The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1

Molecular and Cellular Biology

Volumn 19, Issue 12, 1999, Pages 8383-8392

  Bevan, Charlotte L ^a,c   Hoare, Sue ^a   Claessens, Frank ^b   Heery, David M ^a,d   Parker, Malcolm G ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

^d UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ESTROGEN RECEPTOR; STEROID RECEPTOR COACTIVATOR 1;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE DELETION; HUMAN; HUMAN CELL; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN STRUCTURE;

ANIMALIA;

EID: 0033512783     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.12.8383     Document Type: Article

References (84)

1. Alen, P., F. Claessens, E. Schoenmakers, J. V. Swinnen, G. Verhoeven, W. Rombauts, and B. Peelers. 1999. Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1a with multiple steroid receptors and identification of an internally deleted ELE1β isoform. Mol. Endocrinol. 13:117-128.
2. Anzick, S. L., J. Kononen, R. L. Walker, D. O. Azorsa, M. M. Tanner, X.-Y. Guan, G. Sauter, O.-P. Kallioniemi, J. M. Trent, and P. S. Meltzer. 1997. A1B1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science 277:965-968.
3. Baniahmad, A., I. Ha, D. Reinberg, S. Tsai, M.-J. Tsai, and B. W. O'Malley. 1993. Interaction of human thyroid hormone receptor β with transcription factor TFIIB may mediate target gene derepression and activation by thyroid hormone. Proc. Natl. Acad. Sci. USA 90:8832-8836.
4. Bannister, A. J., and T. Kouzarides. 1996. The CBP co-activator is a histone acetyltransferase. Nature 1996:641-643.
5. Barettino, D., M. Vivanca Ruiz, and H. Stunnenburg. 1994. Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor. EMBO J. 13:3039-3049.
6. Beato, M., P. Herrlich, and G. Schutz. 1995. Steroid hormone receptors - many actors in search of a plot. Cell 83:851-857.
7. Berrevoets, C. A., P. Doesburg, K. Sketetee, J. Trapman, and A. O. Brinkmann. 1998. Functional interactions of the AF-2 domain core region of the human androgen receptor with the amino-terminal domain and with the transcriptional coactivator TIF-2 (transcriptional intermediary factor-2). Mol. Endocrinol. 12:1172-1183.
8. Brinkmann, A. O., P. W. Faber, H. C. J. van Rooij, G. G. J. M. Kuiper, C. Ris, P. Klaasen, J. A. G. M. van der Korput, M. M. Voorhorst, J. H. van Laar, E. Mulder, and J. Trapman. 1989. The human androgen receptor: domain structure, genomic organisation and regulation of expression. J. Steroid Biochem. 34:307-310.
9. Brou, C., S. Chaudhary, I. Davidson, Y. Lutz, J. Wu, J.-M. Egly, L. Tora, and P. Chambon. 1993. Distinct TFIID complexes mediate the effect of different transcriptional activators. EMBO J. 12:489-499.
10. Brou, C., J. Wu, S. Ali, E. Scheer, C. Lang, I. Davidson, P. Chambon, and L. Tora. 1993. Different TBP-associated factors are required for mediating the stimulation of transcription in vitro by the acidic transactivator GAL-VP16 and the two nonacidic activation functions of the estrogen receptor. Nucleic Acids Res. 21:5-12.
11. Buchert, M., S. Schneider, M. T. Adams, H. Hefti, K. Moelling, and C. M. Hovens. 1997. Useful vectors for the two-hybrid system in mammalian cells. BioTechniques 23:396-402.
12. Cavailles, V., S. Dauvois, F. L'Horset, G. Lopez, S. Hoare, P. J. Kushner, and M. G. Parker. 1995. Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. EMBO J. 14:3741-3751.
13. Chen, C., and H. Okayama. 1987. High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7:2745-2752.
14. Chen, H., R. J. Lin, R. L. Schiltz, D. Chakravarti, A. Nash, L. Nagy, M. L. Privalsky, Y. Nakatani, and R. M. Evans. 1997. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with p/CAF and CBP/p300. Cell 90:569-580.
