimanoff, and G. Storme Improved survival in patients with locally advanced prostate cancer treated with radiotherapy and goserelin N Engl J Med 337 1997 295 300
    • (1997) N Engl J Med , vol.337 , pp. 295-300
    • Bolla, M.1    Gonzalez, D.2    Warde, P.3    Dubois, J.B.4    Mirimanoff, R.O.5    Storme, G.6
  • 27
    • 0033557839 scopus 로고    scopus 로고
    • Survey of gene amplifications during prostate cancer progression by high-throughout fluorescence in situ hybridization on tissue microarrays
    • L. Bubendorf, J. Kononen, P. Koivisto, P. Schraml, H. Moch, and T.C. Gasser Survey of gene amplifications during prostate cancer progression by high-throughout fluorescence in situ hybridization on tissue microarrays Cancer Res 59 1999 803 806
    • (1999) Cancer Res , vol.59 , pp. 803-806
    • Bubendorf, L.1    Kononen, J.2    Koivisto, P.3    Schraml, P.4    Moch, H.5    Gasser, T.C.6
  • 28
    • 80054021222 scopus 로고    scopus 로고
    • Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors
    • C. Cai, S. Chen, P. Ng, G.J. Bubley, P.S. Nelson, and E.A. Mostaghel Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors Cancer Res 71 2011 6503 6513
    • (2011) Cancer Res , vol.71 , pp. 6503-6513
    • Cai, C.1    Chen, S.2    Ng, P.3    Bubley, G.J.4    Nelson, P.S.5    Mostaghel, E.A.6
  • 29
    • 79955975429 scopus 로고    scopus 로고
    • Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer
    • B.S. Carver, C. Chapinski, J. Wongvipat, H. Hieronymus, Y. Chen, and S. Chandarlapaty Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer Cancer Cell 19 2011 575 586
    • (2011) Cancer Cell , vol.19 , pp. 575-586
    • Carver, B.S.1    Chapinski, C.2    Wongvipat, J.3    Hieronymus, H.4    Chen, Y.5    Chandarlapaty, S.6
  • 30
    • 66749188650 scopus 로고    scopus 로고
    • Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate
    • B.S. Carver, J. Tran, A. Gopalan, Z. Chen, S. Shaikh, and A. Carracedo Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate Nat Genet 41 2009 619 624
    • (2009) Nat Genet , vol.41 , pp. 619-624
    • Carver, B.S.1    Tran, J.2    Gopalan, A.3    Chen, Z.4    Shaikh, S.5    Carracedo, A.6
  • 31
    • 84861728843 scopus 로고    scopus 로고
    • Androgen receptor splice variants activate androgen receptor target genes and support aberrant prostate cancer cell growth independent of canonical androgen receptor nuclear localization signal
    • S.C. Chan, Y. Li, and S.M. Dehm Androgen receptor splice variants activate androgen receptor target genes and support aberrant prostate cancer cell growth independent of canonical androgen receptor nuclear localization signal J Biol Chem 287 2012 19736 19749
    • (2012) J Biol Chem , vol.287 , pp. 19736-19749
    • Chan, S.C.1    Li, Y.2    Dehm, S.M.3
  • 32
    • 80051963331 scopus 로고    scopus 로고
    • Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer
    • K.H. Chang, R. Li, M. Papari-Zareei, L. Watumull, Y.D. Zhao, and R.J. Auchus Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer Proc Natl Acad Sci U S A 108 2011 13728 13733
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 13728-13733
    • Chang, K.H.1    Li, R.2    Papari-Zareei, M.3    Watumull, L.4    Zhao, Y.D.5    Auchus, R.J.6
  • 33
    • 51449087794 scopus 로고    scopus 로고
    • Targeting the androgen receptor pathway in prostate cancer
    • Y. Chen, C.L. Sawyers, and H.I. Scher Targeting the androgen receptor pathway in prostate cancer Curr Opin Pharmacol 8 2008 440 448
    • (2008) Curr Opin Pharmacol , vol.8 , pp. 440-448
    • Chen, Y.1    Sawyers, C.L.2    Scher, H.I.3
  • 35
    • 34250844474 scopus 로고    scopus 로고
    • Genetic ablation of the amplified-in-breast cancer 1 inhibits spontaneous prostate cancer progression in mice
    • A.C. Chung, S. Zhou, L. Liao, J.C. Tien, N.M. Greenberg, and J. Xu Genetic ablation of the amplified-in-breast cancer 1 inhibits spontaneous prostate cancer progression in mice Cancer Res 67 2007 5965 5975
    • (2007) Cancer Res , vol.67 , pp. 5965-5975
    • Chung, A.C.1    Zhou, S.2    Liao, L.3    Tien, J.C.4    Greenberg, N.M.5    Xu, J.6
  • 38
    • 0033022342 scopus 로고    scopus 로고
    • A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase
    • (Comment in Nat Med;5(3):264-265, 1999)
    • N. Craft, Y. Shostak, M. Carey, and C.L. Sawyers A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase Nat Med 5 1999 280 285 (Comment in Nat Med;5(3):264-265, 1999)
    • (1999) Nat Med , vol.5 , pp. 280-285
    • Craft, N.1    Shostak, Y.2    Carey, M.3    Sawyers, C.L.4
  • 39
    • 0033838227 scopus 로고    scopus 로고
    • Androgen receptor - An update of mechanisms of action in prostate cancer
    • Z. Culig, A. Hobisch, G. Bartsch, and H. Klocker Androgen receptor - an update of mechanisms of action in prostate cancer Urol Res 28 2000 211 219
    • (2000) Urol Res , vol.28 , pp. 211-219
    • Culig, Z.1    Hobisch, A.2    Bartsch, G.3    Klocker, H.4
  • 40
    • 0028113415 scopus 로고
    • Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor
    • Z. Culig, A. Hobisch, M.V. Cronauer, C. Radmayr, J. Trapman, and A. Hittmair Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor Cancer Res 54 1994 5474 5478
    • (1994) Cancer Res , vol.54 , pp. 5474-5478
    • Culig, Z.1    Hobisch, A.2    Cronauer, M.V.3    Radmayr, C.4    Trapman, J.5    Hittmair, A.6
  • 41
    • 15844426173 scopus 로고    scopus 로고
    • Role of stromal-epithelial interactions in hormonal responses
    • G.R. Cunha, P.S. Cooke, and T. Kurita Role of stromal-epithelial interactions in hormonal responses Arch Histol Cytol 67 2004 417 434
    • (2004) Arch Histol Cytol , vol.67 , pp. 417-434
    • Cunha, G.R.1    Cooke, P.S.2    Kurita, T.3
  • 42
    • 38349164176 scopus 로고    scopus 로고
    • Androgen suppression and radiation vs radiation alone for prostate cancer: A randomized trial
    • A.V. D'Amico, M.H. Chen, A.A. Renshaw, M. Loffredo, and P.W. Kantoff Androgen suppression and radiation vs radiation alone for prostate cancer: A randomized trial JAMA 299 2008 289 295
    • (2008) JAMA , vol.299 , pp. 289-295
    • D'Amico, A.V.1    Chen, M.H.2    Renshaw, A.A.3    Loffredo, M.4    Kantoff, P.W.5
  • 43
    • 80052808323 scopus 로고    scopus 로고
    • Taxane-induced blockade to nuclear accumulation of the androgen receptor predicts clinical responses in metastatic prostate cancer
    • M.S. Darshan, M.S. Loftus, M. Thadani-Mulero, B.P. Levy, D. Esciun, and X.K. Zhou Taxane-induced blockade to nuclear accumulation of the androgen receptor predicts clinical responses in metastatic prostate cancer Cancer Res 71 2011 6019 6029
    • (2011) Cancer Res , vol.71 , pp. 6019-6029
    • Darshan, M.S.1    Loftus, M.S.2    Thadani-Mulero, M.3    Levy, B.P.4    Esciun, D.5    Zhou, X.K.6
  • 45
    • 0036847724 scopus 로고    scopus 로고
    • Expression of epidermal growth factor receptor correlates with disease relapse and progression to androgen-independence in human prostate cancer
    • G. de Lorenzo, G. Tortora, F.P. D'Armiento, G. de Rosa, S. Staibano, and R. Autorino Expression of epidermal growth factor receptor correlates with disease relapse and progression to androgen-independence in human prostate cancer Clin Cancer Res 8 2002 3438 3444
    • (2002) Clin Cancer Res , vol.8 , pp. 3438-3444
    • De Lorenzo, G.1    Tortora, G.2    D'Armiento, F.P.3    De Rosa, G.4    Staibano, S.5    Autorino, R.6
  • 46
    • 0037108955 scopus 로고    scopus 로고
    • P300 mediates androgen-independent transactivation of the androgen receptor by interleukin 6
    • J.D. Debes, L.J. Schmidt, H. Huang, and D.J. Tindall p300 mediates androgen-independent transactivation of the androgen receptor by interleukin 6 Cancer Res 62 2002 5632 5636
    • (2002) Cancer Res , vol.62 , pp. 5632-5636
    • Debes, J.D.1    Schmidt, L.J.2    Huang, H.3    Tindall, D.J.4
  • 47
    • 48549089747 scopus 로고    scopus 로고
    • Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance
    • S.M. Dehm, L.J. Schmidt, H.V. Heemers, R.L. Vessella, and D.J. Tindall Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance Cancer Res 68 2008 5469 5477
    • (2008) Cancer Res , vol.68 , pp. 5469-5477
    • Dehm, S.M.1    Schmidt, L.J.2    Heemers, H.V.3    Vessella, R.L.4    Tindall, D.J.5
  • 48
    • 80054931284 scopus 로고    scopus 로고
    • Alternatively spliced androgen receptor variants
    • S.M. Dehm, and D.J. Tindall Alternatively spliced androgen receptor variants Endocr Relat Cancer 18 2011 R183 R196
    • (2011) Endocr Relat Cancer , vol.18
    • Dehm, S.M.1    Tindall, D.J.2
  • 49
    • 79955470908 scopus 로고    scopus 로고
    • Short-term neoadjuvant androgen deprivation and radiotherapy for locally advanced prostate cancer: 10-Year data from the TROG 96.01 randomised trial
    • J.W. Denham, A. Steigler, D.S. Lamb, D. Joseph, S. Turner, and J. Matthews Short-term neoadjuvant androgen deprivation and radiotherapy for locally advanced prostate cancer: 10-Year data from the TROG 96.01 randomised trial Lancet Oncol 12 2011 451 459
    • (2011) Lancet Oncol , vol.12 , pp. 451-459
    • Denham, J.W.1    Steigler, A.2    Lamb, D.S.3    Joseph, D.4    Turner, S.5    Matthews, J.6
  • 50
    • 84856477784 scopus 로고    scopus 로고
    • Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001
    • N.M. DeVore, and E.E. Scott Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001 Nature 482 2012 116 119
    • (2012) Nature , vol.482 , pp. 116-119
    • Devore, N.M.1    Scott, E.E.2
  • 51
    • 54849435425 scopus 로고    scopus 로고
    • Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterol
    • P.R. Dillard, M.F. Lin, and S.A. Khan Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterol Mol Cell Endocrinol 295 2008 115 120
    • (2008) Mol Cell Endocrinol , vol.295 , pp. 115-120
    • Dillard, P.R.1    Lin, M.F.2    Khan, S.A.3
  • 52
    • 0027195141 scopus 로고
    • Assessment of prostatic protein secretion in tissue recombinants made of urogenital sinus mesenchyme and urothelium from normal or androgen-insensitive mice
