Structural basis for antagonism and resistance of bicalutamide in prostate cancer

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 17, 2005, Pages 6201-6206

  Bohl, Casey E ^a   Gao, Wenqing ^a   Miller, Duane D ^b   Bell, Charles E ^c   Dalton, James T ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Androgen receptor; Crystallography

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANOLONE; ANTIANDROGEN; BICALUTAMIDE; INDOLE;

ARTICLE; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG RESISTANCE; DRUG STRUCTURE; HUMAN; LIGAND BINDING; MUTATION; PRIORITY JOURNAL; PROSTATE CANCER; WITHDRAWAL SYNDROME;

AMINO ACID SEQUENCE; ANDROGEN ANTAGONISTS; ANILIDES; ANTINEOPLASTIC AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, NEOPLASM; HUMANS; MALE; MODELS, MOLECULAR; PROSTATIC NEOPLASMS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, ANDROGEN;

EID: 17844376217     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0500381102     Document Type: Article

References (33)

1. Anonymous (1989) Med. Lett. Drugs Ther. 31, 72 (Clinical trial).
2. Anonymous (1996) Am. J. Health Syst. Pharm. 53, 2784 (News).
3. Kolvenbag, G. J. & Furr, B. J. (1999) Urology 54, 194-197.
4. Kolvenbag, G. J. & Blackledge, G. R. (1996) Urology 47, 70-79, discussion 80-84.
5. Schellhammer, P. F. & Davis, J. W. (2004) Clin. Prostate Cancer 2, 213-219.
6. Fradet, Y. (2004) Expert Rev. Anticancer Ther. 4, 37-48.
7. See, W. A., Wirth, M. P., McLeod, D. G., Iversen, P., Klimberg, I., Gleason, D., Chodak, G., Montie, J., Tyrrell, C., Wallace, D. M., et al. (2002) J. Urol. 168, 429-435.
8. Akaza, H., Yamaguchi, A., Matsuda, T., Igawa, M., Kumon, H., Soeda, A., Arai, Y., Usami, M., Naito, S., Kanetake, H. & Ohashi, Y. (2004) Jpn. J. Clin. Oncol. 34, 20-28.
9. Smith, M. R., Goode, M., Zietman, A. L., McGovern, F. J., Lee, H. & Finkelstein, J. S. (2004) J. Clin. Oncol. 22, 2546-2553.
10. Iversen, P. (2003) J. Urol. 170, S48-S52; discussion S52-S4.
11. Iversen, P., Johansson, J. E., Lodding, P., Lukkarinen, O., Lundmo, P., Klarskov, P., Tammela, T. L., Tasdemir, I., Morris, T. & Carroll, K. (2004) J. Urol. 172, 1871-1876.
12. Wirth, M. P., See, W. A., McLeod, D. G., Iversen, P., Morris, T. & Carroll, K. (2004) J. Urol. 172, 1865-1870.
13. Scher, H. I., Steineck, G. & Kelly, W. K. (1995) Urology 46, 142-148.
14. Suzuki, H., Akakura, K., Komiya, A., Aida, S., Akimoto, S. & Shimazaki, J. (1996) Prostate 29, 153-158.
15. Hara, T., Miyazaki, J., Araki, H., Yamaoka, M., Kanzaki, N., Kusaka, M. & Miyamoto, M. (2003) Cancer Res. 63, 149-153.
16. Bohl, C. E., Chang, C., Mohler, M. L., Chen, J., Miller, D. D., Swaan, P. W. & Dalton, J. T. (2004) J. Med. Chem. 47, 3765-3776.
17. Mukherjee, A., Kirkovsky, L., Yao, X. T., Yates, R. C., Miller, D. D. & Dalton, J. T. (1996) Xenobiotica 26, 117-122.
18. Matias, P. M., Donner, P., Coelho, R., Thomaz, M., Peixoto, C., Macedo, S., Otto, N., Joschko, S., Scholz, P., Wegg, A., et al. (2000) J. Biol. Chem. 275, 26164-26171.
19. Hur, E., Pfaff, S. J., Payne, E. S., Gron, H., Buehrer, B. M. & Fletterick, R. J. (2004) PLoS Biol. 2, E274.
20. Dalton, J. T., Mukherjee, A., Zhu, Z., Kirkovsky, L. & Miller, D. D. (1998) Biochem. Biophys. Res. Commun. 244, 1-4.
21. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., et al. (1998) Acta Crystallogr. D 54, 905-921.
22. Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjeldgaard (1991) Acta Crystallogr. A 47, 110-119.
23. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950.
24. Merritt, E. A. & Murphy, M. E. (1994) Acta Crystallogr. D 50, 869-873.
25. Matias, P. M., Carrondo, M. A., Coelho, R., Thomaz, M., Zhao, X. Y., Wegg, A., Crusius, K., Egner, U. & Donner, P. (2002) J. Med. Chem. 45, 1439-1446.
26. Sack, J. S., Kish, K. F., Wang, C., Attar, R. M., Kiefer, S. E., An, Y., Wu, G. Y., Scheffler, J. E., Salvati, M. E., Krystek, S. R., Jr., et al. (2001) Proc. Natl. Acad. Sci. USA 98, 4904-4909.
27. Tucker, H., Crook, J. W. & Chesterson, G. J. (1988) J. Med. Chem. 31, 954-959.
28. He, B., Gampe, R. T., Jr., Kole, A. J., Hnat, A. T., Stanley, T. B., An, G., Stewart, E. L., Kalman, R. I., Minges, J. T. & Wilson, E. M. (2004) Mol. Cell 16, 425-438.
29. Masiello, D., Cheng, S., Bubley, G. J., Lu, M. L. & Balk, S. P. (2002) J. Biol. Chem. 277, 26321-26326.
30. Yin, D., He, Y., Perera, M. A., Hong, S. S., Marhefka, C., Stourman, N., Kirkovsky, L., Miller, D. D. & Dalton, J. T. (2003) Mol. Pharmacol. 63, 211-223.
31. Marhefka, C. A., Gao, W., Chung, K., Kim, J., He, Y., Yin, D., Bohl, C., Dalton, J. T. & Miller, D. D. (2004) J. Med. Chem. 47, 993-998.
32. Chen, J., Hwang, D. J., Bohl, C. E., Miller, D. D. & Dalton, J. T. (2005) J. Pharmacol. Exp. Ther. 312, 546-553.
33. Gao, W., Kearbey, J. D., Nair, V. A., Chung, K., Parlow, A. F., Miller, D. D. & Dalton, J. T. (2004) Endocrinology 145, 5420-5428.