15. Danielian, P. S., R. White, J. A. Lees, and M. G. Parker. 1992. Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors. EMBO J. 11:1025-1033.
16. Darimont, B. D., R. L. Wagner, J. W. Apriletti, M. R. Stallcup, P. J. Kushner, J. D. Baxter, R. J. Flelterick, and K. R. Yamamoto. 1998. Structure and specificity of nuclear receptor-coactivator interactions. Genes Dev. 12:3343-3356.
17. Dodou, E., and R. Treisman. 1997. The Saccharomyces cerevisiae MADS-box transcription factor Rlm1 is a target for the Mpk1 mitogen-activated protein kinase pathway. Mol. Cell. Biol. 17:1848-1859.
18. Doesburg, P., C. W. Kuil, C. A. Berrevoets, K. Steketee, P. W. Faber, E. Mulder, A. O. Brinkmann, and J. Trapman. 1997. Functional in vivo interaction between the amino-terminal, transactivating domain and the ligand binding domain of the androgen receptor. Biochemistry 36:1052-1064.
19. Durand, B., M. Saunders, C. Gaudon, B. Roy, R. Losson, and P. Chambon. 1994. Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity. EMBO J. 13:5370-5382.
20. Folkers, G. E., and P. T. van der Saag. 1995. Adenovirus E1A functions as a cofactor for retinoic acid receptor β (RARβ) through direct interaction with RARβ Mol. Cell. Biol. 15:5868-5878.
21. Freedman, L. P. 1999. Increasing the complexity of coactivation in nuclear receptor signaling. Cell 97:5-8.
22. Fronsdal, K., N. Engedal, T. Slagsvold, and F. Saatcioglu. 1998. CREB binding protein is a coactivator for the androgen receptor and mediates cross-talk with AP-1. J. Biol. Chem. 273:31853-31859.
23. Glass, C., D. W. Rose, and M. G. Rosenfeld. 1997. Nuclear receptor coactivators. Curr. Opin. Cell Biol. 9:222-232.
24. Glynne, R., L. A. Kerr, I. Mockridge, S. Beck, A. Kelly, and J. Trowsdale. 1993. The major histocompatibility complex-encoded proteosome component LMP7: alternative first exons and post-translational processing. Eur. J. Immunol. 23:860-866.
25. Heery, D. M. Unpublished data.
26. Heery, D. M., E. Kalkhoven, S. Hoare, and M. G. Parker. 1997. A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 387:733-736.
27. Heery, D. M., T. Zacharewski, B. Pierrat, H. Gronemeyer, P. Chambon, and R. Losson. 1993. Efficient transactivation by retinoic acid receptors in yeast requires retinoid X receptors. Proc. Natl. Acad. Sci. USA 90:4281-4285.
28. Henttu, P. M., E. Kalkhoven, and M. G. Parker. 1997. AF-2 activity and recruitment of steroid receptor coactivator-1 to the estrogen receptor depend on a lysine residue conserved in nuclear receptors. Mol. Cell. Biol. 17: 1832-1839.
29. Higuchi, R. 1990. Recombinant PCR, p. 177-183. In M. Innis, D. Gelfand, J. Sninsky, and T. White (ed.), PCR protocols: a guide to methods and applications. Academic Press Ltd.. London, United Kingdom.
30. Hong, H., K. Kohli, A. Trivedi, D. L. Johnson, and M. R. Stallcup. 1996. GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors. Proc. Natl. Acad. Sci. USA 93:4948-4952.
31. Ikonen, T., J. J. Palvimo, and O. A. Janne. 1998. Heterodimerization is mainly responsible for the dominant negative activity of amino-terminally truncated rat androgen receptor forms. FEBS Lett. 430:393-396.
32. Ikonen, T., J. J. Palvimo, and O. A. Janne. 1997. Interaction between the amino- and carboxyl-terminal regions of the rat androgen receptor modulates transcriplional activity and is influenced by nuclear receptor coactivators. J. Biol. Chem. 272:29821-29828.
