Broadened ligand responsiveness of androgen receptor mutants obtained by random amino acid substitution of H874 and mutation hot spot T877 in prostate cancer

International Journal of Cancer

Volumn 100, Issue 3, 2002, Pages 309-317

  Steketee, Karine ^a   Timmerman, Leon ^a   Ziel Van Der Made, Angelique C J ^a   Doesburg, Paul ^a   Brinkmann, Albert O ^b   Trapman, Jan ^a  

^a JOSEPHINE NEFKENS INSTITUTE   (Netherlands)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

Androgen receptor; Codon 874; Codon 877; Glucocorticoid; Prostate cancer; Random mutagenesis

Indexed keywords

AMINO ACID; ANDROGEN; ANDROGEN RECEPTOR; ANDROSTANOLONE; PRASTERONE; PROGESTERONE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CODON; CONFORMATION; GENE MUTATION; HORMONAL THERAPY; HUMAN; HUMAN CELL; LIGAND BINDING; MALE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DOMAIN; PROTEIN STRUCTURE; RECEPTOR BINDING; THREE DIMENSIONAL IMAGING;

ANDROGENS; BINDING SITES; CODON; GLUCOCORTICOIDS; HUMANS; LIGANDS; MALE; MUTATION; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; TRANSCRIPTION, GENETIC;

EID: 0037143096     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.10495     Document Type: Article

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