The cytochrome P450 2AA gene cluster in zebrafish (Danio rerio): Expression of CYP2AA1 and CYP2AA2 and response to phenobarbital-type inducers

Toxicology and Applied Pharmacology

Volumn 272, Issue 1, 2013, Pages 172-179

  Kubota, Akira ^a   Bainy, Afonso C D ^a,b   Woodin, Bruce R ^a   Goldstone, Jared V ^a   Stegeman, John J ^a  

^a WOODS HOLE OCEANOGRAPHIC INSTITUTION   (United States)

^b FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

CYP2; Cytochrome P450; Homology modeling; Molecular evolution; Phenobarbital; Zebrafish

Indexed keywords

1,4 BIS(3,5 DICHLORO 2 PYRIDYLOXY)BENZENE; 16ALPHA CYANOPREGNENOLONE; CYTOCHROME P450; CYTOCHROME P450 2AA1; CYTOCHROME P450 2AA2; CYTOCHROME P450 2AA3; CYTOCHROME P450 2AA8; CYTOCHROME P450 2AA9; CYTOCHROME P450 2B; DIMETHYL SULFOXIDE; MESSENGER RNA; PHENOBARBITAL; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE CLUSTER; GENE DUPLICATION; GENE EXPRESSION; GENE MAPPING; GENE SEQUENCE; GENETIC CONSERVATION; INTESTINE; KIDNEY; LIVER; MALE; MAXIMUM LIKELIHOOD METHOD; MOLECULAR CLONING; MOLECULAR EVOLUTION; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PARSIMONY ANALYSIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; SEX DIFFERENCE; TISSUE DISTRIBUTION; UPREGULATION; WILD TYPE; ZEBRA FISH;

CYP2; CYTOCHROME P450; HOMOLOGY MODELING; MOLECULAR EVOLUTION; PHENOBARBITAL; ZEBRAFISH;

ANIMALS; BIOLOGICAL EVOLUTION; CLONING, MOLECULAR; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MALE; MODELS, MOLECULAR; ORGAN SPECIFICITY; PHENOBARBITAL; PREGNENOLONE CARBONITRILE; PYRIDINES; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; XENOBIOTICS; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84882772915     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.05.017     Document Type: Article

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