33. Ing, N., J. M. Beekman, S. Y. Tsai, M.-J. Tsai, and B. O'Malley. 1992. Members of the steroid hormone superfamily interact with TFIIB (S300-II). J. Biol. Chem. 267:17617-17623.
34. Ito, M., C.-X. Yuan, S. Malik, W. Gu, J. D. Fondell, S. Yamamura, Z.-Y. Fu, X. Zhang, J. Qin, and R. G. Roeder. 1999. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. Mol. Cell 3:361-370.
35. Jenster, G., H. van der Korput, J. Trapman, and A. O. Brinkmann. 1995. Identification of two transcription activation units in the N-terminal domain of the human androgen receptor. J. Biol. Chem. 270:7341-7346.
36. Jenster, G., H. A. G. M. van der Korput, C. van Vroonhoven, T. H. van der Kwast, J. Trapman, and A. O. Brinkmann. 1991. Domains of the human androgen receptor involved in steroid binding, transcriptional activation, and subcellular localization. Mol. Endocrinol. 5:1396-1404.
37. Kaiser, C., S. Michaelis, and A. Mitchell. 1994. Methods in yeast genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
38. Kalkhoven, E., J. E. Valentine, D. M. Heery, and M. G. Parker. 1998. Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor. EMBO J. 17:232-243.
39. Karvonen, U., P. J. Kallio, O. A. Janne, and J. J. Palvimo. 1997. Interaction of androgen receptors with androgen response element in intact cells. Roles of amino- and carboxyl-terminal regions and the ligand. J. Biol. Chem. 272: 15973-15979.
40. Langley, E., J. A. Kemppainen, and E. M. Wilson. 1998. Intermolecular NH2-/carboxy-terminal interactions in androgen receptor dimerization revealed by mutations that cause androgen insensitivity. J. Biol. Chem. 273: 92-101.
41. Langley, E., Z.-X. Zhou, and E. M. Wilson. 1995. Evidence for anti-parallel orientation of the ligand-activated human androgen receptor dimer. J. Biol. Chem. 270:29983-29990.
42. Lanz, R. B., N. J. McKenna, S. Onate, U. Albrecht, J. Wong, S. Y. Tsai, M.-J. Tsai, and B. W. O'Malley. 1999. A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex. Cell 97:17-27.
43. Le Douarin, B., B. Pierrat, E. vom Baur, P. Chambon, and R. Losson. 1995. A new version of the two-hybrid assay for detection of protein-protein interactions. Nucleic Acids Res. 23:875-878.
44. Li, H., P. J. Gomes, and J. D. Chen. 1997. RAC3, a steroid/nuclear receptor-associated protein that is related to SRC-1 and TIF-2. Proc. Natl. Acad. Sci. USA 94:8479-8484.
45. Mak, H. Y., S. Hoare, P. M. Henttu, and M. G. Parker. 1999. Molecular determinants of the estrogen receptor-coactivator interface. Mol. Cell. Biol. 19:3895-3903.
46. Mangelsdorf, D. J., C. Thummel, M. Beato, P. Herrlich, G. Schütz, K. Umesono, B. Blumberg, P. Kastner, M. Mark, P. Chambon, and R. M. Evans. 1995. The nuclear receptor superfamily: the second decade. Cell 83: 835-839.
47. McEwan, I. J., and J. Gustafsson. 1997. Interaction of the human androgen receptor transactivation function with the general transcription factor TFIIF. Proc. Natl. Acad. Sci. USA 94:8485-8490.
48. McInerney, E., M.-J. Tsai, B. O'Malley, and B. S. Katzenellenbogen. 1998. Analysis of estrogen receptor transcriptional enhancement by a nuclear hormone coactivator. Proc. Natl. Acad. Sci. USA 93:10069-10073.
49. Metzger, D., R. Losson, J.-M. Bornet, V. Lemoine, and P. Chambon. 1992. Promoter specificity of the two transcriptional activation functions of the human oestrogen receptor in yeast. Nucleic Acids Res. 20:2813-2817.
