-
2
-
-
4043181214
-
Cancer genes and the pathways they control
-
Vogelstein B, Kinzler KW (2004) Cancer genes and the pathways they control. Nat Med 10:789-799.
-
(2004)
Nat Med
, vol.10
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
3
-
-
0034307013
-
Molecular genetics of prostate cancer
-
Abate-Shen C, Shen MM (2000) Molecular genetics of prostate cancer. Genes Dev 14:2410-2434.
-
(2000)
Genes Dev
, vol.14
, pp. 2410-2434
-
-
Abate-Shen, C.1
Shen, M.M.2
-
4
-
-
0030658039
-
Oncogenic transcription factors in the human acute leukemias
-
Look AT (1997) Oncogenic transcription factors in the human acute leukemias. Science 278:1059-1064.
-
(1997)
Science
, vol.278
, pp. 1059-1064
-
-
Look, A.T.1
-
5
-
-
33750378672
-
Evidence of recurrent gene fusions in common epithelial tumors
-
Kumar-Sinha C, Tomlins SA, Chinnaiyan AM (2006) Evidence of recurrent gene fusions in common epithelial tumors. Trends Mol Med 12:529-536.
-
(2006)
Trends Mol Med
, vol.12
, pp. 529-536
-
-
Kumar-Sinha, C.1
Tomlins, S.A.2
Chinnaiyan, A.M.3
-
6
-
-
27344451557
-
Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
-
Tomlins SA, et al. (2005) Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 310:644-648.
-
(2005)
Science
, vol.310
, pp. 644-648
-
-
Tomlins, S.A.1
-
7
-
-
33645750799
-
TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer
-
Tomlins SA, et al. (2006) TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer. Cancer Res 66:3396-3400.
-
(2006)
Cancer Res
, vol.66
, pp. 3396-3400
-
-
Tomlins, S.A.1
-
8
-
-
34547642493
-
Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer
-
Tomlins SA, et al. (2007) Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer. Nature 448:595-599.
-
(2007)
Nature
, vol.448
, pp. 595-599
-
-
Tomlins, S.A.1
-
9
-
-
39049170313
-
Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer
-
Helgeson BE, et al. (2008) Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer. Cancer Res 68:73-80.
-
(2008)
Cancer Res
, vol.68
, pp. 73-80
-
-
Helgeson, B.E.1
-
10
-
-
33845329915
-
TMPRSS2:ERG fusion by translocation or interstitial deletion is highly relevant in androgen-dependent prostate cancer, but is bypassed in late-stage androgen receptor-negative prostate cancer
-
Hermans KG, et al. (2006) TMPRSS2:ERG fusion by translocation or interstitial deletion is highly relevant in androgen-dependent prostate cancer, but is bypassed in late-stage androgen receptor-negative prostate cancer. Cancer Res 66:10658-10663.
-
(2006)
Cancer Res
, vol.66
, pp. 10658-10663
-
-
Hermans, K.G.1
-
12
-
-
33749029695
-
TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer
-
Perner S, et al. (2006) TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer. Cancer Res 66:8337-8341.
-
(2006)
Cancer Res
, vol.66
, pp. 8337-8341
-
-
Perner, S.1
-
13
-
-
41149097040
-
Acausal role for ERG in neoplastic transformation of prostate epithelium
-
Klezovitch O, et al. (2008) Acausal role for ERG in neoplastic transformation of prostate epithelium. Proc Natl Acad Sci USA 105:2105-2110.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 2105-2110
-
-
Klezovitch, O.1
-
14
-
-
0034520311
-
A small composite probasin promoter confers high levels of prostate-specific gene expression through regulation by androgens and glucocorticoids in vitro and in vivo
-
Zhang J, Thomas TZ, Kasper S, Matusik RJ (2000) A small composite probasin promoter confers high levels of prostate-specific gene expression through regulation by androgens and glucocorticoids in vitro and in vivo. Endocrinology 141:4698-4710.
-
(2000)
Endocrinology
, vol.141
, pp. 4698-4710
-
-
Zhang, J.1
Thomas, T.Z.2
Kasper, S.3
Matusik, R.J.4
-
15
-
-
0035113825
-
Generation of a prostate epithelial cell-specific Cre transgenic mouse model for tissue-specific gene ablation
-
Wu X, et al. (2001) Generation of a prostate epithelial cell-specific Cre transgenic mouse model for tissue-specific gene ablation. Mech Dev 101:61-69.
-
(2001)
Mech Dev
, vol.101
, pp. 61-69
-
-
Wu, X.1
-
16
-
-
39049150843
-
Role of the TMPRSS2-ERG gene fusion in prostate cancer
-
Tomlins SA, et al. (2008) Role of the TMPRSS2-ERG gene fusion in prostate cancer. Neoplasia 10:177-188.
-
(2008)
Neoplasia
, vol.10
, pp. 177-188
-
-
Tomlins, S.A.1
-
17
-
-
60149091983
-
ETS rearrangements and prostate cancer initiation
-
discussion E2-3
-
Carver BS, et al. (2009) ETS rearrangements and prostate cancer initiation. Nature 457:E1; discussion E2-3.
