Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in Zebrafish (Danio rerio)

Aquatic Toxicology

Volumn 142-143, Issue , 2013, Pages 447-457

  Bainy, Afonso C D ^a,b   Kubota, Akira ^a   Goldstone, Jared V ^a   Lille Langøy, Roger ^c   Karchner, Sibel I ^a   Celander, Malin C ^d   Hahn, Mark E ^a   Goksøyr, Anders ^c   Stegeman, John J ^a  

^a WOODS HOLE OCEANOGRAPHIC INSTITUTION   (United States)

^b FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^c UNIVERSITY OF BERGEN   (Norway)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Cytochrome P450; Pregnane X receptor; Steroid xenobiotic receptor; Zebrafish

Indexed keywords

16ALPHA CYANOPREGNENOLONE; CLOTRIMAZOLE; COMPLEMENTARY DNA; CONSTITUTIVE ANDROSTANE RECEPTOR; PREGNANE X RECEPTOR;

ALLELE; CYPRINID; CYTOCHROME; DNA; GENE EXPRESSION; GENETIC ANALYSIS; PROTEIN; STEROID; XENOBIOTICS;

ADULT ANIMAL; ALLELE; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BRAIN; CONTROLLED STUDY; DNA BINDING; EYE; FEMALE; GENE EXPRESSION; GENETIC TRANSFECTION; GENETIC VARIABILITY; HEART; IN VIVO STUDY; INTESTINE; KIDNEY; LIGAND BINDING; LIVER; MALE; MOLECULAR CLONING; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PXR GENE; REAL TIME POLYMERASE CHAIN REACTION; REPORTER GENE; SEQUENCE HOMOLOGY; SYNTENY; ZEBRA FISH;

1,4-BIS [2-(3,5-DICHLOROPYRIDYLOXY)] BENZENE; ABC TRANSPORTERS; ARNT2; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; ATP-BINDING CASSETTE TRANSPORTERS; CAR; CLO; CLOTRIMAZOLE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYP; CYTOCHROME P450; DBD; DIMETHYLSULFOXIDE; DMSO; DNA BINDING DOMAIN; EF1Α; ELONGATION FACTOR 1Α; LBD; LIGAND BINDING DOMAIN; NIF; NIFEDIPINE; NR; NUCLEAR RECEPTOR; PB; PCN; PHENOBARBITAL; PREGNANE X RECEPTOR; PREGNENOLONE 16Α-CARBONITRILE; PXR; RACE; RAPID AMPLIFICATION OF CDNA ENDS; RETINOID X-RECEPTOR; RIF; RIFAMPICIN; RXR; SINGLE-NUCLEOTIDE POLYMORPHISMS; SNPS; STEROID XENOBIOTIC RECEPTOR; SXR; TCPOBOP; UNTRANSLATED REGION; UTR; VDR; VITAMIN D RECEPTOR; ZEBRAFISH;

ALLELES; ANIMALS; BRAIN; EYE; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE ORDER; LIVER; MALE; MOLECULAR SEQUENCE DATA; PHENOBARBITAL; PHYLOGENY; PROTEIN BINDING; PYRIDINES; RECEPTORS, STEROID; WATER POLLUTANTS, CHEMICAL; ZEBRAFISH;

EID: 84885414355     PISSN: 0166445X     EISSN: 18791514     Source Type: Journal    
DOI: 10.1016/j.aquatox.2013.09.014     Document Type: Article

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