    • A.A. Donjacour, and G.R. Cunha Assessment of prostatic protein secretion in tissue recombinants made of urogenital sinus mesenchyme and urothelium from normal or androgen-insensitive mice Endocrinology 132 1993 2342 2350
    • (1993) Endocrinology , vol.132 , pp. 2342-2350
    • Donjacour, A.A.1    Cunha, G.R.2
  • 53
    • 28144439276 scopus 로고    scopus 로고
    • Mutation of histidine 874 in the androgen receptor ligand-binding domain leads to promiscuous ligand activation and altered p160 coactivator interactions
    • J. Duff, and I.J. McEwan Mutation of histidine 874 in the androgen receptor ligand-binding domain leads to promiscuous ligand activation and altered p160 coactivator interactions Mol Endocrinol 19 2005 2943 2954
    • (2005) Mol Endocrinol , vol.19 , pp. 2943-2954
    • Duff, J.1    McEwan, I.J.2
  • 54
    • 50949117490 scopus 로고    scopus 로고
    • Predictive value of PTEN and AR coexpression of sustained responsiveness to hormonal therapy in prostate cancer - A pilot study
    • S.S. El Sheikh, H.M. Romanska, P. Abel, J. Domin, and N. Lalani Predictive value of PTEN and AR coexpression of sustained responsiveness to hormonal therapy in prostate cancer - a pilot study Neoplasia 10 2008 949 953
    • (2008) Neoplasia , vol.10 , pp. 949-953
    • El Sheikh, S.S.1    Romanska, H.M.2    Abel, P.3    Domin, J.4    Lalani, N.5
  • 55
    • 0035496220 scopus 로고    scopus 로고
    • The development of androgen-independent prostate cancer
    • B.J. Feldman, and D. Feldman The development of androgen-independent prostate cancer Nat Rev Cancer 1 2001 34 45
    • (2001) Nat Rev Cancer , vol.1 , pp. 34-45
    • Feldman, B.J.1    Feldman, D.2
  • 56
    • 84873025061 scopus 로고    scopus 로고
    • Abiraterone and novel antiandrogens: Overcoming castration resistance in prostate cancer
    • R. Ferraldeschi, C. Pezaro, V. Karavasilis, and J. de Bono Abiraterone and novel antiandrogens: Overcoming castration resistance in prostate cancer Annu Rev Med 64 2013 1 13
    • (2013) Annu Rev Med , vol.64 , pp. 1-13
    • Ferraldeschi, R.1    Pezaro, C.2    Karavasilis, V.3    De Bono, J.4
  • 58
    • 33847076262 scopus 로고    scopus 로고
    • Transit of hormonal and EGF receptor-dependent signals through cholesterol-rich membranes
    • M.R. Freeman, B. Cinar, J. Kim, N.K. Mukhopadhyay, D. Di Vizio, and R.M. Adam Transit of hormonal and EGF receptor-dependent signals through cholesterol-rich membranes Steroids 72 2006 210 217
    • (2006) Steroids , vol.72 , pp. 210-217
    • Freeman, M.R.1    Cinar, B.2    Kim, J.3    Mukhopadhyay, N.K.4    Di Vizio, D.5    Adam, R.M.6
  • 59
    • 70350532518 scopus 로고    scopus 로고
    • Inhibition of the androgen receptor as a novel mechanism of taxol chemotherapy in prostate cancer
    • L. Gan, S. Chen, Y. Wang, A. Watahiki, L. Rohrer, and Z. Sun Inhibition of the androgen receptor as a novel mechanism of taxol chemotherapy in prostate cancer Cancer Res 69 2009 8386 8394
    • (2009) Cancer Res , vol.69 , pp. 8386-8394
    • Gan, L.1    Chen, S.2    Wang, Y.3    Watahiki, A.4    Rohrer, L.5    Sun, Z.6
  • 60
    • 0035392953 scopus 로고    scopus 로고
    • Conversion from a paracrine to an autocrine mechanism of androgen-stimulated growth during malignant transformation of prostatic epithelial cells
    • J. Gao, J.T. Arnold, and J.T. Isaacs Conversion from a paracrine to an autocrine mechanism of androgen-stimulated growth during malignant transformation of prostatic epithelial cells Cancer Res 61 2001 5038 5044
    • (2001) Cancer Res , vol.61 , pp. 5038-5044
    • Gao, J.1    Arnold, J.T.2    Isaacs, J.T.3
  • 61
    • 0036645414 scopus 로고    scopus 로고
    • Molecular biology of the androgen receptor
    • E.P. Gelmann Molecular biology of the androgen receptor J Clin Oncol 20 2002 3001 3015
    • (2002) J Clin Oncol , vol.20 , pp. 3001-3015
    • Gelmann, E.P.1
  • 62
    • 84876831537 scopus 로고    scopus 로고
    • Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover
    • C. Geng, B. He, L. Xu, C.E. Barbieri, V.K. Eedunuri, and S.A. Chew Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover Proc Natl Acad Sci U S A 110 2013 6997 7002
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 6997-7002
    • Geng, C.1    He, B.2    Xu, L.3    Barbieri, C.E.4    Eedunuri, V.K.5    Chew, S.A.6
  • 64
    • 0035555872 scopus 로고    scopus 로고
    • Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer
    • V.J. Gnanapragasam, H.Y. Leung, A.S. Pulimood, D.E. Neal, and C.N. Robson Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer Br J Cancer 85 2001 1928 1936
    • (2001) Br J Cancer , vol.85 , pp. 1928-1936
    • Gnanapragasam, V.J.1    Leung, H.Y.2    Pulimood, A.S.3    Neal, D.E.4    Robson, C.N.5
  • 66
    • 2642544224 scopus 로고    scopus 로고
    • The androgen receptor gene mutations database (ARDB)
    • B. Gottlieb, L.K. Beitel, J.H. Wu, and M. Trifiro The androgen receptor gene mutations database (ARDB) Hum Mutat 23 2004 527 533
    • (2004) Hum Mutat , vol.23 , pp. 527-533
    • Gottlieb, B.1    Beitel, L.K.2    Wu, J.H.3    Trifiro, M.4
  • 68
    • 0032535307 scopus 로고    scopus 로고
    • Androgen receptor expression in androgen-independent prostate cancer is associated with increased expression of androgen-regulated genes
    • C.W. Gregory, K.G. Hamil, D. Kim, S.H. Hall, T.G. Pretlow, and J.L. Mohler Androgen receptor expression in androgen-independent prostate cancer is associated with increased expression of androgen-regulated genes Cancer Res 58 1998 5718 5724
    • (1998) Cancer Res , vol.58 , pp. 5718-5724
    • Gregory, C.W.1    Hamil, K.G.2    Kim, D.3    Hall, S.H.4    Pretlow, T.G.5    Mohler, J.L.6
  • 69
    • 0035300409 scopus 로고    scopus 로고
    • Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen
    • C.W. Gregory, R.T.J. Johnson, J.L. Mohler, F.S. French, and E.M. Wilson Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen Cancer Res 61 2001 2892 2898
    • (2001) Cancer Res , vol.61 , pp. 2892-2898
    • Gregory, C.W.1    Johnson, R.T.J.2    Mohler, J.L.3    French, F.S.4    Wilson, E.M.5
  • 70
    • 33749445413 scopus 로고    scopus 로고
    • Regulation of androgen receptor activity by tyrosine phosphorylation
    • Z. Guo, B. Dai, T. Jiang, K. Xu, Y. Xie, and O. Kim Regulation of androgen receptor activity by tyrosine phosphorylation Cancer Cell 10 2006 309 319
    • (2006) Cancer Cell , vol.10 , pp. 309-319
    • Guo, Z.1    Dai, B.2    Jiang, T.3    Xu, K.4    Xie, Y.5    Kim, O.6
  • 71
    • 0030979568 scopus 로고    scopus 로고
    • Down-regulation of protein and mRNA expression for transforming growth factor-beta (TGF-beta1) type 1 and type II receptors in human prostate cancer
    • Y. Guo, S.C. Jacobs, and N. Kyprianou Down-regulation of protein and mRNA expression for transforming growth factor-beta (TGF-beta1) type 1 and type II receptors in human prostate cancer Int J Cancer 71 1997 573 579
    • (1997) Int J Cancer , vol.71 , pp. 573-579
    • Guo, Y.1    Jacobs, S.C.2    Kyprianou, N.3
  • 72
    • 65549168746 scopus 로고    scopus 로고
    • A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth
    • Z. Guo, X. Yang, F. Sun, R. Jiang, D.E. Linn, and H. Chen A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth Cancer Res 69 2009 2305 2313
    • (2009) Cancer Res , vol.69 , pp. 2305-2313
    • Guo, Z.1    Yang, X.2    Sun, F.3    Jiang, R.4    Linn, D.E.5    Chen, H.6
  • 74
    • 0642311912 scopus 로고    scopus 로고
    • Phase III trial of long-term adjuvant androgen deprivation after neoadjuvant hormonal cytoreduction and radiotherapy in locally advanced carcinoma of the prostate: The Radiation Therapy Oncology Group Protocol 92-02
    • G.E. Hanks, T.F. Pajak, A. Porter, D. Grignon, H. Brereton, and V. Venkatesan Phase III trial of long-term adjuvant androgen deprivation after neoadjuvant hormonal cytoreduction and radiotherapy in locally advanced carcinoma of the prostate: the Radiation Therapy Oncology Group Protocol 92-02 J Clin Oncol 21 2003 3972 3978
    • (2003) J Clin Oncol , vol.21 , pp. 3972-3978
    • Hanks, G.E.1    Pajak, T.F.2    Porter, A.3    Grignon, D.4    Brereton, H.5    Venkatesan, V.6
  • 75
    • 26644444330 scopus 로고    scopus 로고
    • Possible role of adaptive mutation in resistance to antiandrogen in prostate cancer cells
    • T. Hara, J. Kouno, K. Nakamura, M. Kusaka, and M. Yamaoka Possible role of adaptive mutation in resistance to antiandrogen in prostate cancer cells Prostate 65 2005 268 275
    • (2005) Prostate , vol.65 , pp. 268-275
    • Hara, T.1    Kouno, J.2    Nakamura, K.3    Kusaka, M.4    Yamaoka, M.5
  • 76
    • 84857713667 scopus 로고    scopus 로고
    • The impact of point mutations in the human androgen receptor: Classification of mutations on the basis of transcriptional activity
    • C.W. Hay, and I.J. McEwan The impact of point mutations in the human androgen receptor: Classification of mutations on the basis of transcriptional activity PLoS One 7 2012 e32514
    • (2012) PLoS One , vol.7 , pp. 32514
    • Hay, C.W.1    McEwan, I.J.2
  • 77
    • 84873122850 scopus 로고    scopus 로고
    • Potent activity of the Hsp90 inhibitor ganetespib in prostate cancer cells irrespective of androgen receptor status or variant receptor expression
    • S. He, C. Zhang, A.A. Shafi, M. Sequeira, J. Acquaviva, and J.C. Friedland Potent activity of the Hsp90 inhibitor ganetespib in prostate cancer cells irrespective of androgen receptor status or variant receptor expression Int J Oncol 42 2013 35 43
    • (2013) Int J Oncol , vol.42 , pp. 35-43
    • He, S.1    Zhang, C.2    Shafi, A.A.3    Sequeira, M.4    Acquaviva, J.5    Friedland, J.C.6
  • 79
    • 37349118115 scopus 로고    scopus 로고
    • Androgen receptor (AR) coregulators: A diversity of functions converging on and regulating the AR transcriptional complex
    • H.V. Heemers, and D.J. Tindall Androgen receptor (AR) coregulators: A diversity of functions converging on and regulating the AR transcriptional complex Endocr Rev 28 2007 778 808
    • (2007) Endocr Rev , vol.28 , pp. 778-808
    • Heemers, H.V.1    Tindall, D.J.2
