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Volumn 13, Issue 3, 1999, Pages 440-454

Distinguishing androgen receptor agonists and antagonists: Distinct mechanisms of activation by medroxyprogesterone acetate and dihydrotestosterone

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ANDROSTANOLONE; ANTIANDROGEN; CYPROTERONE ACETATE; ESTRADIOL; FLUOXYMESTERONE; HYDROXYFLUTAMIDE; MEDROXYPROGESTERONE ACETATE; METRIBOLONE; MIBOLERONE; OXANDROLONE; RU 56187; TESTOSTERONE; UNCLASSIFIED DRUG;

EID: 0032935119     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.13.3.0255     Document Type: Article
Times cited : (186)

References (67)
  • 2
    • 0030981923 scopus 로고    scopus 로고
    • Environmental antiandrogens: Developmental effects, molecular mechanisms and clinical implications
    • 2. Kelce WR, Wilson EM 1997 Environmental antiandrogens: developmental effects, molecular mechanisms and clinical implications. J Mol Med 75:198-207
    • (1997) J Mol Med , vol.75 , pp. 198-207
    • Kelce, W.R.1    Wilson, E.M.2
  • 3
    • 0025974356 scopus 로고
    • Carcinoma of the prostate
    • 3. Gittes RF 1991 Carcinoma of the prostate. N Engl J Med 324:236-245
    • (1991) N Engl J Med , vol.324 , pp. 236-245
    • Gittes, R.F.1
  • 4
    • 0029560494 scopus 로고
    • Evidence for an anti-parallel orientation of the ligand-activated human androgen receptor dimer
    • 4. Langley E, Zhou ZX, Wilson EM 1995 Evidence for an anti-parallel orientation of the ligand-activated human androgen receptor dimer. J Biol Chem 270:29983-29990
    • (1995) J Biol Chem , vol.270 , pp. 29983-29990
    • Langley, E.1    Zhou, Z.X.2    Wilson, E.M.3
  • 5
    • 0029616211 scopus 로고
    • Ligand-dependent, transcriptionally productive association of the amino- and carboxyl-terminal regions of a steroid hormone nuclear receptor
    • 5. Kraus WL, McInerney EM, Katzenellenbogen BS 1995 Ligand-dependent, transcriptionally productive association of the amino- and carboxyl-terminal regions of a steroid hormone nuclear receptor. Proc Natl Acad Sci USA 92:12314-12318
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 12314-12318
    • Kraus, W.L.1    McInerney, E.M.2    Katzenellenbogen, B.S.3
  • 6
    • 0031594713 scopus 로고    scopus 로고
    • 2-/carboxyl-terminal interactions in androgen receptor dimerization revealed by mutations that cause androgen insensitivity
    • 2-/carboxyl-terminal interactions in androgen receptor dimerization revealed by mutations that cause androgen insensitivity. J Biol Chem 273:92-101
    • (1998) J Biol Chem , vol.273 , pp. 92-101
    • Langley, E.1    Kemppainen, J.A.2    Wilson, E.M.3
  • 8
    • 0000814012 scopus 로고
    • Receptor binding as a tool in the development of new bioactive steroids
    • Ariens EJ (ed) Academic Press, New York
    • 8. Raynaud JP, Ojasoo T, Bouton MM, Philibert D 1979 Receptor binding as a tool in the development of new bioactive steroids. In: Ariens EJ (ed) Drug Design. Academic Press, New York, vol 8:169-214
    • (1979) Drug Design , vol.8 , pp. 169-214
    • Raynaud, J.P.1    Ojasoo, T.2    Bouton, M.M.3    Philibert, D.4
  • 10
    • 0022262769 scopus 로고
    • 3H19-nortestosterone for the estimation of androgen receptor in rat liver cytosol
