Identification of the major oxidative 3α-hydroxysteroid dehydrogenase in human prostate that converts 5α-androstane-3α,17β-diol to 5α-dihydrotestosterone: A potential therapeutic target for androgen-dependent disease

Molecular Endocrinology

Volumn 20, Issue 2, 2006, Pages 444-458

  Bauman, David R ^a   Steckelbroeck, Stephan ^a   Williams, Michelle V ^a   Peehl, Donna M ^b   Penning, Trevor M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3ALPHA HYDROXYSTEROID DEHYDROGENASE; ANDROGEN; ANDROSTANEDIOL; ANDROSTANOLONE; RETINOL DEHYDROGENASE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CATALYSIS; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; HORMONE METABOLISM; HUMAN; HUMAN CELL; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROSTATE; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; REDUCTION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEADY STATE; STROMA CELL; TISSUE DISTRIBUTION;

3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (B-SPECIFIC); ANDROGENS; ANDROSTANE-3,17-DIOL; ANIMALS; CELLS, CULTURED; DIHYDROTESTOSTERONE; FATTY ACID SYNTHETASE COMPLEX; HUMANS; MALE; NADH, NADPH OXIDOREDUCTASES; PROSTATE; PROSTATIC DISEASES; RECEPTORS, ANDROGEN; TRANS-ACTIVATION (GENETICS); TRANSFECTION;

ANIMALIA; MAMMALIA;

EID: 31444440675     PISSN: 08888809     EISSN: 08888809     Source Type: Journal    
DOI: 10.1210/me.2005-0287     Document Type: Article

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