  • 80
    • 0036219918 scopus 로고    scopus 로고
    • Androgen receptor (AR) coregulators: An overview
    • C.A. Heinlein, and C. Chang Androgen receptor (AR) coregulators: An overview Endocr Rev 23 2002 175 200
    • (2002) Endocr Rev , vol.23 , pp. 175-200
    • Heinlein, C.A.1    Chang, C.2
  • 81
    • 0036793098 scopus 로고    scopus 로고
    • The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions
    • C.A. Heinlein, and C. Chang The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions Mol Endocrinol 16 2002 2181 2187
    • (2002) Mol Endocrinol , vol.16 , pp. 2181-2187
    • Heinlein, C.A.1    Chang, C.2
  • 82
    • 0032532688 scopus 로고    scopus 로고
    • Interleukin-6 regulates prostate-specific protein expression in prostate carcinoma cells by activation of the androgen receptor
    • A. Hobisch, I.E. Eder, T. Putz, W. Horninger, G. Bartsch, and H. Klocker Interleukin-6 regulates prostate-specific protein expression in prostate carcinoma cells by activation of the androgen receptor Cancer Res 58 1998 4640 4645
    • (1998) Cancer Res , vol.58 , pp. 4640-4645
    • Hobisch, A.1    Eder, I.E.2    Putz, T.3    Horninger, W.4    Bartsch, G.5    Klocker, H.6
  • 83
    • 0034817053 scopus 로고    scopus 로고
    • Prostate cancer cells (LNCaP) generated after long-term interleukin 6 (IL-6) treatment express IL-6 and acquire an IL-6 partially resistant phenotype
    • A. Hobisch, R. Ramoner, D. Fuchs, S. Godoy-Tundidor, G. Bartsch, and H. Klocker Prostate cancer cells (LNCaP) generated after long-term interleukin 6 (IL-6) treatment express IL-6 and acquire an IL-6 partially resistant phenotype Clin Cancer Res 7 2001 2941 2948
    • (2001) Clin Cancer Res , vol.7 , pp. 2941-2948
    • Hobisch, A.1    Ramoner, R.2    Fuchs, D.3    Godoy-Tundidor, S.4    Bartsch, G.5    Klocker, H.6
  • 84
    • 78751535990 scopus 로고    scopus 로고
    • Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer
    • M.C. Hodgson, L.J. Shao, A. Frolov, R. Li, L.E. Peterson, and G. Ayala Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer Cancer Res 71 2011 572 582
    • (2011) Cancer Res , vol.71 , pp. 572-582
    • Hodgson, M.C.1    Shao, L.J.2    Frolov, A.3    Li, R.4    Peterson, L.E.5    Ayala, G.6
  • 85
    • 8044231306 scopus 로고    scopus 로고
    • Epidemiologic survey of lower urinary tract symptoms in Asia and Australia using the international prostate symptom score
    • Y. Homma, K. Kawabe, T. Tsukamoto, H. Yamanaka, K. Okada, and E. Okajima Epidemiologic survey of lower urinary tract symptoms in Asia and Australia using the international prostate symptom score Int J Urol 4 1997 40 46
    • (1997) Int J Urol , vol.4 , pp. 40-46
    • Homma, Y.1    Kawabe, K.2    Tsukamoto, T.3    Yamanaka, H.4    Okada, K.5    Okajima, E.6
  • 86
    • 79955719838 scopus 로고    scopus 로고
    • Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival
    • E. Hörnberg, E.B. Ylitalo, S. Crnalic, H. Antti, P. Stattin, and A. Widmark Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival PLoS One 6 2011 e19059
    • (2011) PLoS One , vol.6 , pp. 19059
    • Hörnberg, E.1    Ylitalo, E.B.2    Crnalic, S.3    Antti, H.4    Stattin, P.5    Widmark, A.6
  • 88
    • 58249110391 scopus 로고    scopus 로고
    • Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer
    • R. Hu, T.A. Dunn, S. Wei, S. Isharwal, R.W. Veltri, and E. Humphreys Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer Cancer Res 69 2009 16 22
    • (2009) Cancer Res , vol.69 , pp. 16-22
    • Hu, R.1    Dunn, T.A.2    Wei, S.3    Isharwal, S.4    Veltri, R.W.5    Humphreys, E.6
  • 89
    • 79959312739 scopus 로고    scopus 로고
    • A snapshot of the expression signature of androgen receptor splicing variants and their distinctive transcriptional activities
    • R. Hu, W.B. Isaacs, and J. Luo A snapshot of the expression signature of androgen receptor splicing variants and their distinctive transcriptional activities Prostate 71 2011 1656 1667
    • (2011) Prostate , vol.71 , pp. 1656-1667
    • Hu, R.1    Isaacs, W.B.2    Luo, J.3
  • 91
    • 84856757508 scopus 로고    scopus 로고
    • Selective roles for cAMP response element-binding protein binding protein and p300 protein as coregulators for androgen-regulated gene expression in advanced prostate cancer cells
    • I. Ianculescu, D.Y. Wu, K.D. Siegmund, and M.R. Stallcup Selective roles for cAMP response element-binding protein binding protein and p300 protein as coregulators for androgen-regulated gene expression in advanced prostate cancer cells J Biol Chem 287 2012 4000 4013
    • (2012) J Biol Chem , vol.287 , pp. 4000-4013
    • Ianculescu, I.1    Wu, D.Y.2    Siegmund, K.D.3    Stallcup, M.R.4
  • 92
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • R.K. Jain Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy Science 307 2005 58 62
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 96
    • 0032935119 scopus 로고    scopus 로고
    • Distinguishing androgen receptor agonists and antagonists: Distinct mechanisms of activation by medroxyprogesterone acetate and dihydrotestosterone
    • J.A. Kemppainen, E. Langley, C.I. Wong, K. Bobseine, W.R. Kelce, and E.M. Wilson Distinguishing androgen receptor agonists and antagonists: Distinct mechanisms of activation by medroxyprogesterone acetate and dihydrotestosterone Mol Endocrinol 13 1999 440 454
    • (1999) Mol Endocrinol , vol.13 , pp. 440-454
    • Kemppainen, J.A.1    Langley, E.2    Wong, C.I.3    Bobseine, K.4    Kelce, W.R.5    Wilson, E.M.6
  • 98
    • 77956443521 scopus 로고    scopus 로고
    • Androgen receptor signaling and mutations in prostate cancer
    • S. Koochekpour Androgen receptor signaling and mutations in prostate cancer Asian J Androl 12 2010 639 657
    • (2010) Asian J Androl , vol.12 , pp. 639-657
    • Koochekpour, S.1
  • 99
    • 33845298019 scopus 로고    scopus 로고
    • Receptor for activated C kinase 1 (RACK1) and Src regulate the tyrosine phosphorylation and function of the androgen receptor
    • S. Kraus, D. Gioeli, T. Vomastek, V. Gordon, and M.J. Weber Receptor for activated C kinase 1 (RACK1) and Src regulate the tyrosine phosphorylation and function of the androgen receptor Cancer Res 66 2006 11047 11054
    • (2006) Cancer Res , vol.66 , pp. 11047-11054
    • Kraus, S.1    Gioeli, D.2    Vomastek, T.3    Gordon, V.4    Weber, M.J.5
  • 101
    • 84864799215 scopus 로고    scopus 로고
    • Loss of stromal androgen receptor leads to suppressed prostate tumourigenesis via modulation of pro-inflammatory cytokines/chemokines
    • K.P. Lai, S. Yamashita, C.K. Huang, S. Yeh, and C. Chang Loss of stromal androgen receptor leads to suppressed prostate tumourigenesis via modulation of pro-inflammatory cytokines/chemokines EMBO Mol Med 4 2012 791 807
    • (2012) EMBO Mol Med , vol.4 , pp. 791-807
    • Lai, K.P.1    Yamashita, S.2    Huang, C.K.3    Yeh, S.4    Chang, C.5
  • 102
    • 1542267900 scopus 로고    scopus 로고
    • The efficacy and sequencing of a short course of androgen suppression on freedom from biochemical failure when administered with radiation therapy for T2-T3 prostate cancer
    • J. Laverdière, A. Nabid, L.D. De Bedoya, A. Ebacher, A. Fortin, and C.S. Wang The efficacy and sequencing of a short course of androgen suppression on freedom from biochemical failure when administered with radiation therapy for T2-T3 prostate cancer J Urol 171 2004 1137 1140
    • (2004) J Urol , vol.171 , pp. 1137-1140
    • Laverdière, J.1    Nabid, A.2    De Bedoya, L.D.3    Ebacher, A.4    Fortin, A.5    Wang, C.S.6
  • 104
    • 0035869725 scopus 로고    scopus 로고
    • Updated results of the phase III Radiation Therapy Oncology Group (RTOG) trial 85-31 evaluating the potential benefit of androgen suppression following standard radiation therapy for unfavorable prognosis carcinoma of the prostate
    • C.A. Lawton, K. Winter, K. Murray, M. Machtay, J.B. Mesic, and G.E. Hanks Updated results of the phase III Radiation Therapy Oncology Group (RTOG) trial 85-31 evaluating the potential benefit of androgen suppression following standard radiation therapy for unfavorable prognosis carcinoma of the prostate Int J Radiat Oncol Biol Phys 49 2001 937 946
    • (2001) Int J Radiat Oncol Biol Phys , vol.49 , pp. 937-946
    • Lawton, C.A.1    Winter, K.2    Murray, K.3    Machtay, M.4    Mesic, J.B.5    Hanks, G.E.6
  • 106
    • 76149137405 scopus 로고    scopus 로고
    • Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model
    • C.G. Leon, J.A. Locke, H.H. Adomat, S.L. Etinger, A.L. Twiddy, and R.D. Neumann Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model Prostate 70 2010 390 400
    • (2010) Prostate , vol.70 , pp. 390-400
    • Leon, C.G.1    Locke, J.A.2    Adomat, H.H.3    Etinger, S.L.4    Twiddy, A.L.5    Neumann, R.D.6
  • 107
    • 34548354892 scopus 로고    scopus 로고
    • Crosstalk between androgen receptor and epidermal growth factor receptor-signalling pathways: A molecular switch for epithelial cell differentiation
    • L. Léotoing, M. Manin, D. Monté, S. Baron, Y. Communal, and C. Lours Crosstalk between androgen receptor and epidermal growth factor receptor-signalling pathways: a molecular switch for epithelial cell differentiation J Mol Endocrinol 39 2007 151 162
    • (2007) J Mol Endocrinol , vol.39 , pp. 151-162
    • Léotoing, L.1    Manin, M.2    Monté, D.3    Baron, S.4    Communal, Y.5    Lours, C.6
  • 108
    • 79952772097 scopus 로고    scopus 로고
    • Intragenic rearrangement and altered RNA splicing of the androgen receptor in a cell-based model of prostate cancer progression
    • Y. Li, M. Alsagabi, D. Fan, G.S. Bova, A.H. Tewfik, and S.M. Dehm Intragenic rearrangement and altered RNA splicing of the androgen receptor in a cell-based model of prostate cancer progression Cancer Res 71 2011 2108 2117
    • (2011) Cancer Res , vol.71 , pp. 2108-2117
    • Li, Y.1    Alsagabi, M.2    Fan, D.3    Bova, G.S.4    Tewfik, A.H.5    Dehm, S.M.6
  • 109
    • 80054908957 scopus 로고    scopus 로고
    • Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1