    • 3H]19-nortestosterone for the estimation of androgen receptor in rat liver cytosol. J Steroid Biochem 23:121-123
    • (1985) J Steroid Biochem , vol.23 , pp. 121-123
    • Bannister, P.1    Sheridan, P.2    Losowsky, M.S.3
  • 11
    • 0021083304 scopus 로고
    • Progestins can mimic, inhibit and potentiate the actions of androgens
    • 11. Bardin CW, Brown T, Isomaa W, Janne OA 1984 Progestins can mimic, inhibit and potentiate the actions of androgens. Pharmacol Ther 23:443-459
    • (1984) Pharmacol Ther , vol.23 , pp. 443-459
    • Bardin, C.W.1    Brown, T.2    Isomaa, W.3    Janne, O.A.4
  • 12
    • 0016295796 scopus 로고
    • Synandrogenic and antiandrogenic effect of progestins: Comparison with nonprogestational antiandrogens
    • 12. Mowszowicz I, Bieber DE, Chung KW, Bullock LP, Bardin CW 1974 Synandrogenic and antiandrogenic effect of progestins: comparison with nonprogestational antiandrogens. Endocrinology 95:1589-1599
    • (1974) Endocrinology , vol.95 , pp. 1589-1599
    • Mowszowicz, I.1    Bieber, D.E.2    Chung, K.W.3    Bullock, L.P.4    Bardin, C.W.5
  • 15
    • 0028347104 scopus 로고
    • RU 58841, a new specific topical antiandrogen: A candidate of choice for the treatment of acne, androgenic alopecia and hirsutism
    • 15. Battmann T, Bonfils A, Branche C, Humbert J, Goubet F, Teutsch G, Philibert D 1994 RU 58841, a new specific topical antiandrogen: a candidate of choice for the treatment of acne, androgenic alopecia and hirsutism. J Steroid Biochem Mol Biol 48:55-60
    • (1994) J Steroid Biochem Mol Biol , vol.48 , pp. 55-60
    • Battmann, T.1    Bonfils, A.2    Branche, C.3    Humbert, J.4    Goubet, F.5    Teutsch, G.6    Philibert, D.7
  • 16
    • 0030200951 scopus 로고    scopus 로고
    • Agonist and antagonist activities of hydroxyflutamide and casodex relate to androgen receptor stabilization
    • 16. Kemppainen JA, Wilson EM 1996 Agonist and antagonist activities of hydroxyflutamide and casodex relate to androgen receptor stabilization. Urology 48:157-163
    • (1996) Urology , vol.48 , pp. 157-163
    • Kemppainen, J.A.1    Wilson, E.M.2
  • 17
    • 0024208947 scopus 로고
    • Many transcription factors interact synergistically with steroid receptors
    • 17. Schule R, Muller M, Kaltschmidt C, Renkawitz R 1988 Many transcription factors interact synergistically with steroid receptors. Science 242:1418-1420
    • (1988) Science , vol.242 , pp. 1418-1420
    • Schule, R.1    Muller, M.2    Kaltschmidt, C.3    Renkawitz, R.4
  • 18
    • 0024002556 scopus 로고
    • Luciferase reporter gene vectors for analysis of promoters and enhancers
    • 18. Nordeen SK 1988 Luciferase reporter gene vectors for analysis of promoters and enhancers. Biotechniques 6:454-458
    • (1988) Biotechniques , vol.6 , pp. 454-458
    • Nordeen, S.K.1
  • 19
    • 0025174830 scopus 로고
    • Synthetic progestins stimulate prostatic binding protein messenger RNAs in the rat ventral prostate
    • 19. Labrie C, Simard J, Zhao HF, Pelletier G, Labrie F 1990 Synthetic progestins stimulate prostatic binding protein messenger RNAs in the rat ventral prostate. Mol Cell Endocrinol 68:169-179
    • (1990) Mol Cell Endocrinol , vol.68 , pp. 169-179
    • Labrie, C.1    Simard, J.2    Zhao, H.F.3    Pelletier, G.4    Labrie, F.5