50. Moilanen, A., N. Rouleau, T. Ikonen, J. J. Palvimo, and O. A. Janne. 1998. The presence of a transcription activation function in the hormone-binding domain of androgen receptor is revealed by studies in yeast cells. FEBS Lett. 412:355-358.
51. Needham, M., et al. Unpublished observations.
52. Nolte, R. T., G. B. Wisely, S. Westin, J. E. Cobb, M. H. Lambert, R. Kurokawa, M. G. Rosenfeld, T. M. Willson, C. K. Glass, and M. V. Milburn. 1998. Ligand binding and co-activator assembly of the peroxisome proliferatoractivated receptor-gamma. Nature 395:137-143.
53. Ogryzko, V. V, R. L. Schiltz, V. Russanova, B. H. Howard, and V. Nakaiani. 1996. The transcriptional co-activator p300 and CBP are histone acetyltransferases. Cell 87:953-960.
54. Onate, S. A., V. Boonyaratanakornkit, T. E. Spencer, S. V. Tsai, M.-J. Tsai, D. P. Edwards, and B. W. O'Malley. 1998. The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooper-atively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors. J. Biol. Chem. 273:12101-12108.
55. Oñate, S. A., S. Y. Tsai, M.-J. Tsai, and B. W. O'Malley. 1995. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270:1354-1357.
56. Parker, M. G., and R. White. 1996. Nuclear receptors spring into action. Nat. Struct. Biol. 3:113-115.
57. Rachez, C., B. D. Lemon, Z. Suldan, V. Bromleigh, M. Gamble, A. M. Näär, H. Erdjument-Bromage, P. Tempst, and L. P. Freedman. 1999. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. Nature 398:824-828.
58. Rundlett, S. E., X.-P. Wu, and R. L. Miesfeld. 1990. Functional characterizations of the androgen receptor confirm that the molecular basis of androgen action is transcriptional regulation. Mol. Endocrinol. 4:708-714.
59. Scheller, A., E. Hughes, K. L. Golden, and D. Robins. 1998. Multiple receptor domains interact to permit, or restrict, androgen-specifk gene activation. J. Biol. Chem. 273:24216-24222.
60. Schule, R., M. Muller, C. Kaltschmidt, and R. Renkawitz. 1988. Many transcription factors interact synergistically with steroid receptors. Science 242:1418-1420.
61. Schulman, I. G., D. Chakravarti, H. Juguilon, A. Romo, and R. M. Evans. 1995. Interactions between the retinoid X receptor and a conserved region of the tata-binding protein mediate hormone-dependent transactivation. Proc. Natl. Acad. Sci. USA 92:8288-8292.
62. Shikama, N., J. Lyon, and N. B. La Thangue. 1997. The p300/CBP family: integrating signals with transcription factors and chromatin. Trends Cell Biol. 7:230-236.
63. Simental, J. A., M. Sar, M. V. Lane, F. S. French, and E. M. Wilson. 1991. Transcriptional activation and nuclear targeting signals of the human androgen receptor. J. Biol. Chem. 266:510-518.
64. Sleigh, M. J. 1986. A nonchromatographic assay for expression of the chloramphenicol acetyltransferase gene in eucaryotic cells. Anal. Biochem. 156: 251-256.
65. Spencer, T. E., G. Jenster, M. M. Burcin, C D. Allis, J. Zhou, C. A. Mizzen, N. J. McKenna, S. A. Onate, S. Y. Tsai, M. J. Tsai, and B. W. O'Malley. 1997. Steroid receptor coactivator-1 is a histone acetyltransferase. Nature 389: 194-198.
66. Takeshita, A., G. R. Cardona, N. Koibuchi, C. S. Suen, and W. W. Chin. 1997. TRAM-1, a novel 160-kDa thyroid hormone receptor activator molecule, exhibits properties distinct from steroid receptor co-activator-1. J. Biol. Chem. 272:27629-27634.
67. Tasset, D., L. Tora, C. Fromental, E. Scheer, and P. Chambon. 1990. Distinct classes of transcriptional activating domains function by different mechanisms. Cell 62:1177-1187.