    • C. Li, J. Ao, J. Fu, D.F. Lee, J. Xu, and D.M. Lonard Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1 Oncogene 30 2011 4350 4364
    • (2011) Oncogene , vol.30 , pp. 4350-4364
    • Li, C.1    Ao, J.2    Fu, J.3    Lee, D.F.4    Xu, J.5    Lonard, D.M.6
  • 110
    • 84869094406 scopus 로고    scopus 로고
    • AR intragenic deletions linked to androgen receptor splice variant expression and activity in models of prostate cancer progression
    • Y. Li, T.H. Hwang, L.A. Oseth, A. Hauge, R.L. Vessella, and S.C. Schmechel AR intragenic deletions linked to androgen receptor splice variant expression and activity in models of prostate cancer progression Oncogene 31 2012 4759 4767
    • (2012) Oncogene , vol.31 , pp. 4759-4767
    • Li, Y.1    Hwang, T.H.2    Oseth, L.A.3    Hauge, A.4    Vessella, R.L.5    Schmechel, S.C.6
  • 111
    • 35148833549 scopus 로고    scopus 로고
    • Evidence for calpain-mediated androgen receptor cleavage as a mechanism for androgen independence
    • S.J. Libertini, C.G. Tepper, V. Rodriguez, D.M. Asmuth, H.J. Kung, and M. Mudryj Evidence for calpain-mediated androgen receptor cleavage as a mechanism for androgen independence Cancer Res 67 2007 9001 9005
    • (2007) Cancer Res , vol.67 , pp. 9001-9005
    • Libertini, S.J.1    Tepper, C.G.2    Rodriguez, V.3    Asmuth, D.M.4    Kung, H.J.5    Mudryj, M.6
  • 112
    • 71249101060 scopus 로고    scopus 로고
    • Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer
    • C. Lin, L. Yang, B. Tanasa, K. Hutt, B.G. Ju, and K. Ohgi Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer Cell 139 2009 1069 1083
    • (2009) Cell , vol.139 , pp. 1069-1083
    • Lin, C.1    Yang, L.2    Tanasa, B.3    Hutt, K.4    Ju, B.G.5    Ohgi, K.6
  • 114
    • 48249153087 scopus 로고    scopus 로고
    • Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer
    • W. Liu, C.C. Xie, Y. Zhu, T. Li, J. Sun, and Y. Cheng Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer Neoplasia 10 2008 897 907
    • (2008) Neoplasia , vol.10 , pp. 897-907
    • Liu, W.1    Xie, C.C.2    Zhu, Y.3    Li, T.4    Sun, J.5    Cheng, Y.6
  • 115
    • 51049098138 scopus 로고    scopus 로고
    • Androgen levels increase by intratumoral de novo steroidogenesis during progressing of castration-resistant prostate cancer
    • J.A. Locke, E.S. Guns, A.A. Lubik, H.H. Adomat, S.C. Hendy, and C.A. Wood Androgen levels increase by intratumoral de novo steroidogenesis during progressing of castration-resistant prostate cancer Cancer Res 68 2008 6407 6415
    • (2008) Cancer Res , vol.68 , pp. 6407-6415
    • Locke, J.A.1    Guns, E.S.2    Lubik, A.A.3    Adomat, H.H.4    Hendy, S.C.5    Wood, C.A.6
  • 116
    • 33751541647 scopus 로고    scopus 로고
    • International union of pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: Glucocorticoid, mineralocorticoid, progesterone, and androgen receptors
    • N.Z. Lu, S.E. Wardell, K.L. Burnstein, D. DeFranco, P.J. Fuller, and V. Giguere International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors Pharmacol Rev 58 2006 782 797
    • (2006) Pharmacol Rev , vol.58 , pp. 782-797
    • Lu, N.Z.1    Wardell, S.E.2    Burnstein, K.L.3    Defranco, D.4    Fuller, P.J.5    Giguere, V.6
  • 117
    • 0032766843 scopus 로고    scopus 로고
    • Multiple signal input and output domains of the 160-kilodalton nuclear receptor coactivator proteins
    • H. Ma, H. Hong, S.-M. Huang, R.A. Irvine, P. Webb, and P.J. Kushner Multiple signal input and output domains of the 160-kilodalton nuclear receptor coactivator proteins Mol Cell Biol 19 1999 6164 6173
    • (1999) Mol Cell Biol , vol.19 , pp. 6164-6173
    • Ma, H.1    Hong, H.2    Huang, S.-M.3    Irvine, R.A.4    Webb, P.5    Kushner, P.J.6
  • 118
    • 34347263425 scopus 로고    scopus 로고
    • Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation
    • N.P. Mahajan, Y. Liu, S. Majumder, M.R. Warren, C.E. Parker, and J.L. Mohler Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation Proc Natl Acad Sci U S A 104 2007 8438 8443
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 8438-8443
    • Mahajan, N.P.1    Liu, Y.2    Majumder, S.3    Warren, M.R.4    Parker, C.E.5    Mohler, J.L.6
  • 120
    • 0033812827 scopus 로고    scopus 로고
    • Acquisition of androgen-mediated expression of mouse vas deferens protein (MVDP) gene in cultured epithelial cells and in vas deferens during postnatal development
    • M. Manin, A. Martinez, B. van der Schueren, I. Reynaert, and C. Jean Acquisition of androgen-mediated expression of mouse vas deferens protein (MVDP) gene in cultured epithelial cells and in vas deferens during postnatal development J Androl 21 2000 641 650
    • (2000) J Androl , vol.21 , pp. 641-650
    • Manin, M.1    Martinez, A.2    Van Der Schueren, B.3    Reynaert, I.4    Jean, C.5
  • 121
    • 79960071366 scopus 로고    scopus 로고
    • The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis
    • C.E. Massie, A. Lynch, A. Ramos-Montoya, J. Boren, R. Stark, and L. Fazli The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis EMBO J 30 2011 2719 2733
    • (2011) EMBO J , vol.30 , pp. 2719-2733
    • Massie, C.E.1    Lynch, A.2    Ramos-Montoya, A.3    Boren, J.4    Stark, R.5    Fazli, L.6
  • 122
    • 7944234374 scopus 로고    scopus 로고
    • HER2/neu kinase-dependent modulation of androgen receptor function through effects on DNA binding and stability
    • I.K. Mellinghoff, I. Vivanco, A. Kwon, C. Tran, J. Wongvipat, and C.L. Sawyers HER2/neu kinase-dependent modulation of androgen receptor function through effects on DNA binding and stability Cancer Cell 6 2004 517 527
    • (2004) Cancer Cell , vol.6 , pp. 517-527
    • Mellinghoff, I.K.1    Vivanco, I.2    Kwon, A.3    Tran, C.4    Wongvipat, J.5    Sawyers, C.L.6
  • 123
    • 36649036989 scopus 로고    scopus 로고
    • Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor
    • S. Memarzadeh, L. Xin, D.J. Mulholland, A. Mansukhani, H. Wu, and M.A. Teitell Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor Cancer Cell 12 2007 572 585
    • (2007) Cancer Cell , vol.12 , pp. 572-585
    • Memarzadeh, S.1    Xin, L.2    Mulholland, D.J.3    Mansukhani, A.4    Wu, H.5    Teitell, M.A.6
  • 124
    • 33646866593 scopus 로고    scopus 로고
    • Immediate versis deferred androgen deprivation treatment in patients with node-positive prostate cancer after radical prostatectomy and pelvic lymphadenectomy
    • E.M. Messing, J. Manola, J. Yao, M. Kiernan, D. Crawford, and G. Wilding Immediate versis deferred androgen deprivation treatment in patients with node-positive prostate cancer after radical prostatectomy and pelvic lymphadenectomy Lancet Oncol 7 2006 472 479
    • (2006) Lancet Oncol , vol.7 , pp. 472-479
    • Messing, E.M.1    Manola, J.2    Yao, J.3    Kiernan, M.4    Crawford, D.5    Wilding, G.6
  • 125
    • 80052927758 scopus 로고    scopus 로고
    • Analysis of androgen receptor rapid actions in cellular signaling pathways: Receptor/Src association
    • A. Migliaccio, G. Castoria, and F. Auricchio Analysis of androgen receptor rapid actions in cellular signaling pathways: receptor/Src association Methods Mol Biol 776 2011 361 370
    • (2011) Methods Mol Biol , vol.776 , pp. 361-370
    • Migliaccio, A.1    Castoria, G.2    Auricchio, F.3
  • 126
    • 34648849274 scopus 로고    scopus 로고
    • Inhibition of the SH3 domain-mediated binding of Src to the androgen receptor and its effect on tumor growth
    • A. Migliaccio, L. Varricchio, A. De Falco, G. Castoria, C. Arra, and H. Yamaguchi Inhibition of the SH3 domain-mediated binding of Src to the androgen receptor and its effect on tumor growth Oncogene 26 2007 6619 6629
    • (2007) Oncogene , vol.26 , pp. 6619-6629
    • Migliaccio, A.1    Varricchio, L.2    De Falco, A.3    Castoria, G.4    Arra, C.5    Yamaguchi, H.6
  • 127
    • 0041415826 scopus 로고    scopus 로고
    • Prostate carcinoma presentation, diagnosis, and staging: An update from the National Cancer Data Base
    • D.C. Miller, K.S. Hafez, A. Stewart, J.E. Montie, and J.T. Wei Prostate carcinoma presentation, diagnosis, and staging: an update from the National Cancer Data Base Cancer 98 2003 1169 1178
    • (2003) Cancer , vol.98 , pp. 1169-1178
    • Miller, D.C.1    Hafez, K.S.2    Stewart, A.3    Montie, J.E.4    Wei, J.T.5
  • 128
    • 30344477367 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
    • S. Minucci, and P.G. Pelicci Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer Nat Rev Cancer 6 2006 38 51
    • (2006) Nat Rev Cancer , vol.6 , pp. 38-51
    • Minucci, S.1    Pelicci, P.G.2
  • 129
    • 0032849766 scopus 로고    scopus 로고
    • Androgen receptor expression of proliferating basal and luminal cells in adult murine ventral prostate
    • J. Mirosevich, J.M. Bentel, N. Zeps, S.L. Redmond, M.F. D'Antuono, and H.J. Dawkins Androgen receptor expression of proliferating basal and luminal cells in adult murine ventral prostate J Endocrinol 162 1999 341 350
    • (1999) J Endocrinol , vol.162 , pp. 341-350
    • Mirosevich, J.1    Bentel, J.M.2    Zeps, N.3    Redmond, S.L.4    D'Antuono, M.F.5    Dawkins, H.J.6
  • 130
    • 84870336847 scopus 로고    scopus 로고
    • Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumors
    • N. Mitsiades, C.C. Sung, N. Schultz, D.C. Danila, B. He, and V.K. Eedunuri Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumors Cancer Res 72 2012 6142 6152
    • (2012) Cancer Res , vol.72 , pp. 6142-6152
    • Mitsiades, N.1    Sung, C.C.2    Schultz, N.3    Danila, D.C.4    He, B.5    Eedunuri, V.K.6
  • 131
    • 0032560555 scopus 로고    scopus 로고
    • Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells
    • H. Miyamoto, S.-H. Yeh, G. Wilding, and C. Chang Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells Proc Natl Acad Sci U S A 95 1998 7379 7384
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 7379-7384
    • Miyamoto, H.1    Yeh, S.-H.2    Wilding, G.3    Chang, C.4
  • 133
    • 49249119358 scopus 로고    scopus 로고
    • Maintenance of intratumoral androgens in metastatic prostate cancer: A mechanism for castration-resistant tumor growth