  • 22
    • 0028809317 scopus 로고
    • Specificity of ligand dependent androgen receptor stabilization: Receptor domain interactions influence ligand dissociation and receptor stability
    • 22. Zhou ZX, Lane MV, Kemppainen JA, French FS, Wilson EM 1995 Specificity of ligand dependent androgen receptor stabilization: receptor domain interactions influence ligand dissociation and receptor stability. Mol Endocrinol 9:208-218
    • (1995) Mol Endocrinol , vol.9 , pp. 208-218
    • Zhou, Z.X.1    Lane, M.V.2    Kemppainen, J.A.3    French, F.S.4    Wilson, E.M.5
  • 23
    • 0013534472 scopus 로고    scopus 로고
    • Deleted in proof
    • 23. Deleted in proof
  • 26
    • 0029123855 scopus 로고
    • Androgen receptor antagonist versus agonist activities of the fungicide vinclozolin relative to hydroxyflutamide
    • 26. Wong CI, Kelce WR, Sar M, Wilson EM 1995 Androgen receptor antagonist versus agonist activities of the fungicide vinclozolin relative to hydroxyflutamide. J Biol Chem 270:19998-20003
    • (1995) J Biol Chem , vol.270 , pp. 19998-20003
    • Wong, C.I.1    Kelce, W.R.2    Sar, M.3    Wilson, E.M.4
  • 27
    • 0026595896 scopus 로고
    • Androgen receptor phosphorylation, turnover, nuclear transport and transcriptional activation: Specificity for steroids and antihormones
    • 27. Kemppainen JA, Lane MV, Sar M, Wilson EM 1992 Androgen receptor phosphorylation, turnover, nuclear transport and transcriptional activation: specificity for steroids and antihormones. J Biol Chem 267:968-974
    • (1992) J Biol Chem , vol.267 , pp. 968-974
    • Kemppainen, J.A.1    Lane, M.V.2    Sar, M.3    Wilson, E.M.4
  • 28
    • 0021078559 scopus 로고
    • Interaction of medroxyprogesterone acetate with cytosol androgen receptors in the rat hypothalamus and pituitary
    • 28. Pérez-Palacios G, Chvez B, Vilchis F, Escobar N, Larrea F, Pérez AE 1983 Interaction of medroxyprogesterone acetate with cytosol androgen receptors in the rat hypothalamus and pituitary. J Steroid Biochem 19:1729-1735
    • (1983) J Steroid Biochem , vol.19 , pp. 1729-1735
    • Pérez-Palacios, G.1    Chvez, B.2    Vilchis, F.3    Escobar, N.4    Larrea, F.5    Pérez, A.E.6
  • 29
    • 0018069695 scopus 로고
    • Androgenic, antiandrogenic, and synandrogenic actions of progestins: Role of steric and allosteric interactions with androgen receptors
    • 29. Bullock LP, Bardin CW, Sherman MR 1978 Androgenic, antiandrogenic, and synandrogenic actions of progestins: role of steric and allosteric interactions with androgen receptors. Endocrinology 103:1768-1782
    • (1978) Endocrinology , vol.103 , pp. 1768-1782
    • Bullock, L.P.1    Bardin, C.W.2    Sherman, M.R.3
  • 30
    • 0018336437 scopus 로고
    • In vivo metabolism and binding of 6α-methylprogesterone: A progestin with anti-androgenic and synandrogenic activities
    • Clark JH, Leavitt WW (eds) Plenum, New York
    • 30. Brown TR, Bullock LP, Bardin CW 1979 In vivo metabolism and binding of 6α-methylprogesterone: a progestin with anti-androgenic and synandrogenic activities. In: Clark JH, Leavitt WW (eds) Steroid Hormone Receptor Systems. Plenum, New York, pp 269-280
    • (1979) Steroid Hormone Receptor Systems , pp. 269-280
    • Brown, T.R.1    Bullock, L.P.2    Bardin, C.W.3
  • 31