-
(2009)
Nature
, vol.457
-
-
Carver, B.S.1
-
18
-
-
66749100105
-
Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis
-
King JC, et al. (2009) Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis. Nat Genet 41:524-526.
-
(2009)
Nat Genet
, vol.41
, pp. 524-526
-
-
King, J.C.1
-
19
-
-
0141483063
-
In vivo regeneration of murine prostate from dissociated cell populations of postnatal epithelia and urogenital sinus mesenchyme
-
Xin L, Ide H, Kim Y, Dubey P, Witte ON (2003) In vivo regeneration of murine prostate from dissociated cell populations of postnatal epithelia and urogenital sinus mesenchyme. Proc Natl Acad Sci USA 100(Suppl 1):11896-11903.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, Issue.SUPPL. 1
, pp. 11896-11903
-
-
Xin, L.1
Ide, H.2
Kim, Y.3
Dubey, P.4
Witte, O.N.5
-
20
-
-
34248569769
-
Morphological features of TMPRSS2-ERG gene fusion prostate cancer
-
Mosquera JM, et al. (2007) Morphological features of TMPRSS2-ERG gene fusion prostate cancer. J Pathol 212:91-101.
-
(2007)
J Pathol
, vol.212
, pp. 91-101
-
-
Mosquera, J.M.1
-
21
-
-
30144432901
-
Purification and unique properties of mammary epithelial stem cells
-
Stingl J, et al. (2006) Purification and unique properties of mammary epithelial stem cells. Nature 439:993-997.
-
(2006)
Nature
, vol.439
, pp. 993-997
-
-
Stingl, J.1
-
22
-
-
33846065145
-
Isolation and functional characterization of murine prostate stem cells
-
Lawson DA, Xin L, Lukacs RU, Cheng D, Witte ON (2007) Isolation and functional characterization of murine prostate stem cells. Proc Natl Acad Sci USA 104:181-186.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 181-186
-
-
Lawson, D.A.1
Xin, L.2
Lukacs, R.U.3
Cheng, D.4
Witte, O.N.5
-
23
-
-
51649115957
-
TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation
-
Sun C, et al. (2008) TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation. Oncogene 27:5348-5353.
-
(2008)
Oncogene
, vol.27
, pp. 5348-5353
-
-
Sun, C.1
-
24
-
-
0035907282
-
Identification of amino acid residues in the ETS transcription factor Erg that mediate Erg-Jun/Fos-DNA ternary complex formation
-
Verger A, et al. (2001) Identification of amino acid residues in the ETS transcription factor Erg that mediate Erg-Jun/Fos-DNA ternary complex formation. J Biol Chem 276:17181-17189.
-
(2001)
J Biol Chem
, vol.276
, pp. 17181-17189
-
-
Verger, A.1
-
25
-
-
1542707081
-
Alterations of p53 are common in early stage prostate cancer
-
Downing SR, Russell PJ, Jackson P (2003) Alterations of p53 are common in early stage prostate cancer. Can J Urol 10:1924-1933.
-
(2003)
Can J Urol
, vol.10
, pp. 1924-1933
-
-
Downing, S.R.1
Russell, P.J.2
Jackson, P.3
-
26
-
-
23244460597
-
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
-
Chen Z, et al. (2005) Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436:725-730.
-
(2005)
Nature
, vol.436
, pp. 725-730
-
-
Chen, Z.1
-
27
-
-
33748078111
-
Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer
-
Zhou Z, et al. (2006) Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer. Cancer Res 66:7889-7898.
-
(2006)
Cancer Res
, vol.66
, pp. 7889-7898
-
-
Zhou, Z.1
-
28
-
-
19244379792
-
Human papilloma virus 16 E7 oncogene does not cooperate with RET/PTC 3 oncogene in the neoplastic transformation of thyroid cells in transgenic mice
-
Portella G, et al. (2001) Human papilloma virus 16 E7 oncogene does not cooperate with RET/PTC 3 oncogene in the neoplastic transformation of thyroid cells in transgenic mice. Oncol Res 12:347-354.
-
(2001)
Oncol Res
, vol.12
, pp. 347-354
-
-
Portella, G.1
-
29
-
-
33747842237
-
Interphase FISH analysis of PTEN in histologic sections shows genomic deletions in 68% of primary prostate cancer and 23% of high-grade prostatic intra-epithelial neoplasias
-
Yoshimoto M, et al. (2006) Interphase FISH analysis of PTEN in histologic sections shows genomic deletions in 68% of primary prostate cancer and 23% of high-grade prostatic intra-epithelial neoplasias. Cancer Genet Cytogenet 169:128-137.