    • R.B. Montgomery, E.A. Mostaghel, R. Vessella, D.L. Hess, T.F. Kalhorn, and C.S. Higano Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth Cancer Res 68 2008 4447 4454
    • (2008) Cancer Res , vol.68 , pp. 4447-4454
    • Montgomery, R.B.1    Mostaghel, E.A.2    Vessella, R.3    Hess, D.L.4    Kalhorn, T.F.5    Higano, C.S.6
  • 134
    • 34250331066 scopus 로고    scopus 로고
    • Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: Therapeutic implications for castration-resistant prostate cancer
    • E.A. Mostaghel, S.T. Page, D.W. Lin, L. Fazli, I.M. Coleman, and L.D. True Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer Cancer Res 67 2007 5033 5041
    • (2007) Cancer Res , vol.67 , pp. 5033-5041
    • Mostaghel, E.A.1    Page, S.T.2    Lin, D.W.3    Fazli, L.4    Coleman, I.M.5    True, L.D.6
  • 135
    • 84863961968 scopus 로고    scopus 로고
    • Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement
    • V.A. Moyer, and U.S. Preventive Services Task Force Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement Ann Intern Med 157 2012 120 134
    • (2012) Ann Intern Med , vol.157 , pp. 120-134
    • Moyer, V.A.1
  • 136
    • 84873033326 scopus 로고    scopus 로고
    • Targeted disruption of the p160 coactivator interface of androgen receptor (AR) selectively inhibits AR activity in both androgen-dependent and castration-resistant AR-expressing prostate cancer cells
    • M. Nakka, I.U. Agoulnik, and N.L. Weigel Targeted disruption of the p160 coactivator interface of androgen receptor (AR) selectively inhibits AR activity in both androgen-dependent and castration-resistant AR-expressing prostate cancer cells Int J Biochem Cell Biol 45 2013 763 772
    • (2013) Int J Biochem Cell Biol , vol.45 , pp. 763-772
    • Nakka, M.1    Agoulnik, I.U.2    Weigel, N.L.3
  • 137
    • 0029814415 scopus 로고    scopus 로고
    • Activation of the human androgen receptor through a protein kinase A signaling pathway
    • L.V. Nazareth, and N.L. Weigel Activation of the human androgen receptor through a protein kinase A signaling pathway J Biol Chem 271 1996 19900 19907
    • (1996) J Biol Chem , vol.271 , pp. 19900-19907
    • Nazareth, L.V.1    Weigel, N.L.2
  • 138
    • 84856652439 scopus 로고    scopus 로고
    • Beyond castration-defining future directions in the hormonal treatment of prostate cancer
    • S. Niraula, K. Chi, and A.M. Joshua Beyond castration-defining future directions in the hormonal treatment of prostate cancer Horm Cancer 3 2012 3 13
    • (2012) Horm Cancer , vol.3 , pp. 3-13
    • Niraula, S.1    Chi, K.2    Joshua, A.M.3
  • 139
    • 50449094553 scopus 로고    scopus 로고
    • Targeting the stromal androgen receptor in primary prostate tumors at earlier stages
    • Y. Niu, S. Altuwaijri, S. Yeh, K.P. Lai, S. Yu, and K.H. Chuang Targeting the stromal androgen receptor in primary prostate tumors at earlier stages Proc Natl Acad Sci U S A 105 2008 12188 12193
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 12188-12193
    • Niu, Y.1    Altuwaijri, S.2    Yeh, S.3    Lai, K.P.4    Yu, S.5    Chuang, K.H.6
  • 140
    • 84874426546 scopus 로고    scopus 로고
    • Interplay between genomic alterations and androgen receptor signaling during prostate cancer development and progression
    • (Jan 2013 [Epub ahead of print])
    • M.D. Nyquist, and S.M. Dehm Interplay between genomic alterations and androgen receptor signaling during prostate cancer development and progression Horm Cancer 2013 1 (Jan 2013 [Epub ahead of print])
    • (2013) Horm Cancer , pp. 1
    • Nyquist, M.D.1    Dehm, S.M.2
  • 141
    • 3042784503 scopus 로고    scopus 로고
    • Hormonal impact of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer
    • A. O'Donnell, I. Judson, M. Dowsett, F. Raynaud, D. Dearnaley, and M. Mason Hormonal impact of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer Br J Cancer 90 2004 2317 2325
    • (2004) Br J Cancer , vol.90 , pp. 2317-2325
    • O'Donnell, A.1    Judson, I.2    Dowsett, M.3    Raynaud, F.4    Dearnaley, D.5    Mason, M.6
  • 142
    • 0035081241 scopus 로고    scopus 로고
    • Fibroblast growth factors
    • (REVIEWS3005)
    • D.M. Ornitz, and N. Itoh Fibroblast growth factors Genome Biol 2 2001 (REVIEWS3005)
    • (2001) Genome Biol , vol.2
    • Ornitz, D.M.1    Itoh, N.2
  • 143
    • 0031047767 scopus 로고    scopus 로고
    • Androgen receptor gene amplification in a recurrent prostate cancer after monotherapy with the nonsteroidal potent antiandrogen Casodex (bicalutamide) with a subsequent favorable response to maximal androgen blockade
    • C. Palmberg, P. Koivisto, E. Hyytinen, J. Isola, T. Visakorpi, and O.P. Kallioniemi Androgen receptor gene amplification in a recurrent prostate cancer after monotherapy with the nonsteroidal potent antiandrogen Casodex (bicalutamide) with a subsequent favorable response to maximal androgen blockade Eur Urol 31 1997 216 219
    • (1997) Eur Urol , vol.31 , pp. 216-219
    • Palmberg, C.1    Koivisto, P.2    Hyytinen, E.3    Isola, J.4    Visakorpi, T.5    Kallioniemi, O.P.6
  • 144
    • 0042303832 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-kappaB, JNK, and Ras signaling pathways
    • J.I. Park, M.G. Lee, K. Cho, B.J. Park, K.S. Chae, and D.S. Byun Transforming growth factor-beta1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-kappaB, JNK, and Ras signaling pathways Oncogene 22 2003 4314 4332
    • (2003) Oncogene , vol.22 , pp. 4314-4332
    • Park, J.I.1    Lee, M.G.2    Cho, K.3    Park, B.J.4    Chae, K.S.5    Byun, D.S.6
  • 145
    • 0028795910 scopus 로고
    • The role of increasing detection in the rising incidence of prostate cancer
    • A.L. Potosky, B.A. Miller, P.C. Albertsen, and B.S. Kramer The role of increasing detection in the rising incidence of prostate cancer JAMA 273 1995 548 552
    • (1995) JAMA , vol.273 , pp. 548-552
    • Potosky, A.L.1    Miller, B.A.2    Albertsen, P.C.3    Kramer, B.S.4
  • 146
    • 0034728828 scopus 로고    scopus 로고
    • Maximum androgen blockade in advanced prostate cancer: An overview of the randomised trials
    • Prostate Cancer Trialists' Collaborative Group Maximum androgen blockade in advanced prostate cancer: An overview of the randomised trials Lancet 355 2000 1491 1498
    • (2000) Lancet , vol.355 , pp. 1491-1498
    • Cancer Trialists'Collaborative Group, P.1
  • 147
    • 84872161627 scopus 로고    scopus 로고
    • COUP-TFII inhibits TGF-b-induced growth barrier to promote prostate tumorigenesis
    • J. Qin, S.P. Wu, C.J. Creighton, F. Dai, X. Xie, and C.M. Cheng COUP-TFII inhibits TGF-b-induced growth barrier to promote prostate tumorigenesis Nature 493 2013 236 240
    • (2013) Nature , vol.493 , pp. 236-240
    • Qin, J.1    Wu, S.P.2    Creighton, C.J.3    Dai, F.4    Xie, X.5    Cheng, C.M.6
  • 148
    • 0032492879 scopus 로고    scopus 로고
    • Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells
    • Y. Qiu, L. Ravi, and H.J. Kung Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells Nature 393 1998 83 85
    • (1998) Nature , vol.393 , pp. 83-85
    • Qiu, Y.1    Ravi, L.2    Kung, H.J.3
  • 149
    • 76949106361 scopus 로고    scopus 로고
    • Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer
    • A.H. Reid, G. Attard, L. Ambroisine, G. Fisher, G. Kovacs, and D. Brewer Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer Br J Cancer 102 2010 678 684
    • (2010) Br J Cancer , vol.102 , pp. 678-684
    • Reid, A.H.1    Attard, G.2    Ambroisine, L.3    Fisher, G.4    Kovacs, G.5    Brewer, D.6
  • 150
    • 84860523917 scopus 로고    scopus 로고
    • Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: A rationale for increasing abiraterone exposure or combining with MDV3100
    • J. Richards, A.C. Lim, C.W. Hay, A.E. Taylor, A. Wingate, and K. Nowakowska Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: A rationale for increasing abiraterone exposure or combining with MDV3100 Cancer Res 72 2012 2176 2182
    • (2012) Cancer Res , vol.72 , pp. 2176-2182
    • Richards, J.1    Lim, A.C.2    Hay, C.W.3    Taylor, A.E.4    Wingate, A.5    Nowakowska, K.6
  • 151
    • 0031020769 scopus 로고    scopus 로고
    • Prooxidant-antioxidant shift induced by androgen treatment of human prostate carcinoma cells
    • M.O. Ripple, W.F. Henry, R.P. Rago, and G. Wilding Prooxidant-antioxidant shift induced by androgen treatment of human prostate carcinoma cells J Natl Cancer Inst 89 1997 40 48
    • (1997) J Natl Cancer Inst , vol.89 , pp. 40-48
    • Ripple, M.O.1    Henry, W.F.2    Rago, R.P.3    Wilding, G.4
  • 152
    • 39149085396 scopus 로고    scopus 로고
    • Short-term neoadjuvant androgen deprivation therapy and external-beam radiotherapy for locally advanced prostate cancer: Long-term results of RTOG 8610
    • M. Roach, K. Bae, J. Speight, H.B. Wolkov, P. Rubin, and R.J. Lee Short-term neoadjuvant androgen deprivation therapy and external-beam radiotherapy for locally advanced prostate cancer: Long-term results of RTOG 8610 J Clin Oncol 26 2008 585 591
    • (2008) J Clin Oncol , vol.26 , pp. 585-591
    • Roach, M.1    Bae, K.2    Speight, J.3    Wolkov, H.B.4    Rubin, P.5    Lee, R.J.6
  • 153
    • 33645125545 scopus 로고    scopus 로고
    • Mechanisms of cell death induced by histone deacetylase inhibitors in androgen receptor-positive prostate cancer cells
    • O.W. Rokhlin, R.B. Glover, N.V. Guseva, A.F. Taghiyev, K.G. Kohlgraf, and M.B. Cohen Mechanisms of cell death induced by histone deacetylase inhibitors in androgen receptor-positive prostate cancer cells Mol Cancer Res 4 2006 113 123
    • (2006) Mol Cancer Res , vol.4 , pp. 113-123
    • Rokhlin, O.W.1    Glover, R.B.2    Guseva, N.V.3    Taghiyev, A.F.4    Kohlgraf, K.G.5    Cohen, M.B.6
  • 155
    • 33746210089 scopus 로고    scopus 로고
    • Secondary hormonal manipulations in prostate cancer
    • C.J. Ryan Secondary hormonal manipulations in prostate cancer Hematol Oncol Clin North Am 20 2006 925 934
    • (2006) Hematol Oncol Clin North Am , vol.20 , pp. 925-934
    • Ryan, C.J.1
  • 157
