DNA strand breaks and hypoxia response inhibition mediate the radiosensitisation effect of nitric oxide donors on prostate cancer under varying oxygen conditions

Biochemical Pharmacology

Volumn 81, Issue 2, 2011, Pages 203-210

  Stewart, Grant D ^a,b   Nanda, Jyoti ^a   Katz, Elad ^a   Bowman, Karen J ^b   Christie, Jill G ^c   Brown, D J Gordon ^a   McLaren, Duncan B ^c   Riddick, Antony C P ^a   Ross, James A ^a   Jones, George D D ^b   Habib, Fouad K ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

^c WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

Hypoxia; Nitric oxide donors; Prostate cancer; Radiation; Radiosensitisation

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; NITRIC OXIDE DONOR; NONSTEROID ANTIINFLAMMATORY AGENT; SULINDAC;

ARTICLE; CELL HYPOXIA; CELL LEVEL; CLONOGENIC ASSAY; DNA REPAIR; DNA STRAND BREAKAGE; DRUG MECHANISM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CANCER; RADIATION DOSE; RADIOSENSITIVITY; STROMA;

ANOXIA; ANTINEOPLASTIC AGENTS; CELL LINE; DNA BREAKS; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, RADIATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; NITRIC OXIDE; NITRIC OXIDE DONORS; OXYGEN; PROSTATE; PROSTATIC NEOPLASMS; RADIATION-SENSITIZING AGENTS; STROMAL CELLS;

EID: 78650178547     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.09.022     Document Type: Article

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