    • 0018774198 scopus 로고
    • Action of a non-steroidal antiandrogen, RU 23908, in peripheral and central tissues
    • 31. Raynaud JP, Bonne C, Bouton MM, Lagace L, Labrie F 1979 Action of a non-steroidal antiandrogen, RU 23908, in peripheral and central tissues. J Steroid Biochem 11:93-99
    • (1979) J Steroid Biochem , vol.11 , pp. 93-99
    • Raynaud, J.P.1    Bonne, C.2    Bouton, M.M.3    Lagace, L.4    Labrie, F.5
  • 32
    • 0018077518 scopus 로고
    • Steroid structure and function. II. Conformational transmission and receptor binding of medroxyprogesterone acetate
    • 32. Duax WL, Cody V, Griffin J, Hazel J, Weeks CM 1978 Steroid structure and function. II. Conformational transmission and receptor binding of medroxyprogesterone acetate. J Steroid Biochem 9:901-907
    • (1978) J Steroid Biochem , vol.9 , pp. 901-907
    • Duax, W.L.1    Cody, V.2    Griffin, J.3    Hazel, J.4    Weeks, C.M.5
  • 34
    • 0016190571 scopus 로고
    • Affinities of progestogen and estrogen receptors in rabbit uterus for synthetic progestins
    • 34. Terenius L 1974 Affinities of progestogen and estrogen receptors in rabbit uterus for synthetic progestins. Steroids 23:909-918
    • (1974) Steroids , vol.23 , pp. 909-918
    • Terenius, L.1
  • 35
    • 0015174948 scopus 로고
    • Adverse effects of large doses of medroxyprogesterone (MPA) in idiopathic isosexual precocity
    • 35. Richman RA, Underwood LE, French FS, Van Wyk JJ 1971 Adverse effects of large doses of medroxyprogesterone (MPA) in idiopathic isosexual precocity. J Pediatr 79:963-971
    • (1971) J Pediatr , vol.79 , pp. 963-971
    • Richman, R.A.1    Underwood, L.E.2    French, F.S.3    Van Wyk, J.J.4
  • 36
    • 0020486575 scopus 로고
    • Medroxyprogesterone in in vitro fertilization
    • 36. Barlow SM 1982 Medroxyprogesterone in in vitro fertilization. Lancet 2:1408
    • (1982) Lancet , vol.2 , pp. 1408
    • Barlow, S.M.1
  • 37
    • 0020664213 scopus 로고
    • Teratogenic effects of Silastic intrauterine devices in the rat with or without added medroxyprogesterone acetate
    • 37. Barlow SM, Knight AF 1983 Teratogenic effects of Silastic intrauterine devices in the rat with or without added medroxyprogesterone acetate. Fertil Steril 39:224-230
    • (1983) Fertil Steril , vol.39 , pp. 224-230
    • Barlow, S.M.1    Knight, A.F.2
  • 38
    • 0001363142 scopus 로고
    • Gonadal hormones and the perinatal development of neuroendocrine function
    • Martini L, Ganong WF (eds) Oxford University Press, New York
    • 38. Gorski RA 1971 Gonadal hormones and the perinatal development of neuroendocrine function. In: Martini L, Ganong WF (eds) Frontiers in Neuroendocrinology. Oxford University Press, New York, pp 237-282
    • (1971) Frontiers in Neuroendocrinology , pp. 237-282
    • Gorski, R.A.1
  • 39
    • 0019191862 scopus 로고
    • Congenital abnormalities and hormones during pregnancy: A clinical review
    • 39. Schardein JL 1980 Congenital abnormalities and hormones during pregnancy: a clinical review. Teratology 22:251-270
    • (1980) Teratology , vol.22 , pp. 251-270
    • Schardein, J.L.1
  • 40
    • 0018854496 scopus 로고
    • Estrogen, androgen, glucocorticoid, and progesterone receptors in progestin-induced regression of human breast cancer