    • 0035942197 scopus 로고    scopus 로고
    • Crystallographic structures of the ligand-binding domains of the androgen
    • J.S. Sack, K.F. Kish, C. Wang, R.M. Attar, S.E. Kiefer, and Y. An Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone Proc Natl Acad Sci U S A 98 2001 4904 4909
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 4904-4909
    • Sack, J.S.1    Kish, K.F.2    Wang, C.3    Attar, R.M.4    Kiefer, S.E.5    An, Y.6
  • 158
    • 0037099723 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of monotherapy compared with combined androgen blockade for patients with advanced prostate carcinoma
    • D.J. Samson, J. Seidenfeld, B. Schmitt, V. Hasselblad, P.C. Albertsen, and C.L. Bennett Systematic review and meta-analysis of monotherapy compared with combined androgen blockade for patients with advanced prostate carcinoma Cancer 95 2002 361 376
    • (2002) Cancer , vol.95 , pp. 361-376
    • Samson, D.J.1    Seidenfeld, J.2    Schmitt, B.3    Hasselblad, V.4    Albertsen, P.C.5    Bennett, C.L.6
  • 159
    • 0032739426 scopus 로고    scopus 로고
    • Luteinizing hormone-releasing hormone analogs: Their impact on the control of tumorigenesis
    • A.V. Schally Luteinizing hormone-releasing hormone analogs: Their impact on the control of tumorigenesis Peptides 20 1999 1247 1262
    • (1999) Peptides , vol.20 , pp. 1247-1262
    • Schally, A.V.1
  • 160
    • 4944246790 scopus 로고    scopus 로고
    • Targeting the androgen receptor: Improving outcomes for castration-resistant prostate cancer
    • H.I. Scher, G. Buchanan, W. Gerald, L.M. Butler, and W.D. Tilley Targeting the androgen receptor: Improving outcomes for castration-resistant prostate cancer Endocr Relat Cancer 11 2004 459 476
    • (2004) Endocr Relat Cancer , vol.11 , pp. 459-476
    • Scher, H.I.1    Buchanan, G.2    Gerald, W.3    Butler, L.M.4    Tilley, W.D.5
  • 161
    • 84858114087 scopus 로고    scopus 로고
    • Effect of MDV3100, an androgen receptor signaling inhibitor (ARSI), on overall survival in patients with prostate cancer postdocetaxel: Results from the phase III AFFIRM study
    • (Abstract LBA1-(ASCO Genitourinary Cancers Symposium Abstracts))
    • H.I. Scher, K. Fizazi, and F. Saad Effect of MDV3100, an androgen receptor signaling inhibitor (ARSI), on overall survival in patients with prostate cancer postdocetaxel: Results from the phase III AFFIRM study J Clin Oncol 30 2012 (Abstract LBA1-(ASCO Genitourinary Cancers Symposium Abstracts))
    • (2012) J Clin Oncol , vol.30
    • Scher, H.I.1    Fizazi, K.2    Saad, F.3
  • 162
    • 33644675811 scopus 로고    scopus 로고
    • Biology of progressive, castration-resistant prostate cancer: Directed therapies targeting the androgen-receptor signaling axis
    • H.I. Scher, and C.L. Sawyers Biology of progressive, castration-resistant prostate cancer: Directed therapies targeting the androgen-receptor signaling axis J Clin Oncol 23 2005 8253 8261
    • (2005) J Clin Oncol , vol.23 , pp. 8253-8261
    • Scher, H.I.1    Sawyers, C.L.2
  • 163
    • 4143086051 scopus 로고    scopus 로고
    • Early versus delayed endocrine treatment of pN1-3 MO prostate cancer without local treatment of the primary tumor: Results of European Organisation for the Research and Treatment of Cancer 30846 - A phase III study
    • F.H. Schröder, K.H. Kurth, S.D. Fosså, W. Hoekstra, P.P. Karthaus, and M. Debois Early versus delayed endocrine treatment of pN1-3 MO prostate cancer without local treatment of the primary tumor: results of European Organisation for the Research and Treatment of Cancer 30846 - a phase III study J Urol 172 2004 923 927
    • (2004) J Urol , vol.172 , pp. 923-927
    • Schröder, F.H.1    Kurth, K.H.2    Fosså, S.D.3    Hoekstra, W.4    Karthaus, P.P.5    Debois, M.6
  • 164
    • 77956555910 scopus 로고    scopus 로고
    • Paxillin regulates androgen- and epidermal growth factor-induced MAPK signaling and cell proliferation in prostate cancer cells
    • A. Sen, K. O'Malley, Z. Wang, G.V. Raj, D.B. DeFranco, and S.R. Hammes Paxillin regulates androgen- and epidermal growth factor-induced MAPK signaling and cell proliferation in prostate cancer cells J Biol Chem 285 2010 28787 28795
    • (2010) J Biol Chem , vol.285 , pp. 28787-28795
    • Sen, A.1    O'Malley, K.2    Wang, Z.3    Raj, G.V.4    Defranco, D.B.5    Hammes, S.R.6
  • 165
    • 85028107326 scopus 로고    scopus 로고
    • Drug resistance in metastatic castration-resistant prostate cancer
    • B. Seruga, A. Ocana, and I.F. Tannock Drug resistance in metastatic castration-resistant prostate cancer Nat Rev Clin Oncol 8 2011 12 23
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 12-23
    • Seruga, B.1    Ocana, A.2    Tannock, I.F.3
  • 166
    • 84876695259 scopus 로고    scopus 로고
    • Androgen receptor splice variants are resistant to inhibitors of Hsp90 and FKBP52, which alter androgen receptor activity and expression
    • A.A. Shafi, M.B. Cox, and N.L. Weigel Androgen receptor splice variants are resistant to inhibitors of Hsp90 and FKBP52, which alter androgen receptor activity and expression Steroids 78 6 2013 548 554
    • (2013) Steroids , vol.78 , Issue.6 , pp. 548-554
    • Shafi, A.A.1    Cox, M.B.2    Weigel, N.L.3
  • 168
    • 0034614108 scopus 로고    scopus 로고
    • Her-2-neu expression and progression toward androgen independence in human prostate cancer
    • S. Signoretti, R. Montironi, J. Manola, A. Altimari, C. Tam, and G. Bubley Her-2-neu expression and progression toward androgen independence in human prostate cancer J Natl Cancer Inst 92 2000 1918 1925
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1918-1925
    • Signoretti, S.1    Montironi, R.2    Manola, J.3    Altimari, A.4    Tam, C.5    Bubley, G.6
  • 169
    • 33746417580 scopus 로고    scopus 로고
    • Hsp90: A novel target for cancer therapy
    • D.B. Solit, and N. Rosen Hsp90: A novel target for cancer therapy Curr Top Med Chem 6 2006 1205 1214
    • (2006) Curr Top Med Chem , vol.6 , pp. 1205-1214
    • Solit, D.B.1    Rosen, N.2
  • 170
    • 77957345152 scopus 로고    scopus 로고
    • DHT selectively reverses Smad3-mediated/TGF-beta-induced responses through transcriptional down-regulation of Smad3 in prostate epithelial cells
    • K. Song, H. Wang, T.L. Krebs, B. Wang, T.J. Kelley, and D. Danielpour DHT selectively reverses Smad3-mediated/TGF-beta-induced responses through transcriptional down-regulation of Smad3 in prostate epithelial cells Mol Endocrinol 24 2010 2019 2029
    • (2010) Mol Endocrinol , vol.24 , pp. 2019-2029
    • Song, K.1    Wang, H.2    Krebs, T.L.3    Wang, B.4    Kelley, T.J.5    Danielpour, D.6
  • 171
    • 0026445528 scopus 로고
    • Transforming growth factor-beta: Recent progress and new challenges
    • M.B. Sporn, and A.B. Roberts Transforming growth factor-beta: Recent progress and new challenges J Cell Biol 119 1992 1017 1021
    • (1992) J Cell Biol , vol.119 , pp. 1017-1021
    • Sporn, M.B.1    Roberts, A.B.2
  • 172
    • 0037143096 scopus 로고    scopus 로고
    • Broadened ligand responsiveness of androgen receptor mutants obtained by random amino acid substitution of H874 and mutation hot spot T877 in prostate cancer
    • K. Steketee, L. Timmerman, A.C. Ziel-van der Made, P. Doesburg, A.O. Brinkmann, and J. Trapman Broadened ligand responsiveness of androgen receptor mutants obtained by random amino acid substitution of H874 and mutation hot spot T877 in prostate cancer Int J Cancer 100 2002 309 317
    • (2002) Int J Cancer , vol.100 , pp. 309-317
    • Steketee, K.1    Timmerman, L.2    Ziel-Van Der Made, A.C.3    Doesburg, P.4    Brinkmann, A.O.5    Trapman, J.6
  • 173
    • 78650178547 scopus 로고    scopus 로고
    • DNA strand breaks and hypoxia response inhibition mediate the radiosensitisation effect of nitric oxide donors on prostate cancer under varying oxygen conditions
    • G.D. Stewart, J. Nanda, E. Katz, K.J. Bowman, J.G. Christie, and D.J. Brown DNA strand breaks and hypoxia response inhibition mediate the radiosensitisation effect of nitric oxide donors on prostate cancer under varying oxygen conditions Biochem Pharmacol 81 2011 203 210
    • (2011) Biochem Pharmacol , vol.81 , pp. 203-210
    • Stewart, G.D.1    Nanda, J.2    Katz, E.3    Bowman, K.J.4    Christie, J.G.5    Brown, D.J.6
  • 174
    • 51649115957 scopus 로고    scopus 로고
    • TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation
    • C. Sun, A. Dobi, A. Mohamed, H. Li, R.L. Thangapazham, and B. Furusato TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation Oncogene 27 2008 5348 5353
    • (2008) Oncogene , vol.27 , pp. 5348-5353
    • Sun, C.1    Dobi, A.2    Mohamed, A.3    Li, H.4    Thangapazham, R.L.5    Furusato, B.6
  • 175
    • 77955296562 scopus 로고    scopus 로고
    • Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant
    • S. Sun, C.C. Sprenger, R.L. Vessella, K. Haugk, K. Soriano, and E.A. Mostaghei Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant J Clin Invest 120 2010 2715 2730
    • (2010) J Clin Invest , vol.120 , pp. 2715-2730
    • Sun, S.1    Sprenger, C.C.2    Vessella, R.L.3    Haugk, K.4    Soriano, K.5    Mostaghei, E.A.6
  • 176
    • 0029825669 scopus 로고    scopus 로고
    • Codon 877 mutation in the androgen receptor gene in advanced prostate cancer: Relation to antiandrogen withdrawal syndrome
    • H. Suzuki, K. Akakura, A. Komiya, S. Aida, S. Akimoto, and J. Shimazaki Codon 877 mutation in the androgen receptor gene in advanced prostate cancer: relation to antiandrogen withdrawal syndrome Prostate 29 1996 153 158
    • (1996) Prostate , vol.29 , pp. 153-158
    • Suzuki, H.1    Akakura, K.2    Komiya, A.3    Aida, S.4    Akimoto, S.5    Shimazaki, J.6
  • 177
    • 4744366279 scopus 로고    scopus 로고
    • Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer
    • I.F. Tannock, R. de Wit, W.R. Bersch, J. Horti, A. Pluzanska, and K.N. Chi Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer N Engl J Med 351 2004 1502 1512
    • (2004) N Engl J Med , vol.351 , pp. 1502-1512