68. Tone, Y., T. N. Collingwood, M. Adams, and V. K. Chatterjee. 1994. Functional analysis of a transactivation domain in the thyroid hormone receptor. J. Biol. Chem. 269:31157-31161.
69. Tora, L., J. White, C. Brou, D. Tasset, N. Webster, E. Scheer, and P. Chambon. 1989. The human estrogen receptor has two independent non-acidic transcriptional activation functions. Cell 59:477-497.
70. Torchia, J., C. Glass, and M. G. Rosenfeld. 1998. Co-activators and co-repressors in the integration of transcriptional responses. Curr. Opin. Cell Biol. 10:373-383.
71. Torchia, J., D. W. Rose, J. Inostroza, Y. Kmei, S. Westin, C. Glass, and M. Rosenfeld. 1997. The transcriptional coactivator p/CIP binds CBP and mediates nuclear-receptor function. Nature 382:677-684.
72. Tremblay, A., G. B. Tremblay, F. Labrie, and V. Giguere. 1999. Ligand-independent recruitment of SRC-1 to estrogen receptor β through phosphorylation of activation function AF-1. Mol. Cell 3:513-9.
73. Treuter, E., T. Albrektsen, L. Johansson, J. Leers, and J. A. Gustafsson. 1998. A regulatory role for RIP140 in nuclear receptor activation. Mol. Endocrinol. 12:864-881.
74. Voegel, J. J, M. J. S. Heine, M. Tini, V. Vivat, P. Chambon, and H. Gronemeyer. 1998. The co-activator TIF2 contains three nuclear receptor binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways. EMBO J. 17:507-519.
75. Voegel, J. J., M. J. S. Heine, C. Zechel, P. Chambon, and H. Gronemeyer. 1996. TIF2, a 160kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J. 15:101-108.
76. Vojtek, B. A., S. M. Hollenberg, and J. A. Cooper. 1993. Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74:205-214.
77. Webb, P., P. Nguyen, J. Shinsako, C. Anderson, W. Feng, M. P. Nguyen, D. Chen, S.-M. Huang, S. Subramanian, E. McKinerny, B. S. Katzenellenbogen, M. R. Stallcup, and P. J. Kushner. 1998. Estrogen receptor activation function 1 works by binding p160 proteins. Mol. Endocrinol. 12:1605-1618.
78. Webster, N. J. G., S. Green, D. Tasset, M. Ponglikitmongkol, and P. Chambon. 1988. The transcriptional activation function located in the hormone-binding domain of the human oestrogen receptor is not encoded in a single exon. EMBO J. 8:1441-1446.
79. White, R., M. Sjöberg, E. Kalkhoven, and M. G. Parker. 1997. Ligand-independent activation of the oestrogen receptor by mutation of a conserved tyrosine. EMBO J. 16:1427-1435.
80. Wurtz, J.-M., W. Bourguet, J.-P. Renaud, V. Vivat, P. Chambon, D. Moras, and H. Gronemeyer. 1996. A canonical structure for the ligand-binding domain of nuclear receptors. Nat. Struct. Biol. 3:87-94.
81. Yeh, S., H. Miyamoto, H. Shima, and C. Chang. 1998. From estrogen to androgen receptor: a new pathway for sex hormones in prostate. Proc. Natl. Acad. Sci. USA 95:5527-5532.
82. Yeh, S. Y., and C. S. Chang. 1996. Cloning and characterization of a specific coactivator, ARA(70), for the androgen receptor in human prostate cells. Proc. Natl. Acad. Sci. USA 93:5517-5521.
83. Zhou, Z.-X., M. V. Lane, J. A. Kemppainen, F. S. French, and E. M. Wilson. 1995. Specificity of ligand-dependent androgen receptor stabilization: receptor domain interactions influence ligand dissociation and receptor stability. Mol. Endocrinol. 9:208-218.
84. Zhou, Z.-X., M. Sar, J. A. Simental, M. V. Lane, and E. M. Wilson. 1994. A ligand-dependent bipartite nuclear targeting signal in the human androgen receptor. J. Biol. Chem. 269:13115-13123.