    • 40. Teulings FAG, van Gilse HA, Henkelman MS, Portengen H, Alexieva-Figusch J 1980 Estrogen, androgen, glucocorticoid, and progesterone receptors in progestin-induced regression of human breast cancer. Cancer Res 40:2557-2561
    • (1980) Cancer Res , vol.40 , pp. 2557-2561
    • Teulings, F.A.G.1    Van Gilse, H.A.2    Henkelman, M.S.3    Portengen, H.4    Alexieva-Figusch, J.5
  • 42
    • 0027298799 scopus 로고
    • Medroxyprogesterone acetate inhibits the proliferation of estrogen and progesterone receptor negative MFM-223 human mammary cancer cells via the androgen receptor
    • 42. Hackenberg R, Hawighorst T, Filmer A, Nia AH, Schulz KD 1993 Medroxyprogesterone acetate inhibits the proliferation of estrogen and progesterone receptor negative MFM-223 human mammary cancer cells via the androgen receptor. Breast Cancer Res Treat 25:217-224
    • (1993) Breast Cancer Res Treat , vol.25 , pp. 217-224
    • Hackenberg, R.1    Hawighorst, T.2    Filmer, A.3    Nia, A.H.4    Schulz, K.D.5
  • 43
    • 0029055265 scopus 로고
    • Medroxyprogesterone acetate therapy in advanced breast cancer: The predictive value of androgen receptor expression
    • 43. Birrell SN, Roder DM, Horsfall DJ, Bentel JM, Tilley WD 1995 Medroxyprogesterone acetate therapy in advanced breast cancer: the predictive value of androgen receptor expression. J Clin Oncol 13:1572-1577
    • (1995) J Clin Oncol , vol.13 , pp. 1572-1577
    • Birrell, S.N.1    Roder, D.M.2    Horsfall, D.J.3    Bentel, J.M.4    Tilley, W.D.5
  • 44
    • 0027473495 scopus 로고
    • Androgen receptor mediated stimulation of 17α-hydroxysteroid dehydrogenase activity by dihydrotestosterone and medroxyprogesterone acetate in ZR-75-1 human breast cancer cells
    • 44. Couture P, Thériault C, Simard J, Labrie F 1993 Androgen receptor mediated stimulation of 17α-hydroxysteroid dehydrogenase activity by dihydrotestosterone and medroxyprogesterone acetate in ZR-75-1 human breast cancer cells. Endocrinology 132:179-185
    • (1993) Endocrinology , vol.132 , pp. 179-185
    • Couture, P.1    Thériault, C.2    Simard, J.3    Labrie, F.4
  • 46
    • 0028222529 scopus 로고
    • Reviews of trimetrexate and oxandrolone
    • 46. Levien TL, Baker DE 1994 Reviews of trimetrexate and oxandrolone. Hosp Pharm 29:696-707
    • (1994) Hosp Pharm , vol.29 , pp. 696-707
    • Levien, T.L.1    Baker, D.E.2
  • 47
    • 0021794301 scopus 로고
    • Oxandrolone in low dose for constitutional delay of growth and puberty in boys
    • 47. Stanhope S, Brook C 1985 Oxandrolone in low dose for constitutional delay of growth and puberty in boys. Arch Dis Child 60:379-381
    • (1985) Arch Dis Child , vol.60 , pp. 379-381
    • Stanhope, S.1    Brook, C.2
  • 48
    • 0023575406 scopus 로고
    • Oxandrolone therapy in boys of short stature
    • 48. Hochberg Z, Korman S 1987 Oxandrolone therapy in boys of short stature. J Pediatr Endocrinol 2:115-120
    • (1987) J Pediatr Endocrinol , vol.2 , pp. 115-120
    • Hochberg, Z.1    Korman, S.2
  • 49
    • 0027478061 scopus 로고
    • Long-term results of treatment with low-dose fluoxymesterone in constitutional delay of growth and puberty and in genetic short stature