    • Tannock, I.F.1    De Wit, R.2    Bersch, W.R.3    Horti, J.4    Pluzanska, A.5    Chi, K.N.6
  • 178
    • 0033152164 scopus 로고    scopus 로고
    • Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist
    • M.E. Taplin, G.J. Bubley, Y.J. Ko, E.J. Small, M. Upton, and B. Rajeshkumar Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist Cancer Res 59 1999 2511 2515
    • (1999) Cancer Res , vol.59 , pp. 2511-2515
    • Taplin, M.E.1    Bubley, G.J.2    Ko, Y.J.3    Small, E.J.4    Upton, M.5    Rajeshkumar, B.6
  • 181
    • 0034982410 scopus 로고    scopus 로고
    • Disrupted amino- and carboxyl-terminal interactions of the androgen receptor are linked to androgen insensitivity
    • J. Thompson, F. Saatcioglu, O.A. Jänne, and J.J. Palvimo Disrupted amino- and carboxyl-terminal interactions of the androgen receptor are linked to androgen insensitivity Mol Endocrinol 15 2001 923 935
    • (2001) Mol Endocrinol , vol.15 , pp. 923-935
    • Thompson, J.1    Saatcioglu, F.2    Jänne, O.A.3    Palvimo, J.J.4
  • 182
    • 0034758863 scopus 로고    scopus 로고
    • Discovery in surgical investigation: The essence of Charles Brenton Huggins
    • L.H. Toledo-Pereyra Discovery in surgical investigation: The essence of Charles Brenton Huggins J Invest Surg 14 2001 251 252
    • (2001) J Invest Surg , vol.14 , pp. 251-252
    • Toledo-Pereyra, L.H.1
  • 184
    • 27344451557 scopus 로고    scopus 로고
    • Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
    • S.A. Tomlins, D.R. Rhodes, S. Perner, S.M. Dhanasekaran, R. Mehra, and X.W. Sun Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer Science 310 2005 644 648
    • (2005) Science , vol.310 , pp. 644-648
    • Tomlins, S.A.1    Rhodes, D.R.2    Perner, S.3    Dhanasekaran, S.M.4    Mehra, R.5    Sun, X.W.6
  • 185
    • 65649090203 scopus 로고    scopus 로고
    • Development of a second-generation antiandrogen for treatment of advanced prostate cancer
    • C. Tran, S. Ouk, N.J. Clegg, Y. Chen, P.A. Watson, and V. Arora Development of a second-generation antiandrogen for treatment of advanced prostate cancer Science 324 2009 787 790
    • (2009) Science , vol.324 , pp. 787-790
    • Tran, C.1    Ouk, S.2    Clegg, N.J.3    Chen, Y.4    Watson, P.A.5    Arora, V.6
  • 186
    • 34547936357 scopus 로고    scopus 로고
    • Gene fusions between TMPRSS2 and ETS family genes in prostate cancer: Frequency and transcript variant analysis by RT-PCR and FISH on paraffin-embedded tissues
    • J.J. Tu, S. Rohan, J. Kao, N. Kitabayashi, S. Mathew, and Y.T. Chen Gene fusions between TMPRSS2 and ETS family genes in prostate cancer: Frequency and transcript variant analysis by RT-PCR and FISH on paraffin-embedded tissues Mod Pathol 20 2007 921 928
    • (2007) Mod Pathol , vol.20 , pp. 921-928
    • Tu, J.J.1    Rohan, S.2    Kao, J.3    Kitabayashi, N.4    Mathew, S.5    Chen, Y.T.6
  • 187
    • 0037064106 scopus 로고    scopus 로고
    • Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells
    • T. Ueda, N.R. Mawji, N. Bruchovsky, and M.D. Sadar Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells J Biol Chem 277 2002 38087 38094
    • (2002) J Biol Chem , vol.277 , pp. 38087-38094
    • Ueda, T.1    Mawji, N.R.2    Bruchovsky, N.3    Sadar, M.D.4
  • 188
    • 77951170767 scopus 로고    scopus 로고
    • Systematic structure-function analysis of androgen receptor Leu701 mutants explains the properties of the prostate cancer mutant L701H
    • D.J. van de Wijngaart, M. Molier, S.J. Lusher, R. Hersmus, G. Jenster, and J. Trapman Systematic structure-function analysis of androgen receptor Leu701 mutants explains the properties of the prostate cancer mutant L701H J Biol Chem 285 2010 5097 5105
    • (2010) J Biol Chem , vol.285 , pp. 5097-5105
    • Van De Wijngaart, D.J.1    Molier, M.2    Lusher, S.J.3    Hersmus, R.4    Jenster, G.5    Trapman, J.6
  • 189
    • 77749321132 scopus 로고    scopus 로고
    • The cancer-related Runx2 protein enhances cell growth and responses to androgen and TGFbeta in prostate cancer cells
    • M. van der Deen, J. Akech, T. Wang, T.J. FitzGerald, D.C. Altieri, and L.R. Languino The cancer-related Runx2 protein enhances cell growth and responses to androgen and TGFbeta in prostate cancer cells J Cell Biochem 109 2010 828 837
    • (2010) J Cell Biochem , vol.109 , pp. 828-837
    • Van Der Deen, M.1    Akech, J.2    Wang, T.3    Fitzgerald, T.J.4    Altieri, D.C.5    Languino, L.R.6
  • 190
    • 0025644325 scopus 로고
    • A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to antiandrogens
    • J. Veldscholte, C. Ris-Stalpers, G.G.J.M. Kuiper, G. Jenster, C. Berrevoets, and E. Claassen A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to antiandrogens Biochem Biophys Res Commun 173 1990 534 540
    • (1990) Biochem Biophys Res Commun , vol.173 , pp. 534-540
    • Veldscholte, J.1    Ris-Stalpers, C.2    Kuiper, G.G.J.M.3    Jenster, G.4    Berrevoets, C.5    Claassen, E.6
  • 191
    • 0028944138 scopus 로고
    • In vivo amplification of the androgen receptor gene and progression of human prostate cancer
    • T. Visakorpi, E. Hyytinen, P. Koivisto, M. Tanner, R. Keinanen, and C. Palmberg In vivo amplification of the androgen receptor gene and progression of human prostate cancer Nat Genet 9 1995 401 406
    • (1995) Nat Genet , vol.9 , pp. 401-406
    • Visakorpi, T.1    Hyytinen, E.2    Koivisto, P.3    Tanner, M.4    Keinanen, R.5    Palmberg, C.6
  • 192
    • 70350244512 scopus 로고    scopus 로고
    • Increased expression of androgen receptor sensitizes prostate cancer cells to low levels of androgens
    • K.K. Waltering, M.A. Helenius, B. Sahu, V. Manni, M.J. Linja, and O.A. Jänne Increased expression of androgen receptor sensitizes prostate cancer cells to low levels of androgens Cancer Res 69 2009 8141 8149
    • (2009) Cancer Res , vol.69 , pp. 8141-8149
    • Waltering, K.K.1    Helenius, M.A.2    Sahu, B.3    Manni, V.4    Linja, M.J.5    Jänne, O.A.6
  • 193
    • 33749034498 scopus 로고    scopus 로고
    • Expression of variant TMPRSS2/ERG fusion mRNAs is associated with aggressive prostate cancer
    • J. Wang, Y. Cai, C. Ren, and M. Ittmann Expression of variant TMPRSS2/ERG fusion mRNAs is associated with aggressive prostate cancer Cancer Res 66 2006 8347 8351
    • (2006) Cancer Res , vol.66 , pp. 8347-8351
    • Wang, J.1    Cai, Y.2    Ren, C.3    Ittmann, M.4
  • 194
    • 54249154706 scopus 로고    scopus 로고
    • Pleiotropic biological activities of alternatively spliced TMPRSS2/ERG fusion gene transcripts
    • J. Wang, Y. Cai, W. Yu, C. Ren, D.M. Spencer, and M. Ittmann Pleiotropic biological activities of alternatively spliced TMPRSS2/ERG fusion gene transcripts Cancer Res 68 2008 8516 8524
    • (2008) Cancer Res , vol.68 , pp. 8516-8524
    • Wang, J.1    Cai, Y.2    Yu, W.3    Ren, C.4    Spencer, D.M.5    Ittmann, M.6
  • 195
    • 24044540381 scopus 로고    scopus 로고
    • Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking
    • Q. Wang, J.S. Carroll, and M. Brown Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking Mol Cell 19 2005 631 642
    • (2005) Mol Cell , vol.19 , pp. 631-642
    • Wang, Q.1    Carroll, J.S.2    Brown, M.3
  • 196
    • 10744222860 scopus 로고    scopus 로고
    • Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
    • S. Wang, J. Gao, Q. Lei, N. Rozengurt, C. Pritchard, and J. Jiao Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer Cancer Cell 4 2003 209 221
    • (2003) Cancer Cell , vol.4 , pp. 209-221
    • Wang, S.1    Gao, J.2    Lei, Q.3    Rozengurt, N.4    Pritchard, C.5    Jiao, J.6
  • 197
    • 70349438989 scopus 로고    scopus 로고
    • A luminal epithelial stem cell that is a cell of origin for prostate cancer
    • X. Wang, J.M. Kruithof-de, K.D. Economides, D. Walker, H. Yu, and M.V. Halili A luminal epithelial stem cell that is a cell of origin for prostate cancer Nature 461 2009 495 500
    • (2009) Nature , vol.461 , pp. 495-500
    • Wang, X.1    Kruithof-De, J.M.2    Economides, K.D.3    Walker, D.4    Yu, H.5    Halili, M.V.6
  • 198
    • 34547214787 scopus 로고    scopus 로고
    • A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth
    • Q. Wang, W. Li, X.S. Liu, J.S. Carroll, O.A. Jänne, and E.K. Keeton A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth Mol Cell 27 2007 380 392
    • (2007) Mol Cell , vol.27 , pp. 380-392
    • Wang, Q.1    Li, W.2    Liu, X.S.3    Carroll, J.S.4    Jänne, O.A.5    Keeton, E.K.6
  • 199
    • 67650758019 scopus 로고    scopus 로고
    • Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer
    • Q. Wang, W. Li, Y. Zhang, X. Yuan, K. Xu, and J. Yu Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer Cell 138 2009 245 256
    • (2009) Cell , vol.138 , pp. 245-256
    • Wang, Q.1    Li, W.2    Zhang, Y.3    Yuan, X.4    Xu, K.5    Yu, J.6
  • 200
    • 84874645057 scopus 로고    scopus 로고
    • Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell-of-origin model for prostate cancer heterogeneity
    • Z.A. Wang, A. Mitrofanova, S.K. Bergren, C. Abate-Shen, R.D. Cardiff, and A. Califano Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell-of-origin model for prostate cancer heterogeneity Nat Cell Biol 15 2013 274 283
    • (2013) Nat Cell Biol , vol.15 , pp. 274-283
    • Wang, Z.A.1    Mitrofanova, A.2    Bergren, S.K.3    Abate-Shen, C.4    Cardiff, R.D.5    Califano, A.6
  • 201
    • 78049280194 scopus 로고    scopus 로고
    • Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor
    • P.A. Watson, Y.F. Chen, M.D. Balbas, J. Wongvipat, N.D. Socci, and A. Viale Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor Proc Natl Acad Sci U S A 107 2010 16759 16765
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 16759-16765
    • Watson, P.A.1    Chen, Y.F.2    Balbas, M.D.3    Wongvipat, J.4    Socci, N.D.5    Viale, A.6
  • 202
    • 0028014597 scopus 로고
    • A and B forms of the androgen receptor are present in human genital skin fibroblasts
    • C.M. Wilson, and M.J. McPhaul A and B forms of the androgen receptor are present in human genital skin fibroblasts Proc Natl Acad Sci U S A 91 1994 1234 1238