-
(2006)
Cancer Genet Cytogenet
, vol.169
, pp. 128-137
-
-
Yoshimoto, M.1
-
30
-
-
18744377702
-
The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis
-
Xin L, Lawson DA, Witte ON (2005) The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis. Proc Natl Acad Sci USA 102:6942-6947.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 6942-6947
-
-
Xin, L.1
Lawson, D.A.2
Witte, O.N.3
-
31
-
-
33646739524
-
Progression of prostate cancer by synergy of AKT with genotropic and nongenotropic actions of the androgen receptor
-
Xin L, et al. (2006) Progression of prostate cancer by synergy of AKT with genotropic and nongenotropic actions of the androgen receptor. Proc Natl Acad Sci USA 103:7789 -7794.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 7789-7794
-
-
Xin, L.1
-
32
-
-
0038271762
-
Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: The MPAKT model
-
Majumder PK, et al. (2003) Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: The MPAKT model. Proc Natl Acad Sci USA 100:7841-7846.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 7841-7846
-
-
Majumder, P.K.1
-
33
-
-
10744222860
-
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
-
Wang S, et al. (2003) Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell 4:209-221.
-
(2003)
Cancer Cell
, vol.4
, pp. 209-221
-
-
Wang, S.1
-
34
-
-
30044448659
-
Breaking the rules of cancer
-
Shaffer DR, Pandolfi PP (2006) Breaking the rules of cancer. Nat Med 12:14-15.
-
(2006)
Nat Med
, vol.12
, pp. 14-15
-
-
Shaffer, D.R.1
Pandolfi, P.P.2
-
35
-
-
1842612441
-
Molecular determinants of resistance to antiandrogen therapy
-
Chen CD, et al. (2004) Molecular determinants of resistance to antiandrogen therapy. Nat Med 10:33-39.
-
(2004)
Nat Med
, vol.10
, pp. 33-39
-
-
Chen, C.D.1
-
37
-
-
0035392953
-
Conversion from a paracrine to an autocrine mechanism of androgen-stimulated growth during malignant transformation of prostatic epithelial cells
-
Gao J, Arnold JT, Isaacs JT (2001) Conversion from a paracrine to an autocrine mechanism of androgen-stimulated growth during malignant transformation of prostatic epithelial cells. Cancer Res 61:5038-5044.
-
(2001)
Cancer Res
, vol.61
, pp. 5038-5044
-
-
Gao, J.1
Arnold, J.T.2
Isaacs, J.T.3
-
38
-
-
59749095425
-
Pleiotropic functional properties of androgen receptor mutants in prostate cancer
-
Bergerat JP, Ceraline J (2009) Pleiotropic functional properties of androgen receptor mutants in prostate cancer. Hum Mutat 30:145-157.
-
(2009)
Hum Mutat
, vol.30
, pp. 145-157
-
-
Bergerat, J.P.1
Ceraline, J.2
-
39
-
-
0032493377
-
Retroviral transduction of TLS-ERG initiates a leukemogenic program in normal human hematopoietic cells
-
Pereira DS, et al. (1998) Retroviral transduction of TLS-ERG initiates a leukemogenic program in normal human hematopoietic cells. Proc Natl Acad Sci USA 95:8239-8244.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 8239-8244
-
-
Pereira, D.S.1
-
40
-
-
12844274300
-
Mutation of the androgen receptor causes oncogenic transformation of the prostate
-
Han G, et al. (2005) Mutation of the androgen receptor causes oncogenic transformation of the prostate. Proc Natl Acad Sci USA 102:1151-1156.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 1151-1156
-
-
Han, G.1
-
41
-
-
34547116209
-
c-Jun has multiple enhancing activities in the novel cross talk between the androgen receptor and Ets variant gene 1 in prostate cancer
-
Cai C, Hsieh CL, Shemshedini L (2007) c-Jun has multiple enhancing activities in the novel cross talk between the androgen receptor and Ets variant gene 1 in prostate cancer. Mol Cancer Res 5:725-735.
-
(2007)
Mol Cancer Res
, vol.5
, pp. 725-735
-
-
Cai, C.1
Hsieh, C.L.2
Shemshedini, L.3
-
42
-
-
39149123820
-
A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity
-
Garlich JR, et al. (2008) A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity. Cancer Res 68:206-215.
-
(2008)
Cancer Res
, vol.68
, pp. 206-215
-
-
Garlich, J.R.1
-
43
-
-
51049109033
-
Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
-
Maira SM, et al. (2008) Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther 7:1851-1863.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 1851-1863
-
-
Maira, S.M.1
-
44
-
-
51449087794
-
Targeting the androgen receptor pathway in prostate cancer
-
Chen Y, Sawyers CL, Scher HI (2008) Targeting the androgen receptor pathway in prostate cancer. Curr Opin Pharmacol 8:440-448.
-
(2008)
Curr Opin Pharmacol
, vol.8
, pp. 440-448
-
-
Chen, Y.1
Sawyers, C.L.2
Scher, H.I.3
-
45
-
-
36649036989
-
Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor
-
Memarzadeh S, et al. (2007) Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor. Cancer Cell 12:572-585.
-
(2007)
Cancer Cell
, vol.12
, pp. 572-585
-
-
Memarzadeh, S.1
|