    • 49. Strickland AL 1993 Long-term results of treatment with low-dose fluoxymesterone in constitutional delay of growth and puberty and in genetic short stature. Pediatrics 91:716-720
    • (1993) Pediatrics , vol.91 , pp. 716-720
    • Strickland, A.L.1
  • 50
    • 0018404331 scopus 로고
    • Oxandrolone therapy in patients with Turner's syndrome
    • 50. Urban M, Lee P, Dorst J, Plotnick M, Migeon C 1979 Oxandrolone therapy in patients with Turner's syndrome. J Pediatr 94:823-827
    • (1979) J Pediatr , vol.94 , pp. 823-827
    • Urban, M.1    Lee, P.2    Dorst, J.3    Plotnick, M.4    Migeon, C.5
  • 51
    • 0029012842 scopus 로고
    • Treatment of patients with Ullrich-Turner syndrome with conventional doses of growth hormone and the combination with testosterone or oxandrolone: Effect on growth, IGF-1 and IGFBP-3 concentrations
    • 51. Haeusler G, Frisch H, Schmitt K, Blümel P, Plöchl E, Zachmann, Waldhör T 1995 Treatment of patients with Ullrich-Turner syndrome with conventional doses of growth hormone and the combination with testosterone or oxandrolone: effect on growth, IGF-1 and IGFBP-3 concentrations. Eur J Pediatr 154:437-444
    • (1995) Eur J Pediatr , vol.154 , pp. 437-444
    • Haeusler, G.1    Frisch, H.2    Schmitt, K.3    Blümel, P.4    Plöchl, E.5    Zachmann6    Waldhör, T.7
  • 52
    • 0029643780 scopus 로고
    • Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid
    • 52. Renaud JP, Rochel N, Ruff M, Vivat V, Chambon P, Gronemeyer H, Moras D 1995 Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid. Nature 378:681-689
    • (1995) Nature , vol.378 , pp. 681-689
    • Renaud, J.P.1    Rochel, N.2    Ruff, M.3    Vivat, V.4    Chambon, P.5    Gronemeyer, H.6    Moras, D.7
  • 55
    • 0029012163 scopus 로고
    • Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α
    • 55. Bourguet W, Ruff M, Chambon P, Gronemeyer H, Moras D 1995 Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α. Nature 375:377-382
    • (1995) Nature , vol.375 , pp. 377-382
    • Bourguet, W.1    Ruff, M.2    Chambon, P.3    Gronemeyer, H.4    Moras, D.5
  • 57
    • 0031039480 scopus 로고    scopus 로고
    • Functional in vivo interaction between the amino-terminal, transactivation domain and the ligand binding domain of the androgen receptor
    • 57. Doesburg P, Kuil CW, Berrevoets CA, Steketee K, Faber PW, Mulder E, Brinkmann AO, Trapman J 1997 Functional in vivo interaction between the amino-terminal, transactivation domain and the ligand binding domain of the androgen receptor. Biochemistry 36:1052-1064
    • (1997) Biochemistry , vol.36 , pp. 1052-1064
    • Doesburg, P.1    Kuil, C.W.2    Berrevoets, C.A.3    Steketee, K.4    Faber, P.W.5    Mulder, E.6    Brinkmann, A.O.7    Trapman, J.8
  • 58
    • 0030955767 scopus 로고    scopus 로고
    • Hinge and amino-terminal sequences contribute to solution dimerization of human progesterone receptor
    • 58. Tetel MJ, Jung S, Carbajo P, Ladtkow T, Skafar DF, Edwards DP 1997 Hinge and amino-terminal sequences contribute to solution dimerization of human progesterone receptor. Mol Endocrinol 11:1114-1128
    • (1997) Mol Endocrinol , vol.11 , pp. 1114-1128
    • Tetel, M.J.1    Jung, S.2    Carbajo, P.3    Ladtkow, T.4    Skafar, D.F.5    Edwards, D.P.6
  • 59
    • 0028228821 scopus 로고