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 1234-1238
    • Wilson, C.M.1    McPhaul, M.J.2
  • 203
    • 33845580082 scopus 로고    scopus 로고
    • Antiandrogens in the treatment of prostate cancer
    • M.P. Wirth, O.W. Hakenberg, and M. Froehner Antiandrogens in the treatment of prostate cancer Eur Urol 51 2007 306 313
    • (2007) Eur Urol , vol.51 , pp. 306-313
    • Wirth, M.P.1    Hakenberg, O.W.2    Froehner, M.3
  • 205
    • 84858228703 scopus 로고    scopus 로고
    • Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: Effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys
    • M. Yamaoka, T. Hara, T. Hitaka, T. Kaku, T. Takeuchi, and J. Takahashi Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: Effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys J Steroid Biochem Mol Biol 129 2012 115 128
    • (2012) J Steroid Biochem Mol Biol , vol.129 , pp. 115-128
    • Yamaoka, M.1    Hara, T.2    Hitaka, T.3    Kaku, T.4    Takeuchi, T.5    Takahashi, J.6
  • 206
    • 48549086542 scopus 로고    scopus 로고
    • Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression
    • J. Yan, H. Erdem, Y. Cai, G. Ayala, M. Ittmann, and L. Yu-Lee Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression Cancer Res 68 2008 5460 5468
    • (2008) Cancer Res , vol.68 , pp. 5460-5468
    • Yan, J.1    Erdem, H.2    Cai, Y.3    Ayala, G.4    Ittmann, M.5    Yu-Lee, L.6
  • 207
    • 80053923164 scopus 로고    scopus 로고
    • Novel membrane-associated androgen receptor splice variant potentiates proliferative and survival responses in prostate cancer cells
    • X. Yang, Z. Guo, F. Sun, W. Li, A. Alfano, and H. Shimelis Novel membrane-associated androgen receptor splice variant potentiates proliferative and survival responses in prostate cancer cells J Biol Chem 286 2011 36152 36160
    • (2011) J Biol Chem , vol.286 , pp. 36152-36160
    • Yang, X.1    Guo, Z.2    Sun, F.3    Li, W.4    Alfano, A.5    Shimelis, H.6
  • 208
    • 58249103866 scopus 로고    scopus 로고
    • Aberrant activation of androgen receptor in a new neuropeptide-autocrine model of androgen-insensitive prostate cancer
    • J.C. Yang, J.H. Ok, J.E. Busby, A.D. Borowsky, H.J. Kung, and C.P. Evans Aberrant activation of androgen receptor in a new neuropeptide-autocrine model of androgen-insensitive prostate cancer Cancer Res 69 2009 151 160
    • (2009) Cancer Res , vol.69 , pp. 151-160
    • Yang, J.C.1    Ok, J.H.2    Busby, J.E.3    Borowsky, A.D.4    Kung, H.J.5    Evans, C.P.6
  • 209
    • 0029951486 scopus 로고    scopus 로고
    • Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells
    • S. Yeh, and C. Chang Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells Proc Natl Acad Sci U S A 93 1996 5517 5521
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 5517-5521
    • Yeh, S.1    Chang, C.2
  • 210
    • 27544485276 scopus 로고    scopus 로고
    • Antiandrogen bicalutamide promotes tumor growth in a novel androgen-dependent prostate cancer xenograft model derived from a bicalutamide-treated patient
    • T. Yoshida, H. Kinoshita, T. Segawa, E. Nakamura, T. Inoue, and Y. Shimizu Antiandrogen bicalutamide promotes tumor growth in a novel androgen-dependent prostate cancer xenograft model derived from a bicalutamide-treated patient Cancer Res 65 2005 9611 9666
    • (2005) Cancer Res , vol.65 , pp. 9611-9666
    • Yoshida, T.1    Kinoshita, H.2    Segawa, T.3    Nakamura, E.4    Inoue, T.5    Shimizu, Y.6
  • 211
    • 56649091295 scopus 로고    scopus 로고
    • Absence of TMPRSS2:ERG fusions and PTEN losses in prostate cancer is associated with a favorable outcome
    • M. Yoshimoto, A.M. Joshua, I.W. Cunha, R.A. Coudry, F.P. Fonseca, and O. Ludkovski Absence of TMPRSS2:ERG fusions and PTEN losses in prostate cancer is associated with a favorable outcome Mod Pathol 21 2008 1451 1460
    • (2008) Mod Pathol , vol.21 , pp. 1451-1460
    • Yoshimoto, M.1    Joshua, A.M.2    Cunha, I.W.3    Coudry, R.A.4    Fonseca, F.P.5    Ludkovski, O.6
  • 212
    • 69449084106 scopus 로고    scopus 로고
    • The diverse and contrasting effects of using human prostate cancer cell lines to study androgen receptor roles in prostate cancer
    • S.Q. Yu, K.P. Lai, S.J. Xia, H.C. Chang, C. Chang, and S. Yeh The diverse and contrasting effects of using human prostate cancer cell lines to study androgen receptor roles in prostate cancer Asian J Androl 11 2009 39 48
    • (2009) Asian J Androl , vol.11 , pp. 39-48
    • Yu, S.Q.1    Lai, K.P.2    Xia, S.J.3    Chang, H.C.4    Chang, C.5    Yeh, S.6
  • 213
    • 77952103123 scopus 로고    scopus 로고
    • An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression
    • J. Yu, J. Yu, R.S. Mani, Q. Cao, C.J. Brenner, and X. Cao An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression Cancer Cell 17 2010 443 454
    • (2010) Cancer Cell , vol.17 , pp. 443-454
    • Yu, J.1    Yu, J.2    Mani, R.S.3    Cao, Q.4    Brenner, C.J.5    Cao, X.6
  • 214
    • 0036170838 scopus 로고    scopus 로고
    • Disruption of androgen receptor function inhibits proliferation of androgen-refractory prostate cancer cells
    • O.L. Zegarra-Moro, L.J. Schmidt, H. Huang, and D.J. Tindall Disruption of androgen receptor function inhibits proliferation of androgen-refractory prostate cancer cells Cancer Res 62 2002 1008 1013
    • (2002) Cancer Res , vol.62 , pp. 1008-1013
    • Zegarra-Moro, O.L.1    Schmidt, L.J.2    Huang, H.3    Tindall, D.J.4
  • 215
    • 81255150464 scopus 로고    scopus 로고
    • Androgen receptor variants occur frequently in castration resistant prostate cancer metastases
    • X. Zhang, C. Morrissey, S. Sun, M. Ketchandji, P.S. Nelson, and L.D. True Androgen receptor variants occur frequently in castration resistant prostate cancer metastases PLoS One 6 2011 e27970
    • (2011) PLoS One , vol.6 , pp. 27970
    • Zhang, X.1    Morrissey, C.2    Sun, S.3    Ketchandji, M.4    Nelson, P.S.5    True, L.D.6
  • 216
    • 77956245786 scopus 로고    scopus 로고
    • Detection of TMPRSS2 gene deletions and translocations in carcinoma, intraepithelial neoplasia, and normal epithelium of the prostate by direct fluorescence in situ hybridization
    • S. Zhang, B. Pavlovitz, J. Tull, Y. Wang, F.M. Deng, and C. Fuller Detection of TMPRSS2 gene deletions and translocations in carcinoma, intraepithelial neoplasia, and normal epithelium of the prostate by direct fluorescence in situ hybridization Diagn Mol Pathol 19 2010 151 156
    • (2010) Diagn Mol Pathol , vol.19 , pp. 151-156
    • Zhang, S.1    Pavlovitz, B.2    Tull, J.3    Wang, Y.4    Deng, F.M.5    Fuller, C.6
  • 217
    • 24744440805 scopus 로고    scopus 로고
    • SRC-3 is required for prostate cancer cell proliferation and survival
    • H.J. Zhou, J. Yan, W. Luo, G. Ayala, S.H. Lin, and H. Erdem SRC-3 is required for prostate cancer cell proliferation and survival Cancer Res 65 2005 7976 7983
    • (2005) Cancer Res , vol.65 , pp. 7976-7983
    • Zhou, H.J.1    Yan, J.2    Luo, W.3    Ayala, G.4    Lin, S.H.5    Erdem, H.6
  • 218
    • 78049294167 scopus 로고    scopus 로고
    • Tubulin-targeting chemotherapy impairs androgen receptor activity in prostate cancer
    • M.L. Zhu, C.M. Horbinski, M. Garzotto, D.Z. Qian, T.M. Beer, and N. Kyprianou Tubulin-targeting chemotherapy impairs androgen receptor activity in prostate cancer Cancer Res 70 2010 7992 8002
    • (2010) Cancer Res , vol.70 , pp. 7992-8002
    • Zhu, M.L.1    Horbinski, C.M.2    Garzotto, M.3    Qian, D.Z.4    Beer, T.M.5    Kyprianou, N.6
  • 219
    • 58249122148 scopus 로고    scopus 로고
    • Androgen receptor and growth factor signaling cross-talk in prostate cancer cells
    • M.L. Zhu, and N. Kyprianou Androgen receptor and growth factor signaling cross-talk in prostate cancer cells Endocr Relat Cancer 15 2008 841 849
    • (2008) Endocr Relat Cancer , vol.15 , pp. 841-849
    • Zhu, M.L.1    Kyprianou, N.2
  • 220
    • 0030934512 scopus 로고    scopus 로고
    • The effect of androgen deprivation and radiation therapy on an androgen-sensitive murine tumor: An in vitro and in vivo study
    • A.L. Zietman, B.M. Nakfoor, E.A. Prince, and L.E. Gerweck The effect of androgen deprivation and radiation therapy on an androgen-sensitive murine tumor: An in vitro and in vivo study Cancer J Sci Am 3 1997 31 36
    • (1997) Cancer J Sci Am , vol.3 , pp. 31-36
    • Zietman, A.L.1    Nakfoor, B.M.2    Prince, E.A.3    Gerweck, L.E.4
  • 221
    • 0030944552 scopus 로고    scopus 로고
    • Neoadjuvant androgen suppression with radiation in the management of locally advanced adenocarcinoma of the prostate: Experimental and clinical results
    • A.L. Zietman, E.A. Prince, B.M. Nakfoor, and W.U. Shipley Neoadjuvant androgen suppression with radiation in the management of locally advanced adenocarcinoma of the prostate: Experimental and clinical results Urol J 49 1997 74 83
    • (1997) Urol J , vol.49 , pp. 74-83
    • Zietman, A.L.1    Prince, E.A.2    Nakfoor, B.M.3    Shipley, W.U.4
  • 222
    • 68149159298 scopus 로고    scopus 로고
    • ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells
    • Y. Zong, L. Xin, A.S. Goldstein, D.A. Lawson, M.A. Teitell, and O.N. Witte ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells Proc Natl Acad Sci U S A 106 2009 12465 12470
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 12465-12470
    • Zong, Y.1    Xin, L.2    Goldstein, A.S.3    Lawson, D.A.4    Teitell, M.A.5    Witte, O.N.6
  • 223
    • 33749042584 scopus 로고    scopus 로고
    • ACTR/AIB1/SRC-3 and androgen receptor control prostate cancer cell proliferation and tumor growth through direct control of cell cycle genes
    • J.X. Zou, Z. Zhong, X.B. Shi, C.G. Tepper, R.W. deVere White, and H.J. Kung ACTR/AIB1/SRC-3 and androgen receptor control prostate cancer cell proliferation and tumor growth through direct control of cell cycle genes Prostate 66 2006 1474 1486
    • (2006) Prostate , vol.66 , pp. 1474-1486
    • Zou, J.X.1    Zhong, Z.2    Shi, X.B.3    Tepper, C.G.4    Devere White, R.W.5    Kung, H.J.6


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