    • Environmental hormone disruptors: Evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolites
    • 59. Kelce WR, Monosson E, Gamcsik MP, Laws SC, Gray LE 1994 Environmental hormone disruptors: evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolites. Toxicol Appl Pharmacol 126:276-285
    • (1994) Toxicol Appl Pharmacol , vol.126 , pp. 276-285
    • Kelce, W.R.1    Monosson, E.2    Gamcsik, M.P.3    Laws, S.C.4    Gray, L.E.5
  • 60
    • 0024571802 scopus 로고
    • Transcription activation by the adenovirus E1a protein
    • 60. Lillie JW, Green MR 1989 Transcription activation by the adenovirus E1a protein. Nature 338:39-44
    • (1989) Nature , vol.338 , pp. 39-44
    • Lillie, J.W.1    Green, M.R.2
  • 62
    • 0017089430 scopus 로고
    • Binding properties of androgen receptors: Evidence for identical receptors in rat testis, epididymis and prostate
    • 62. Wilson EM, French FS 1976 Binding properties of androgen receptors: evidence for identical receptors in rat testis, epididymis and prostate. J Biol Chem 251:5620-5629
    • (1976) J Biol Chem , vol.251 , pp. 5620-5629
    • Wilson, E.M.1    French, F.S.2
  • 63
    • 0021686004 scopus 로고
    • The use of radioactive 7α, 17α-dimethyl-19-nortestosterone (mibolerone) in the assay of androgen receptors
    • 63. Schilling K, Liao S 1984 The use of radioactive 7α, 17α-dimethyl-19-nortestosterone (mibolerone) in the assay of androgen receptors. Prostate 5:581-588
    • (1984) Prostate , vol.5 , pp. 581-588
    • Schilling, K.1    Liao, S.2
  • 64
    • 0016774967 scopus 로고
    • Methyltrienolone, a specific ligand for cellular androgen receptors
    • 64. Bonne C, Raynaud JP 1975 Methyltrienolone, a specific ligand for cellular androgen receptors. Steroids 26:227-232
    • (1975) Steroids , vol.26 , pp. 227-232
    • Bonne, C.1    Raynaud, J.P.2
  • 65
    • 0014541589 scopus 로고
    • Antagonistic action of anti-androgens on the formation of a specific dihydrotestosterone-receptor protein complex in rat ventral prostate
    • 65. Fang S, Liao S 1969 Antagonistic action of anti-androgens on the formation of a specific dihydrotestosterone-receptor protein complex in rat ventral prostate. Mol Pharmacol 5:428-431
    • (1969) Mol Pharmacol , vol.5 , pp. 428-431
    • Fang, S.1    Liao, S.2
  • 66
    • 0015377166 scopus 로고
    • A biological profile of a nonsteroidal antiandrogen, SCH 13521 (4′-nitro-3′-trifluoromethylisobutyranilide)
    • 66. Neri R, Florance K, Koziol P, S Van Cleave 1972 A biological profile of a nonsteroidal antiandrogen, SCH 13521 (4′-nitro-3′-trifluoromethylisobutyranilide). Endocrinology 91:427-437
    • (1972) Endocrinology , vol.91 , pp. 427-437
    • Neri, R.1    Florance, K.2    Koziol, P.3    Van Cleave, S.4
  • 67
    • 0016365709 scopus 로고
    • Action of a nonsteroidal antiandrogen, flutamide, on the receptor binding and nuclear retention of 5α-dihydrotestosterone in rat ventral prostate
    • 67. Liao S, Howell DK, Chang TM 1974 Action of a nonsteroidal antiandrogen, flutamide, on the receptor binding and nuclear retention of 5α-dihydrotestosterone in rat ventral prostate. Endocrinology 94:1205-1209
    • (1974) Endocrinology , vol.94 , pp. 1205-1209
    • Liao, S.1    Howell, D.K.2    Chang, T.M.3


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